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Extract from the Register of European Patents

EP About this file: EP3555107

EP3555107 - PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO)PROPANAMIDE [Right-click to bookmark this link]
Former [2019/43]PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO) PROPANAMIDE
[2020/36]
StatusNo opposition filed within time limit
Status updated on  24.12.2021
Database last updated on 16.11.2024
FormerThe patent has been granted
Status updated on  15.01.2021
FormerGrant of patent is intended
Status updated on  07.09.2020
FormerRequest for examination was made
Status updated on  20.09.2019
FormerThe international publication has been made
Status updated on  23.06.2018
Formerunknown
Status updated on  06.02.2018
Most recent event   Tooltip13.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 16.10.2024  [2024/42]
Applicant(s)For all designated states
F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
[2019/43]
Inventor(s)01 / GOSSELIN, Francis
c/o Genentech Inc.
1 DNA Way
South San Francisco, California 94080 / US
02 / HAN, Chong
c/o Genentech Inc.
1 DNA Way
South San Francisco, California 94080 / US
03 / CRAVILLION, Theresa
c/o Genentech Inc.
1 DNA Way
South San Francisco, California 94080 / US
04 / KELLY, Sean M.
c/o Genentech Inc.
1 DNA Way
South San Francisco, California 94080 / US
05 / SAVAGE, Scott
545 Middlefield Road
Suite 208
Menlo Park, California 94025 / US
 [2019/43]
Representative(s)Sauer, Frank
F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124
4070 Basel / CH
[2019/43]
Application number, filing date17835634.115.12.2017
[2019/43]
WO2017EP83143
Priority number, dateUS201662434836P15.12.2016         Original published format: US 201662434836 P
[2019/43]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018109204
Date:21.06.2018
Language:EN
[2018/25]
Type: A1 Application with search report 
No.:EP3555107
Date:23.10.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 21.06.2018 takes the place of the publication of the European patent application.
[2019/43]
Type: B1 Patent specification 
No.:EP3555107
Date:17.02.2021
Language:EN
[2021/07]
Search report(s)International search report - published on:EP21.06.2018
ClassificationIPC:C07D498/04
[2019/43]
CPC:
C07D498/04 (EP,IL,KR,US); A61K31/553 (KR); A61P35/00 (IL,KR)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/43]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON (S)-2-((2-((S)-4-(DIFLUORMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO)PROPANAMID[2019/43]
English:PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO)PROPANAMIDE[2020/36]
French:PROCÉDÉ DE PRÉPARATION DE (S)-2-((2-((S)-4-(DIFLUOROMÉTHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZÉPIN-9-YL)AMINO) PROPANAMIDE[2019/43]
Former [2019/43]PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO) PROPANAMIDE
Entry into regional phase15.07.2019National basic fee paid 
15.07.2019Designation fee(s) paid 
15.07.2019Examination fee paid 
Examination procedure15.07.2019Examination requested  [2019/43]
15.07.2019Date on which the examining division has become responsible
24.01.2020Amendment by applicant (claims and/or description)
08.09.2020Communication of intention to grant the patent
18.12.2020Fee for grant paid
18.12.2020Fee for publishing/printing paid
18.12.2020Receipt of the translation of the claim(s)
Divisional application(s)EP20209166.6  / EP3851441
Opposition(s)18.11.2021No opposition filed within time limit [2022/04]
Fees paidRenewal fee
10.12.2019Renewal fee patent year 03
09.12.2020Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU15.12.2017
AL17.02.2021
CY17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
FI17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
MK17.02.2021
MT17.02.2021
RS17.02.2021
SK17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
IS17.06.2021
PT17.06.2021
[2024/42]
Former [2024/23]HU15.12.2017
AL17.02.2021
CY17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
FI17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
MK17.02.2021
RS17.02.2021
SK17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
IS17.06.2021
PT17.06.2021
Former [2023/33]HU15.12.2017
AL17.02.2021
CY17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
FI17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
RS17.02.2021
SK17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
IS17.06.2021
PT17.06.2021
Former [2023/30]AL17.02.2021
CY17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
FI17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
RS17.02.2021
SK17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
IS17.06.2021
PT17.06.2021
Former [2022/33]AL17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
FI17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
RS17.02.2021
SK17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
IS17.06.2021
PT17.06.2021
Former [2022/23]AL17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
FI17.02.2021
LT17.02.2021
LV17.02.2021
RS17.02.2021
SK17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
IS17.06.2021
PT17.06.2021
Former [2022/10]AL17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
FI17.02.2021
LT17.02.2021
LV17.02.2021
RS17.02.2021
SK17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
PT17.06.2021
Former [2022/07]AL17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
FI17.02.2021
LT17.02.2021
LV17.02.2021
RS17.02.2021
SK17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
IS17.06.2021
PT17.06.2021
Former [2021/50]CZ17.02.2021
DK17.02.2021
EE17.02.2021
FI17.02.2021
LT17.02.2021
LV17.02.2021
RS17.02.2021
SK17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
IS17.06.2021
PT17.06.2021
Former [2021/49]CZ17.02.2021
DK17.02.2021
EE17.02.2021
FI17.02.2021
LT17.02.2021
LV17.02.2021
RS17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
IS17.06.2021
PT17.06.2021
Former [2021/48]CZ17.02.2021
EE17.02.2021
FI17.02.2021
LT17.02.2021
LV17.02.2021
RS17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
IS17.06.2021
PT17.06.2021
Former [2021/46]FI17.02.2021
LT17.02.2021
LV17.02.2021
RS17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
IS17.06.2021
PT17.06.2021
Former [2021/42]FI17.02.2021
LT17.02.2021
LV17.02.2021
RS17.02.2021
BG17.05.2021
NO17.05.2021
IS17.06.2021
PT17.06.2021
Former [2021/37]FI17.02.2021
LT17.02.2021
LV17.02.2021
RS17.02.2021
BG17.05.2021
NO17.05.2021
PT17.06.2021
Former [2021/36]FI17.02.2021
LT17.02.2021
BG17.05.2021
NO17.05.2021
PT17.06.2021
Former [2021/33]FI17.02.2021
LT17.02.2021
NO17.05.2021
PT17.06.2021
Cited inInternational search[AD]WO2011036280  (HOFFMANN LA ROCHE [CH], et al) [AD] 1-11 * claims 1,6 *;
 [ADP]WO2017001645  (HOFFMANN LA ROCHE [CH], et al) [ADP] 1-11* compound 101 on page 23, Scheme 2 on page 70;; claim 1 *
by applicantWO2011036280
 US8242104
 US8343955
 WO2017001645
 US2017015678
    - CHEMICAL ABSTRACTS, Database accession no. 1282512-48-4
    - NDUBAKU, C. O. et al., J. Med. Chem., (20130000), vol. 56, pages 4597 - 4610
    - EDGAR K. et al., Preclinical characterization of GDC-0077, a specific PI3K alpha inhibitor in early clinical development
    - LOUIS F. FIESER; MARY FIESER, Reagents for Organic Synthesis, Wiley, (19670000), vol. 1-19
    - Beilsteins Handbuch der organischen Chemie, Springer-Verlag
    - CHEMICAL ABSTRACTS, Database accession no. 69-65-8
    - CHEMICAL ABSTRACTS, Database accession no. 63517-29-3
    - CHEMICAL ABSTRACTS, Database accession no. 63517-33-9
    - CHEMICAL ABSTRACTS, Database accession no. 32315-10-9
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.