EP3195857 - USE OF A TRP MODULATOR FOR THE PROPHYLAXIS AND/OR ALLEVIATING OF GRASS TETANY AND/OR PARTURIENT PARESIS IN TYLOPODA OR RUMINANTS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 03.01.2020 Database last updated on 03.09.2024 | |
Former | The patent has been granted Status updated on 25.01.2019 | ||
Former | Grant of patent is intended Status updated on 08.10.2018 | ||
Former | Request for examination was made Status updated on 19.01.2018 | ||
Former | The application has been published Status updated on 23.06.2017 | Most recent event Tooltip | 08.07.2022 | Lapse of the patent in a contracting state New state(s): MK | published on 10.08.2022 [2022/32] | Applicant(s) | For all designated states PerformaNat GmbH Hohentwielsteig 6 14163 Berlin / DE | [2017/50] |
Former [2017/30] | For all designated states Freie Universität Berlin Kaiserswerther Strasse 16-18 14195 Berlin / DE | Inventor(s) | 01 /
STUMPFF, Friederike Schwanheimerstraße 8 12209 Berlin / DE | 02 /
ROSENDAHL, Julia Fasanenstraße 35a 10719 Berlin / DE | 03 /
ASCHENBACH, Jörg Blumenbogen 2a 04288 Leipzig / DE | [2017/30] | Representative(s) | Maikowski & Ninnemann Patentanwälte Partnerschaft mbB Postfach 15 09 20 10671 Berlin / DE | [2017/30] | Application number, filing date | 17153072.8 | 31.07.2013 | [2017/30] | Priority number, date | DE20121015029 | 31.07.2012 Original published format: DE102012015029 | [2017/30] | Filing language | DE | Procedural language | DE | Publication | Type: | A1 Application with search report | No.: | EP3195857 | Date: | 26.07.2017 | Language: | DE | [2017/30] | Type: | B1 Patent specification | No.: | EP3195857 | Date: | 27.02.2019 | Language: | DE | [2019/09] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 28.06.2017 | Classification | IPC: | A61K9/00, A61K31/045, A61K31/05, A61K31/11, A61K31/085, A61K31/122, A61K31/351, A61P1/00 | [2018/31] | CPC: |
A61K31/05 (EP,US);
A23K20/10 (EP,US);
A23K20/105 (EP,US);
A23K20/111 (EP,US);
A23K50/10 (EP,US);
A61K31/045 (EP,US);
|
Former IPC [2017/30] | A61K9/00 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2018/08] |
Former [2017/30] | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR | Title | German: | VERWENDUNG EINES TRP-MODULATORS ZUR PROPHYLAXE UND/ODER LINDERUNG VON WEIDETETANIE UND/ODER GEBÄRPARESE BEI WIEDERKÄUERN ODER SCHWIELENSOHLERN | [2017/30] | English: | USE OF A TRP MODULATOR FOR THE PROPHYLAXIS AND/OR ALLEVIATING OF GRASS TETANY AND/OR PARTURIENT PARESIS IN TYLOPODA OR RUMINANTS | [2017/30] | French: | UTILISATION D'UN MODULATEUR TRP DE PROPHYLAXIE ET/OU D'ATTÉNUATION DE LA TÉTANIE D'HERBAGE ET/OU DE LA PARÉSIE POST-PARTUM CHEZ LES RUMINANTS OU LES TYLOPODES | [2017/30] | Examination procedure | 25.01.2017 | Date on which the examining division has become responsible | 03.01.2018 | Examination requested [2018/08] | 09.10.2018 | Communication of intention to grant the patent | 14.01.2019 | Fee for grant paid | 14.01.2019 | Fee for publishing/printing paid | 14.01.2019 | Receipt of the translation of the claim(s) | Parent application(s) Tooltip | EP13744529.2 / EP2879662 | Opposition(s) | 28.11.2019 | No opposition filed within time limit [2020/06] | Fees paid | Renewal fee | 02.02.2017 | Renewal fee patent year 03 | 02.02.2017 | Renewal fee patent year 04 | 07.07.2017 | Renewal fee patent year 05 | 01.06.2018 | Renewal fee patent year 06 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 31.07.2013 | AL | 27.02.2019 | CY | 27.02.2019 | CZ | 27.02.2019 | EE | 27.02.2019 | ES | 27.02.2019 | FI | 27.02.2019 | HR | 27.02.2019 | LT | 27.02.2019 | LV | 27.02.2019 | MC | 27.02.2019 | MK | 27.02.2019 | MT | 27.02.2019 | RO | 27.02.2019 | RS | 27.02.2019 | SE | 27.02.2019 | SI | 27.02.2019 | SK | 27.02.2019 | SM | 27.02.2019 | TR | 27.02.2019 | BG | 27.05.2019 | NO | 27.05.2019 | GR | 28.05.2019 | IS | 27.06.2019 | PT | 27.06.2019 | BE | 31.07.2019 | LU | 31.07.2019 | [2022/32] |
Former [2021/34] | HU | 31.07.2013 | |
AL | 27.02.2019 | ||
CY | 27.02.2019 | ||
CZ | 27.02.2019 | ||
EE | 27.02.2019 | ||
ES | 27.02.2019 | ||
FI | 27.02.2019 | ||
HR | 27.02.2019 | ||
LT | 27.02.2019 | ||
LV | 27.02.2019 | ||
MC | 27.02.2019 | ||
MT | 27.02.2019 | ||
RO | 27.02.2019 | ||
RS | 27.02.2019 | ||
SE | 27.02.2019 | ||
SI | 27.02.2019 | ||
SK | 27.02.2019 | ||
SM | 27.02.2019 | ||
TR | 27.02.2019 | ||
BG | 27.05.2019 | ||
NO | 27.05.2019 | ||
GR | 28.05.2019 | ||
IS | 27.06.2019 | ||
PT | 27.06.2019 | ||
BE | 31.07.2019 | ||
LU | 31.07.2019 | ||
Former [2021/33] | HU | 31.07.2013 | |
AL | 27.02.2019 | ||
CY | 27.02.2019 | ||
CZ | 27.02.2019 | ||
EE | 27.02.2019 | ||
ES | 27.02.2019 | ||
FI | 27.02.2019 | ||
HR | 27.02.2019 | ||
LT | 27.02.2019 | ||
LV | 27.02.2019 | ||
MC | 27.02.2019 | ||
RO | 27.02.2019 | ||
RS | 27.02.2019 | ||
SE | 27.02.2019 | ||
SI | 27.02.2019 | ||
SK | 27.02.2019 | ||
SM | 27.02.2019 | ||
TR | 27.02.2019 | ||
BG | 27.05.2019 | ||
NO | 27.05.2019 | ||
GR | 28.05.2019 | ||
IS | 27.06.2019 | ||
PT | 27.06.2019 | ||
BE | 31.07.2019 | ||
LU | 31.07.2019 | ||
Former [2021/26] | AL | 27.02.2019 | |
CY | 27.02.2019 | ||
CZ | 27.02.2019 | ||
EE | 27.02.2019 | ||
ES | 27.02.2019 | ||
FI | 27.02.2019 | ||
HR | 27.02.2019 | ||
LT | 27.02.2019 | ||
LV | 27.02.2019 | ||
MC | 27.02.2019 | ||
RO | 27.02.2019 | ||
RS | 27.02.2019 | ||
SE | 27.02.2019 | ||
SI | 27.02.2019 | ||
SK | 27.02.2019 | ||
SM | 27.02.2019 | ||
TR | 27.02.2019 | ||
BG | 27.05.2019 | ||
NO | 27.05.2019 | ||
GR | 28.05.2019 | ||
