blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3464278

EP3464278 - XANTHONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  22.04.2022
Database last updated on 24.08.2024
FormerThe patent has been granted
Status updated on  14.05.2021
FormerGrant of patent is intended
Status updated on  20.01.2021
FormerExamination is in progress
Status updated on  05.10.2019
FormerRequest for examination was made
Status updated on  08.03.2019
FormerThe international publication has been made
Status updated on  01.12.2017
Formerunknown
Status updated on  15.06.2017
Most recent event   Tooltip14.06.2024Lapse of the patent in a contracting state
New state(s): TR		published on 17.07.2024  [2024/29]
Applicant(s)For all designated states
F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
[2019/15]
Inventor(s)01 / CHEN, Dongdong
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
02 / CHEN, Wenming
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
03 / FENG, Song
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
04 / GAO, Lu
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
05 / SHEN, Hong
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
06 / TAN, Xuefei
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
07 / WANG, Li
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
 [2019/15]
Representative(s)Bernard, Guillaume
F. Hoffmann-La Roche AG
Patent Department
Grenzacherstrasse 124
4070 Basel / CH
[2019/15]
Application number, filing date17726894.323.05.2017
[2019/15]
WO2017EP62320
Priority number, dateWO2016CN8347226.05.2016         Original published format: PCT/CN2016/083472
WO2017CN8091418.04.2017         Original published format: PCT/CN2017/080914
[2019/15]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017202798
Date:30.11.2017
Language:EN
[2017/48]
Type: A1 Application with search report 
No.:EP3464278
Date:10.04.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 30.11.2017 takes the place of the publication of the European patent application.
[2019/15]
Type: B1 Patent specification 
No.:EP3464278
Date:16.06.2021
Language:EN
[2021/24]
Search report(s)International search report - published on:EP30.11.2017
ClassificationIPC:C07D405/14, C07D311/82, C07D311/86, C07D405/04, C07D407/04, C07D409/04, C07D487/10, C07D491/052, C07D493/10, A61K31/352, A61P31/12
[2019/15]
CPC:
C07D311/86 (EP,US); A61P31/20 (EP,US); C07D311/82 (EP,US);
C07D405/04 (EP,US); C07D405/14 (EP,US); C07D407/04 (EP,US);
C07D409/04 (EP,US); C07D487/10 (EP,US); C07D491/052 (EP,US);
C07D493/04 (EP,US); C07D493/10 (EP,US); C07D495/04 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/15]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:XANTHONDERIVATE ZUR BEHANDLUNG UND PROPHYLAXE VON HEPATITIS-B-VIRUSERKRANKUNGEN[2021/07]
English:XANTHONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE[2019/15]
French:DÉRIVÉS DE XANTHONE POUR LE TRAITEMENT ET LA PROPHYLAXIE D'UNE MALADIE À VIRUS DE L'HÉPATITE B[2019/15]
Former [2019/15]XANTHONDERIVATE ZUR BEHANDLUNG UND PROPHYLAXE VON HEPATITIS-B-VIRUSERKRANUNGEN
Entry into regional phase02.01.2019National basic fee paid 
02.01.2019Designation fee(s) paid 
02.01.2019Examination fee paid 
Examination procedure02.01.2019Examination requested  [2019/15]
02.01.2019Date on which the examining division has become responsible
17.07.2019Amendment by applicant (claims and/or description)
09.10.2019Despatch of a communication from the examining division (Time limit: M06)
02.04.2020Reply to a communication from the examining division
06.08.2020Despatch of a communication from the examining division (Time limit: M04)
24.11.2020Reply to a communication from the examining division
21.01.2021Communication of intention to grant the patent
23.04.2021Fee for grant paid
23.04.2021Fee for publishing/printing paid
23.04.2021Receipt of the translation of the claim(s)
Opposition(s)17.03.2022No opposition filed within time limit [2022/21]
Fees paidRenewal fee
08.05.2019Renewal fee patent year 03
30.03.2020Renewal fee patent year 04
11.05.2021Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU23.05.2017
AL16.06.2021
AT16.06.2021
CY16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
IT16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
MK16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
TR16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
