blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP3195857

EP3195857 - USE OF A TRP MODULATOR FOR THE PROPHYLAXIS AND/OR ALLEVIATING OF GRASS TETANY AND/OR PARTURIENT PARESIS IN TYLOPODA OR RUMINANTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.01.2020
Database last updated on 03.09.2024
FormerThe patent has been granted
Status updated on  25.01.2019
FormerGrant of patent is intended
Status updated on  08.10.2018
FormerRequest for examination was made
Status updated on  19.01.2018
FormerThe application has been published
Status updated on  23.06.2017
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK
published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
PerformaNat GmbH
Hohentwielsteig 6
14163 Berlin / DE
[2017/50]
Former [2017/30]For all designated states
Freie Universität Berlin
Kaiserswerther Strasse 16-18
14195 Berlin / DE
Inventor(s)01 / STUMPFF, Friederike
Schwanheimerstraße 8
12209 Berlin / DE
02 / ROSENDAHL, Julia
Fasanenstraße 35a
10719 Berlin / DE
03 / ASCHENBACH, Jörg
Blumenbogen 2a
04288 Leipzig / DE
 [2017/30]
Representative(s)Maikowski & Ninnemann Patentanwälte Partnerschaft mbB
Postfach 15 09 20
10671 Berlin / DE
[2017/30]
Application number, filing date17153072.831.07.2013
[2017/30]
Priority number, dateDE2012101502931.07.2012         Original published format: DE102012015029
[2017/30]
Filing languageDE
Procedural languageDE
PublicationType: A1 Application with search report 
No.:EP3195857
Date:26.07.2017
Language:DE
[2017/30]
Type: B1 Patent specification 
No.:EP3195857
Date:27.02.2019
Language:DE
[2019/09]
Search report(s)(Supplementary) European search report - dispatched on:EP28.06.2017
ClassificationIPC:A61K9/00, A61K31/045, A61K31/05, A61K31/11, A61K31/085, A61K31/122, A61K31/351, A61P1/00
[2018/31]
CPC:
A61K31/05 (EP,US); A23K20/10 (EP,US); A23K20/105 (EP,US);
A23K20/111 (EP,US); A23K50/10 (EP,US); A61K31/045 (EP,US);
A61P1/00 (EP); A61K9/0056 (EP,US) (-)
Former IPC [2017/30]A61K9/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/08]
Former [2017/30]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:VERWENDUNG EINES TRP-MODULATORS ZUR PROPHYLAXE UND/ODER LINDERUNG VON WEIDETETANIE UND/ODER GEBÄRPARESE BEI WIEDERKÄUERN ODER SCHWIELENSOHLERN[2017/30]
English:USE OF A TRP MODULATOR FOR THE PROPHYLAXIS AND/OR ALLEVIATING OF GRASS TETANY AND/OR PARTURIENT PARESIS IN TYLOPODA OR RUMINANTS[2017/30]
French:UTILISATION D'UN MODULATEUR TRP DE PROPHYLAXIE ET/OU D'ATTÉNUATION DE LA TÉTANIE D'HERBAGE ET/OU DE LA PARÉSIE POST-PARTUM CHEZ LES RUMINANTS OU LES TYLOPODES[2017/30]
Examination procedure25.01.2017Date on which the examining division has become responsible
03.01.2018Examination requested  [2018/08]
09.10.2018Communication of intention to grant the patent
14.01.2019Fee for grant paid
14.01.2019Fee for publishing/printing paid
