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Extract from the Register of European Patents

EP About this file: EP3512943

EP3512943 - CRISP-SEQ, AN INTEGRATED METHOD FOR MASSIVELY PARALLEL SINGLE CELL RNA-SEQ AND CRISPR POOLED SCREENS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  16.02.2024
Database last updated on 07.10.2024
FormerThe patent has been granted
Status updated on  10.03.2023
FormerGrant of patent is intended
Status updated on  01.03.2023
FormerExamination is in progress
Status updated on  28.04.2020
FormerRequest for examination was made
Status updated on  21.06.2019
FormerThe international publication has been made
Status updated on  24.03.2018
Formerunknown
Status updated on  12.10.2017
Most recent event   Tooltip02.08.2024Lapse of the patent in a contracting state
New state(s): BE		published on 04.09.2024  [2024/36]
Applicant(s)For all designated states
Yeda Research and Development Co. Ltd.
at the Weizmann Institute of Science
P.O. Box 95
7610002 Rehovot / IL
[2019/30]
Inventor(s)01 / AMIT, Ido
Meonot Wolfson 31C The Weizmann Institute of Science
7610002 Rehovot / IL
02 / JAITIN, Diego
c/o Yeda Research and Development Co. Ltd.
at the Weizmann Institute of Science
P.O. Box 95
7610002 Rehovot / IL
03 / LARA-ASTIASO, David
c/o Yeda Research and Development Co. Ltd.
at the Weizmann Institute of Science
P.O. Box 95
7610002 Rehovot / IL
04 / WEINER, Assaf
c/o Yeda Research and Development Co. Ltd.
at the Weizmann Institute of Science
P.O. Box 95
7610002 Rehovot / IL
05 / YOFE, Ido
c/o Yeda Research and Development Co. Ltd.
at the Weizmann Institute of Science
P.O. Box 95
7610002 Rehovot / IL
 [2019/30]
Representative(s)Dennemeyer & Associates S.A.
Postfach 70 04 25
81304 München / DE
[2019/30]
Application number, filing date17777660.614.09.2017
[2019/30]
WO2017IL51043
Priority number, dateUS201662394324P14.09.2016         Original published format: US 201662394324 P
US201662421503P14.11.2016         Original published format: US 201662421503 P
US201662427325P29.11.2016         Original published format: US 201662427325 P
[2019/30]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018051347
Date:22.03.2018
Language:EN
[2018/12]
Type: A1 Application with search report 
No.:EP3512943
Date:24.07.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 22.03.2018 takes the place of the publication of the European patent application.
[2019/30]
Type: B1 Patent specification 
No.:EP3512943
Date:12.04.2023
Language:EN
[2023/15]
Search report(s)International search report - published on:EP22.03.2018
ClassificationIPC:C12N15/10, C12N15/63
[2019/30]
CPC:
C40B40/02 (EP); C12N15/11 (US); C12N15/102 (EP,US);
C12N15/1093 (EP,US); C12N15/63 (EP,US); C12N15/86 (EP);
C12N9/22 (EP,US); C12Q1/6883 (US); C40B40/06 (EP);
C07H21/02 (US); C07H21/04 (US); C12N15/85 (US);
C12N2310/20 (EP,US); C12N2740/16043 (EP); C12N2800/80 (US) (-)
C-Set:
C12N15/1093, C12Q2563/179 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/30]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:CRISP-SEQ, INTEGRIERTES VERFAHREN FÜR MASSIV PARALLELE EINZELZELLEN-RNA-SEQ UND CRISPR-GEPOOLTE SCREENS[2019/30]
English:CRISP-SEQ, AN INTEGRATED METHOD FOR MASSIVELY PARALLEL SINGLE CELL RNA-SEQ AND CRISPR POOLED SCREENS[2019/30]
