EP3554551 - CYCLODEXTRIN CONJUGATES [Right-click to bookmark this link] | Status | Examination is in progress Status updated on 16.04.2021 Database last updated on 31.08.2024 | |
Former | Request for examination was made Status updated on 20.09.2019 | ||
Former | The international publication has been made Status updated on 23.06.2018 | ||
Former | unknown Status updated on 09.02.2018 | Most recent event Tooltip | 07.02.2024 | New entry: Decision on request for further processing | Applicant(s) | For all designated states University College Cork-National University of Ireland, Cork College Road Cork / IE | [2019/43] | Inventor(s) | 01 /
DARCY, Raphael 58 Clonard Drive Dublin D16 Y3E3 / IE | 02 /
O'DRISCOLL, Caitriona 1 The View Lover's Walk Montenotte Cork T23 F9R3 / IE | 03 /
MALHOTRA, Meenakshi 331 Curtner Avenue Apt. L Palo Alto, CA 94306 / US | [2019/43] | Representative(s) | Purdylucey Intellectual Property 6-7 Harcourt Terrace D02 FH73 Dublin 2 / IE | [2019/43] | Application number, filing date | 17835816.4 | 14.12.2017 | [2019/43] | WO2017EP82941 | Priority number, date | EP20160204184 | 14.12.2016 Original published format: EP 16204184 | [2019/43] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2018109138 | Date: | 21.06.2018 | Language: | EN | [2018/25] | Type: | A1 Application with search report | No.: | EP3554551 | Date: | 23.10.2019 | Language: | EN | The application published by WIPO in one of the EPO official languages on 21.06.2018 takes the place of the publication of the European patent application. | [2019/43] | Search report(s) | International search report - published on: | EP | 21.06.2018 | Classification | IPC: | A61K47/61, A61K47/62, A61K47/69 | [2019/43] | CPC: |
A61K47/61 (EP,US);
A61K47/6951 (EP,US);
A61K31/7105 (US);
A61K47/62 (EP,US);
A61K47/6929 (US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2019/43] | Title | German: | CYCLODEXTRINKONJUGATE | [2019/43] | English: | CYCLODEXTRIN CONJUGATES | [2019/43] | French: | CONJUGUÉS DE CYCLODEXTRINE | [2019/43] | Entry into regional phase | 08.07.2019 | National basic fee paid | 08.07.2019 | Designation fee(s) paid | 08.07.2019 | Examination fee paid | Examination procedure | 08.07.2019 | Examination requested [2019/43] | 08.07.2019 | Date on which the examining division has become responsible | 18.03.2020 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time | 13.05.2020 | Amendment by applicant (claims and/or description) | 16.04.2021 | Despatch of a communication from the examining division (Time limit: M06) | 26.10.2021 | Reply to a communication from the examining division | 15.09.2023 | Despatch of a communication from the examining division (Time limit: M04) | 29.01.2024 | Reply to a communication from the examining division | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 29.01.2024 | Request for further processing filed | 29.01.2024 | Full payment received (date of receipt of payment) Request granted | 06.02.2024 | Decision despatched | 13.05.2020 | Request for further processing filed | 13.05.2020 | Full payment received (date of receipt of payment) Request granted | 25.05.2020 | Decision despatched | Fees paid | Renewal fee | 20.12.2019 | Renewal fee patent year 03 | 22.12.2020 | Renewal fee patent year 04 | 22.12.2021 | Renewal fee patent year 05 | 22.12.2022 | Renewal fee patent year 06 | 29.12.2023 | Renewal fee patent year 07 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [AD]WO2010000869 (UNIV DUBLIN [IE], et al) [AD] 1 * examples 3-4; claims 1-11, 16, 21-23 *; | [A]WO2014194250 (UNIV CINCINNATI [US]) [A] 1* paragraphs [00120] - [00126] *; | [XI]WO2015107115 (BASF SE [DE]) [X] 1-4,7,8,22-36 * page 17, paragraph last - page 19, paragraph 3rd; figures 1-7 * * page 13, lines 23-27 * [I] 5,6,9-13; | [A] - GOODING MATT ET AL, "Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells:In vitroanalysis", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER, AMSTERDAM, NL, (20150219), vol. 71, doi:10.1016/J.EJPS.2015.02.007, ISSN 0928-0987, pages 80 - 92, XP029146347 [A] 1 * abstract * * page 81, column l, paragraphs 1-3 * DOI: http://dx.doi.org/10.1016/j.ejps.2015.02.007 | by applicant | EP1287039 | US2006148756 | US7786095 | EP2303929 | US2011124103 | - FITZGERALD KA.; MALHOTRA M.; GOODING M.; SALLAS F.; EVANS JC.; DARCY R.; O' DRISCOLL CM., "A novel, anisamide-targeted cyclodextrin nanoformulation for siRNA delivery to prostate cancer cells expressing the sigma-1 receptor", Int. J., Pharm., (20160000), vol. 499, pages 131 - 145 | - FITZGERALD KA.; GUO G.; TIERNEY EG.; CURTIN CM.; MALHOTRA M.; DARCY R.; O' BRIEN FJ.; O'DRISCOLL