14.01.2019Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP13744529.2  / EP2879662
Opposition(s)28.11.2019No opposition filed within time limit [2020/06]
Fees paidRenewal fee
02.02.2017Renewal fee patent year 03
02.02.2017Renewal fee patent year 04
07.07.2017Renewal fee patent year 05
01.06.2018Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU31.07.2013
AL27.02.2019
CY27.02.2019
CZ27.02.2019
EE27.02.2019
ES27.02.2019
FI27.02.2019
HR27.02.2019
LT27.02.2019
LV27.02.2019
MC27.02.2019
MK27.02.2019
MT27.02.2019
RO27.02.2019
RS27.02.2019
SE27.02.2019
SI27.02.2019
SK27.02.2019
SM27.02.2019
TR27.02.2019
BG27.05.2019
NO27.05.2019
GR28.05.2019
IS27.06.2019
PT27.06.2019
BE31.07.2019
LU31.07.2019
[2022/32]
Former [2021/34]HU31.07.2013
AL27.02.2019
CY27.02.2019
CZ27.02.2019
EE27.02.2019
ES27.02.2019
FI27.02.2019
HR27.02.2019
LT27.02.2019
LV27.02.2019
MC27.02.2019
MT27.02.2019
RO27.02.2019
RS27.02.2019
SE27.02.2019
SI27.02.2019
SK27.02.2019
SM27.02.2019
TR27.02.2019
BG27.05.2019
NO27.05.2019
GR28.05.2019
IS27.06.2019
PT27.06.2019
BE31.07.2019
LU31.07.2019
Former [2021/33]HU31.07.2013
AL27.02.2019
CY27.02.2019
CZ27.02.2019
EE27.02.2019
ES27.02.2019
FI27.02.2019
HR27.02.2019
LT27.02.2019
LV27.02.2019
MC27.02.2019
RO27.02.2019
RS27.02.2019
SE27.02.2019
SI27.02.2019
SK27.02.2019
SM27.02.2019
TR27.02.2019
BG27.05.2019
NO27.05.2019
GR28.05.2019
IS27.06.2019
PT27.06.2019
BE31.07.2019
LU31.07.2019
Former [2021/26]AL27.02.2019
CY27.02.2019
CZ27.02.2019
EE27.02.2019
ES27.02.2019
FI27.02.2019
HR27.02.2019
LT27.02.2019
LV27.02.2019
MC27.02.2019
RO27.02.2019
RS27.02.2019
SE27.02.2019
SI27.02.2019
SK27.02.2019
SM27.02.2019
TR27.02.2019
BG27.05.2019
NO27.05.2019
GR28.05.2019
IS27.06.2019
PT27.06.2019
BE31.07.2019
LU31.07.2019
Former [2020/26]AL27.02.2019
CZ27.02.2019
EE27.02.2019
ES27.02.2019
FI27.02.2019
HR27.02.2019
LT27.02.2019
LV27.02.2019
MC27.02.2019
RO27.02.2019
RS27.02.2019
SE27.02.2019
SI27.02.2019
SK27.02.2019
SM27.02.2019
TR27.02.2019
BG27.05.2019
NO27.05.2019
GR28.05.2019
IS27.06.2019
PT27.06.2019
BE31.07.2019
LU31.07.2019
Former [2020/17]AL27.02.2019
CZ27.02.2019
EE27.02.2019
ES27.02.2019
FI27.02.2019
HR27.02.2019
LT27.02.2019
LV27.02.2019
MC27.02.2019
RO27.02.2019
RS27.02.2019
SE27.02.2019
SI27.02.2019
SK27.02.2019
SM27.02.2019
TR27.02.2019
BG27.05.2019
NO27.05.2019
GR28.05.2019
IS27.06.2019
PT27.06.2019
Former [2020/14]AL27.02.2019
CZ27.02.2019
EE27.02.2019
ES27.02.2019
FI27.02.2019
HR27.02.2019
LT27.02.2019
LV27.02.2019
MC27.02.2019
RO27.02.2019
RS27.02.2019
SE27.02.2019
SI27.02.2019
SK27.02.2019
SM27.02.2019
BG27.05.2019
NO27.05.2019
GR28.05.2019
IS27.06.2019
PT27.06.2019
Former [2020/13]AL27.02.2019
CZ27.02.2019
EE27.02.2019
ES27.02.2019
FI27.02.2019
HR27.02.2019
LT27.02.2019
LV27.02.2019
RO27.02.2019
RS27.02.2019
SE27.02.2019
SI27.02.2019
SK27.02.2019
SM27.02.2019