French:CRISP-SEQ, PROCÉDÉ INTÉGRÉ POUR SÉQUENÇAGE MASSIVEMENT PARALLÈLE D'ARN UNICELLULAIRE ET CRIBLAGES REGROUPÉS PAR CRISPR[2019/30]
Entry into regional phase03.04.2019National basic fee paid 
03.04.2019Designation fee(s) paid 
03.04.2019Examination fee paid 
Examination procedure03.04.2019Amendment by applicant (claims and/or description)
03.04.2019Examination requested  [2019/30]
03.04.2019Date on which the examining division has become responsible
04.05.2020Despatch of a communication from the examining division (Time limit: M06)
05.11.2020Reply to a communication from the examining division
01.03.2021Despatch of a communication from the examining division (Time limit: M04)
17.06.2021Reply to a communication from the examining division
15.11.2022Communication of intention to grant the patent
01.03.2023Fee for grant paid
01.03.2023Fee for publishing/printing paid
01.03.2023Receipt of the translation of the claim(s)
Opposition(s)15.01.2024No opposition filed within time limit [2024/12]
Fees paidRenewal fee
13.09.2019Renewal fee patent year 03
14.09.2020Renewal fee patent year 04
10.09.2021Renewal fee patent year 05
27.09.2022Renewal fee patent year 06
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL12.04.2023
AT12.04.2023
CZ12.04.2023
DK12.04.2023
EE12.04.2023
ES12.04.2023
FI12.04.2023
HR12.04.2023
IT12.04.2023
LT12.04.2023
LV12.04.2023
MC12.04.2023
NL12.04.2023
PL12.04.2023
RO12.04.2023
RS12.04.2023
SE12.04.2023
SI12.04.2023
SK12.04.2023
SM12.04.2023
NO12.07.2023
GR13.07.2023
IS12.08.2023
PT14.08.2023
IE14.09.2023
LU14.09.2023
BE30.09.2023
CH30.09.2023
[2024/36]
Former [2024/34]AL12.04.2023
AT12.04.2023
CZ12.04.2023
DK12.04.2023
EE12.04.2023
ES12.04.2023
FI12.04.2023
HR12.04.2023
IT12.04.2023
LT12.04.2023
LV12.04.2023
MC12.04.2023
NL12.04.2023
PL12.04.2023
RO12.04.2023
RS12.04.2023
SE12.04.2023
SI12.04.2023
SK12.04.2023
SM12.04.2023
NO12.07.2023
GR13.07.2023
IS12.08.2023
PT14.08.2023
IE14.09.2023
LU14.09.2023
CH30.09.2023
Former [2024/33]AL12.04.2023
AT12.04.2023
CZ12.04.2023
DK12.04.2023
EE12.04.2023
ES12.04.2023
FI12.04.2023
HR12.04.2023
IT12.04.2023
LT12.04.2023
LV12.04.2023
MC12.04.2023
NL12.04.2023
PL12.04.2023
RO12.04.2023
RS12.04.2023
SE12.04.2023
SI12.04.2023
SK12.04.2023
SM12.04.2023
NO12.07.2023
GR13.07.2023
IS12.08.2023
PT14.08.2023
IE14.09.2023
LU14.09.2023
Former [2024/28]AL12.04.2023
AT12.04.2023
CZ12.04.2023
DK12.04.2023
EE12.04.2023
ES12.04.2023
FI12.04.2023
HR12.04.2023
IT12.04.2023
LT12.04.2023
LV12.04.2023
MC12.04.2023
NL12.04.2023
PL12.04.2023
RO12.04.2023
RS12.04.2023
SE12.04.2023
SI12.04.2023
SK12.04.2023
SM12.04.2023
NO12.07.2023
GR13.07.2023
IS12.08.2023
PT14.08.2023
LU14.09.2023
Former [2024/26]AL12.04.2023
AT12.04.2023
CZ12.04.2023
DK12.04.2023
EE12.04.2023
ES12.04.2023
FI12.04.2023
HR12.04.2023
IT12.04.2023
LT12.04.2023
LV12.04.2023
NL12.04.2023
PL12.04.2023
RO12.04.2023
RS12.04.2023
SE12.04.2023
SI12.04.2023
SK12.04.2023
SM12.04.2023
NO12.07.2023
GR13.07.2023
IS12.08.2023
PT14.08.2023
LU14.09.2023
Former [2024/25]AL12.04.2023
AT12.04.2023
CZ12.04.2023
DK12.04.2023
EE12.04.2023
ES12.04.2023
FI12.04.2023
HR12.04.2023
LT12.04.2023
LV12.04.2023
NL12.04.2023
PL12.04.2023
RO12.04.2023
RS12.04.2023
SE12.04.2023
SI12.04.2023
SK12.04.2023
SM12.04.2023
NO12.07.2023
GR13.07.2023
IS12.08.2023
PT14.08.2023
