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Extract from the Register of European Patents

EP About this file: EP3523280

EP3523280 - PROCESSES AND INTERMEDIATES FOR PREPARING A BTK INHIBITOR [Right-click to bookmark this link]
Status	Examination is in progress Status updated on 10.05.2021 Database last updated on 02.11.2024
Former	Request for examination was made Status updated on 12.07.2019
Former	The international publication has been made Status updated on 14.04.2018
Former	unknown Status updated on 30.10.2017
Most recent event Tooltip	02.11.2024	New entry: Renewal fee paid
Applicant(s)	For all designated states Janssen Pharmaceutica NV Turnhoutseweg 30 2340 Beerse / BE
	[2019/33]
Inventor(s)	01 / BEN HAÏM, Cyril c/o Janssen Pharmaceutica NV Turnhoutseweg 30 2340 Beerse / BE
	02 / MICHIELS, Thomas Joost Martti c/o Leiden Academic Centre for Drug Research Universiteit of Leiden Einsteinweg 55 2333 CC Leiden / NL
	03 / MEDINA, Florian Damien c/o Janssen Pharmaceutica NV Turnhoutseweg 30 2340 Beerse / BE
	04 / WAGSCHAL, Simon Albert c/o Cilag AG Hochstrasse 201 8200 Schaffhausen / CH
	05 / DEPRÉ, Dominique Paul M c/o Janssen Pharmaceutica NV Turnhoutseweg 30 2340 Beerse / BE
	[2019/33]
Representative(s)	Purewal, Savroop Janssen Pharmaceutica NV J&J Patent Law Department Turnhoutseweg 30 2340 Beerse / BE
	[2019/33]
Application number, filing date	17786855.1	05.10.2017
	[2019/33]
	WO2017EP75289
Priority number, date	EP20160192603	06.10.2016 Original published format: EP 16192603
	[2019/33]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2018065504
	Date:	12.04.2018
	Language:	EN
	[2018/15]
	Type:	A1 Application with search report
	No.:	EP3523280
	Date:	14.08.2019
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 12.04.2018 takes the place of the publication of the European patent application.
	[2019/33]
Search report(s)	International search report - published on:	EP	12.04.2018
Classification	IPC:	C07D211/42	[2019/33]
	CPC:	C07D211/42 (EP); C07D473/32 (US); A61P35/00 (EP); A61P35/02 (EP); C07B55/00 (US)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2019/33]
Title	German:	VERFAHREN UND ZWISCHENPRODUKTE ZUR HERSTELLUNG EINES BTK-HEMMERS	[2019/33]
	English:	PROCESSES AND INTERMEDIATES FOR PREPARING A BTK INHIBITOR	[2019/33]
	French:	PROCÉDÉS ET INTERMÉDIAIRES POUR PRÉPARER UN INHIBITEUR DE BTK	[2019/33]
Entry into regional phase	06.05.2019	National basic fee paid
	06.05.2019	Designation fee(s) paid
	06.05.2019	Examination fee paid
Examination procedure	06.05.2019	Examination requested [2019/33]
	06.05.2019	Date on which the examining division has become responsible
	19.11.2019	Amendment by applicant (claims and/or description)
	11.05.2021	Despatch of a communication from the examining division (Time limit: M06)
	18.11.2021	Reply to a communication from the examining division
	12.01.2023	Despatch of a communication from the examining division (Time limit: M06)
	16.08.2023	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
	20.10.2023	Reply to a communication from the examining division
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the examination report
	20.10.2023	Request for further processing filed
	20.10.2023	Full payment received (date of receipt of payment) Request granted
	31.10.2023	Decision despatched
Fees paid	Renewal fee
	31.10.2019	Renewal fee patent year 03
	02.11.2020	Renewal fee patent year 04
	02.11.2021	Renewal fee patent year 05
	31.10.2022	Renewal fee patent year 06
