blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3405101

EP3405101 - DIFFERENTIAL DIAGNOSIS OF ECTOPIC CUSHING'S SYNDROME [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  29.10.2021
Database last updated on 25.09.2024
FormerThe patent has been granted
Status updated on  20.11.2020
FormerGrant of patent is intended
Status updated on  06.07.2020
FormerRequest for examination was made
Status updated on  26.10.2018
FormerThe international publication has been made
Status updated on  28.07.2017
Most recent event   Tooltip13.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 16.10.2024 [2024/42]
Applicant(s)For all designated states
Corcept Therapeutics, Inc.
149 Commonwealth Avenue
Menlo Park, CA 94025 / US
[2018/48]
Inventor(s)01 / MORAITIS, Andreas G.
149 Commonwealth Drive
Menlo Park, CA 94025 / US
 [2020/52]
Former [2018/48]01 / MORAITIS, Andreas G.
149 Commonwealth Drive
Menlo Park California 94025 / US
Representative(s)Geling, Andrea
ZSP Patentanwälte PartG mbB
Hansastraße 32
80686 München / DE
[2018/48]
Application number, filing date17741860.518.01.2017
[2018/48]
WO2017US13974
Priority number, dateUS201662280424P19.01.2016         Original published format: US 201662280424 P
[2018/48]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017127448
Date:27.07.2017
Language:EN
[2017/30]
Type: A1 Application with search report 
No.:EP3405101
Date:28.11.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 27.07.2017 takes the place of the publication of the European patent application.
[2018/48]
Type: B1 Patent specification 
No.:EP3405101
Date:23.12.2020
Language:EN
[2020/52]
Search report(s)International search report - published on:KR27.07.2017
(Supplementary) European search report - dispatched on:EP21.06.2019
ClassificationIPC:A61B5/00, G01N33/74
[2018/48]
CPC:
G01N33/743 (EP,IL,KR,US); A61B5/4227 (EP,IL,KR,US); A61P5/38 (EP,IL);
G01N33/74 (IL,US); G16H20/17 (EP,IL,US); G16H50/20 (EP,IL,US);
G16H50/30 (EP,IL,US); G01N2333/575 (EP,IL,US); G01N2333/723 (EP,IL,US);
G01N2800/04 (EP,IL,KR,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/48]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:DIFFERENTIALDIAGNOSE VON EKTOPISCHEM CUSHING-SYNDROM[2018/48]
English:DIFFERENTIAL DIAGNOSIS OF ECTOPIC CUSHING'S SYNDROME[2018/48]
French:DIAGNOSTIC DIFFÉRENTIEL DU SYNDROME DE CUSHING ECTOPIQUE[2018/48]
Entry into regional phase30.07.2018National basic fee paid 
30.07.2018Search fee paid 
30.07.2018Designation fee(s) paid 
30.07.2018Examination fee paid 
Examination proceduredeletedDate on which the examining division has become responsible
30.07.2018Examination requested  [2018/48]
09.01.2020Amendment by applicant (claims and/or description)
07.07.2020Communication of intention to grant the patent
16.11.2020Fee for grant paid
16.11.2020Fee for publishing/printing paid
16.11.2020Receipt of the translation of the claim(s)
Opposition(s)24.09.2021No opposition filed within time limit [2021/48]
Fees paidRenewal fee
15.01.2019Renewal fee patent year 03
14.01.2020Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU18.01.2017
AL23.12.2020
AT23.12.2020
CY23.12.2020
CZ23.12.2020
DK23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
MK23.12.2020
MT23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SI23.12.2020
SK23.12.2020
SM23.12.2020
IE18.01.2021
BE31.01.2021
CH31.01.2021
LI31.01.2021
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
[2024/42]
Former [2024/22]HU18.01.2017
AL23.12.2020
AT23.12.2020
CY23.12.2020
CZ23.12.2020
DK23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
MK23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SI23.12.2020
SK23.12.2020
SM23.12.2020
IE18.01.2021
BE31.01.2021
CH31.01.2021
LI31.01.2021
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2023/33]HU18.01.2017
AL23.12.2020
AT23.12.2020
CY23.12.2020
CZ23.12.2020
DK23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SI23.12.2020
SK23.12.2020
SM23.12.2020
IE18.01.2021
BE31.01.2021
CH31.01.2021
LI31.01.2021
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2023/30]AL23.12.2020
AT23.12.2020
CY23.12.2020
CZ23.12.2020
DK23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SI23.12.2020
SK23.12.2020
SM23.12.2020
IE18.01.2021
BE31.01.2021
CH31.01.2021
LI31.01.2021
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2022/34]AL23.12.2020
AT23.12.2020
CZ23.12.2020
DK23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SI23.12.2020
SK23.12.2020
SM23.12.2020
IE18.01.2021
BE31.01.2021
CH31.01.2021
LI31.01.2021
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2022/23]AL23.12.2020
AT23.12.2020
CZ23.12.2020
DK23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SI23.12.2020
SK23.12.2020
SM23.12.2020
IE18.01.2021
CH31.01.2021
LI31.01.2021
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2022/13]AL23.12.2020
AT23.12.2020
CZ23.12.2020
DK23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SI23.12.2020
SK23.12.2020
SM23.12.2020
IE18.01.2021
CH31.01.2021
LI31.01.2021
BG23.03.2021
NO23.03.2021
GR24.03.2021
PT23.04.2021
Former [2022/10]AL23.12.2020
AT23.12.2020
CZ23.12.2020
DK23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SK23.12.2020
SM23.12.2020
IE18.01.2021
CH31.01.2021
LI31.01.2021
BG23.03.2021
NO23.03.2021
GR24.03.2021
PT23.04.2021
Former [2022/07]AL23.12.2020
AT23.12.2020
CZ23.12.2020
DK23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SK23.12.2020
SM23.12.2020
IE18.01.2021
CH31.01.2021
LI31.01.2021
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2021/52]AL23.12.2020
AT23.12.2020
CZ23.12.2020
DK23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SK23.12.2020
SM23.12.2020
CH31.01.2021
LI31.01.2021
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2021/49]AL23.12.2020
AT23.12.2020
CZ23.12.2020
DK23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2021/45]AL23.12.2020
AT23.12.2020
CZ23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2021/42]AT23.12.2020
CZ23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2021/39]AT23.12.2020
CZ23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
PT23.04.2021
Former [2021/37]AT23.12.2020
CZ23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
PT23.04.2021
Former [2021/36]CZ23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
PT23.04.2021
Former [2021/35]CZ23.12.2020
FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
PT23.04.2021
Former [2021/33]FI23.12.2020
HR23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
RS23.12.2020
SE23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
PT23.04.2021
Former [2021/32]FI23.12.2020
HR23.12.2020
LV23.12.2020
NL23.12.2020
RS23.12.2020
SE23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
Former [2021/30]FI23.12.2020
HR23.12.2020
LV23.12.2020
NL23.12.2020
RS23.12.2020
SE23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
Former [2021/28]FI23.12.2020
HR23.12.2020
LV23.12.2020
RS23.12.2020
SE23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
Former [2021/23]FI23.12.2020
LV23.12.2020
RS23.12.2020
SE23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
Former [2021/22]FI23.12.2020
RS23.12.2020
NO23.03.2021
Former [2021/20]FI23.12.2020
Documents cited:Search[A]  - Tsigos ET AL, "DIFFERENTIAL DIAGNOSIS AND MANAGEMENT OF CUSHING'S SYNDROME 1", Annual Review of Medicine, 4139 El Camino Way, P.O. Box 10139, doi:10.1146/annurev.med.47.1.443, (19960201), pages 443 - 461, URL: http://annualreviews.org/doi/pdf/10.1146/annurev.med.47.1.443, XP055364773 [A] 1-15 * page 447 - page 455 *