LU14.09.2023
Former [2024/24]AL12.04.2023
AT12.04.2023
CZ12.04.2023
DK12.04.2023
EE12.04.2023
ES12.04.2023
FI12.04.2023
HR12.04.2023
LT12.04.2023
LV12.04.2023
NL12.04.2023
PL12.04.2023
RO12.04.2023
RS12.04.2023
SE12.04.2023
SI12.04.2023
SK12.04.2023
SM12.04.2023
NO12.07.2023
GR13.07.2023
IS12.08.2023
PT14.08.2023
Former [2024/10]AL12.04.2023
AT12.04.2023
CZ12.04.2023
DK12.04.2023
EE12.04.2023
ES12.04.2023
FI12.04.2023
HR12.04.2023
LT12.04.2023
LV12.04.2023
NL12.04.2023
PL12.04.2023
RO12.04.2023
RS12.04.2023
SE12.04.2023
SK12.04.2023
SM12.04.2023
NO12.07.2023
GR13.07.2023
IS12.08.2023
PT14.08.2023
Former [2024/08]AL12.04.2023
AT12.04.2023
ES12.04.2023
FI12.04.2023
HR12.04.2023
LT12.04.2023
LV12.04.2023
NL12.04.2023
PL12.04.2023
RS12.04.2023
SE12.04.2023
SK12.04.2023
SM12.04.2023
NO12.07.2023
GR13.07.2023
IS12.08.2023
PT14.08.2023
Former [2024/03]AL12.04.2023
AT12.04.2023
ES12.04.2023
FI12.04.2023
HR12.04.2023
LT12.04.2023
LV12.04.2023
NL12.04.2023
PL12.04.2023
RS12.04.2023
SE12.04.2023
NO12.07.2023
GR13.07.2023
IS12.08.2023
PT14.08.2023
Former [2024/01]AL12.04.2023
AT12.04.2023
ES12.04.2023
HR12.04.2023
LT12.04.2023
LV12.04.2023
NL12.04.2023
PL12.04.2023
RS12.04.2023
SE12.04.2023
NO12.07.2023
GR13.07.2023
IS12.08.2023
PT14.08.2023
Former [2023/51]AL12.04.2023
AT12.04.2023
ES12.04.2023
HR12.04.2023
NL12.04.2023
PL12.04.2023
RS12.04.2023
SE12.04.2023
NO12.07.2023
GR13.07.2023
IS12.08.2023
PT14.08.2023
Former [2023/50]AL12.04.2023
AT12.04.2023
ES12.04.2023
NL12.04.2023
PL12.04.2023
SE12.04.2023
NO12.07.2023
GR13.07.2023
IS12.08.2023
PT14.08.2023
Former [2023/48]AT12.04.2023
ES12.04.2023
NL12.04.2023
SE12.04.2023
NO12.07.2023
PT14.08.2023
Former [2023/46]ES12.04.2023
NL12.04.2023
PT14.08.2023
Former [2023/43]NL12.04.2023
Cited inInternational search[Y]CA2932478  (MASSACHUSETTS INST TECHNOLOGY [US], et al) [Y] 2-4,15-17* figure 1 *;
 [XP]  - JAITIN DIEGO ADHEMAR ET AL, "Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq", CELL, CELL PRESS, US, (20161215), vol. 167, no. 7, doi:10.1016/J.CELL.2016.11.039, ISSN 0092-8674, page 1883, XP029850714 [XP] 1-29 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.cell.2016.11.039
 [XI]  - WONG ALAN S L ET AL, Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, VOL. 113, NR. 9, PAGE(S) 2544-2549, (201603), ISSN 0027-8424, XP002775745 [X] 1,5-8,10-14,18-20,22-24,27,29 * figures 1,2 * [I] 9,21,25,26,28

DOI:   http://dx.doi.org/10.1073/pnas.1517883113
 [Y]  - CASSANDRA L LOVE, JANE HEALY, ADRIENNE GREENOUGH, SANDEEP S. DAVE AND GUOJIE LI, "Silencing Mutations in NOTCH1 Activate Calcium Signaling in B Cells", BLOOD, 56TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; SAN FRANCISCO, CA, USA; DECEMBER 06 -09, 2014, (20141204), vol. 124, no. 21, ISSN 0006-4971, XP002775746 [Y] 2-4,15-17 * paragraph [0004] *
 [Y]  - GUHA SIDDARTH ET AL, "Tu1957: Functional Characterization of a Novel Oncogene GNAS in Pancreatic Cancer Cells", GASTROENTEROLOGY, 46TH ANNUAL DIGESTIVE DISEASE WEEK (DDW); WASHINGTON, DC, USA; MAY 16 -19, 2015, (201504), vol. 148, no. 4, Suppl. 1, doi:10.1016/S0016-5085(15)33224-8, ISSN 0016-5085, page S945, XP002775747 [Y] 2-4,15-17 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0016-5085(15)33224-8
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.