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Extract from the Register of European Patents

EP About this file: EP3555099

EP3555099 - PROCESS FOR PREPARING BTK INHIBITORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  24.06.2022
Database last updated on 03.09.2024
FormerThe patent has been granted
Status updated on  16.07.2021
FormerGrant of patent is intended
Status updated on  07.04.2021
FormerExamination is in progress
Status updated on  02.06.2020
FormerRequest for examination was made
Status updated on  20.09.2019
FormerThe international publication has been made
Status updated on  23.06.2018
Formerunknown
Status updated on  31.01.2018
Most recent event   Tooltip03.05.2024Lapse of the patent in a contracting state
New state(s): MK		published on 05.06.2024  [2024/23]
Applicant(s)For all designated states
F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
[2019/43]
Inventor(s)01 / BEAUDRY, Danial
c/o Genentech Inc.
1 DNA Way
South San Francisco, California 94080 / US
02 / CRAVILLION, Theresa
c/o Genentech Inc.
1 DNA Way
South San Francisco, California 94080 / US
03 / GOSSELIN, Francis
c/o Genentech Inc.
1 DNA Way
South San Francisco, California 94080 / US
04 / LIM, Ngiap-Kie
c/o Genentech Inc.
1 DNA Way
South San Francisco, California 94080 / US
05 / MALHOTRA, Sushant
c/o Genentech Inc.
1 DNA Way
South San Francisco, California 94080 / US
06 / TIAN, Qingping
c/o Genentech Inc.
1 DNA Way
South San Francisco, California 94080 / US
07 / ZHANG, Haiming
c/o Genentech Inc.
1 DNA Way
South San Francisco, California 94080 / US
08 / GMEHLING, Alexander
Hemburnnstrasse 17
5605 Dottikon / CH
09 / FETTES, Alec
c/o F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
10 / BACHMANN, Stephan
c/o F. Hoffmann-La Roche AG
Grenzacherstrasse 124
94080 Basel / CH
 [2019/43]
Representative(s)Sauer, Frank
F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124
4070 Basel / CH
[2019/43]
Application number, filing date17832491.913.12.2017
[2019/43]
WO2017EP82723
Priority number, dateUS201662434569P15.12.2016         Original published format: US 201662434569 P
[2019/43]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018109050
Date:21.06.2018
Language:EN
[2018/25]
Type: A1 Application with search report 
No.:EP3555099
Date:23.10.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 21.06.2018 takes the place of the publication of the European patent application.
[2019/43]
Type: B1 Patent specification 
No.:EP3555099
Date:18.08.2021
Language:EN
[2021/33]
Search report(s)International search report - published on:EP21.06.2018
ClassificationIPC:C07D487/04
[2019/43]
CPC:
C07D487/04 (EP,CN,IL,KR,US); B01J31/2409 (CN,IL,KR,US); B01J31/2414 (CN,IL,KR,US);
B01J2231/40 (CN,IL,KR,US); B01J2531/824 (CN,IL,KR,US); C07B2200/09 (CN,IL,KR,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/43]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON BTK-INHIBITOREN[2019/43]
English:PROCESS FOR PREPARING BTK INHIBITORS[2019/43]
French:PROCÉDÉ DE PRÉPARATION D'INHIBITEURS DE BTK[2019/43]
Entry into regional phase15.07.2019National basic fee paid 
15.07.2019Designation fee(s) paid 
15.07.2019Examination fee paid 
Examination procedure15.07.2019Examination requested  [2019/43]
15.07.2019Date on which the examining division has become responsible
31.01.2020Amendment by applicant (claims and/or description)
05.06.2020Despatch of a communication from the examining division (Time limit: M06)
03.12.2020Reply to a communication from the examining division
08.04.2021Communication of intention to grant the patent
08.07.2021Fee for grant paid
08.07.2021Fee for publishing/printing paid
08.07.2021Receipt of the translation of the claim(s)
Divisional application(s)EP20189072.0  / EP3825317
Opposition(s)19.05.2022No opposition filed within time limit [2022/30]
Fees paidRenewal fee
10.12.2019Renewal fee patent year 03
09.12.2020Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU13.12.2017
AL18.08.2021
CY18.08.2021
CZ18.08.2021
DK18.08.2021
EE18.08.2021
FI18.08.2021
LT18.08.2021
LV18.08.2021
MC18.08.2021
MK18.08.2021