IS | 27.06.2019 | ||
PT | 27.06.2019 | ||
BE | 31.07.2019 | ||
LU | 31.07.2019 | ||
Former [2020/26] | AL | 27.02.2019 | |
CZ | 27.02.2019 | ||
EE | 27.02.2019 | ||
ES | 27.02.2019 | ||
FI | 27.02.2019 | ||
HR | 27.02.2019 | ||
LT | 27.02.2019 | ||
LV | 27.02.2019 | ||
MC | 27.02.2019 | ||
RO | 27.02.2019 | ||
RS | 27.02.2019 | ||
SE | 27.02.2019 | ||
SI | 27.02.2019 | ||
SK | 27.02.2019 | ||
SM | 27.02.2019 | ||
TR | 27.02.2019 | ||
BG | 27.05.2019 | ||
NO | 27.05.2019 | ||
GR | 28.05.2019 | ||
IS | 27.06.2019 | ||
PT | 27.06.2019 | ||
BE | 31.07.2019 | ||
LU | 31.07.2019 | ||
Former [2020/17] | AL | 27.02.2019 | |
CZ | 27.02.2019 | ||
EE | 27.02.2019 | ||
ES | 27.02.2019 | ||
FI | 27.02.2019 | ||
HR | 27.02.2019 | ||
LT | 27.02.2019 | ||
LV | 27.02.2019 | ||
MC | 27.02.2019 | ||
RO | 27.02.2019 | ||
RS | 27.02.2019 | ||
SE | 27.02.2019 | ||
SI | 27.02.2019 | ||
SK | 27.02.2019 | ||
SM | 27.02.2019 | ||
TR | 27.02.2019 | ||
BG | 27.05.2019 | ||
NO | 27.05.2019 | ||
GR | 28.05.2019 | ||
IS | 27.06.2019 | ||
PT | 27.06.2019 | ||
Former [2020/14] | AL | 27.02.2019 | |
CZ | 27.02.2019 | ||
EE | 27.02.2019 | ||
ES | 27.02.2019 | ||
FI | 27.02.2019 | ||
HR | 27.02.2019 | ||
LT | 27.02.2019 | ||
LV | 27.02.2019 | ||
MC | 27.02.2019 | ||
RO | 27.02.2019 | ||
RS | 27.02.2019 | ||
SE | 27.02.2019 | ||
SI | 27.02.2019 | ||
SK | 27.02.2019 | ||
SM | 27.02.2019 | ||
BG | 27.05.2019 | ||
NO | 27.05.2019 | ||
GR | 28.05.2019 | ||
IS | 27.06.2019 | ||
PT | 27.06.2019 | ||
Former [2020/13] | AL | 27.02.2019 | |
CZ | 27.02.2019 | ||
EE | 27.02.2019 | ||
ES | 27.02.2019 | ||
FI | 27.02.2019 | ||
HR | 27.02.2019 | ||
LT | 27.02.2019 | ||
LV | 27.02.2019 | ||
RO | 27.02.2019 | ||
RS | 27.02.2019 | ||
SE | 27.02.2019 | ||
SI | 27.02.2019 | ||
SK | 27.02.2019 | ||
SM | 27.02.2019 | ||
BG | 27.05.2019 | ||
NO | 27.05.2019 | ||
GR | 28.05.2019 | ||
IS | 27.06.2019 | ||
PT | 27.06.2019 | ||
Former [2019/51] | AL | 27.02.2019 | |
CZ | 27.02.2019 | ||
EE | 27.02.2019 | ||
ES | 27.02.2019 | ||
FI | 27.02.2019 | ||
HR | 27.02.2019 | ||
LT | 27.02.2019 | ||
LV | 27.02.2019 | ||
RO | 27.02.2019 | ||
RS | 27.02.2019 | ||
SE | 27.02.2019 | ||
SK | 27.02.2019 | ||
SM | 27.02.2019 | ||
BG | 27.05.2019 | ||
NO | 27.05.2019 | ||
GR | 28.05.2019 | ||
IS | 27.06.2019 | ||
PT | 27.06.2019 | ||
Former [2019/49] | AL | 27.02.2019 | |
CZ | 27.02.2019 | ||
EE | 27.02.2019 | ||
ES | 27.02.2019 | ||
FI | 27.02.2019 | ||
HR | 27.02.2019 | ||
LT | 27.02.2019 | ||
LV | 27.02.2019 | ||
RO | 27.02.2019 | ||
RS | 27.02.2019 | ||
SE | 27.02.2019 | ||
SK | 27.02.2019 | ||
BG | 27.05.2019 | ||
NO | 27.05.2019 | ||
GR | 28.05.2019 | ||
IS | 27.06.2019 | ||
PT | 27.06.2019 | ||
Former [2019/47] | ES | 27.02.2019 | |
FI | 27.02.2019 | ||
