blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP3543701

EP3543701 - BIOMARKER, METHOD FOR SEARCHING DISEASE-RELATED GENE, AND RENAL CANCER MARKER [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  28.01.2022
Database last updated on 18.11.2024
FormerExamination is in progress
Status updated on  14.05.2021
FormerRequest for examination was made
Status updated on  23.08.2019
FormerThe international publication has been made
Status updated on  05.05.2018
Most recent event   Tooltip28.01.2022Application deemed to be withdrawnpublished on 02.03.2022  [2022/09]
Applicant(s)For all designated states
Japanese Foundation For Cancer Research
3-8-31, Ariake
Koto-ku
Tokyo 135-8550 / JP
For all designated states
Osaka University
1-1 Yamadaoka
Suita-shi, Osaka 565-0871 / JP
[2019/39]
Inventor(s)01 / UEDA, Koji
c/o JAPANESE FOUNDATION FOR CANCER RESEARCH
8-31 Ariake 3-chome
Koto-ku
Tokyo 135-8550 / JP
02 / OHNISHI, Naomi
c/o JAPANESE FOUNDATION FOR CANCER RESEARCH
8-31 Ariake 3-chome
Koto-ku
Tokyo 135-8550 / JP
03 / NONOMURA, Norio
c/o OSAKA UNIVERSITY
1-1 Yamadaoka
Suita-shi Osaka 565-0871 / JP
04 / UEMURA, Motohide
c/o OSAKA UNIVERSITY
1-1 Yamadaoka
Suita-shi Osaka 565-0871 / JP
05 / FUJITA, Kazutoshi
c/o OSAKA UNIVERSITY
1-1 Yamadaoka
Suita-shi Osaka 565-0871 / JP
06 / TSUJIKAWA, Kazutake
c/o OSAKA UNIVERSITY
1-1 Yamadaoka
Suita-shi Osaka 565-0871 / JP
07 / JINGUSHI, Kentarou
c/o OSAKA UNIVERSITY
1-1 Yamadaoka
Suita-shi Osaka 565-0871 / JP
 [2019/39]
Representative(s)Schön, Christoph
Dr. Schön, Neymeyr & Partner mbB
Bavariaring 26
80336 München / DE
[2019/39]
Application number, filing date17864046.226.10.2017
[2019/39]
WO2017JP38812
Priority number, dateJP2016021123928.10.2016         Original published format: JP 2016211239
[2019/39]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018079689
Date:03.05.2018
Language:JA
[2018/18]
Type: A1 Application with search report 
No.:EP3543701
Date:25.09.2019
Language:EN
[2019/39]
Search report(s)International search report - published on:JP03.05.2018
(Supplementary) European search report - dispatched on:EP26.06.2020
ClassificationIPC:G01N33/68, C12Q1/68, G01N33/15, G01N33/50, G01N33/574, G01N33/92
[2019/39]
CPC:
C12Q1/6886 (EP,US); G01N33/57438 (EP,US); G01N33/50 (US);
G01N33/574 (US); G01N33/57488 (EP,US); G01N33/68 (US);
G01N33/92 (US); C12Q2600/158 (EP,US); G01N2333/4721 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/39]
TitleGerman:BIOMARKER, VERFAHREN ZUM SUCHEN VON KRANKHEITSASSOZIIERTEM GEN UND NIERENKREBSMARKER[2019/39]
English:BIOMARKER, METHOD FOR SEARCHING DISEASE-RELATED GENE, AND RENAL CANCER MARKER[2019/39]
French:BIOMARQUEUR, PROCÉDÉ DE RECHERCHE D'UN GÈNE ASSOCIÉ À UNE MALADIE, ET MARQUEUR DU CANCER DU REIN[2019/39]
Entry into regional phase20.05.2019Translation filed 
20.05.2019National basic fee paid 
20.05.2019Search fee paid 
20.05.2019Designation fee(s) paid 
20.05.2019Examination fee paid 
Examination procedure26.04.2018Request for preliminary examination filed
International Preliminary Examining Authority: JP
20.05.2019Examination requested  [2019/39]
21.01.2021Amendment by applicant (claims and/or description)
18.05.2021Despatch of a communication from the examining division (Time limit: M04)
29.09.2021Application deemed to be withdrawn, date of legal effect  [2022/09]
15.10.2021Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2022/09]
Fees paidRenewal fee
20.05.2019Renewal fee patent year 03
30.10.2020Renewal fee patent year 04
Penalty fee
Additional fee for renewal fee
31.10.202105   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]  - F. RAIMONDO ET AL, "Differential protein profiling of renal cell carcinoma urinary exosomes", MOLECULAR BIOSYSTEMS, GB, (20130228), vol. 9, no. 6, doi:10.1039/c3mb25582d, ISSN 1742-206X, page 1220, XP055659684 [X] 1-6 * abstract * * page 1226; tables 2-3 *