BG27.05.2019
NO27.05.2019
GR28.05.2019
IS27.06.2019
PT27.06.2019
Former [2019/51]AL27.02.2019
CZ27.02.2019
EE27.02.2019
ES27.02.2019
FI27.02.2019
HR27.02.2019
LT27.02.2019
LV27.02.2019
RO27.02.2019
RS27.02.2019
SE27.02.2019
SK27.02.2019
SM27.02.2019
BG27.05.2019
NO27.05.2019
GR28.05.2019
IS27.06.2019
PT27.06.2019
Former [2019/49]AL27.02.2019
CZ27.02.2019
EE27.02.2019
ES27.02.2019
FI27.02.2019
HR27.02.2019
LT27.02.2019
LV27.02.2019
RO27.02.2019
RS27.02.2019
SE27.02.2019
SK27.02.2019
BG27.05.2019
NO27.05.2019
GR28.05.2019
IS27.06.2019
PT27.06.2019
Former [2019/47]ES27.02.2019
FI27.02.2019
HR27.02.2019
LT27.02.2019
LV27.02.2019
RS27.02.2019
SE27.02.2019
BG27.05.2019
NO27.05.2019
GR28.05.2019
IS27.06.2019
PT27.06.2019
Former [2019/39]FI27.02.2019
HR27.02.2019
LT27.02.2019
LV27.02.2019
RS27.02.2019
SE27.02.2019
BG27.05.2019
NO27.05.2019
GR28.05.2019
IS27.06.2019
PT27.06.2019
Former [2019/38]FI27.02.2019
LT27.02.2019
SE27.02.2019
BG27.05.2019
NO27.05.2019
GR28.05.2019
PT27.06.2019
Former [2019/37]FI27.02.2019
LT27.02.2019
SE27.02.2019
NO27.05.2019
GR28.05.2019
PT27.06.2019
Former [2019/34]FI27.02.2019
LT27.02.2019
SE27.02.2019
NO27.05.2019
PT27.06.2019
Former [2019/33]FI27.02.2019
LT27.02.2019
NO27.05.2019
PT27.06.2019
Documents cited:Search[A]WO0249657  (UNIV MASSEY [NZ], et al) [A] 1-15* claims 1-6 *;
 [A]EP1609372  (TECHNA [FR]) [A] 1-15 * example 1; claims 1-11 *;
 [A]EP2368440  (DSM IP ASSETS BV [NL]) [A] 1-15 * paragraphs [0003] , [0010] , [0013] , [0066] *;
 [A]WO2011153299  (PENN STATE RES FOUND [US], et al) [A] 1-15 * page 7, line 21 - page 9, line 16; claims 1-11 * * page 14 - pages 17, 23,2 *
by applicantDE102006026512
 US2009004308
 WO2011153299
    - VRIENS, NILIUS ET AL., CURR NEUROPHARMACOL, (2008), vol. 6, pages 79 - 96
    - EVANS; MARTIN, CURR MICROBIOL, (2000), vol. 41, pages 336 - 340
    - MACHEBOEUF ET AL., ANIM. FEED SCI. TECHNOL., (2008), vol. 145, pages 335 - 350
    - CASTILLEJOS ET AL., J. DAIRY SCI., (2006), vol. 89, pages 2649 - 2658
    - AGARWAL ET AL., ANIM. FEED SCI. TECHNOL., (2009), vol. 148, pages 321 - 327
    - HOFFMANN, W., Rinderkrankheiten. Band 1: Innere und chirurgische Erkrankungen, VERLAG EUGEN ULMER, (1992), pages 304 - 305
    - HOFFMANN, M.H., Fütterungsregime für Rinder in Tierfütterung, DT. LANDWIRTSCHAFTSVERLAG, (1990), vol. 2, page 3485
    - PIATKOWSKI, B.; GÜRTLER, H.; VOIGT, J., Grundzüge der Wiederkäuerernährung, GUSTAV-FISCHER-VERLAG, (1990), page 236
    - STEINWIDDER, A., Milchviehfütterung: Tier- und leistungsgerecht, STOCKER, (2005), page 240 P
    - COOK ET AL., "Modern techniques for monitoring high producing dairy cows", PRACTICE, (2006), vol. 28, pages 598 - 603
    - DE CAMPENEERE S; DE BOEVER JL; VANACKER JM; MESSENS W; DE BRABANDER DL, "Feeding measures to reduce nitrogen excretion in dairy cattle.", ARCH ANIM NUTR, (2009), vol. 63, no. 2, pages 87 - 103
