blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3452581

EP3452581 - 4HPR AND ITS USE IN THE CULTURING OF HEMATOPOIETIC STEM CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  17.11.2023
Database last updated on 03.09.2024
FormerThe patent has been granted
Status updated on  09.12.2022
FormerGrant of patent is intended
Status updated on  16.08.2022
FormerExamination is in progress
Status updated on  04.12.2020
FormerRequest for examination was made
Status updated on  08.02.2019
FormerThe international publication has been made
Status updated on  10.11.2017
Most recent event   Tooltip24.05.2024Lapse of the patent in a contracting state
New state(s): IT		published on 26.06.2024  [2024/26]
Applicant(s)For all designated states
University Health Network
190 Elizabeth Street R. Frazer Elliott Building - Room 1S-417
Toronto, Ontario M5G 2C4 / CA
[2019/11]
Inventor(s)01 / DICK, John
67 MacLean Ave.
Toronto, Ontario M4E 2ZS / CA
02 / XIE, Stephanie
c/o University Health Network
190 Fraser Elliott Building - Room 1S-417
Toronto, Ontario M5G 2C4 / CA
03 / LAURENTI, Elisa
10 Ashtead Court
Mill Road Cambridge CB1 3UG / GB
04 / PRAT, Laura Garcia
77 Gerrard Street West
Toronto, Ontario M5G 2A1 / CA
05 / FERRARI, Robin Thomas
11 Rue Ferrus
75014 Paris / FR
 [2019/11]
Representative(s)AWA Sweden AB
Box 45086
104 30 Stockholm / SE
[2023/02]
Former [2019/11]AWA Sweden AB
P.O. Box 45086
104 30 Stockholm / SE
Application number, filing date17792305.903.05.2017
[2019/11]
WO2017CA00107
Priority number, dateUS201662331019P03.05.2016         Original published format: US 201662331019 P
[2019/11]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017190214
Date:09.11.2017
Language:EN
[2017/45]
Type: A1 Application with search report 
No.:EP3452581
Date:13.03.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 09.11.2017 takes the place of the publication of the European patent application.
[2019/11]
Type: B1 Patent specification 
No.:EP3452581
Date:11.01.2023
Language:EN
[2023/02]
Search report(s)International search report - published on:CA09.11.2017
(Supplementary) European search report - dispatched on:EP04.11.2019
ClassificationIPC:C12N5/0789, C12N5/02, C12N5/078
[2019/11]
CPC:
C12N5/0647 (EP,US); A01N1/0226 (US); C12N5/0018 (US);
C12N2500/38 (EP,US); C12N2501/385 (EP); C12N2501/999 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/11]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:4HPR UND DESSEN VERWENDUNG IN DER ZÜCHTUNG VON HÄMATOPOETISCHEN STAMMZELLEN[2019/11]
English:4HPR AND ITS USE IN THE CULTURING OF HEMATOPOIETIC STEM CELLS[2019/11]
French:4HPR ET SON UTILISATION DANS LA CULTURE DE CELLULES SOUCHES HÉMATOPOÏÉTIQUES[2019/11]
Entry into regional phase27.11.2018National basic fee paid 
27.11.2018Search fee paid 
27.11.2018Designation fee(s) paid 
27.11.2018Examination fee paid 
Examination proceduredeletedDate on which the examining division has become responsible
27.11.2018Examination requested  [2019/11]
28.05.2020Amendment by applicant (claims and/or description)
04.12.2020Despatch of a communication from the examining division (Time limit: M04)
31.03.2021Reply to a communication from the examining division
17.08.2022Communication of intention to grant the patent
30.11.2022Fee for grant paid
30.11.2022Fee for publishing/printing paid
30.11.2022Receipt of the translation of the claim(s)
Opposition(s)12.10.2023No opposition filed within time limit [2023/51]
Fees paidRenewal fee
28.05.2019Renewal fee patent year 03
11.03.2020Renewal fee patent year 04
21.05.2021Renewal fee patent year 05
20.05.2022Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT11.01.2023
CZ11.01.2023
DK11.01.2023
EE11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
IT11.01.2023
LT11.01.2023
LV11.01.2023
MC11.01.2023
NL11.01.2023
PL11.01.2023
RO11.01.2023
RS11.01.2023
SE11.01.2023
SI11.01.2023
SK11.01.2023
SM11.01.2023
NO11.04.2023
GR12.04.2023
IE03.05.2023
LU03.05.2023
IS11.05.2023
PT11.05.2023
BE31.05.2023
CH31.05.2023
LI31.05.2023
[2024/26]
Former [2024/24]AT11.01.2023
CZ11.01.2023
DK11.01.2023
EE11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
LT11.01.2023
LV11.01.2023
MC11.01.2023
NL11.01.2023
PL11.01.2023
RO11.01.2023
RS11.01.2023
SE11.01.2023
