blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

Italy joins the Federated Register

Click here for more information on the Federated Register.

2025-06-12

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register User Manual
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3497204

EP3497204 - METHOD FOR GENERATING MESODERM AND/OR ENDOTHELIAL COLONY FORMING CELL-LIKE CELLS HAVING IN VIVO BLOOD VESSEL FORMING CAPACITY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  06.03.2026
Database last updated on 28.03.2026
FormerThe patent has been granted
Status updated on  28.03.2025
FormerGrant of patent is intended
Status updated on  27.11.2024
FormerExamination is in progress
Status updated on  23.07.2021
FormerRequest for examination was made
Status updated on  17.05.2019
FormerThe international publication has been made
Status updated on  17.02.2018
Most recent event   Tooltip06.03.2026No opposition filed within time limitpublished on 08.04.2026 [2026/15]
Applicant(s)For all designated states
Indiana University Research & Technology Corporation
518 Indiana Avenue
Indianapolis, IN 46202 / US
[2025/18]
Former [2019/25]For all designated states
Indiana University Research & Technology Corporation
518 Indiana Avenue
Indianapolis, IN 46202 / US
Inventor(s)01 / YODER, Mervin C.
6826 West 71st Street
Indianapolis Indiana 46278 / US
02 / PRASAIN, Nutan
P.O. Box 1142
Marlborough Massachusetts 01752 / US
 [2019/25]
Representative(s)V.O.
P.O. Box 87930
2508 DH Den Haag / NL
[2025/18]
Former [2019/25]Appleyard Lees IP LLP
15 Clare Road
Halifax HX1 2HY / GB
Application number, filing date17840057.804.08.2017
[2019/25]
WO2017US45496
Priority number, dateUS201662372907P10.08.2016         Original published format: US 201662372907 P
[2019/25]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018031404
Date:15.02.2018
Language:EN
[2018/07]
Type: A1 Application with search report 
No.:EP3497204
Date:19.06.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 15.02.2018 takes the place of the publication of the European patent application.
[2019/25]
Type: B1 Patent specification 
No.:EP3497204
Date:30.04.2025
Language:EN
[2025/18]
Search report(s)International search report - published on:US15.02.2018
(Supplementary) European search report - dispatched on:EP08.04.2020
ClassificationIPC:A61P11/00, A61P13/12, A61P9/00, C12N5/071, A61K35/12
[2024/46]
CPC:
A61K35/12 (EP,IL,KR,US); C12N5/069 (EP,IL,KR,US); C12N5/0606 (IL,US);
A61P11/00 (EP,IL); A61P13/12 (EP,IL); A61P9/00 (EP,IL);
C12N2501/115 (EP,IL,KR,US); C12N2501/155 (EP,IL,KR,US); C12N2501/16 (EP,IL,KR,US);
C12N2501/165 (EP,IL,KR,US); C12N2501/65 (IL,US); C12N2506/02 (EP,IL,KR,US);
C12N2506/03 (IL,US); C12N2506/45 (EP,IL,KR,US); C12N2533/54 (EP,IL,KR,US) (-)
Former IPC [2020/19]C12N5/07, C12N5/071, C12N5/0735, C12N5/074, A61K35/12
Former IPC [2019/25]C12N5/07, C12N5/071, C12N5/0735, C12N5/074
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/25]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:VERFAHREN ZUR ERZEUGUNG VON MESODERMEN UND/ODER ENDOTHELIALEN KOLONIEBILDENDEN ZELLEN MIT FÄHIGKEIT ZUR IN-VIVO-BILDUNG VON BLUTGEFÄSSEN[2019/25]