HR | 27.02.2019 | ||
LT | 27.02.2019 | ||
LV | 27.02.2019 | ||
RS | 27.02.2019 | ||
SE | 27.02.2019 | ||
BG | 27.05.2019 | ||
NO | 27.05.2019 | ||
GR | 28.05.2019 | ||
IS | 27.06.2019 | ||
PT | 27.06.2019 | ||
Former [2019/39] | FI | 27.02.2019 | |
HR | 27.02.2019 | ||
LT | 27.02.2019 | ||
LV | 27.02.2019 | ||
RS | 27.02.2019 | ||
SE | 27.02.2019 | ||
BG | 27.05.2019 | ||
NO | 27.05.2019 | ||
GR | 28.05.2019 | ||
IS | 27.06.2019 | ||
PT | 27.06.2019 | ||
Former [2019/38] | FI | 27.02.2019 | |
LT | 27.02.2019 | ||
SE | 27.02.2019 | ||
BG | 27.05.2019 | ||
NO | 27.05.2019 | ||
GR | 28.05.2019 | ||
PT | 27.06.2019 | ||
Former [2019/37] | FI | 27.02.2019 | |
LT | 27.02.2019 | ||
SE | 27.02.2019 | ||
NO | 27.05.2019 | ||
GR | 28.05.2019 | ||
PT | 27.06.2019 | ||
Former [2019/34] | FI | 27.02.2019 | |
LT | 27.02.2019 | ||
SE | 27.02.2019 | ||
NO | 27.05.2019 | ||
PT | 27.06.2019 | ||
Former [2019/33] | FI | 27.02.2019 | |
LT | 27.02.2019 | ||
NO | 27.05.2019 | ||
PT | 27.06.2019 | Documents cited: | Search | [A]WO0249657 (UNIV MASSEY [NZ], et al) [A] 1-15* claims 1-6 *; | [A]EP1609372 (TECHNA [FR]) [A] 1-15 * example 1; claims 1-11 *; | [A]EP2368440 (DSM IP ASSETS BV [NL]) [A] 1-15 * paragraphs [0003] , [0010] , [0013] , [0066] *; | [A]WO2011153299 (PENN STATE RES FOUND [US], et al) [A] 1-15 * page 7, line 21 - page 9, line 16; claims 1-11 * * page 14 - pages 17, 23,2 * | by applicant | DE102006026512 | US2009004308 | WO2011153299 | - VRIENS, NILIUS ET AL., CURR NEUROPHARMACOL, (2008), vol. 6, pages 79 - 96 | - EVANS; MARTIN, CURR MICROBIOL, (2000), vol. 41, pages 336 - 340 | - MACHEBOEUF ET AL., ANIM. FEED SCI. TECHNOL., (2008), vol. 145, pages 335 - 350 | - CASTILLEJOS ET AL., J. DAIRY SCI., (2006), vol. 89, pages 2649 - 2658 | - AGARWAL ET AL., ANIM. FEED SCI. TECHNOL., (2009), vol. 148, pages 321 - 327 | - HOFFMANN, W., Rinderkrankheiten. Band 1: Innere und chirurgische Erkrankungen, VERLAG EUGEN ULMER, (1992), pages 304 - 305 | - HOFFMANN, M.H., Fütterungsregime für Rinder in Tierfütterung, DT. LANDWIRTSCHAFTSVERLAG, (1990), vol. 2, page 3485 | - PIATKOWSKI, B.; GÜRTLER, H.; VOIGT, J., Grundzüge der Wiederkäuerernährung, GUSTAV-FISCHER-VERLAG, (1990), page 236 | - STEINWIDDER, A., Milchviehfütterung: Tier- und leistungsgerecht, STOCKER, (2005), page 240 P | - COOK ET AL., "Modern techniques for monitoring high producing dairy cows", PRACTICE, (2006), vol. 28, pages 598 - 603 | - DE CAMPENEERE S; DE BOEVER JL; VANACKER JM; MESSENS W; DE BRABANDER DL, "Feeding measures to reduce nitrogen excretion in dairy cattle.", ARCH ANIM NUTR, (2009), vol. 63, no. 2, pages 87 - 103 | - VANHATALO A; KUOPPALA K; AHVENJARVI S; RINNE M, "Effects of feeding grass or red clever silage cut at two maturity