SI11.01.2023
SK11.01.2023
SM11.01.2023
NO11.04.2023
GR12.04.2023
IE03.05.2023
LU03.05.2023
IS11.05.2023
PT11.05.2023
BE31.05.2023
CH31.05.2023
LI31.05.2023
Former [2024/21]AT11.01.2023
CZ11.01.2023
DK11.01.2023
EE11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
LT11.01.2023
LV11.01.2023
MC11.01.2023
NL11.01.2023
PL11.01.2023
RO11.01.2023
RS11.01.2023
SE11.01.2023
SI11.01.2023
SK11.01.2023
SM11.01.2023
NO11.04.2023
GR12.04.2023
IE03.05.2023
LU03.05.2023
IS11.05.2023
PT11.05.2023
CH31.05.2023
LI31.05.2023
Former [2024/11]AT11.01.2023
CZ11.01.2023
DK11.01.2023
EE11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
LT11.01.2023
LV11.01.2023
MC11.01.2023
NL11.01.2023
PL11.01.2023
RO11.01.2023
RS11.01.2023
SE11.01.2023
SI11.01.2023
SK11.01.2023
SM11.01.2023
NO11.04.2023
GR12.04.2023
LU03.05.2023
IS11.05.2023
PT11.05.2023
CH31.05.2023
LI31.05.2023
Former [2024/09]AT11.01.2023
CZ11.01.2023
DK11.01.2023
EE11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
LT11.01.2023
LV11.01.2023
MC11.01.2023
NL11.01.2023
PL11.01.2023
RO11.01.2023
RS11.01.2023
SE11.01.2023
SK11.01.2023
SM11.01.2023
NO11.04.2023
GR12.04.2023
LU03.05.2023
IS11.05.2023
PT11.05.2023
CH31.05.2023
LI31.05.2023
Former [2024/08]AT11.01.2023
CZ11.01.2023
DK11.01.2023
EE11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
LT11.01.2023
LV11.01.2023
MC11.01.2023
NL11.01.2023
PL11.01.2023
RO11.01.2023
RS11.01.2023
SE11.01.2023
SK11.01.2023
SM11.01.2023
NO11.04.2023
GR12.04.2023
LU03.05.2023
IS11.05.2023
PT11.05.2023
Former [2023/50]AT11.01.2023
CZ11.01.2023
DK11.01.2023
EE11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
LT11.01.2023
LV11.01.2023
NL11.01.2023
PL11.01.2023
RO11.01.2023
RS11.01.2023
SE11.01.2023
SK11.01.2023
SM11.01.2023
NO11.04.2023
GR12.04.2023
IS11.05.2023
PT11.05.2023
Former [2023/49]AT11.01.2023
CZ11.01.2023
DK11.01.2023
EE11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
LT11.01.2023
LV11.01.2023
NL11.01.2023
PL11.01.2023
RO11.01.2023
RS11.01.2023
SE11.01.2023
SM11.01.2023
NO11.04.2023
GR12.04.2023
IS11.05.2023
PT11.05.2023
Former [2023/48]AT11.01.2023
DK11.01.2023
EE11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
LT11.01.2023
LV11.01.2023
NL11.01.2023
PL11.01.2023
RS11.01.2023
SE11.01.2023
SM11.01.2023
NO11.04.2023
GR12.04.2023
IS11.05.2023
PT11.05.2023
Former [2023/46]AT11.01.2023
DK11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
LT11.01.2023
LV11.01.2023
NL11.01.2023
PL11.01.2023
RS11.01.2023
SE11.01.2023
SM11.01.2023
NO11.04.2023
GR12.04.2023
IS11.05.2023
PT11.05.2023
Former [2023/39]AT11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
LT11.01.2023
LV11.01.2023
NL11.01.2023
PL11.01.2023
RS11.01.2023
SE11.01.2023
NO11.04.2023
GR12.04.2023
IS11.05.2023
PT11.05.2023
Former [2023/38]AT11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
LT11.01.2023
LV11.01.2023
NL11.01.2023
PL11.01.2023
RS11.01.2023
SE11.01.2023
NO11.04.2023
GR12.04.2023
PT11.05.2023
Former [2023/37]AT11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
LT11.01.2023
LV11.01.2023
NL11.01.2023
RS11.01.2023
SE11.01.2023
NO11.04.2023
GR12.04.2023
PT11.05.2023
Former [2023/36]AT11.01.2023
ES11.01.2023
FI11.01.2023
HR11.01.2023
LT11.01.2023
LV11.01.2023
NL11.01.2023
RS11.01.2023
SE11.01.2023
NO11.04.2023
PT11.05.2023
Former [2023/35]AT11.01.2023
ES11.01.2023
HR11.01.2023
LT11.01.2023
NL11.01.2023
RS11.01.2023
NO11.04.2023
PT11.05.2023
Former [2023/34]ES11.01.2023
LT11.01.2023
NL11.01.2023
RS11.01.2023
PT11.05.2023
Former [2023/33]ES11.01.2023
LT11.01.2023
NL11.01.2023
Former [2023/31]NL11.01.2023
Documents cited:Search[XA]WO03062369  (GAMIDA CELL LTD [IL], et al) [X] 12 * example all * [A] 1-11;
 [XI]WO2007033331  (UNIV DUKE [US], et al) [X] 12 * example 1 * [I] 1-11;
 [X]CN101623277  (RUIJIN HOSPITAL SHANGHAI JIAOT) [X] 1,6,7,9,10,12 * examples 3, 4 *;
 [X]US2010008896  (ZHANG JI [US], et al) [X] 1,6,7,9,10,12 * example 3 *;
 [X]  - ZHANG HUI ET AL, "Preferential eradication of acute myelogenous leukemia stem cells by fenretinide", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (20130402), vol. 110, no. 14, doi:10.1073/PNAS.1302352110, pages 5606 - 5611, XP002755484 [X] 1-4,6,7,9,10,12 * supplemental material and methods; page 5607; table 1 *

