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Extract from the Register of European Patents

EP About this file: EP3515887

EP3515887 - TRPV4 ANTAGONISTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.05.2022
Database last updated on 31.08.2024
FormerThe patent has been granted
Status updated on  12.06.2021
FormerGrant of patent is intended
Status updated on  15.02.2021
FormerExamination is in progress
Status updated on  04.03.2020
FormerRequest for examination was made
Status updated on  28.06.2019
FormerThe international publication has been made
Status updated on  30.03.2018
Formerunknown
Status updated on  25.10.2017
Most recent event   Tooltip17.06.2022Lapse of the patent in a contracting statepublished on 20.07.2022  [2022/29]
Applicant(s)For all designated states
GlaxoSmithKline Intellectual Property (No. 2) Limited
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
[2019/31]
Inventor(s)01 / BRNARDIC, Edward J.
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
02 / BROOKS, Carl A.
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
03 / LAWHORN, Brian Griffin
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
04 / YE, Guosen
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
05 / BARTON, Linda S.
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
06 / BUDZIK, Brian W.
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
07 / MATTHEWS, Jay M.
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
08 / MCATEE, John Jeffrey
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
09 / PATTERSON, Jaclyn R.
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
10 / PERO, Joseph E.
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
11 / SANCHEZ, Robert
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
12 / SENDER, Matthew Robert
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
13 / TERRELL, Lamont Roscoe
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
14 / BEHM, David J.
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
15 / THOMAS, James V.
709 Swedeland Road
King of Prussia, Pennsylvania 19406 / US
 [2019/31]
Representative(s)Knight, Lucie Viktoria, et al
GlaxoSmithKline
Global Patents (CN925.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
[2021/27]
Former [2019/31]Hillier, Mark
GlaxoSmithKline
Global Patents (CN925.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
Application number, filing date17784400.820.09.2017
[2019/31]
WO2017IB55700
Priority number, dateUS201662396991P20.09.2016         Original published format: US 201662396991 P
US201762482296P06.04.2017         Original published format: US 201762482296 P
[2019/31]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018055524
Date:29.03.2018
Language:EN
[2018/13]
Type: A1 Application with search report 
No.:EP3515887
Date:31.07.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 29.03.2018 takes the place of the publication of the European patent application.
[2019/31]
Type: B1 Patent specification 
No.:EP3515887
Date:07.07.2021
Language:EN
[2021/27]
Search report(s)International search report - published on:EP29.03.2018
ClassificationIPC:C07D207/48, C07D401/12, C07D403/12, C07D413/12, C07D498/10, A61K31/40, A61K31/4439, A61K31/41, A61K31/506, A61P9/00, A61P1/16, A61P11/00, A61P11/14, A61P13/10
[2019/31]
CPC:
A61K31/40 (EP,KR,US); C07D207/48 (EP,KR,US); A61K31/4025 (EP,US);
A61K31/407 (EP,US); A61K31/41 (KR); A61K31/4155 (EP,US);
A61K31/424 (EP,US); A61K31/4245 (EP,US); A61K31/427 (EP,US);
A61K31/429 (EP,US); A61K31/4439 (EP,KR,US); A61K31/501 (EP,US);
A61K31/506 (EP,KR,US); A61K31/5386 (EP,US); A61K31/695 (EP,US);
A61K45/06 (US); A61K9/0019 (US); A61K9/0053 (US);
A61K9/0073 (US); A61K9/2059 (US); A61K9/4866 (US);
A61P1/00 (EP); A61P1/04 (EP); A61P1/10 (EP);
A61P1/16 (EP,KR); A61P1/18 (EP); A61P11/00 (EP,KR);
A61P11/02 (EP); A61P11/06 (EP); A61P11/14 (EP,KR);
A61P13/10 (EP,KR); A61P13/12 (EP); A61P15/00 (EP);
A61P17/00 (EP); A61P17/04 (EP); A61P19/00 (EP);
A61P19/02 (EP); A61P25/00 (EP); A61P25/06 (EP);
A61P25/28 (EP); A61P27/02 (EP); A61P27/06 (EP);
A61P29/00 (EP); A61P3/00 (EP); A61P3/04 (EP);
A61P3/10 (EP); A61P31/04 (EP); A61P37/04 (EP);
A61P37/06 (EP); A61P43/00 (EP); A61P7/10 (EP);
A61P9/00 (EP,KR); A61P9/04 (EP); A61P9/10 (EP);
A61P9/12 (EP); C07D401/12 (EP,KR,US); C07D403/12 (EP,KR,US);
C07D409/12 (EP,US); C07D413/12 (EP,KR,US); C07D417/12 (EP,US);
C07D491/107 (EP,US); C07D498/10 (EP,KR,US); C07D513/04 (EP,US);
C07F7/0812 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/31]
Extension statesBA25.03.2019
ME25.03.2019
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:TRPV4-ANTAGONISTEN[2019/31]
English:TRPV4 ANTAGONISTS[2019/31]
French:ANTAGONISTES DE TRPV4[2019/31]
Entry into regional phase25.03.2019National basic fee paid 
25.03.2019Designation fee(s) paid 
25.03.2019Examination fee paid 
Examination procedure25.03.2019Examination requested  [2019/31]
25.03.2019Date on which the examining division has become responsible
22.10.2019Amendment by applicant (claims and/or description)
09.03.2020Despatch of a communication from the examining division (Time limit: M06)
02.09.2020Reply to a communication from the examining division
16.02.2021Communication of intention to grant the patent
26.05.2021Fee for grant paid
26.05.2021Fee for publishing/printing paid
26.05.2021Receipt of the translation of the claim(s)
Opposition(s)08.04.2022No opposition filed within time limit [2022/24]
Fees paidRenewal fee
11.09.2019Renewal fee patent year 03
11.09.2020Renewal fee patent year 04
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competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL07.07.2021
[2022/29]
Cited inInternational search[A]WO2007082262  (SMITHKLINE BEECHAM CORP [US], et al) [A] 1-25 * claims 1,11 *;
 [A]US2011021487  (HUEBSCH WALTER [DE], et al) [A] 1-25 * paragraph [0017]; examples 11a,28a; claim 1 *;
 [AD]  - SARAH E. SKERRATT ET AL, "Identification of false positives in "HTS hits to lead": The application of Bayesian models in HTS triage to rapidly deliver a series of selective TRPV4 antagonists", MEDCHEMCOMM, United Kingdom, (20130101), vol. 4, no. 1, doi:10.1039/C2MD20259J, ISSN 2040-2503, pages 244 - 251, XP055421415 [AD] 1-25 * figure 3; table 1 *

DOI:   http://dx.doi.org/10.1039/C2MD20259J
 [A]  - MASAMI KURIYAMA ET AL, "Copper(II)-Catalyzed Monoarylation of Vicinal Diols with Diaryliodonium Salts", CHEMISTRY - A EUROPEAN JOURNAL, (20120206), vol. 18, no. 6, doi:10.1002/chem.201102770, ISSN 0947-6539, pages 1591 - 1594, XP055421552 [A] 1-25 * table 3; compound 1g *

DOI:   http://dx.doi.org/10.1002/chem.201102770
by applicantGB2064336
 EP0069715
 GB2129691
 GB2169265
 GB2178965
 US4778054
 US4811731
 US5035237
 GB2242134
 US5590645
 US5860419
 US5873360
 US6032666
 US6321747
 US6378519
 US6536427
 WO03061743
 WO2007012871
 WO2007068896
 US8113199
 US8161968
 US8511304
 US8534281
 US8746242
 US9333310
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