stages in dairy cows. 1. Nitrogen metabolism and supply of amino acids", J DAIRY SCI, (2009), vol. 92, no. 11, pages 5620 - 5633, XP026954804 | - REMOND D; BERNARD L; SAVARY-AUZELOUX I; NOZIERE P, "Partitioning of nutrient net fluxes across the portal-drained viscera in sheep fed twice daily: effect of dietary protein degradability.", BR J NUTR, (2009), pages 1 - 12 | - ABDOUN K; STUMPFF F; MARTENS H, "Ammonia and urea transport across the rumen epithelium: a review", ANIM HEALTH RES REV, (2006), vol. 7, no. 1-2, pages 43 - 59 | - HARMEYER J; MARTENS H, "Aspects of urea metabolism in ruminants with reference to the goat", J DAIRY SCI, (1980), vol. 63, no. 10, pages 1707 - 1728 | - MCDONALD IW, "The absorption of ammonia from the rumen of the sheep", BIOCHEM J, (1948), vol. 42, no. 4, pages 584 - 587 | - GÄRTNER K; DECKER P; HILI H, "Untersuchungen über die Passage von Harnstoff und Ammoniak durch die Pansenwand von Ziegen", PFLUGERS ARCH, (1961), vol. 274, pages 281 - 288 | - ABDOUN K; STUMPFF F; WOLF K; MARTENS H, "Modulation of electroneutral Na transport in sheep rumen epithelium by luminal ammonia.", AM J PHYSIOL, (2005), vol. 289, no. 3, pages G508 - 520 | - GALFI, P.; S. NEOGRADY ET AL., "Culture of epithelial cells from bovine ruminal mucosa", VET RES COMMUN, (1981), vol. 4, no. 4, pages 295 - 300 | - STUMPFF, F.; O. STRAUSS ET AL., "Characterization of maxi-K-channels in bovine trabecular meshwork and their activation by cyclic guanosine monophosphate", INVEST OPHTHALMOL VIS SCI, (1997), vol. 38, no. 9, pages 1883 - 1892 | - SCHWEIGEL, M.; I. LANG ET AL., "Mg(2+) transport in sheep rumen epithelium: evidence for an electrodiffusive uptake mechanism", AM J PHYSIOL, (1999), vol. 277, pages G976 - 982 | - STUMPFF, F.; Y. QUE ET AL., "Stimulation of maxi-K channels in trabecular meshwork by tyrosine kinase inhibitors", INVEST OPHTHALMOL VIS SCI, (1999), vol. 40, no. 7, pages 1404 - 1417 | - ABDOUN, K.; F. STUMPFF ET AL., "Modulation of electroneutral Na transport in sheep rumen epithelium by luminal ammonia", AM J PHYSIOL, (2005), vol. 289, no. 3, pages G508 - 520 | - LEONHARD-MAREK, S.; F. STUMPFF ET AL., "Basolateral Mg2+/Na+ exchange regulates apical nonselective cation channel in sheep rumen epithelium via cytosolic Mg2+.", AM J PHYSIOL, (2005), vol. 288, no. 4, pages G630 - 645 | - STUMPFF, F.; M. BOXBERGER ET AL., "Stimulation of cannabinoid (CB1) and prostanoid (EP2) receptors opens BKCa channels and relaxes ocular trabecular meshwork", EXP EYE RES, (2005), vol. 80, no. 5, doi:doi:10.1016/j.exer.2004.12.003, pages 697 - 708, XP004864107 DOI: http://dx.doi.org/10.1016/j.exer.2004.12.003 | - "A role for magnesium in the regulation of ruminal sodium transport", STUMPFF, F.; H. MARTENS, Focus