DOI:   http://dx.doi.org/10.1073/PNAS.1302352110
 [XI]  - J. P. CHUTE, "Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20060801), vol. 103, no. 31, doi:10.1073/pnas.0603806103, ISSN 0027-8424, pages 11707 - 11712, XP055056573 [X] 12 * material and methods;; table 1 * [I] 1-11

DOI:   http://dx.doi.org/10.1073/pnas.0603806103
 [XI]  - ANTHONY E. BOITANO ET AL, "Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells", SCIENCE, (20100805), vol. 329, no. 5997, doi:10.1126/science.1191536, ISSN 0036-8075, pages 1345 - 1348, XP055558705 [X] 12 * page 1346 * [I] 5,11

DOI:   http://dx.doi.org/10.1126/science.1191536
 [XI]  - IMAN FARES ET AL, "Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal", SCIENCE (NEW YORK, N.Y.), United States, (20140919), vol. 345, no. 6203, pages 1509 - 1512, XP055370388 [X] 12 * figures 1-3 * [I] 5,11
 [T]  - XIE STEPHANIE ZHI-JUAN ET AL, "Sphingolipid Perturbation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal", BLOOD, PHILADELPHIA,PA,US, (20181129), vol. 132, no. Suppl. 1, doi:10.1182/blood-2018-170, ISSN 0006-4971, page 170, XP002795058

