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Extract from the Register of European Patents

EP About this file: EP3535024

EP3535024 - TRANSDERMAL OPTOGENETIC PERIPHERAL NERVE STIMULATION [Right-click to bookmark this link]
StatusGrant of patent is intended
Status updated on  16.06.2024
Database last updated on 31.08.2024
FormerExamination is in progress
Status updated on  25.05.2020
FormerRequest for examination was made
Status updated on  09.08.2019
FormerThe international publication has been made
Status updated on  11.05.2018
Formerunknown
Status updated on  24.11.2017
Most recent event   Tooltip16.06.2024New entry: Communication of intention to grant a patent 
Applicant(s)For all designated states
Massachusetts Institute Of Technology
77 Massachusetts Avenue
Cambridge, MA 02139 / US
[2019/37]
Inventor(s)01 / HERR, Hugh, M.
51 Montrose Street
Somerville MA 02143 / US
02 / MAIMON, Benjamin
184 Saint Paul Street Apt. 3
Brookline MA 02446 / US
03 / ZORZOS, Anthony
40 Shepard Street Apt. 2
Cambridge MA 02138 / US
 [2019/37]
Representative(s)D Young & Co LLP
3 Noble Street
London EC2V 7BQ / GB
[N/P]
Former [2019/37]D Young & Co LLP
120 Holborn
London EC1N 2DY / GB
Application number, filing date17797828.531.10.2017
[2019/37]
WO2017US59247
Priority number, dateUS201662415817P01.11.2016         Original published format: US 201662415817 P
[2019/37]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018085253
Date:11.05.2018
Language:EN
[2018/19]
Type: A1 Application with search report 
No.:EP3535024
Date:11.09.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 11.05.2018 takes the place of the publication of the European patent application.
[2019/37]
Search report(s)International search report - published on:EP11.05.2018
ClassificationIPC:A61N5/06, A01K67/0275, C12N15/86, // A61F2/50, C07K14/47
[2024/25]
CPC:
A61N5/0618 (EP); A61N1/327 (US); A01K67/0275 (EP);
A61K9/0009 (US); A61K9/0019 (US); A61N1/0412 (US);
A61N5/062 (US); A61N5/0622 (EP,US); C07K14/47 (EP,US);
C12N15/86 (EP,US); A01K2217/052 (EP); A01K2217/206 (EP);
A01K2227/105 (EP); A01K2267/03 (EP); A61B2562/0219 (US);
A61B5/1126 (US); A61F2002/5061 (EP); A61N2005/0645 (EP,US);
A61N2005/0651 (US); A61N2005/0659 (US); A61N2005/0661 (US);
A61N2005/0663 (US); A61N5/067 (US); C12N2750/14143 (EP,US);
C12N2830/008 (EP,US) (-)
Former IPC [2019/37]A61N5/06, A61K48/00, A61F2/50
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/37]
TitleGerman:TRANSDERMALE OPTOGENETISCHE PERIPHERE NERVENSTIMULATION[2019/37]
English:TRANSDERMAL OPTOGENETIC PERIPHERAL NERVE STIMULATION[2019/37]
French:STIMULATION OPTOGÉNÉTIQUE TRANSDERMIQUE DU NERF PÉRIPHÉRIQUE[2019/37]
Entry into regional phase31.05.2019National basic fee paid 
31.05.2019Designation fee(s) paid 
31.05.2019Examination fee paid 
Examination procedure31.05.2019Examination requested  [2019/37]
31.05.2019Date on which the examining division has become responsible
20.12.2019Amendment by applicant (claims and/or description)
28.05.2020Despatch of a communication from the examining division (Time limit: M04)
05.10.2020Reply to a communication from the examining division
05.02.2021Despatch of a communication from the examining division (Time limit: M04)
15.06.2021Reply to a communication from the examining division
13.07.2022Despatch of a communication from the examining division (Time limit: M02)
23.09.2022Reply to a communication from the examining division
17.06.2024Communication of intention to grant the patent
Fees paidRenewal fee
28.10.2019Renewal fee patent year 03
27.10.2020Renewal fee patent year 04
27.10.2021Renewal fee patent year 05
27.10.2022Renewal fee patent year 06
27.10.2023Renewal fee patent year 07
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Cited inInternational search[Y]WO2007024391  (UNIV LELAND STANFORD JUNIOR [US], et al) [Y] 1-10 * paragraphs [0088] , [0147] , [0157] , [0167] , [0208] - [0211] *;
 [Y]WO2012061684  (UNIV LELAND STANFORD JUNIOR [US], et al) [Y] 1-10 * page 26, line 11 - page 27, line 9 * * page 37, line 24 - line 31; figure 3 * * page 38, line 12 - line 22 *;
 [A]WO2015200380  (FLEXLITE CORP [US]) [A] 1-10 * abstract * * paragraphs [0055] , [0061] , [0062] *;
 [A]US2016175611  (KIM TAE-IL [KR], et al) [A] 1-10* paragraphs [0045] - [0049] - [0066]; figure 4b *
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    - YE, H.; DAOUD-EL BABA, M.; PENG, R.-W.; FUSSENEGGER, M., "A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice", Science, (20110000), vol. 332, doi:doi:10.1126/science.1203535, pages 1565 - 1568, XP002699843