[2024/29]
Former [2024/22]HU23.05.2017
AL16.06.2021
AT16.06.2021
CY16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
IT16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
MK16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
Former [2024/20]HU23.05.2017
AL16.06.2021
AT16.06.2021
CY16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
IT16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
Former [2024/18]HU23.05.2017
AL16.06.2021
AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
IT16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
Former [2023/06]AL16.06.2021
AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
IT16.06.2021
LT16.06.2021
LV16.06.2021
MC16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/36]AL16.06.2021
AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
IT16.06.2021
LT16.06.2021
LV16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/29]AL16.06.2021
AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SI16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/26]AL16.06.2021
AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/21]AT16.06.2021
CZ16.06.2021
DK16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/10]AT16.06.2021
CZ16.06.2021
EE16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
NL16.06.2021
PL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
IS16.10.2021
PT18.10.2021
Former [2022/09]AT16.06.2021
CZ16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
NL16.06.2021
RO16.06.2021
RS16.06.2021
SE16.06.2021
SK16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
PT18.10.2021
Former [2022/08]AT16.06.2021
CZ16.06.2021
ES16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
NL16.06.2021
RS16.06.2021
SE16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
Former [2022/07]AT16.06.2021
FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
NL16.06.2021
RS16.06.2021
SE16.06.2021
SM16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
Former [2021/51]FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
RS16.06.2021
SE16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
Former [2021/49]FI16.06.2021
HR16.06.2021
LT16.06.2021
LV16.06.2021
SE16.06.2021
BG16.09.2021
NO16.09.2021
GR17.09.2021
Former [2021/47]FI16.06.2021
LT16.06.2021
BG16.09.2021
Former [2021/46]FI16.06.2021
LT16.06.2021
Cited inInternational search[A]US2012184578  (TEOW VINCENT I [US]) [A] 1-37 * example - * * claim - * * claim 1 * * page 8 *;
 [AD]CN104370871  (UNIV BEIJING) [AD] 1-37 * example - * * claim - *;
 [A]  - ZHANG FAN ET AL, "A review of non-nucleoside anti-hepatitis B virus agents", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, (20141230), vol. 75, doi:10.1016/J.EJMECH.2014.01.046, ISSN 0223-5234, pages 267 - 281, XP028625376 [A] 1-37 * abstract * * page 268; figure 1 *

DOI:   http://dx.doi.org/10.1016/j.ejmech.2014.01.046
Examination   - Pubchem, "1-[5-Fluoro-9-(oxetan-3-yl)-9H-xanthen-3-yl]pyrrolidine | C20H20FNO2 - PubChem", (20160301), URL: https://pubchem.ncbi.nlm.nih.gov/compound/138687203, (20200731), XP055719525
by applicantCN104370871
    - LOZANO, R ET AL., LANCET, (2012), vol. 380, no. 9859, pages 2095 - 2128
    - GOLDSTEIN, S.T. ET AL., INT J EPIDEMIOL, (2005), vol. 34, no. 6, pages 1329 - 1339
    - CHEN, D.S., J HEPATOL, (2009), vol. 50, no. 4, pages 805 - 816
    - LI, X.M ET AL., WORLD J GASTROENTEROL, (2003), vol. 9, no. 7, pages 1501 - 1503
    - AHMED, M ET AL., DRUG DISCOV TODAY, (2015), vol. 20, no. 5, pages 548 - 561
    - ZOULIM, F.; LOCARNINI, S., GASTROENTEROLOGY, (2009), vol. 137, no. 5, pages 1593 - 1608 E1591,1592
    - NASSAL, M., GUT, (2015), vol. 64, no. 12, pages 1972 - 1984
    - GISH, R.G ET AL., ANTIVIRAL RES, (2015), vol. 121, pages 47 - 58
    - LEVRERO, M ET AL., J HEPATOL, (2009), vol. 51, no. 3, pages 581 - 592
    - AHMED, M. ET AL., DRUG DISCOV TODAY, (2015), vol. 20, no. 5, pages 548 - 561
    - BASTIN R.J. ET AL., ORGANIC PROCESS RESEARCH & DEVELOPMENT, (2000), vol. 4, pages 427 - 435
    - PEGG, DAVID E., "Principles of cryopreservation", METHODS IN MOLECULAR BIOLOGY, (20070101), vol. 368, pages 39 - 57
    - ZHOU, T ET AL., ANTIVIRAL RES, (2006), vol. 72, no. 2, pages 116 - 124
    - GUO, H. ET AL., J. VIROL, (2007), vol. 81, no. 22, pages 12472 - 12484
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.