    - VANHATALO A; KUOPPALA K; AHVENJARVI S; RINNE M, "Effects of feeding grass or red clever silage cut at two maturity stages in dairy cows. 1. Nitrogen metabolism and supply of amino acids", J DAIRY SCI, (2009), vol. 92, no. 11, pages 5620 - 5633, XP026954804
    - REMOND D; BERNARD L; SAVARY-AUZELOUX I; NOZIERE P, "Partitioning of nutrient net fluxes across the portal-drained viscera in sheep fed twice daily: effect of dietary protein degradability.", BR J NUTR, (2009), pages 1 - 12
    - ABDOUN K; STUMPFF F; MARTENS H, "Ammonia and urea transport across the rumen epithelium: a review", ANIM HEALTH RES REV, (2006), vol. 7, no. 1-2, pages 43 - 59
    - HARMEYER J; MARTENS H, "Aspects of urea metabolism in ruminants with reference to the goat", J DAIRY SCI, (1980), vol. 63, no. 10, pages 1707 - 1728
    - MCDONALD IW, "The absorption of ammonia from the rumen of the sheep", BIOCHEM J, (1948), vol. 42, no. 4, pages 584 - 587
    - GÄRTNER K; DECKER P; HILI H, "Untersuchungen über die Passage von Harnstoff und Ammoniak durch die Pansenwand von Ziegen", PFLUGERS ARCH, (1961), vol. 274, pages 281 - 288
    - ABDOUN K; STUMPFF F; WOLF K; MARTENS H, "Modulation of electroneutral Na transport in sheep rumen epithelium by luminal ammonia.", AM J PHYSIOL, (2005), vol. 289, no. 3, pages G508 - 520
    - GALFI, P.; S. NEOGRADY ET AL., "Culture of epithelial cells from bovine ruminal mucosa", VET RES COMMUN, (1981), vol. 4, no. 4, pages 295 - 300
    - STUMPFF, F.; O. STRAUSS ET AL., "Characterization of maxi-K-channels in bovine trabecular meshwork and their activation by cyclic guanosine monophosphate", INVEST OPHTHALMOL VIS SCI, (1997), vol. 38, no. 9, pages 1883 - 1892
    - SCHWEIGEL, M.; I. LANG ET AL., "Mg(2+) transport in sheep rumen epithelium: evidence for an electrodiffusive uptake mechanism", AM J PHYSIOL, (1999), vol. 277, pages G976 - 982
    - STUMPFF, F.; Y. QUE ET AL., "Stimulation of maxi-K channels in trabecular meshwork by tyrosine kinase inhibitors", INVEST OPHTHALMOL VIS SCI, (1999), vol. 40, no. 7, pages 1404 - 1417
    - ABDOUN, K.; F. STUMPFF ET AL., "Modulation of electroneutral Na transport in sheep rumen epithelium by luminal ammonia", AM J PHYSIOL, (2005), vol. 289, no. 3, pages G508 - 520
    - LEONHARD-MAREK, S.; F. STUMPFF ET AL., "Basolateral Mg2+/Na+ exchange regulates apical nonselective cation channel in sheep rumen epithelium via cytosolic Mg2+.", AM J PHYSIOL, (2005), vol. 288, no. 4, pages G630 - 645
    - STUMPFF, F.; M. BOXBERGER ET AL., "Stimulation of cannabinoid (CB1) and prostanoid (EP2) receptors opens BKCa channels and relaxes ocular trabecular meshwork", EXP EYE RES, (2005), vol. 80, no. 5, doi:doi:10.1016/j.exer.2004.12.003, pages 697 - 708, XP004864107

DOI:   http://dx.doi.org/10.1016/j.exer.2004.12.003