DOI:   http://dx.doi.org/10.1182/blood-2018-170
International search[X]US8088822  (ZHANG JI [US], et al) [X] 10 and 11;
 [X]  - PARK, B. et al., "Hematopoietic stem cell expansion and generation: the ways to make a breakthrough", Blood Research, vol. 50, no. 4, ISSN 2288-0011, (20151200), pages 194 - 203, URL: http://dx.doi.Org/10.5045/br.2015.50.4.194, (20170814), XP055435854 [X] 12

DOI:   http://dx.doi.org/10.5045/br.2015.50.4.194
 [T]  - HO T. T. et al., "Autophagy maintains the metabolism andfunction of young and old stem cells", Nature, vol. 543, ISSN 1476-4687, (20170309), pages 205 - 210, URL: http://palgrave.nature.com/nature/journal/v543/n7644/full/nature21388.html, XP055435861 [T] 1-12

DOI:   http://dx.doi.org/10.1038/nature21388
by applicant   - BOITANO AEWANG JROMEO RBOUCHEZ LCPARKER AESUTTON SEWALKER JRFLAVENY CAPERDEW GHDENISON MS, "Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells", Science, (20100000), vol. 329, doi:10.1126/science.1191536, pages 1345 - 8, XP055558705

DOI:   http://dx.doi.org/10.1126/science.1191536
    - FARES ICHAGRAOUI JGAREAU YGINGRAS SRUEL RMAYOTTE NCSASZAR EKNAPP DJMILLER PNGOM M, "Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal", Science, (20140000), vol. 345, pages 1509 - 12
    - WAGNER JEBRUNSTEIN CGBOITANO AEDEFOR TEMCKENNA DSUMSTAD DBLAZAR BRTOLAR JLE CJONES J, "Phase / Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft", Cell Stem Cell, (20160000), vol. 18, doi:10.1016/j.stem.2015.10.004, pages 144 - 55, XP055558717

DOI:   http://dx.doi.org/10.1016/j.stem.2015.10.004
    - MACEYKA MSPIEGEL S, "Sphingolipid metabolites in inflammatory disease", Nature, (20140000), vol. 510, doi:10.1038/nature13475, pages 58 - 67, XP055689592

DOI:   http://dx.doi.org/10.1038/nature13475
    - HO TTWARR MRADELMAN ERLANSINGER OMFLACH JVEROVSKAYA EVFIGUEROA MEPASSEGUE E, "Autophagy maintains the metabolism and function of young and old stem cells", Nature, (20170000), vol. 543, doi:10.1038/nature21388, pages 205 - 10, XP055435861

DOI:   http://dx.doi.org/10.1038/nature21388
    - ANTHONY E. BOITANO et al., "Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells", SCIENCE, (20100805), vol. 329, no. 5997, doi:10.1126/science.1191536, pages 1345 - 1348, XP055558705

DOI:   http://dx.doi.org/10.1126/science.1191536
    - IMAN FARES et al., "Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal", SCIENCE (NEW YORK, N.Y., (20140919), vol. 345, no. 6203, pages 1509 - 1512
    - SINGH RKAUSHIK SWANG YXIANG YNOVAK IKOMATSU MTANAKA KCUERVO AMCZAJA MJ, "Autophagy regulates lipid metabolism", Nature, (20090000), vol. 458, doi:10.1038/nature07976, pages 1131 - 5, XP055157034

DOI:   http://dx.doi.org/10.1038/nature07976
    - BENVENISTE PCANTIN CHYAM DISCOVE NN, "Hematopoietic stem cells engraft in mice with absolute efficiency", Nat Immunol, (20030000), vol. 4, pages 708 - 13
    - LAI W-LWONG N-S, "The PERK/eIF2a signaling pathway of Unfolded Protein Response is essential for N-(4-hydroxyphenyl)retinamide (4HPR)-induced cytotoxicity in cancer cells", Experimental Cell Research, (20080000), vol. 314, doi:10.1016/j.yexcr.2008.02.002, pages 1667 - 82, XP022627448