on signal transduction research., NEW NOVA SCIENCE PUBLISHERS, INC., (2006), pages 37 - 66 | - STUMPFF, F.; A. BONDZIO ET AL., "Effects of the Bacillus thuringiensis toxin CrylAb on membrane currents of isolated cells of the ruminal epithelium", J MEMBR BIOL, (2007), vol. 219, no. 1-3, doi:doi:10.1007/s00232-007-9059-3, pages 37 - 47, XP019560258 DOI: http://dx.doi.org/10.1007/s00232-007-9059-3 | - VRIENS, J.; B. NILIUS ET AL., "Herbai compounds and toxins modulating TRP channels", CURR NEUROPHARMACOL, (2008), vol. 6, no. 1, pages 79 - 96, XP002556013 | - SCHWEIGEL, M.; J. KUZINSKI ET AL., "Rumen epithelial cells adapt magnesium transport to high and low extracellular magnesium conditions", MAGNES RES, (2009), vol. 22, no. 3, pages 133 - 150, XP008132389 | - STUMPFF, F.; H. MARTENS ET AL., "Cultured ruminal epithelial cells express a largeconductance channel permeable to chloride, bicarbonate, and acetate", PFLUGERS ARCH, (2009), vol. 457, no. 5, pages 1003 - 1022, XP019715346 | - ABDOUN, K.; F. STUMPFF ET AL., "Modulation of urea transport across sheep rumen epithelium in vitro by SCFA and C02", AM J PHYSIOL, (2010), vol. 298, no. 2, pages G190 - 202 | - LEONHARD-MAREK, S.; F. STUMPFF ET AL., "Transport of cations and anions across forestomach epithelia: conclusions from in vitro studies", ANIMAL, (2010), vol. 4, pages 1037 - 1056 | - NILIUS, B.; G. OWSIANIK, "The transient receptor potential family of ion channels", GENOME BIOL, (2011), vol. 12, no. 3, page 218 | - STRECKER, K., "Untersuchungen zur pH-Regulation am Blättermagenepithel des Schafes mit H+-sensitiven Mikroelektroden", FB VETERINäRMEDIZIN, (2011), page 178 | - STUMPFF, F.; M. I. GEORGI ET AL., "Sheep rumen and omasum primary cultures and source epithelia: barrier function aligns with expression of tight junction proteins", J EXP BIOL, (2011), vol. 214, pages 2871 - 2882 | - ALLEN WM; DAVIES DC, "Milk fever, hypomagnesaemia and the ''downer cow'' syndrome.", BR. VET. J., (1981), vol. 137, doi:doi:10.1016/S0007-1935(17)31644-5, pages 435 - 441, XP085327615 DOI: http://dx.doi.org/10.1016/S0007-1935(17)31644-5 | - BLUM J W; FISCHER JA, "Ätiologie, Pathophysiologie und Prophylaxe der hypocalcämischen Gebärparese des Rindes - eine Übersicht", SCHWEIZ. ARCH. TIERHEIK, (1974), vol. 116, pages 603 - 628 | - DUCUSIN, R. J.; Y. UZUKA; E. SATOH; M. OTANI; M. NISHIMURA; S. TANABE; T. SARASHINA, "Effects of extracellular Ca2+ on phagocytosis and intracellular Ca2+ concentrations in polymorphonuclear leukocytes of postpartum dairy cows.", RES VET SCI., (2003), vol. 75, no. 1, pages 27 - 32 | - ENEMARK, J.M.; JORGENSEN, R.J.; KRISTENSEN, N.B., "An evaluation of parameters for the detection of subclinical rumen acidosis in