English:METHOD FOR GENERATING MESODERM AND/OR ENDOTHELIAL COLONY FORMING CELL-LIKE CELLS HAVING IN VIVO BLOOD VESSEL FORMING CAPACITY[2019/25]
French:PROCÉDÉ DE GÉNÉRATION DE CELLULES MÉSODERMIQUES ET/OU DE CELLULES DE TYPE CELLULES DE FORMATION DE COLONIES ENDOTHÉLIALES PRÉSENTANT UNE CAPACITÉ DE FORMATION DE VAISSEAUX SANGUINS IN VIVO[2019/25]
Entry into regional phase05.03.2019National basic fee paid 
05.03.2019Search fee paid 
05.03.2019Designation fee(s) paid 
05.03.2019Examination fee paid 
Examination procedure05.03.2019Examination requested  [2019/25]
26.10.2020Amendment by applicant (claims and/or description)
26.07.2021Despatch of a communication from the examining division (Time limit: M06)
26.01.2022Reply to a communication from the examining division
03.03.2023Despatch of a communication from the examining division (Time limit: M04)
28.06.2023Reply to a communication from the examining division
28.11.2024Communication of intention to grant the patent
21.03.2025Fee for grant paid
21.03.2025Fee for publishing/printing paid
21.03.2025Receipt of the translation of the claim(s)
Opposition(s)02.02.2026No opposition filed within time limit [2026/15]
Fees paidRenewal fee
27.08.2019Renewal fee patent year 03
27.08.2020Renewal fee patent year 04
27.08.2021Renewal fee patent year 05
29.08.2022Renewal fee patent year 06
28.08.2023Renewal fee patent year 07
27.08.2024Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT30.04.2025
BG30.04.2025
CZ30.04.2025
DK30.04.2025
EE30.04.2025
ES30.04.2025
FI30.04.2025
HR30.04.2025
IT30.04.2025
LV30.04.2025
NL30.04.2025
PL30.04.2025
RO30.04.2025
SK30.04.2025
SM30.04.2025
NO30.07.2025
GR31.07.2025
RS31.07.2025
IS30.08.2025
PT01.09.2025
[2026/10]
Former [2026/09]AT30.04.2025
BG30.04.2025
CZ30.04.2025
DK30.04.2025
ES30.04.2025
FI30.04.2025
HR30.04.2025
LV30.04.2025
NL30.04.2025
PL30.04.2025
SM30.04.2025
NO30.07.2025
GR31.07.2025
RS31.07.2025
IS30.08.2025
PT01.09.2025
Former [2026/08]AT30.04.2025
BG30.04.2025
DK30.04.2025
ES30.04.2025
FI30.04.2025
HR30.04.2025
LV30.04.2025
NL30.04.2025
PL30.04.2025
SM30.04.2025
NO30.07.2025
GR31.07.2025
RS31.07.2025
IS30.08.2025
PT01.09.2025
Former [2025/49]AT30.04.2025
BG30.04.2025
ES30.04.2025
FI30.04.2025
HR30.04.2025
LV30.04.2025
NL30.04.2025
PL30.04.2025
NO30.07.2025
GR31.07.2025
RS31.07.2025
IS30.08.2025
PT01.09.2025
Former [2025/48]AT30.04.2025
BG30.04.2025
ES30.04.2025
FI30.04.2025
HR30.04.2025
NL30.04.2025
PL30.04.2025
NO30.07.2025
GR31.07.2025
RS31.07.2025
PT01.09.2025
Former [2025/47]BG30.04.2025
ES30.04.2025
FI30.04.2025
NL30.04.2025
PL30.04.2025
NO30.07.2025
GR31.07.2025
PT01.09.2025
Former [2025/46]ES30.04.2025
FI30.04.2025
PT01.09.2025
Documents cited:Search[XI] US2016194610  (SLUKVIN IGOR I et al.)
 [XI]   NUTAN PRASAIN ET AL: "Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony?forming cells", NATURE BIOTECHNOLOGY, vol. 32, no. 11, 12 October 2014 (2014-10-12), New York, pages 1151 - 1157, XP055383069, ISSN: 1087-0156, DOI: 10.1038/nbt.3048 [I] 1-7

