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EP3541932

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Extract from the Register of European Patents

EP About this file: EP3541932

EP3541932 - INHIBITORS OF CRISPR-CAS9 [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 12.09.2025 Database last updated on 18.03.2026
Former	Examination is in progress Status updated on 01.12.2023
Former	Request for examination was made Status updated on 23.08.2019
Former	The international publication has been made Status updated on 25.05.2018
Most recent event Tooltip	12.09.2025	Application deemed to be withdrawn	published on 15.10.2025 [2025/42]
Applicant(s)	For all designated states The Regents of the University of California 1111 Franklin Street, 12th Floor Oakland, CA 94607-5200 / US
	[2019/39]
Inventor(s)	01 / BONDY-DENOMY, Joseph c/o The Regents of The University of California 1111 Franklin Street 12th Floor Oakland, California 94607-5200 / US
	02 / RAUCH, Benjamin c/o The Regents of The University of California 1111 Franklin Street 12th Floor Oakland, California 94607-5200 / US
	[2019/39]
Representative(s)	J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB
	[N/P]
Former [2019/39]	J A Kemp 14 South Square Gray's Inn London WC1R 5JJ / GB
Application number, filing date	17872333.4	16.11.2017
	[2019/39]
	WO2017US61932
Priority number, date	US201662422850P	16.11.2016 Original published format: US 201662422850 P
	[2019/39]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2018093990
	Date:	24.05.2018
	Language:	EN
	[2018/21]
	Type:	A1 Application with search report
	No.:	EP3541932
	Date:	25.09.2019
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 24.05.2018 takes the place of the publication of the European patent application.
	[2019/39]
Search report(s)	International search report - published on:	US	24.05.2018
	(Supplementary) European search report - dispatched on:	EP	02.02.2021
Classification	IPC:	C12N5/0789, C12N5/10, C12N9/22, C12N15/63, C12N15/79, C12N15/85, C07K14/195, A61P43/00	[2020/50]
	CPC:	C12N9/22 (EP,KR); C12N15/74 (KR); C07K14/195 (EP,US); A61K35/14 (US); A61K35/28 (US); A61P43/00 (EP); (+) C07K14/005 (KR); C12N15/102 (KR); C12N15/85 (US); C12N15/902 (KR) (-)
	Former IPC [2019/39]	C12N5/0789, C12N5/10, C12N9/22, C12N15/63, C12N15/79, C12N15/85, C07K14/195
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2019/39]
Title	German:	INHIBITOREN VON CRISPR-CAS9	[2019/39]
	English:	INHIBITORS OF CRISPR-CAS9	[2019/39]
	French:	INHIBITEURS DE CRISPR-CAS9	[2019/39]
Entry into regional phase	05.06.2019	National basic fee paid
	05.06.2019	Search fee paid
	05.06.2019	Designation fee(s) paid
	05.06.2019	Examination fee paid
Examination procedure	05.06.2019	Examination requested [2019/39]
	01.09.2021	Amendment by applicant (claims and/or description)
	30.11.2023	Despatch of a communication from the examining division (Time limit: M06)
	24.05.2024	Reply to a communication from the examining division
	03.06.2025	Application deemed to be withdrawn, date of legal effect [2025/42]
	18.06.2025	Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time [2025/42]
Fees paid	Renewal fee
	05.06.2019	Renewal fee patent year 03
	27.11.2020	Renewal fee patent year 04
	27.04.2022	Renewal fee patent year 05
	28.11.2022	Renewal fee patent year 06
	30.05.2024	Renewal fee patent year 07
	Penalty fee
	Additional fee for renewal fee
	30.11.2021	05 M06 Fee paid on 27.04.2022
	30.11.2023	07 M06 Fee paid on 30.05.2024