DOI:   http://dx.doi.org/10.1016/j.yexcr.2008.02.002
    - MATHEW RKARP CMBEAUDOIN BVUONG NCHEN GCHEN HYBRAY KREDDY ABHANOT GGELINAS C, Cell, (20090000), vol. 137, pages 1062 - 75
    - BENVENISTE PFRELIN CJANMOHAMED SBARBARA MHERRINGTON RHYAM DISCOVE NN, "Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential", Cell Stem Cell, (20100000), vol. 6, pages 48 - 58
    - LIU XWSU YZHU HCAO JDING WJZHAO YCHE QJYANG B, "HIF-1alpha-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia", Pharmacol Res, (20100000), vol. 62, pages 416 - 25, XP027320681
    - EPPERT KTAKENAKA KLECHMAN ERWALDRON LNILSSON BVAN GALEN PMETZELER KHPOEPPL ALING VBEYENE J, "Stem cell gene expression programs influence clinical outcome in human leukemia", Nat Med, (20110000), vol. 17, doi:10.1038/nm.2415, pages 1086 - 93, XP055611746

DOI:   http://dx.doi.org/10.1038/nm.2415
    - GOESSLING WALLEN RSGUAN XJIN PUCHIDA NDOVEY MHARRIS JMMETZGER MEBONIFACINO ACSTRONCEK D, "Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models", Cell Stem Cell, (20110000), vol. 8, doi:10.1016/j.stem.2011.02.003, pages 445 - 58, XP055722086

DOI:   http://dx.doi.org/10.1016/j.stem.2011.02.003
    - MERRILL AH, JR, "Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics", Chem Rev, (20110000), vol. 111, pages 6387 - 422
    - NOTTA FDOULATOV SLAURENTI EPOEPPL AJURISICA IDICK JE, "Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment", Science, (20110000), vol. 333, doi:10.1126/science.1201219, pages 218 - 21, XP055069664

DOI:   http://dx.doi.org/10.1126/science.1201219
    - OUIMET MFRANKLIN VMAK ELIAO XTABAS IMARCEL YL, "Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase", Cell Metab, (20110000), vol. 13, doi:10.1016/j.cmet.2011.03.023, pages 655 - 67, XP028376152

DOI:   http://dx.doi.org/10.1016/j.cmet.2011.03.023
    - RAHMANIYAN MCURLEY RWOBEID LMHANNUN YAKRAVEKA JM, "Identification of Dihydroceramide Desaturase as a Direct in Vitro Target for Fenretinide", The Journal of Biological Chemistry, (20110000), vol. 286, pages 24754 - 64
    - CSASZAR EKIROUAC DCYU MWANG WQIAO WCOOKE MPBOITANO AEITO CZANDSTRA PW, "Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling", Cell Stem Cell, (20120000), vol. 10, doi:10.1016/j.stem.2012.01.003, pages 218 - 29, XP028397787

DOI:   http://dx.doi.org/10.1016/j.stem.2012.01.003
    - DOULATOV SNOTTA FLAURENTI EDICK JE, "Hematopoiesis: a human perspective", Cell Stem Cell, (20120000), vol. 10, doi:10.1016/j.stem.2012.01.006, pages 120 - 36, XP028397783

DOI:   http://dx.doi.org/10.1016/j.stem.2012.01.006
    - LECHMAN ERGENTNER BVAN GALEN PGIUSTACCHINI ASAINI MBOCCALATTE FEHIRAMATSU HRESTUCCIA UBACHI AVOISIN V, "Attenuation of miR-126 activity expands HSC in vivo without exhaustion", Cell Stem Cell, (20120000), vol. 1, no. 1, pages 799 - 811
    - TANIGUCHI MKITATANI KKONDO THASHIMOTO-NISHIMURA MASANO SHAYASHI AMITSUTAKE SIGARASHI YUMEHARA HTAKEYA H, "Regulation of autophagy and its associated cell death by ''sphingolipid rheostat'': reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway", J Biol Chem, (20120000), vol. 287, pages 39898 - 910
    - CHANDA BDITADI AISCOVE NNKELLER G, "Retinoic acid signaling is essential for embryonic hematopoietic stem cell development", Cell, (20130000), vol. 155, doi:10.1016/j.cell.2013.08.055, pages 215 - 27, XP028729738