    - "A role for magnesium in the regulation of ruminal sodium transport", STUMPFF, F.; H. MARTENS, Focus on signal transduction research., NEW NOVA SCIENCE PUBLISHERS, INC., (2006), pages 37 - 66
    - STUMPFF, F.; A. BONDZIO ET AL., "Effects of the Bacillus thuringiensis toxin CrylAb on membrane currents of isolated cells of the ruminal epithelium", J MEMBR BIOL, (2007), vol. 219, no. 1-3, doi:doi:10.1007/s00232-007-9059-3, pages 37 - 47, XP019560258

DOI:   http://dx.doi.org/10.1007/s00232-007-9059-3
    - VRIENS, J.; B. NILIUS ET AL., "Herbai compounds and toxins modulating TRP channels", CURR NEUROPHARMACOL, (2008), vol. 6, no. 1, pages 79 - 96, XP002556013
    - SCHWEIGEL, M.; J. KUZINSKI ET AL., "Rumen epithelial cells adapt magnesium transport to high and low extracellular magnesium conditions", MAGNES RES, (2009), vol. 22, no. 3, pages 133 - 150, XP008132389
    - STUMPFF, F.; H. MARTENS ET AL., "Cultured ruminal epithelial cells express a largeconductance channel permeable to chloride, bicarbonate, and acetate", PFLUGERS ARCH, (2009), vol. 457, no. 5, pages 1003 - 1022, XP019715346
    - ABDOUN, K.; F. STUMPFF ET AL., "Modulation of urea transport across sheep rumen epithelium in vitro by SCFA and C02", AM J PHYSIOL, (2010), vol. 298, no. 2, pages G190 - 202
    - LEONHARD-MAREK, S.; F. STUMPFF ET AL., "Transport of cations and anions across forestomach epithelia: conclusions from in vitro studies", ANIMAL, (2010), vol. 4, pages 1037 - 1056
    - NILIUS, B.; G. OWSIANIK, "The transient receptor potential family of ion channels", GENOME BIOL, (2011), vol. 12, no. 3, page 218
    - STRECKER, K., "Untersuchungen zur pH-Regulation am Blättermagenepithel des Schafes mit H+-sensitiven Mikroelektroden", FB VETERINäRMEDIZIN, (2011), page 178
    - STUMPFF, F.; M. I. GEORGI ET AL., "Sheep rumen and omasum primary cultures and source epithelia: barrier function aligns with expression of tight junction proteins", J EXP BIOL, (2011), vol. 214, pages 2871 - 2882
    - ALLEN WM; DAVIES DC, "Milk fever, hypomagnesaemia and the ''downer cow'' syndrome.", BR. VET. J., (1981), vol. 137, doi:doi:10.1016/S0007-1935(17)31644-5, pages 435 - 441, XP085327615

DOI:   http://dx.doi.org/10.1016/S0007-1935(17)31644-5
    - BLUM J W; FISCHER JA, "Ätiologie, Pathophysiologie und Prophylaxe der hypocalcämischen Gebärparese des Rindes - eine Übersicht", SCHWEIZ. ARCH. TIERHEIK, (1974), vol. 116, pages 603 - 628
    - DUCUSIN, R. J.; Y. UZUKA; E. SATOH; M. OTANI; M. NISHIMURA; S. TANABE; T. SARASHINA, "Effects of extracellular Ca2+ on phagocytosis and intracellular Ca2+ concentrations in polymorphonuclear leukocytes of postpartum dairy cows.", RES VET SCI., (2003), vol. 75, no. 1, pages 27 - 32