DOI:   http://dx.doi.org/10.1038/nbt.3048
 [X]   MERVIN C. YODER: "Differentiation of pluripotent stem cells into endothelial cells :", CURRENT OPINION IN HEMATOLOGY, vol. 22, no. 3, 1 May 2015 (2015-05-01), US, pages 252 - 257, XP055648936, ISSN: 1065-6251, DOI: 10.1097/MOH.0000000000000140 [X] 10,12,14,15 * page 15 - page 20; figures 1-4 *

DOI:   http://dx.doi.org/10.1097/MOH.0000000000000140
International search[Y] WO2015138634  (UNIV INDIANA RES & TECH CORP et al.) [Y] 1-4, 17-20 * entire document *
 [Y] US2010261274  (VODYANYK MAKSYM A et al.) [Y] 1-4, 17-20 * entire document *
 [A] US2015329821  (ANG LAY TENG et al.) [A] 1-4, 17-20 * entire document *
 [A] WO2010011352  (UNIV GEORGIA RES FOUND et al.) [A] 1-4, 17-20 * entire document *
 [Y]   CALLONI ET AL.: "Reviewing and Updating the Major Molecular Markers for Stem Cells", STEM CELLS AND DEVELOPMENT, vol. 22, no. 9, 22 January 2013 (2013-01-22), pages 1455 - 1476, XP055240597 [Y] 2, 18 * . entire document *

DOI:   http://dx.doi.org/10.1089/scd.2012.0637
Examination  MAXIM A VODYANIK ET AL: "A mesoderm-derived precursor for mesenchymal stem and endothelial cells", CELL STEM CELL, ELSEVIER, CELL PRESS, AMSTERDAM, NL, vol. 7, no. 6, 3 December 2010 (2010-12-03), pages 718 - 729, XP002638197, ISSN: 1934-5909, [retrieved on 20101202], DOI: 10.1016/J.STEM.2010.11.011

DOI:   http://dx.doi.org/10.1016/J.STEM.2010.11.011
by applicantUS2015020008
   YODER, M.C. ET AL., BLOOD, vol. 109, 2007, pages 1801 - 1809
   INGRAM D.A., BLOOD, vol. 105, 2005, pages 2783 - 2786 [Y] 2, 18 * . entire document *
   INGRAM, D.A. ET AL., BLOOD, vol. 104, 2004, pages 2752 - 2760
   CRITSER, P.J. ET AL., MICRO VASE RES, vol. 80, 2010, pages 23 - 30
   AU, P ET AL., BLOOD, vol. 111, 2008, pages 1302 - 1305
   MELERO-MARTIN J.M., CIRC RES, vol. 103, 2008, pages 194 - 202
   MOUBARIK, C ET AL., STEM CELL REV, vol. 7, 2011, pages 208 - 220
   SCHWARZ, T.M. ET AL., ARTERIOSCLER THROMB VASE BIOL, vol. 32, 2012, pages 13 - 21
   BOUVARD, C ET AL., ARTERIOSCLER THROMB VASE BIOL, vol. 30, 2010, pages 1569 - 1575
   DUBOIS, C ET AL., J AM COLL CARDIOL, vol. 55, 2010, pages 2232 - 2243
   SCHUH, A ET AL., BASIC RES CARDIOL, vol. 103, 2008, pages 69 - 77
   STITT, A.W. ET AL., PROG RETIN EYE RES, vol. 30, 2011, pages 149 - 166
   MEDINA, R.J. ET AL., INVEST OPHTHALMOL VIS SCI, vol. 51, 2010, pages 5906 - 5913
   LEE, J.H. ET AL., ARTERIOSCLER THROMB VASE BIOL, 2013
   STRONCEK, J.D. ET AL., ACTA BIOMATER, vol. 8, 2012, pages 201 - 208
   ROBBINS, R.D. ET AL., CURR OPIN ORGAN TRANSPLANT, vol. 15, 2010, pages 61 - 67
   BROXMEYER, H.E. ET AL., BLOOD, vol. 117, 2011, pages 4773 - 4777
   LEE, M.R. ET AL., STEM CELLS, vol. 31, 2013, pages 666 - 681
   PRASAIN, N ET AL., NATURE BIOTECHNOLOGY, vol. 32, 2014, pages 1151 - 1157
   VODYANIK ET AL., CELL STEM CELL, vol. 7, 2010, pages 718 - 729
   THOMSON ET AL., SCIENCE, vol. 282, 1998, pages 1145 - 1147
   YU ET AL., SCIENCE, vol. 324, 2009, pages 797 - 801
   GINSBERG ET AL., CELL, vol. 151, 2012, pages 559 - 575
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.