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Extract from the Register of European Patents

EP About this file: EP3541951

EP3541951 - NON-UNIQUE BARCODES IN A GENOTYPING ASSAY [Right-click to bookmark this link]
StatusThe patent has been granted
Status updated on  18.10.2024
Database last updated on 19.10.2024
FormerGrant of patent is intended
Status updated on  11.06.2024
FormerExamination is in progress
Status updated on  12.08.2021
FormerRequest for examination was made
Status updated on  23.08.2019
FormerThe international publication has been made
Status updated on  25.05.2018
Most recent event   Tooltip18.10.2024(Expected) grantpublished on 20.11.2024 [2024/47]
Applicant(s)For all designated states
Personal Genome Diagnostics Inc.
2809 Boston Street
Suite 503
Baltimore, MD 21224 / US
[2019/39]
Inventor(s)01 / SAUSEN, Mark
2809 Boston Street
Suite 503
Baltimore, MD 21224 / US
02 / VELCULESCU, Victor
14064 Big Branch Drive
Baltimore, MD 21036 / US
03 / DIAZ, Luis
5135 Crystal Springs
Ellicott City, MD 21043 / US
 [2019/39]
Representative(s)Kilburn & Strode LLP
Lacon London
84 Theobalds Road
Holborn
London WC1X 8NL / GB
[2024/47]
Former [2019/39]Cornish, Kristina Victoria Joy, et al
Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL / GB
Application number, filing date17872140.314.11.2017
[2019/39]
WO2017US61447
Priority number, dateUS201662422355P15.11.2016         Original published format: US 201662422355 P
[2019/39]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2018093744
Date:24.05.2018
Language:EN
[2018/21]
Type: A2 Application without search report 
No.:EP3541951
Date:25.09.2019
Language:EN
The application published by WIPO in one of the EPO official languages on 24.05.2018 takes the place of the publication of the European patent application.
[2019/39]
Type: B1 Patent specification
No.:EP3541951
Date:20.11.2024
Language:EN
[2024/47]
Search report(s)International search report - published on:KR02.08.2018
(Supplementary) European search report - dispatched on:EP06.05.2020
ClassificationIPC:C40B40/06, C40B50/06, C12Q1/6827, C12Q1/6874, C12Q1/6886, C12N15/10
[2024/28]
CPC:
C12N15/1065 (EP,US); C12Q1/6827 (EP,US); C12Q1/6874 (EP,US);
C12Q1/6886 (EP,US); C12Q2525/161 (US); C12Q2535/122 (EP,US);
C12Q2535/131 (US); C12Q2537/143 (US); C12Q2537/159 (US);
C12Q2563/179 (US); C12Q2600/156 (EP,US) (-)
C-Set:
C12Q1/6827, C12Q2525/161, C12Q2535/122, C12Q2535/131, C12Q2537/143 (EP);
C12Q1/6874, C12Q2525/161, C12Q2535/122, C12Q2535/131, C12Q2537/143 (EP);
C12Q2535/122, C12Q1/6855, C12Q2537/159, C12Q2563/179 (EP,US)
Former IPC [2020/23]C12Q1/68, C40B40/06, C40B50/06, C12Q1/6827, C12Q1/6874, C12Q1/6886, C12N15/10
Former IPC [2019/39]C12Q1/68, G06F19/18, C40B40/06, C40B50/06
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/39]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:NICHT EINDEUTIGE STRICHCODES IN EINEM GENOTYPISIERUNGSTEST[2019/39]
English:NON-UNIQUE BARCODES IN A GENOTYPING ASSAY[2019/39]
French:CODES-BARRES NON UNIQUES DANS UN TEST DE GÉNOTYPAGE[2019/39]
Entry into regional phase11.06.2019National basic fee paid 
11.06.2019Search fee paid 
11.06.2019Designation fee(s) paid 
11.06.2019Examination fee paid 
Examination procedure11.06.2019Examination requested  [2019/39]
22.01.2021Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
01.04.2021Amendment by applicant (claims and/or description)
11.08.2021Despatch of a communication from the examining division (Time limit: M04)
21.12.2021Reply to a communication from the examining division
25.01.2023Despatch of a communication from the examining division (Time limit: M06)
02.08.2023Reply to a communication from the examining division
12.06.2024Communication of intention to grant the patent
10.10.2024Fee for grant paid
10.10.2024Fee for publishing/printing paid
10.10.2024Receipt of the translation of the claim(s)
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
01.04.2021Request for further processing filed
01.04.2021Full payment received (date of receipt of payment)
Request granted
13.04.2021Decision despatched
The application is deemed to be withdrawn due to failure to indicate the wish to proceed further with the application
01.04.2021Request for further processing filed
01.04.2021Full payment received (date of receipt of payment)
Request granted
13.04.2021Decision despatched
Fees paidRenewal fee
27.11.2019Renewal fee patent year 03
25.02.2021Renewal fee patent year 04
18.11.2021Renewal fee patent year 05
13.10.2022Renewal fee patent year 06
27.10.2023Renewal fee patent year 07
11.10.2024Renewal fee patent year 08
Penalty fee
Additional fee for renewal fee
30.11.202004   M06   Fee paid on   25.02.2021
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XY]US2014065621  (MHATRE RAVI [US], et al);
International search[A]US2014066317  (TALASAZ AMIRALI [US]) [A] 1-23* See abstract; and paragraphs [0102]-[0116]. *;
 [A]US2016273049  (VELCULESCU VICTOR [US], et al) [A] 1-23 * See paragraph [0090]; and claims 1-18. *;
 [X]  - KINDE, ISAAC et al., "Detection and quantification of rare mutations with massively parallel sequencing", Proceedings of the National Academy of Science, U.S.A., (20110607), vol. 108, no. 23, pages 9530 - 9535, XP055164202 [X] 1-23 * See pages 9530-9533, 9535; and figures 1-2. *