DOI:   http://dx.doi.org/10.1039/c3mb25582d
 [A]  - TODD M. MORGAN ET AL, "NOVEL RENAL CELL CARCINOMA BIOMARKER IDENTIFICATION FROM URINARY EXOSOMES", JOURNAL OF UROLOGY., BALTIMORE, MD, US, (20120520), vol. 187, no. 4S, doi:10.1016/j.juro.2012.02.501, ISSN 0022-5347, XP055660146 [A] 1-6 * abstract *

DOI:   http://dx.doi.org/10.1016/j.juro.2012.02.501
International search[A]JP2012508577  (CARIS LIFE SCIENCES LUXEMBOURG HOLDINGS) [A] 1-5 * , paragraphs [0224], [0225], [0646] & WO 2010/056337 A2 paragraphs [00223], [00572], [00573] & US 2010/0113290 A1 & EP 2350320 A2 & CN 102301002 A *;
 [A]JP2013544361  (KCI LICENSING, INC.) [A] 1-5 * , paragraph [0029] & WO 2012/071516 A2 paragraph [0031] & US 2012/0129186 A1 & US 2015/0346216 A1 & EP 2643693 A2 & CN 103097892 A *;
 [A]EP2955232  (BORK PEER [DE]) [A] 1-5 * , examples (Family: none) *;
 [A]  - TAKAHASHI, ERI, "2P-11 Search of biomarker proteins in serum extracellular vesicle of renal and bladder cancer patients", Japan Proteome Society Convention Program and Abstracts. JPrOS 2016 Conference (JHUPO 14th Conference), (20160728), doi:10.14889/jhupo.2016.0.108.0, page 108, XP009518613 [A] 1-5

DOI:   http://dx.doi.org/10.14889/jhupo.2016.0.108.0
 [A]  - JINGUJI, KENTARO, "P-3192 Analysis of extracellular vesicles derived from clear cell type renal cell carcinoma tissue", The 74th Annual Meeting of the Japanese Cancer Association; October 8-10, 2015, (20150000), vol. 74, page P-3192, XP009519184 [A] 1-5
 [XY]  - Ran Guo, "Proteins Secreted by Lung Adenocarcinoma Cells ― Identification of Candidate Diagnosis Markers from Culture Supernatants of Dissected Tumor Tissue ", JAPANESE JOURNAL OF LUNG CANCER, (20100101), vol. 50, no. 2, doi:10.2482/haigan.50.141, pages 141 - 150, XP009515257 [X] 1-3, 5 [Y] 4

DOI:   http://dx.doi.org/10.2482/haigan.50.141
 [XY]  - Guo Ran, "Proteome analysis for culture supernatant of primary pulmonary adenocarcinoma tumor tissue", The Journal of Tokyo Medical University, (20091030), vol. 67, no. 4, page 502, XP009504196 [X] 1-3, 5 [Y] 4
 [Y]  - MORITA, TAKUYA, "Identification of exosome surface marker derived from Ewing sarcoma cell applicable to liquid biopsy", The Journal of Japanese Orthopaedic Surgical Society, (20150910), vol. 89, no. 8, pages 1796 2 - 7-22, XP009516050 [Y] 4
 [A]  - KAWAKAMI, FURUO, "Proteomics of biomarker: Proteome statistic analysis using liquid chromatography/tandem mass spectrometry, and applications thereof", JSBSM Lett, (20100325), vol. 35, no. 1, ISSN 1881-5464, pages 4 - 12, XP009515258 [A] 1-5
 [A]  - ZWICKL, H ET AL , "A novel technique to specifically analyze the secretome of cells and tissues", Electrophoresis, (20050701), vol. 26, no. 14, doi:10.1002/elps.200410387, ISSN 0173-0835, pages 2779 - 2785, XP055598872 [A] 1-5 * , abstracts, 1., 2. 1, 3. *