DOI:   http://dx.doi.org/10.1016/j.cell.2013.08.055
    - LAURENTI EDOULATOV SZANDI SPLUMB ICHEN JAPRIL CFAN J-BDICK JE, "The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment", Nature Immunology, (20130000), vol. 14, pages 756 - 63
    - SIDDIQUE MMLI YWANG LCHING JMAL MILKAYEVA OWU YJBAY BHSUMMERS SA, "Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling", Mol Cell Biol, (20130000), vol. 33, pages 2353 - 69
    - LI YLI SQIN XHOU WDONG HYAO LXIONG L, "The pleiotropic roles of sphingolipid signaling in autophagy", Cell Death Dis, (20140000), vol. 5, page e1245
    - LUO YLI LZOU PWANG JSHAO LZHOU DLIU L, "Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence", Transplantation, (20140000), vol. 97, doi:10.1097/TP.0b013e3182a7fcf8, pages 20 - 9, XP055562585

DOI:   http://dx.doi.org/10.1097/TP.0b013e3182a7fcf8
    - VAN GALEN PKRESO AMBONG NKENT DGFITZMAURICE TCHAMBERS JEXIE SLAURENTI EHERMANS KEPPERT K, "The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress", Nature, (20140000), vol. 510, pages 268 - 72
    - VAN GALEN PKRESO AWIENHOLDS ELAURENTI EEPPERT KLECHMAN ERMBONG NHERMANS KDOBSON SAPRIL C, "Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion", Cell Stem Cell, (20140000), vol. 14, pages 94 - 106
    - KOBERLIN MSSNIJDER BHEINZ LXBAUMANN CLFAUSTER AVLADIMER GIGAVIN ACSUPERTI-FURGA G, "A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses", Cell, (20150000), vol. 162, pages 170 - 83
    - LAURENTI EFRELIN CXIE SFERRARI RDUNANT CFZANDI SNEUMANN APLUMB IDOULATOV SCHEN J, "CDK6 levels regulate quiescence exit in human hematopoietic stem cells", Cell Stem Cell, (20150000), vol. 16, pages 302 - 13
    - LUND TCBOITANO AEDELANEY CSSHPALL EJWAGNER JE, "Advances in umbilical cord blood manipulation [mdash] from niche to bedside", Nature Reviews Clinical Oncology, (20150000), vol. 12, pages 163 - 74
    - DELANEY C, "Expansion of Human Hematopoietic Stem Cells", Thomas' Hematopoietic Cell Transplantation, vol. 2016, pages 62 - 70
    - GARCIA-PRAT LMARTINEZ-VICENTE MPERDIGUERO EORTET LRODRIGUEZ-UBREVA JREBOLLO ERUIZ-BONILLA VGUTARRA SBALLESTAR ESERRANO AL, "Autophagy maintains sternness by preventing senescence", Nature, (20160000), vol. 529, pages 37 - 42
    - LECHMAN ERGENTNER BNG SWSCHOOF EMVAN GALEN PKENNEDY JANUCERA SCICERI FKAUFMANN KBTAKAYAMA N, "miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells", Cancer Cell, (20160000), vol. 29, doi:10.1016/j.ccell.2015.12.011, pages 214 - 28, XP029412950

DOI:   http://dx.doi.org/10.1016/j.ccell.2015.12.011
    - NOTTA FZANDI STAKAYAMA NDOBSON SGAN 01WILSON GKAUFMANN KBMCLEOD JLAURENTI EDUNANT CF, "Distinct routes of lineage development reshape the human blood hierarchy across ontogeny", Science, (20160000), vol. 351, page aab2116
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.