DOI:   http://dx.doi.org/10.1146/annurev.med.47.1.443
 [A]  - DIEZ JUAN J ET AL, "Pharmacological therapy of Cushing 's syndrome: drugs and indications", MINI REVIEWS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBL, NL, (20070101), vol. 7, no. 5, doi:10.2174/138955707780619653, ISSN 1389-5575, pages 467 - 480, XP009120098 [A] 1-15 * abstract * * page 474 *

DOI:   http://dx.doi.org/10.2174/138955707780619653
 [A]  - RAFF HERSHEL AURORA, "Cushing Syndrome Update on Testing", ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, W.B. SAUNDERS COMPANY, PHILADELPHIA, vol. 44, no. 1, doi:10.1016/J.ECL.2014.10.005, ISSN 0889-8529, (20150228), pages 43 - 50, X, (20141104), XP009513627 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.ecl.2014.10.005
International search[A]US2004138516  (OSORIO IVAN [US], et al) [A] 9-24* See abstract; claims 25-30. *;
 [A]US2014170768  (EHRENKRANZ JOEL R L [US]) [A] 9-24 * See abstract; claims 1-10. *;
 [A]  - RITZEL, K. et al., "ACTH after 15 min distinguishes between Cushing's disease and ectopic Cushing's syndrome: a proposal for a short and simple CRH test", European Journal of Endocrinology, (20150000), vol. 173, no. 2, pages 197 - 204, XP055402544 [A] 9-24 * See abstract; pages 198 and 199. *

DOI:   http://dx.doi.org/10.1530/EJE-14-0912
 [A]  - REIMONDO, G. et al., "The corticotrophin-releasing hormone test is the most reliable noninvasive method to differentiate pituitary from ectopic ACTH secretion in Cushing' s syndrome", Clinical Endocrinology, (20030000), vol. 58, no. 6, pages 718 - 724, XP055402548 [A] 9-24 * See summary; pages 719-721. *