RS18.08.2021
SK18.08.2021
SM18.08.2021
BG18.11.2021
NO18.11.2021
IT13.12.2021
LU13.12.2021
IS18.12.2021
PT20.12.2021
[2024/23]
Former [2023/33]HU13.12.2017
AL18.08.2021
CY18.08.2021
CZ18.08.2021
DK18.08.2021
EE18.08.2021
FI18.08.2021
LT18.08.2021
LV18.08.2021
MC18.08.2021
RS18.08.2021
SK18.08.2021
SM18.08.2021
BG18.11.2021
NO18.11.2021
IT13.12.2021
LU13.12.2021
IS18.12.2021
PT20.12.2021
Former [2023/30]AL18.08.2021
CY18.08.2021
CZ18.08.2021
DK18.08.2021
EE18.08.2021
FI18.08.2021
LT18.08.2021
LV18.08.2021
MC18.08.2021
RS18.08.2021
SK18.08.2021
SM18.08.2021
BG18.11.2021
NO18.11.2021
IT13.12.2021
LU13.12.2021
IS18.12.2021
PT20.12.2021
Former [2023/10]AL18.08.2021
CZ18.08.2021
DK18.08.2021
EE18.08.2021
FI18.08.2021
LT18.08.2021
LV18.08.2021
MC18.08.2021
RS18.08.2021
SK18.08.2021
SM18.08.2021
BG18.11.2021
NO18.11.2021
IT13.12.2021
LU13.12.2021
IS18.12.2021
PT20.12.2021
Former [2022/46]AL18.08.2021
CZ18.08.2021
DK18.08.2021
EE18.08.2021
FI18.08.2021
LT18.08.2021
LV18.08.2021
MC18.08.2021
RS18.08.2021
SK18.08.2021
SM18.08.2021
BG18.11.2021
NO18.11.2021
LU13.12.2021
IS18.12.2021
PT20.12.2021
Former [2022/33]AL18.08.2021
CZ18.08.2021
DK18.08.2021
EE18.08.2021
FI18.08.2021
LT18.08.2021
LV18.08.2021
MC18.08.2021
RS18.08.2021
SK18.08.2021
SM18.08.2021
BG18.11.2021
NO18.11.2021
IS18.12.2021
PT20.12.2021
Former [2022/29]AL18.08.2021
CZ18.08.2021
DK18.08.2021
EE18.08.2021
FI18.08.2021
LT18.08.2021
LV18.08.2021
RS18.08.2021
SK18.08.2021
SM18.08.2021
BG18.11.2021
NO18.11.2021
IS18.12.2021
PT20.12.2021
Former [2022/25]CZ18.08.2021
DK18.08.2021
EE18.08.2021
FI18.08.2021
LT18.08.2021
LV18.08.2021
RS18.08.2021
SK18.08.2021
SM18.08.2021
BG18.11.2021
NO18.11.2021
IS18.12.2021
PT20.12.2021
Former [2022/24]CZ18.08.2021
DK18.08.2021
EE18.08.2021
FI18.08.2021
LT18.08.2021
LV18.08.2021
RS18.08.2021
SK18.08.2021
BG18.11.2021
NO18.11.2021
IS18.12.2021
PT20.12.2021
Former [2022/21]DK18.08.2021
FI18.08.2021
LT18.08.2021
LV18.08.2021
RS18.08.2021
BG18.11.2021
NO18.11.2021
IS18.12.2021
PT20.12.2021
Former [2022/10]FI18.08.2021
LT18.08.2021
LV18.08.2021
RS18.08.2021
BG18.11.2021
NO18.11.2021
IS18.12.2021
PT20.12.2021
Former [2022/09]FI18.08.2021
LT18.08.2021
RS18.08.2021
BG18.11.2021
NO18.11.2021
PT20.12.2021
Former [2022/08]FI18.08.2021
LT18.08.2021
BG18.11.2021
NO18.11.2021
Former [2022/07]LT18.08.2021
NO18.11.2021
Cited inInternational search[XAYI]WO2013067274  (GENENTECH INC [US], et al) [X] 58,59 * figures 1, 3, 7, 8, 10-12, 19, 21-22, 25 * * page 40; compound 130 * * page 164 - page 167; compounds 130a-130g, 130 * * Page 255, Scheme for the preparation of compound 191h * * Page 256, preparation of the compoung 191j * * Page 346, scheme for the preparation of compound 243g * * page 351; compound 245b * * Page 93, Suzuki coupling * * page 121; compound 107e * * page 141; compound 117e * * page 122; compound 108a * * page 276; example 199c * [A] 27-49 [Y] 50-57 [I] 1-26;
 [A]WO2014056083  (UNIV HEALTH NETWORK [CA]) [A] 19-22 * page 24, paragraph 3 *;
 [XY]US2015158846  (CRAWFORD JAMES JOHN [US], et al) [X] 58,59 * page 40; compound 107f * * pages 34-35; example 103 *[Y] 50-57;
 [XY]WO2016050921  (HOFFMANN LA ROCHE [CH], et al) [X] 58,59 * page 66; compound 3b * [Y] 50-57;
 [A]  - KHOJE A D ET AL, "Reactivity and regioselectivity in Stille couplings of 3-substituted 2,4-dichloropyridines", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 52, no. 4, ISSN 0040-4039, (20110126), pages 523 - 525, (20101221), XP027567759 [A] 5-9 * abstract * * SAcheme 2, page 524 * * page 524; example 1d; table 1 *
 [A]  - BARRY M. TROST ET AL, "Palladium-Catalyzed Dynamic Kinetic Asymmetric Transformations of Vinyl Aziridines with Nitrogen Heterocycles: Rapid Access to Biologically Active Pyrroles and Indoles", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, US, (20101110), vol. 132, no. 44, doi:10.1021/ja1071509, ISSN 0002-7863, pages 15800 - 15807, XP055478150 [A] 27-49 * abstract * * Scheme 1; page 15804 *

DOI:   http://dx.doi.org/10.1021/ja1071509
by applicantUS2013116235
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.