    - ENEMARK, J.M.; JORGENSEN, R.J.; KRISTENSEN, N.B., "An evaluation of parameters for the detection of subclinical rumen acidosis in dairy herds", VET RES COMMUN, (2004), vol. 28, pages 687 - 709
    - FÜRLL, M.; JÄKEL, L.; BAUERFELD, J.; GROPPEL, B., "Gebärpareseprophylaxe mit ''Anionenrationen", PRAKT. TIERARZT, COLL. VET., (1996), vol. XXVI, pages 31 - 34
    - GARRETT, E.F.; PEREIRA, M.N.; NORDLUND, K.V.; ARMENTANO, L.E.; GOODGER, W.J.; OETZEL, G.R., "Diagnostic Methods for the detection of subacute ruminal acidosis in dairy cows", J DAIRY SCI, (1999), vol. 82, pages 1170 - 1178, XP026993356
    - GASTEINER J; FALLAST M; ROSENKRANZ S; HÄUSLER J; SCHNEIDER K; GUGGENBERGER T, "Zum Einsatz einer intraruminalen pH-Datenmesseinheit mit kabelloser Datenübertragung bei Rindern unter verschiedenen Fütterungsbedingungen", WIEN TIERäRZTL MSCHRIFT; VET. MED. AUSTRIA, (2009), vol. 96, pages 188 - 194
    - GELFERT CC; LOEFFLER LM; FRÖMER S; ENGEL M; MÄNNER K; STAUFENBIEL R., "Comparison of the impact of different anionic salts on the acid-base status and calcium metabolism in non-lactating, non-pregnant dairy cows", VET J., (20090825), vol. 185, no. 3, pages 305 - 9, XP027179472
    - GOFF, J.P.; HORST, R.L., "Oral administration of calcium salts for treatment of hypocalcemia in cattle", J. DAIRY SCI., (1993), vol. 76, pages 101 - 108
    - GOFF, J.P.; BROWN, T.R.; STOKES, S.R.; BRAWLEY, C.L.; VALDEZ, F.R., "Titration of the proper dose of calcium propionate (NutroCAL) to be included in an oral drench for fresh cows", J. DAIRY SCI., (2002), vol. 85, no. 1, page 189
    - GOFF JP; RUIZ R; HORST RL., "Relative acidifying activity of anionic salts commonly used to prevent milk fever", J DAIRY SCI., (200405), vol. 87, no. 5, pages 1245 - 55, XP026974603
    - HORST, R.L., "Regulation of calcium and phosphorus homeostasis in the dairy cow", JOURNAL OF DAIRY SCIENCE, (1986), vol. 69, doi:doi:10.3168/jds.S0022-0302(86)80445-3, pages 604 - 616, XP009161053

DOI:   http://dx.doi.org/10.3168/jds.S0022-0302(86)80445-3
    - HORST, R.L.; GOFF, J.P.; REINHARDT, T.A., "Calcium and vitamin D metabolism in the dairy cow", JOURNAL OF DAIRY SCIENCE, (1994), vol. 77, doi:doi:10.3168/jds.S0022-0302(94)77140-X, pages 1936 - 1951, XP009161021

DOI:   http://dx.doi.org/10.3168/jds.S0022-0302(94)77140-X
    - HORST RL; GOFF JP; REINHARDT TA; BUXTON DR, "Strategies for preventing milk fever in dairy cattle", J. DAIRY SCI, (1997), vol. 80, pages 1269 - 1280, XP055278628
    - HOUE, H.; S. OSTERGAARD; T. THILSING-HANSEN; R. J. JORGENSEN; T. LARSEN; J. T. SORENSEN; J. F. AGGER; J. Y. BLOM., "Milk fever and subclinical hypocalcaemia--an evaluation of parameters on incidence risk, diagnosis, risk factors and biological effects as input for a decision support system for disease control", ACTA VET SCAND, (2001), vol. 42, no. 1, pages 1 - 29