DOI:   http://dx.doi.org/10.1073/pnas.1105422108
 [A]  - PENG, QUAN et al., "Reducing amplification artifacts in high multiplex amplicon sequencing by using molecular barcodes", BMC Genomics, (20150807), vol. 16, pages 1 - 12, XP021224943 [A] 1-23 * See pages 2-3, 9-11. *

DOI:   http://dx.doi.org/10.1186/s12864-015-1806-8
 [A]  - NEWMAN, ARON M et al., "Integrated digital error suppression for improved detection of circulating tumor DNA", Nature Biotechnology, (20160500), vol. 34, no. 5, pages 547 - 555, XP055464348 [A] 1-23 * See pages 547, 549, 551; and online methods. *

DOI:   http://dx.doi.org/10.1038/nbt.3520
by applicantUS5234809
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    - NEWMAN et al., "Integrated digital error suppression for improved detection of circulating tumor DNA", Nat. Bio., (20160000), vol. 34, no. 5, doi:10.1038/nbt.3520, XP055802486

DOI:   http://dx.doi.org/10.1038/nbt.3520
    - XUE et al., "Optimizing the Yield and Utility of Circulating Cell-Free DNA from Plasma and Serum", Clin. Chim. Acta., (20090000), vol. 404, no. 2, doi:10.1016/j.cca.2009.02.018, pages 100 - 104, XP055536157

DOI:   http://dx.doi.org/10.1016/j.cca.2009.02.018
    - LI et al., "Whole Genome Amplification of Plasma-Circulating DNA Enables Expanded Screening for Allelic Imbalance in Plasma", J. Mol Diagn., (20060200), vol. 8, no. 1, doi:10.2353/jmoldx.2006.050074, pages 22 - 30, XP055149339

DOI:   http://dx.doi.org/10.2353/jmoldx.2006.050074
    - SAMBROOK, J et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, (20010000), vol. 1-3, page 2,028
    - MARGULIES, M. et al., "Genome sequencing in micro-fabricated high-density picotiter reactors", Nature, (20050000), vol. I-IV, pages 376 - 380
    - ROTHBERG et al., "An integrated semiconductor device enabling non-optical genome sequencing", Nature, (20110000), vol. 475, doi:10.1038/nature10242, pages 348 - 352, XP055268437

DOI:   http://dx.doi.org/10.1038/nature10242
    - KLEIN et al., "LOCAS-A low coverage sequence assembly tool for re-sequencing projects", PLoS One, (20110000), vol. 6, no. 8, page 23455
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