dairy herds", VET RES COMMUN, (2004), vol. 28, pages 687 - 709 | - FÜRLL, M.; JÄKEL, L.; BAUERFELD, J.; GROPPEL, B., "Gebärpareseprophylaxe mit ''Anionenrationen", PRAKT. TIERARZT, COLL. VET., (1996), vol. XXVI, pages 31 - 34 | - GARRETT, E.F.; PEREIRA, M.N.; NORDLUND, K.V.; ARMENTANO, L.E.; GOODGER, W.J.; OETZEL, G.R., "Diagnostic Methods for the detection of subacute ruminal acidosis in dairy cows", J DAIRY SCI, (1999), vol. 82, pages 1170 - 1178, XP026993356 | - GASTEINER J; FALLAST M; ROSENKRANZ S; HÄUSLER J; SCHNEIDER K; GUGGENBERGER T, "Zum Einsatz einer intraruminalen pH-Datenmesseinheit mit kabelloser Datenübertragung bei Rindern unter verschiedenen Fütterungsbedingungen", WIEN TIERäRZTL MSCHRIFT; VET. MED. AUSTRIA, (2009), vol. 96, pages 188 - 194 | - GELFERT CC; LOEFFLER LM; FRÖMER S; ENGEL M; MÄNNER K; STAUFENBIEL R., "Comparison of the impact of different anionic salts on the acid-base status and calcium metabolism in non-lactating, non-pregnant dairy cows", VET J., (20090825), vol. 185, no. 3, pages 305 - 9, XP027179472 | - GOFF, J.P.; HORST, R.L., "Oral administration of calcium salts for treatment of hypocalcemia in cattle", J. DAIRY SCI., (1993), vol. 76, pages 101 - 108 | - GOFF, J.P.; BROWN, T.R.; STOKES, S.R.; BRAWLEY, C.L.; VALDEZ, F.R., "Titration of the proper dose of calcium propionate (NutroCAL) to be included in an oral drench for fresh cows", J. DAIRY SCI., (2002), vol. 85, no. 1, page 189 | - GOFF JP; RUIZ R; HORST RL., "Relative acidifying activity of anionic salts commonly used to prevent milk fever", J DAIRY SCI., (200405), vol. 87, no. 5, pages 1245 - 55, XP026974603 | - HORST, R.L., "Regulation of calcium and phosphorus homeostasis in the dairy cow", JOURNAL OF DAIRY SCIENCE, (1986), vol. 69, doi:doi:10.3168/jds.S0022-0302(86)80445-3, pages 604 - 616, XP009161053 DOI: http://dx.doi.org/10.3168/jds.S0022-0302(86)80445-3 | - HORST, R.L.; GOFF, J.P.; REINHARDT, T.A., "Calcium and vitamin D metabolism in the dairy cow", JOURNAL OF DAIRY SCIENCE, (1994), vol. 77, doi:doi:10.3168/jds.S0022-0302(94)77140-X, pages 1936 - 1951, XP009161021 DOI: http://dx.doi.org/10.3168/jds.S0022-0302(94)77140-X | - HORST RL; GOFF JP; REINHARDT TA; BUXTON DR, "Strategies for preventing milk fever in dairy cattle", J. DAIRY SCI, (1997), vol. 80, pages 1269 - 1280, XP055278628 | - HOUE, H.; S. OSTERGAARD; T. THILSING-HANSEN; R. J. JORGENSEN; T. LARSEN; J. T. SORENSEN; J. F. AGGER; J. Y. BLOM., "Milk fever and subclinical hypocalcaemia--an evaluation of parameters on incidence risk, diagnosis, risk factors and biological effects as input for a decision support system for disease control", ACTA VET SCAND, (2001), vol. 42, no. 1, pages 1 - 29 | - JORIS VRIENS; BERND NILIUS; RUDI