    - JORIS VRIENS; BERND NILIUS; RUDI VENNEKENS, "Herbal Compounds and Toxins Modulating TRP Channels", CURRENT NEUROPHARMACOLOGY, (2008), vol. 6, pages 79 - 96, XP002556013
    - KIMURA, K.; T. A. REINHARDT; J. P. GOFF., "Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle", J DAIRY SCI, (2006), vol. 89, no. 7, pages 2588 - 2595, XP026957094
    - LANG, I.; H. MARTENS, "Na transport in sheep rumen is modulated by voltagedependent cation conductance in apical membrane", AM J PHYSIOL, (1999), vol. 277, pages G609 - 618
    - LITTLEDIKE, E. T.; G. W. ENGSTROM; M. SACHS., "Methods for sequential sampling and analysis of renal 25-hydroxyvitamin D3 1-, 24, and 23-hydroxylase activities of dairy cows and calves injected with la-hydroxyvitamin D3.", J. DAIRY SCI., (1986), vol. 69, pages 990 - 997
    - MALZ, C.; MEYER, C., "Neue Aspekte zur Pathogenese und Therapie der hypocalcämischen Gebärparese", PRAKT. TIERARZT, (1992), vol. 73, pages 507 - 515
    - MARTENS, H.; J. HARMEYER, "Magnesium transport by isolated rumen epithelium of sheep", RES VET SCI, (1978), vol. 24, no. 2, pages 161 - 168
    - "Hypokalzämische Gebärlähmung", MARTIG J, Innere Medizin und Chirurgie des Rindes, BLACKWELL VERLAG, (2002), pages 1245 - 1254
    - NORDLUND KV; GARRETT EF, "Rumenocentesis: a technique for collecting rumen fluid for the diagnosis of subacute rumen acidosis in dairy herds", BOVINE PRACTITIONER, (1994), vol. 28, pages 109 - 112
    - NORDLUND KV; GARRETT EF; OETZEL GR, "Herd-based rumenocentesis - a clinical approach to the diagnosis of subacute rumen acidosis", COMPEND. CONTIN. EDUC. PRACT. VET, (1995), vol. 17, pages 48 - 56
    - OETZEL GR, "Parturient paresis and hypocalcemia in ruminant livestock", VET. CLINICS OF NORTH AMERICA: FOOD ANIM. PRACT., (1988), vol. 4, pages 351 - 364
    - "Parturient paresis (milk fever).", RADOSTITS OM; GAY CG; BLOOD DC; HINCHCLIFF KW, Veterinary Medicine. A textbook of the diseases of cattle, sheep, pigs, goats and horses, W.B. SAUNDERS, (2000), pages 1420 - 1435
    - RAMSEY, I. S.; M. DELLING ET AL., "An introduction to TRP channels", ANNUAL REVIEW OF PHYSIOLOGY, (2006), vol. 68, pages 619 - 647
    - SMITH, P. L.; K. N. MALONEY ET AL., "Bisandrographolide from Andrographis paniculata activates TRPV4 channels", JOURNAL OF BIOLOGICAL CHEMISTRY, (2006), vol. 281, no. 40, pages 29897 - 29904
    - LEONHARD-MAREK, S.; F. STUMPFF ET AL., "Basolateral Mg2+/Na+ exchange regulates apical nonselective cation channel in sheep rumen epithelium via cytosolic Mg2+", AM J PHYSIOL, (2005), vol. 288, no. 4, pages G630 - 645
    - XU, H.; M. DELLING ET AL., "Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels", NAT NEUROSCI, (2006), vol. 9, no. 5, doi:doi:10.1038/nn1692, pages 628 - 635, XP055275296

DOI:   http://dx.doi.org/10.1038/nn1692
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.