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Extract from the Register of European Patents

EP About this file: EP3515457

EP3515457 - MI-RNA PHARMACEUTICAL COMPOSITION AND THERAPEUTIC USES THEREOF [Right-click to bookmark this link]
Former [2019/31]miRNA PHARMACEUTICAL COMPOSITION AND THERAPEUTIC USES THEREOF
[2020/24]
StatusNo opposition filed within time limit
Status updated on  17.09.2021
Database last updated on 02.11.2024
FormerThe patent has been granted
Status updated on  09.10.2020
FormerGrant of patent is intended
Status updated on  28.05.2020
FormerRequest for examination was made
Status updated on  28.06.2019
FormerThe international publication has been made
Status updated on  24.03.2018
Formerunknown
Status updated on  27.10.2017
Most recent event   Tooltip13.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 16.10.2024  [2024/42]
Applicant(s)For all designated states
Fondazione Istituto Italiano di Tecnologia
Via Morego 30
16163 Genova / IT
[2019/31]
Inventor(s)01 / DE PIETRI TONELLI, Davide
Via G. Caproni 118/2
16011 Arenzano (Genova) / IT
02 / PONS ESPINAL, Meritxell
C/Monestir, 33, Esc B, Atic 1
08172 Sant Cugat del Vallès / ES
 [2020/46]
Former [2019/31]01 / DE PIETRI TONELLI, Davide
Via G. Caproni 118/2
16011 Arenzano (Genova) / IT
02 / PONS ESPINAL, Meritxell
c/o FONDAZIONE ISTITUTO ITALIANO Dl TECNOLOGIA
Via Morego 30
16163 Genova / IT
Representative(s)Comoglio, Elena, et al
Jacobacci & Partners S.p.A.
Corso Emilia 8
10152 Torino / IT
[2019/31]
Application number, filing date17784688.818.09.2017
[2019/31]
WO2017IB55617
Priority number, dateIT2016009382519.09.2016         Original published format: IT201600093825
[2019/31]
Filing languageIT
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018051293
Date:22.03.2018
Language:EN
[2018/12]
Type: A1 Application with search report 
No.:EP3515457
Date:31.07.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 22.03.2018 takes the place of the publication of the European patent application.
[2019/31]
Type: B1 Patent specification 
No.:EP3515457
Date:11.11.2020
Language:EN
[2020/46]
Search report(s)International search report - published on:EP22.03.2018
ClassificationIPC:A61K31/7105, C12N15/113, A61P25/08, A61P25/28, A61P25/24, A61P35/00
[2020/24]
CPC:
A61K31/7105 (EP,US); A61P25/08 (EP,US); A61P25/24 (EP,US);
A61P25/28 (EP,US); A61P35/00 (EP,US); C12N15/113 (EP,US);
C12N15/115 (US) (-)
C-Set:
C12N2310/141, C12N2330/10 (EP,US)
Former IPC [2019/31]A61K31/7105, C12N15/115, A61P25/08, A61P25/28
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/31]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:PHARMAZEUTISCHE MI-RNA-ZUSAMMENSETZUNG UND THERAPEUTISCHE VERWENDUNGEN DAVON[2020/24]
English:MI-RNA PHARMACEUTICAL COMPOSITION AND THERAPEUTIC USES THEREOF[2020/24]
French:COMPOSITION PHARMACEUTIQUE COMPRENANT MI-ARN ET SES UTILISATIONS THÉRAPEUTIQUES[2020/24]
Former [2019/31]PHARMAZEUTISCHE MIRNA-ZUSAMMENSETZUNG UND THERAPEUTISCHE VERWENDUNGEN DAVON
Former [2019/31]miRNA PHARMACEUTICAL COMPOSITION AND THERAPEUTIC USES THEREOF
Former [2019/31]COMPOSITION PHARMACEUTIQUE COMPRENANT MIARN ET SES UTILISATIONS THÉRAPEUTIQUES
Entry into regional phase17.04.2019National basic fee paid 
17.04.2019Designation fee(s) paid 
17.04.2019Examination fee paid 
Examination procedure17.04.2019Examination requested  [2019/31]
17.04.2019Date on which the examining division has become responsible
07.11.2019Amendment by applicant (claims and/or description)
29.05.2020Communication of intention to grant the patent
01.10.2020Fee for grant paid
01.10.2020Fee for publishing/printing paid
01.10.2020Receipt of the translation of the claim(s)
Opposition(s)12.08.2021No opposition filed within time limit [2021/42]
Fees paidRenewal fee
26.07.2019Renewal fee patent year 03
25.08.2020Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU18.09.2017
AL11.11.2020
AT11.11.2020
CY11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
ES11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
MK11.11.2020
MT11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
TR11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
[2024/42]
Former [2024/29]HU18.09.2017
AL11.11.2020
AT11.11.2020
CY11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
ES11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
MK11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
TR11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2024/23]HU18.09.2017
AL11.11.2020
AT11.11.2020
CY11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
ES11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
MK11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2023/33]HU18.09.2017
AL11.11.2020
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CZ11.11.2020
DK11.11.2020
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FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2023/30]AL11.11.2020
AT11.11.2020
CY11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
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FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2022/25]AL11.11.2020
AT11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
ES11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2022/23]AL11.11.2020
AT11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
ES11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2022/10]AL11.11.2020
AT11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
ES11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
PT11.03.2021
Former [2022/08]AL11.11.2020
AT11.11.2020
CZ11.11.2020
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EE11.11.2020
ES11.11.2020
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LT11.11.2020
LV11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/50]AL11.11.2020
AT11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/46]AL11.11.2020
AT11.11.2020
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DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/45]AL11.11.2020
AT11.11.2020
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DK11.11.2020
EE11.11.2020
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LV11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/37]AT11.11.2020
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DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
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PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/36]AT11.11.2020
CZ11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/35]AT11.11.2020
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FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
PL11.11.2020
RO11.11.2020
RS11.11.2020
SE11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/33]AT11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
PL11.11.2020
RS11.11.2020
SE11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/32]AT11.11.2020
FI11.11.2020
HR11.11.2020
LV11.11.2020
PL11.11.2020
RS11.11.2020
SE11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/28]AT11.11.2020
FI11.11.2020
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PL11.11.2020
RS11.11.2020
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NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/25]AT11.11.2020
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RS11.11.2020
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GR12.02.2021
IS11.03.2021
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Cited inInternational search[A]WO2006081284  (ROSETTA INPHARMATICS LLC [US], et al) [A] 1-14 * claims 25, 35, 36 *;
 [A]US9078914  (VELIN FLEMMING [DK], et al) [A] 1-14 * examples 8,10 *;
 [A]  - STAPPERT LAURA ET AL, "The role of microRNAs in human neural stem cells, neuronal differentiation and subtype specification", CELL AND TISSUE RESEARCH, SPRINGER, DE, vol. 359, no. 1, doi:10.1007/S00441-014-1981-Y, ISSN 0302-766X, (20140830), pages 47 - 64, (20140830), XP035419580 [A] 1-14 * table 1 *