DOI:   http://dx.doi.org/10.1126/science.1203535
    - BICKEL, C. S.; GREGORY, C. M.; DEAN, J. C., "Motor unit recruitment during neuromuscular electrical stimulation: A critical appraisal", European Journal of Applied Physiology, (20110000), vol. 111, doi:doi:10.1007/s00421-011-2128-4, pages 2399 - 2407, XP019954347

DOI:   http://dx.doi.org/10.1007/s00421-011-2128-4
    - TOWNE, C.; MONTGOMERY, K. L.; IYER, S. M.; DEISSEROTH, K.; DELP, S. L., "Optogenetic control of targeted peripheral axons in freely moving animals", PLoS One, (20130000), vol. 8, page e72691
    - JI, Z.-G. et al., "Light-evoked Somatosensory Perception of Transgenic Rats That Express Channelrhodopsin-2 in Dorsal Root Ganglion Cells", PLoS One, (20120000), vol. 7, page e32699
    - JACQUES, S. L., "Optical properties of biological tissues: a review", Phys. Med. Biol., (20130000), vol. 58, doi:doi:10.1088/0031-9155/58/11/R37, pages R37 - 61, XP020245078

DOI:   http://dx.doi.org/10.1088/0031-9155/58/11/R37
    - AYLING, O. G. S.; HARRISON, T. C.; BOYD, J. D.; GOROSHKOV, A.; MURPHY, T. H., "Automated light-based mapping of motor cortex by photoactivation of channelrhodopsin-2 transgenic mice", Nat. Methods, (20090000), vol. 6, doi:doi:10.1038/nmeth.1303, pages 219 - 224, XP055135047

DOI:   http://dx.doi.org/10.1038/nmeth.1303
    - CHUONG, A. S. et al., "Noninvasive optical inhibition with a red-shifted microbial rhodopsin", Nat. Neurosci., (20140000), vol. 17, pages 1123 - 9
    - LIN, J. Y.; KNUTSEN, P. M.; MULLER, A.; KLEINFELD, D.; TSIEN, R. Y., "ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation", Nat. Neurosci., (20130000), vol. 16, doi:doi:10.1038/nn.3502, pages 1499 - 508, XP055226552