DOI:   http://dx.doi.org/10.1002/elps.200410387
 [A]  - KIYOMI, ANNA, "Immunologic substance secreted from 3-dimensional human breast cancer, and effects on behavior of suppressor T cell thereof", Abstracts of The Pharmaceutical Society of Japan Annual Meeting, (20140000), vol. 134, page 30PMM-89, XP009515162 [A] 1-5
 [A]  - BONIFATI, C ET AL, "IL -lalpha, IL -lbeta and psoriasis: conflicting results in the literature. Opposite behavior of the two cytokines in lessional or non-lessional extracts of whole skin", J Biol Regul Homeost Agents, (19970000), vol. 11, no. 4, ISSN 0393-974X, pages 133 - 136, XP009179746 [A] 1-5 * , MATERIALS AND METHODS *
 [A]  - KIYOHARA, YUMIKO, "Drug screening and grouping by sensitivity with a panel of primary cultured cancer spheroids derived from endometrial cancer", Cancer Science, (20160400), vol. 107, no. 4, doi:10.1111/cas.12898, ISSN 1347-9032, pages 452 - 460, XP055477668 [A] 1-5 * , abstract *

DOI:   http://dx.doi.org/10.1111/cas.12898
 [A]  - BERGMAN A-C ET AL, "Identification of gel-separated tumor marker proteins by mass spectrometry", Electrophoresis , (20000201), vol. 21, no. 3, doi:10.1002/(SICI)1522-2683(20000201)21:3<679::AID-ELPS679>3.0.CO;2-A, ISSN 0173-0835, pages 679 - 686, XP000923086 [A] 1-5 * , Materials and Methods *

DOI:   http://dx.doi.org/10.1002/(SICI)1522-2683(20000201)21:3<679::AID-ELPS679>3.0.CO;2-A
 [PX]  - NAGAYAMA, SATOSHI, "Search for biomarkers for diagnosis of colorectal cancer by comprehensive analysis of resected tissue culture secretion exosome", Journal of Japan Surgical Society, (20170427), vol. 117, page 1, XP009518614 [PX] 1-5
 [PX]  - S. Muraoka, R. Fujii, S. Nagayama, K. Ueda, "Proteome-wide profiling of viable colorectal cancer tissue-derived extracellular vesicle", Abstracts for Annual Meeting of Japanese Proteomics Society - JPrOS 2017 Conference (JHUPO 15th Conference), July 26-28 2017, (20170726), vol. 2017, doi:10.14889/jhupo.2017.0.148.0, page 148, XP009518018 [PX] 1-5

DOI:   http://dx.doi.org/10.14889/jhupo.2017.0.148.0
by applicantJP2016086678
 JP2013140030
 WO2015005965
    - KAHLERT, C.KALLURI, R., J. Mol. Med., (20130000), vol. 91, no. 4, pages 431 - 437
    - AN, T. et al., J. Extracell. Vesicles, (20150000), vol. 4, page 27522
    - PEINADO, H. et al., Nat. Med., (20120000), vol. 18, no. 6, pages 883 - 891
    - COSTA-SLIVA, B. et al., Nat. Cell Biol., (20150000), vol. 17, no. 6, pages 816 - 826
    - HOSHINO, A. et al., Nature, (20150000), vol. 527, no. 7578, pages 329 - 335
    - LASSER, C. et al., J. Vis. Exp., (20120000), vol. 59, page e3037
    - GEISSLER, K. et al., Oncoimmunology, (20150000), vol. 4, page e985082
    - TELTSH, 0. et al., Oncotarget, (20150000), vol. 32, pages 33191 - 33205
    - GULDUR, M. E. et al., J. Pak. Med. Assoc., (20140000), vol. 3, pages 300 - 303
    - BUSSOLATI, B. et al., FASEB J., (20030000), vol. 17, no. 9, pages 1159 - 1161
    - WIKLANDER, O.P. et al., J. Extracell. Vesicles, (20150000), vol. 4, page 26316
    - TOMINAGA, N. et al., Adv. Drug Deliv. Rev., (20150000), vol. 95, pages 50 - 55
    - LAI, C. P. et al., ACS Nano., (20140000), vol. 8, no. 1, pages 483 - 494
    - GRUENWALD, V. et al., BMC Cancer, (20100000), vol. 10, page 695
    - VROLING, L. et al., Angiogenesis, (20090000), vol. 12, no. 1, pages 69 - 79
    - DEL PUERTO-NEVADO, L. et al., Br. J. Cancer, (20140000), vol. 110, pages 2700 - 2707
    - SHANKHAJIT, D. et al., International Journal of Nutrition, Pharmacology, Neurological diseases, (20120000), vol. 2, pages 3 - 7
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.