DOI:   http://dx.doi.org/10.1007/s00441-014-1981-y
 [A]  - LI-CHUN CHENG ET AL, "miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche", NATURE NEUROSCIENCE, US, (20090315), vol. 12, no. 4, doi:10.1038/nn.2294, ISSN 1097-6256, pages 399 - 408, XP055391621 [A] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1038/nn.2294
 [AD]  - MARIJN SCHOUTEN ET AL, "New Neurons in Aging Brains: Molecular Control by Small Non-Coding RNAs", FRONTIERS IN NEUROSCIENCE, (20120101), vol. 6, doi:10.3389/fnins.2012.00025, XP055389821 [AD] 1-14 * page 5 - page 6; table 1 *

DOI:   http://dx.doi.org/10.3389/fnins.2012.00025
 [A]  - BRANDON SMITH ET AL, "Large-Scale Expression Analysis Reveals Distinct MicroRNA Profiles at Different Stages of Human Neurodevelopment", PLOS ONE, (20100615), vol. 5, no. 6, doi:10.1371/journal.pone.0011109, page e11109, XP055389893 [A] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1371/journal.pone.0011109
 [A]  - GERHARD M SCHRATT ET AL, "A brain-specific microRNA regulates dendritic spine development", NATURE, MACMILLAN JOURNALS LTD., ETC, (20060119), vol. 439, no. 7074, doi:10.1038/NATURE04367, ISSN 0028-0836, pages 283 - 289, XP002617828 [A] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1038/nature04367
 [A]  - OLGA BARCA-MAYO ET AL, "Convergent microRNA actions coordinate neocortical development", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES., DE, (20140212), vol. 71, no. 16, doi:10.1007/s00018-014-1576-5, ISSN 1420-682X, pages 2975 - 2995, XP055390028 [A] 1-14 * page 2988 - page 2989; figure 1 *

DOI:   http://dx.doi.org/10.1007/s00018-014-1576-5
 [T]  - MERITXELL PONS-ESPINAL ET AL, "Synergic Functions of miRNAs Determine Neuronal Fate of Adult Neural Stem Cells", STEM CELL REPORTS, United States, (20170401), vol. 8, no. 4, doi:10.1016/j.stemcr.2017.02.012, ISSN 2213-6711, pages 1046 - 1061, XP055390022

DOI:   http://dx.doi.org/10.1016/j.stemcr.2017.02.012
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