VENNEKENS, "Herbal Compounds and Toxins Modulating TRP Channels", CURRENT NEUROPHARMACOLOGY, (2008), vol. 6, pages 79 - 96, XP002556013 | - KIMURA, K.; T. A. REINHARDT; J. P. GOFF., "Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle", J DAIRY SCI, (2006), vol. 89, no. 7, pages 2588 - 2595, XP026957094 | - LANG, I.; H. MARTENS, "Na transport in sheep rumen is modulated by voltagedependent cation conductance in apical membrane", AM J PHYSIOL, (1999), vol. 277, pages G609 - 618 | - LITTLEDIKE, E. T.; G. W. ENGSTROM; M. SACHS., "Methods for sequential sampling and analysis of renal 25-hydroxyvitamin D3 1-, 24, and 23-hydroxylase activities of dairy cows and calves injected with la-hydroxyvitamin D3.", J. DAIRY SCI., (1986), vol. 69, pages 990 - 997 | - MALZ, C.; MEYER, C., "Neue Aspekte zur Pathogenese und Therapie der hypocalcämischen Gebärparese", PRAKT. TIERARZT, (1992), vol. 73, pages 507 - 515 | - MARTENS, H.; J. HARMEYER, "Magnesium transport by isolated rumen epithelium of sheep", RES VET SCI, (1978), vol. 24, no. 2, pages 161 - 168 | - "Hypokalzämische Gebärlähmung", MARTIG J, Innere Medizin und Chirurgie des Rindes, BLACKWELL VERLAG, (2002), pages 1245 - 1254 | - NORDLUND KV; GARRETT EF, "Rumenocentesis: a technique for collecting rumen fluid for the diagnosis of subacute rumen acidosis in dairy herds", BOVINE PRACTITIONER, (1994), vol. 28, pages 109 - 112 | - NORDLUND KV; GARRETT EF; OETZEL GR, "Herd-based rumenocentesis - a clinical approach to the diagnosis of subacute rumen acidosis", COMPEND. CONTIN. EDUC. PRACT. VET, (1995), vol. 17, pages 48 - 56 | - OETZEL GR, "Parturient paresis and hypocalcemia in ruminant livestock", VET. CLINICS OF NORTH AMERICA: FOOD ANIM. PRACT., (1988), vol. 4, pages 351 - 364 | - "Parturient paresis (milk fever).", RADOSTITS OM; GAY CG; BLOOD DC; HINCHCLIFF KW, Veterinary Medicine. A textbook of the diseases of cattle, sheep, pigs, goats and horses, W.B. SAUNDERS, (2000), pages 1420 - 1435 | - RAMSEY, I. S.; M. DELLING ET AL., "An introduction to TRP channels", ANNUAL REVIEW OF PHYSIOLOGY, (2006), vol. 68, pages 619 - 647 | - SMITH, P. L.; K. N. MALONEY ET AL., "Bisandrographolide from Andrographis paniculata activates TRPV4 channels", JOURNAL OF BIOLOGICAL CHEMISTRY, (2006), vol. 281, no. 40, pages 29897 - 29904 | - LEONHARD-MAREK, S.; F. STUMPFF ET AL., "Basolateral Mg2+/Na+ exchange regulates apical nonselective cation channel in sheep rumen epithelium via cytosolic Mg2+", AM J PHYSIOL, (2005), vol. 288, no. 4, pages G630 - 645 | - XU, H.; M. DELLING ET AL., "Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels", NAT NEUROSCI, (2006), vol. 9, no. 5, doi:doi:10.1038/nn1692, pages 628 - 635, XP055275296 DOI: http://dx.doi.org/10.1038/nn1692 |