	30.11.2024	08 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[E] WO2019034784 (UNIV HEIDELBERG et al.) [E] 1-17 * abstract * * page 11, line 20 - page 12, line 8 * * page 33, line 19 - line 26 * * page 34, line 13 - line 22 * * page 37, line 8 - line 14 *
		[A] WO2014093479 (UNIV MONTANA STATE et al.) [A] 1-17 * abstract * * page 2, paragraph 6 * * page 6, paragraph 19 * * page 16, paragraph 42 *
		[XAI] DATABASE EMBL [online] 23 October 2007 (2007-10-23), J. DORSCHT, M. ZIMMER, M.J. LOESSNER: "Bacteriophages of Listeria monocytogenes", XP055744738, retrieved from EBI Database accession no. A8ATW7 [X] 13 * the whole document *[A] 1-7,16,17 [I] 8-12,14,15
		[XI] R. TIMME ET AL: "Listeria monocytogenes anti-CRISPR protein AcrIIA4", EMBL DATABASE, 6 February 2016 (2016-02-06), pages 143, XP055767976, Retrieved from the Internet [retrieved on 20210122] [X] 10,13 * the whole document *[I] 1-9,11,12,14-17
		[XAI] BOROWSKY M RA ET AL: "Listeria monocytogenes J0161 hypothetical protein", XX OS LISTERIA MONOCYTOGENES J0161 OC BACTERIA, 8 September 2011 (2011-09-08), XP055767859, Retrieved from the Internet [retrieved on 20210122] [X] 10,13 * the whole document *[A] 1-7,16,17 [I] 8,9,11,12,14,15
		[AD] JOE BONDY-DENOMY ET AL: "Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system", NATURE, vol. 493, no. 7432, 16 December 2012 (2012-12-16), pages 429 - 432, XP055119254, ISSN: 0028-0836, DOI: 10.1038/nature11723 [AD] 1-17 * the whole document * DOI: http://dx.doi.org/10.1038/nature11723
	International search	[A] WO2014128659 (CELLECTIS et al.) [A] 1-12, 13/1-12, 14/13/1-12, 15/14/13/1-12, 20/1-12, 21-28, 29/27-28, 30, 33 * ; page 3, lines 4-11, page 4, lines 4-16; claims 13, 23, 24. *
		[A] US2006078901 (BUCHRIESER CARMEN et al.) [A] 1-12, 13/1-12, 14/13/1-12, 15/14/13/1-12, 20/1-12, 21-28, 29/27-28, 30, 33 * ; paragraphs [0016]-[0017], [0216]; claim 6. *
		[A] PAWLUK, A. ET AL.: "Inactivation of CRISPR-Cas Systems by Anti-CRISPR Proteins in Diverse Bacterial Species", NATURE MICROBIOLOGY, vol. 1, 13 June 2016 (2016-06-13), pages 1 - 6, XP055474868 [A] 1-12, 13/1-12, 14/13/1-12, 15/14/13/1-12, 20/1-12, 21-28, 29/27-28, 30 * ; abstract; page 3, second column, second paragraph; page 4, first column, first paragraph; page 5, second column, third paragraph. * DOI: http://dx.doi.org/10.1038/nmicrobiol.2016.85
		[A] DATABASE NCBI [O] 11 January 2018 (2018-01-11), "Hypothetical Protein [Listeria monocytogenes", XP055489076, Database accession no. WP_003722518 [A] 1-12, 13/1-12, 14/13/1-12, 15/14/13/1-12, 20/1-12, 21-28, 29/27-28, 30, 33
		[A] BOMDY-DENOMY, J. ET AL.: "Multiple Mechanisms fnr CRISPR-Cas Inhihitinn hy Anti-CRISPR Proteins", NATURE, 23 September 2015 (2015-09-23), pages 1 - 15, XP055474577 [A] 33 * ; page 5, first column, first-second paragraphs. * DOI: http://dx.doi.org/10.1038/nature15254
		[X,P] RAUCH, B.J. ET AL.: "Inhibition of CRISPR-Cas9 with Bacteriophage Proteins", CELL, vol. 168, 12 January 2017 (2017-01-12), pages 150 - 158, XP029882136, Retrieved from the Internet [X,P] 1-12, 13/1-12, 14/13/1-12, 15/14/13/1-12, 20/1-12, 21-28, 29/27-28, 30 * ; entire document * DOI: http://dx.doi.org/10.1016/j.cell.2016.12.009
	Examination	DATABASE GenBank [online] 4 February 2016 (2016-02-04), TIMME R. ET AL: "Hypothetical protein CG42_06730 [Listeria monocytogenes]", XP093105447, retrieved from EBI accession no. GenBank:AMD24318 Database accession no. AMD24318 [X] 13 * the whole document *[A] 1-7,16,17 [I] 8-12,14,15

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