CM., "The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics", Biomaterials, (20150000), vol. 66, pages 53 - 66 | - EVANS JC.; MCCARTHY J.; TORRES-FUENTES C.; CRYAN JF.; OGIER J.; DARCY R.; WATSON RW.; O'DRISCOLL CM., "Cyclodextrin mediated delivery of NF- B and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro", Gene Therapy, (20150000), vol. 22, no. 10, pages 802 - 810 | - GOODING M.; MALHOTRA M.; MCCARTHY DJ.; GODINHO BMDC.; CRYAN JF.; DARCY R.; O'DRISCOLL CM., "Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: in-vitro analysis", Eur J Pharm., Sci., (20150000), vol. 71, pages 80 - 92 | - GODINHO BMDC; OGIER JR; QUINLAN A; DARCY R; GRIFFIN BT; CRYAN JF; O'DRISCOLL CM, "PEGylated cyclodextrins as Novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability", Int. J. Pharm., (20140000), vol. 473, pages 105 - 112 | - O'MAHONY AM.; CRONIN MF.; MCMAHON A.; EVANS JC.; DALY K.; DARCY R.; O'DRISCOLL CM, "Biophysical and Structural Characterisation of Nucleic Acid Complexes with Modified Cyclodextrins Using Circular Dichroism", J. Pharm., Sci., (20140000), vol. 103, pages 1346 - 1355 | - HIBBITTS A; O'MAHONY AM; FORDE E; NOLAN L; OGIER J; DESGRANGES S; DARCY R; MACLOUGHLIN R; O'DRISCOLL CM; CRYAN SA, "Early-Stage Development of Novel Cyclodextrin-siRNA Nanocomplexes Allows for Successful Postnebulization Transfection of Bronchial Epithelial Cells", Journal of Aerosol Medicine & Pulmonary Drug Delivery, (20140000), vol. 27, no. 6, pages 466 - 477 | - GODINHO BMDC.; MCCARTHY DJ.; TORRES-FUENTES C.; BELTRAN CJ.; MCCARTHY J.; QUINLAN A.; OGIER JR.; DARCY R.; O'DRISCOLL CM.; CRYAN J, "Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system", Biomaterials, (20140000), vol. 35, doi:doi:10.1016/j.biomaterials.2013.09.068, pages 489 - 499, XP028762486 DOI: http://dx.doi.org/10.1016/j.biomaterials.2013.09.068 | - O'NEILL M.; O'MAHONY A.; BYRNE C.; DARCY R.; O'DRISCOLL CM., "Gastrointestinal gene delivery by Modified Cyclodextrins - in vitro identification and quantification of extracellular barriers", Int J Pharmaceutics, (20130000), vol. 456, pages 390 - 399 | - O'MAHONY AM; OGIER J; DARCY R; CRYAN JF; O'DRISCOLL CM, "Cationic and PEGylated amphiphilic Cyclodextrins: Co-formulation opportunities for neuronal siRNA delivery", PLoS ONE, (20130000), vol. 8, no. 6, page e66413 | - MCCARTHY J.; O'NEILL MJ.; BOUREE L.; WALSH DP.; QUINLAN A.; HURLEY G.; OGIER J.; SHANAHAN F.; MELGAR S.; DARCY R, "Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system", J. Cont., Rel., (20130000), vol. 168, doi:doi:10.1016/j.jconrel.2013.03.004, pages 28 - 34, XP028543682 DOI: http://dx.doi.org/10.1016/j.jconrel.2013.03.004 | - VILLARI, V.; MAZZAGLIA, A.; DARCY, R.; O'DRISCOLL, CM; MICALI, N, "Nanostructures of cationic amphiphilic cyclodextrin complexes with DNA", Biomacromolecules, (20130000), vol. 14, pages 811 - 817 | - GODINHO BMDC; OGIER JR; DARCY R; O'DRISCOLL CM; CRYAN JF, "Self-assembling Modified Beta-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington's Disease", Molecular Pharmaceutics, (20130000), vol. 10, pages 640 - 649 | - O'MAHONY, AM; DESGRANGES S.; OGIER JR.; QUINLAN A.; DEVOCELLE M.; DARCY, R.; CRYAN, JF; O'DRISCOLL, CM, "In vitro investigations of the efficacy of Cyclodextrin-siRNA complexes modified with Lipid-PEG-Octaarginine: Towards A Formulation Strategy for Effective Neuronal siRNA Delivery", Pharm. Res., (20130000), vol. 30, no. 4, pages 1086 - 1098 | - O'MAHONY, AM; DOYLE, D; DARCY, R; CRYAN, JF; O'DRISCOLL, CM, "Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: effect of reversing primary and secondary face modifications", Eur. J. Pharm., Sci., (20120000), vol. 47, pages 896 - 903 | - O'MAHONY AM; GODINHO BMDC; OGIER J; DEVOCELLE M; DARCY R; CRYAN JF; O'DRISCOLL CM, "Click-modified cyclodextrins as non-viral vectors for neuronal siRNA delivery", ACS Chemical Neuroscience, (20120000), vol. 10, no. 3, pages 744 - 52 | - GUO J; OGIER J; DESGRANGES S; DARCY R; O'DRISCOLL CM, "Anisamide-targeted cyclodextrin nanoparticles for siRNA delivery to prostate tumours in mice", Biomaterials, (20120000), vol. 33, pages 7775 - 7784 | - O'MAHONY AM; OGIER J; DESGRANGES S; CRYAN JF; DARCY R; O'DRISCOLL CM, "A click chemistry route to 2-functionalised PEGylated and cationic Beta-cyclodextrins: co-formulation opportunities for siRNA delivery", Organic & Biomolecular Chemistry, (20120000), vol. 10, pages 4954 - 496 | - MCMAHON A; O'NEILL MJ; GOMEZ E; DONOHUE R; FORDE D; DARCY R; O'DRISCOLL CM, "Targeted gene delivery to hepatocytes with galactosylated amphiphilic cyclodextrins", J. 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