DOI:   http://dx.doi.org/10.1038/nn.3502
    - KIM, T.; FOLCHER, M.; BABA, M. D.-E.; FUSSENEGGER, M. A, "Synthetic Erectile Optogenetic Stimulator Enabling Blue-Light-Inducible Penile Erection", Angew. Chemie Int. Ed., (20150000), vol. 54, pages 5933 - 5938
    - MAGOWN, P.; SHETTAR, B.; ZHANG, Y.; RAFUSE, V. F., "Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy", Nat. Commun., (20150000), vol. 6, page 8506
    - PETERSON, E. J.; TYLER, D. J., "Motor neuron activation in peripheral nerves using infrared neural stimulation", J. Neural Eng., (20130000), vol. 11, page 016001
    - BASHKATOV, A. N.; GENINA, E. A.; TUCHIN, V. V., "OPTICAL PROPERTIES OF SKIN, SUBCUTANEOUS, AND MUSCLE TISSUES: A REVIEW", J. Innov. Opt. Health Sci., (20110000), vol. 04, pages 9 - 38
    - YAROSLAVSKY, A. N. et al., "Optical properties of selected native and coagulated human brain tissues in vitro in the visible and near infrared spectral range", Phys. Med. Biol., (20020000), vol. 47, page 305
    - ISLAM, M. S. et al., "Extracting structural features of rat sciatic nerve using polarization-sensitive spectral domain optical coherence tomography", J. Biomed. Opt., (20120000), vol. 17, page 056012
    - HENDRIKS, B. H. W. et al., "Nerve detection with optical spectroscopy for regional anesthesia procedures", J. Transl. Med., (20150000), vol. 13, page 380
    - MCCARTNEY, C. J. L.; XU, D.; CONSTANTINESCU, C.; ABBAS, S.; CHAN, V. W. S., "Ultrasound examination of peripheral nerves in the forearm", Reg. Anesth. Pain Med., vol. 32, doi:doi:10.1016/j.rapm.2007.02.011, pages 434 - 9, XP022381897

DOI:   http://dx.doi.org/10.1016/j.rapm.2007.02.011
    - HONJOH, T. et al., "Optogenetic Patterning of Whisker-Barrel Cortical System in Transgenic Rat Expressing Channelrhodopsin-2", PLoS One, (20140000), vol. 9, page e93706
    - CHEEVER, T. R.; OLSON, E. A.; ERVASTI, J. M., "Axonal regeneration and neuronal function are preserved in motor neurons lacking ??-actin In Vivo", PLoS One, (20110000), page 6
    - MONTGOMERY, K. L. et al., "Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system", Sci. Transl. Med., (20160000), vol. 8, page 337rv5
    - BAINBRIDGE, J. W. B. et al., Long-Term Effect of Gene Therapy on Leber's Congenital Amaurosis, (20150000), URL: http://dx.doi.org/10.1056/NEJMoa1414221
    - MINGOZZI, F. et al., "Immune responses to AAV vectors: overcoming barriers to successful gene therapy", Blood, (20130000), vol. 122, doi:doi:10.1182/blood-2013-01-306647, pages 23 - 36, XP055175008

DOI:   http://dx.doi.org/10.1182/blood-2013-01-306647
    - SACK, B. K.; HERZOG, R. W., "Evading the immune response upon in vivo gene therapy with viral vectors", Curr. Opin. Mol. Ther., (20090000), vol. 11, pages 493 - 503, XP055128231
    - MASON, M. R. et al., "Comparison of AAV Serotypes for Gene Delivery to Dorsal Root Ganglion Neurons", Mol. Ther., (20100000), vol. 18, doi:doi:10.1038/mt.2010.19, pages 715 - 724, XP055099555

DOI:   http://dx.doi.org/10.1038/mt.2010.19
    - WILLIAMS, E. K. et al., "Sensory Neurons that Detect Stretch and Nutrients in the Digestive System", Cell, (20160000), vol. 166, doi:doi:10.1016/j.cell.2016.05.011, pages 209 - 221, XP029627874

DOI:   http://dx.doi.org/10.1016/j.cell.2016.05.011
    - CHANG, R. B.; STROCHLIC, D. E.; WILLIAMS, E. K.; UMANS, B. D.; LIBERLES, S. D., "Vagal Sensory Neuron Subtypes that Differentially Control Breathing", Cell, (20150000), vol. 161, pages 622 - 33
    - GROSENICK, L.; MARSHEL, J. H.; DEISSEROTH, K., "Closed-Loop and Activity-Guided Optogenetic Control", Neuron, (20150000), vol. 86, pages 106 - 139
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.