DOI:   http://dx.doi.org/10.1046/j.1365-2265.2003.01776.x
 [A]  - EL-SHAFIE, 0. T. et al., "Adrenocorticotropic hormone-dependent Cushing's syndrome: use of an octreotide trial to distinguish between pituitary or ectopic sources", Sultan Qaboos University Medical Journal, (20150121), vol. 15, no. 1, pages 120 - 123, XP055402551 [A] 9-24 * See abstract; page e122. *
by applicantUS4296206
 US4386085
 US4447424
 US4477445
 US4519946
 US4540686
 US4547493
 US4634695
 US4634696
 US4753932
 US4774236
 US4808710
 US4814327
 US4829060
 US4861763
 US4912097
 US4921638
 US4943566
 US4954490
 US4978657
 US5006518
 US5043332
 US5064822
 US5073548
 US5089488
 US5089635
 US5093507
 US5095010
 US5095129
 US5132299
 US5166146
 US5166199
 US5173405
 US5276023
 US5348729
 US5380839
 US5426102
 US5439913
 WO9619458
 US5616458
 EP0683172
 US5696127
 US5929058
 EP0763541
 US6051573
 US6303591
 US2002077356
 US6570020
 WO03043640
 US7928237
 US8461172
 US2014038926
 US8685973
    - "Biosynthesis and Transport of Membrane Lipids and Formation of Cholesterol Derivatives", RAWN et al., Biochemistry, (19890000), page 567
    - TURNERMULLER, J Mol. Endocrinol., (20050000), vol. 35, pages 283 - 292
    - LEFEBVRE, J. Steroid Biochem., (19890000), vol. 33, pages 557 - 563
    - FLESERIU et al., J. Clin. Endocrinol. Metab., (20120609), vol. 7, no. 6, pages 2039 - 49
    - ASSER et al., Mol Cell Endocrinol., (20140000), vol. 395, pages 1 - 9
    - ALBERTSON et al., Eur. J. of Endocrinol., (19940000), vol. 130, pages 195 - 200
    - ASSER et al., Mol. Cell. Endocrino., (20140900), vol. 395, no. 1-2, pages 1 - 9
    - VAN KAMPEN et al., Eur. J. Pharmacol., (20020000), vol. 457, no. 2-3, page 207
    - HOYBERG et al., Int'l J. of Neuro-psychopharmacology, (20020000), vol. 5, no. 1, page S148
    - AGARWAL, FEBS, (19870000), vol. 217, pages 221 - 226
    - BOCQUEL, J. Steroid Biochem. Molec. Biol., (19930000), vol. 45, pages 205 - 215
    - TEUTSCH, Steroids, (19810000), vol. 38, pages 651 - 665
    - MERCIER, J. Steroid Biochem., (19860000), vol. 25, no. 11-20, pages 25 - 32
    - ROUSSEAU, Nature, (19790000), vol. 279, pages 158 - 160
    - WYNNE, Endocrinology, (19800000), vol. 107, pages 1278 - 1280
    - VICENT, Mol. Pharm., (19970000), vol. 52, pages 749 - 753
    - MIZUTANI, J Steroid Biochem Mol. Biol., (19920000), vol. 42, no. 7, pages 695 - 704
    - KIM, J Steroid Biochem Mol. Biol., (19980000), vol. 67, no. 3, pages 213 - 22
    - AMOUR, Int. J. Pept. Protein Res., (19940000), vol. 43, pages 297 - 304
    - DE BONT, Bioorganic & Medicinal Chem., (19960000), vol. 4, pages 667 - 672
    - BRADLEY et al., J. Med. Chem., (20020000), vol. 45, pages 2417 - 2424
    - ROHATAGI, J. Clin. Pharmacol., (19950000), vol. 35, pages 1187 - 1193
    - TJWA, Ann. Allergy Asthma Immunol., (19950000), vol. 75, pages 107 - 111
    - MINTO, J. Pharmacol. Exp. Ther., (19970000), vol. 281, pages 93 - 102
    - RAO, J. Biomater Sci. Polym. Ed., (19950000), vol. 7, pages 623 - 645
    - GAO, Pharm. Res., (19950000), vol. 12, pages 857 - 863
    - EYLES, J. Pharm. Pharmacol., (19970000), vol. 49, pages 669 - 674
    - AL-MUHAMMED, J., Microencapsul., (19960000), vol. 13, pages 293 - 306
    - CHONN, Curr. Opin. Biotechnol., (19950000), vol. 6, pages 698 - 708
    - OSTRO, Am. J. Hasp. Pharm., (19890000), vol. 46, pages 1576 - 1587
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.