	31.10.2023	Renewal fee patent year 07
	31.10.2024	Renewal fee patent year 08
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[X]JP2001002637 (JAPAN SCIENCE & TECH CORP, et al) [X] 1-4,7-13 * Scheme; page 5, paragraph 18 *;
		[XD]WO2008039218 (PHARMACYCLICS INC [US], et al) [XD] 15-19 * page 36 * * page 69 - page 70; example 1 ** claim - *;
		[X] - TATSUYA KIKUCHI ET AL, "Synthesis of piperidinyl and pyrrolidinyl butyrates for potentialIn Vivo measurement of cerebral butyrylcholinesterase activity", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, CHICHESTER; GB, (20010101), vol. 44, no. 1, doi:10.1002/jlcr.429, ISSN 0362-4803, pages 31 - 41, XP055319157 [X] 1-4,7-13 * abstract * * table 1 * * Experimental; page 35; figure 1 * * page 38; figure 3; compounds 5-7 * DOI: http://dx.doi.org/10.1002/jlcr.429
		[X] - RICHARD LIHAMMAR ET AL, "An Efficient Dynamic Kinetic Resolution of N-Heterocyclic 1,2-Amino Alcohols", ADVANCED SYNTHESIS & CATALYSIS, DE, (20110926), vol. 353, no. 13, doi:10.1002/adsc.201100466, ISSN 1615-4150, pages 2321 - 2327, XP055319451 [X] 1-3,7-15 * abstract * * Scheme 1; page 2321 * * table 1 * * Entries 1-16;; table 2 * * Schemes; page 2324 * * Entries 1-9;; table 3 * DOI: http://dx.doi.org/10.1002/adsc.201100466
		[X] - HONIG, HELMUT ET AL, "Enzymic resolutions of heterocyclic alcohols", BIOCATALYSIS , 9(1-4), 61-9 CODEN: BIOCED; ISSN: 0886-4454, (1994), XP009192445 [X] 1-4,7-13 * abstract * * Scheme 1; page 62; compound 11 * * page 64 * * table 1; compound 11 *
		[Y] - TOFANI GIORGIO ET AL, "Preparation of enantiomerically pureN-heterocyclic amino alcohols by enzymatic kinetic resolution", TETRAHEDRON ASYMMETRY, (20150512), vol. 26, no. 12, doi:10.1016/J.TETASY.2015.04.009, ISSN 0957-4166, pages 638 - 643, XP029170502 [Y] 1-13 * abstract * * Scheme 2; page 639 * DOI: http://dx.doi.org/10.1016/j.tetasy.2015.04.009
		[Y] - TOMORI H ET AL, "LIPASE-CATALYZED PRACTICAL SYNTHESIS OF (R)-1-BENZYL-3-HYDROXY-2,5-PYRROLIDINEDIONE AND ITS RELATED COMPOUNDS", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOCIETY OF JAPAN, TOKYO, JP, (19960101), vol. 69, no. 1, ISSN 0009-2673, pages 207 - 215, XP009018934 [Y] 1-13 * abstract * * page 209; table 5 *
	by applicant	JP2001002637
		WO2008039218
		- KUROSAKI, Curr Op Imm, (20000000), pages 276 - 281
		- SCHAEFFER; SCHWARTZBERG, Curr Op Imm, (20000000), pages 282 - 288
		- C. A. JEFFRIES et al., Journal of Biological Chemistry, (20030000), vol. 278, pages 26258 - 26264
		- N. J. HORWOOD et al., The Journal of Experimental Medicine, (20030000), vol. 197, pages 1603 - 1611
		- IWAKI et al., Journal of Biological Chemistry, (20050000), vol. 280, no. 48, pages 40261 - 40270
		- VASSILEV et al., Journal of Biological Chemistry, (19990000), vol. 274, no. 3, pages 1646 - 1656
		- QUEK et al., Current Biology, (19980000), vol. 8, no. 20, pages 1137 - 1140
		- JU et al., Org. Process Res. Dev., (20140000), vol. 18, no. 6, pages 827 - 830
		- HONIG et al., "Enzymatic Resolutions of Heterocyclic Alcohols", Biocatalysis, (19940000), vol. 9, pages 61 - 69, XP009192445
		- TATSUYA KIKUCHI et al., J. Labelled Cpd. Radiopharm., (20010000), vol. 44, pages 31 - 41
		- LIHAMMAR et al., Adv. Synth. Catal., (20110000), vol. 353, pages 2321 - 2317
		- K.M. KOELLER; C.H. WONG, "Enzymes for chemical synthesis", Nature, vol. 409, doi:doi:10.1038/35051706, pages 232 - 240, XP000985343 DOI: http://dx.doi.org/10.1038/35051706

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