blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

Latvia joins the Federated Register
Click here for more information on the Federated Register.

2025-04-16

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3572103

EP3572103 - BIOLOGICAL TISSUE MATRIX MATERIAL, PREPARATION METHOD THEREFOR AND USE THEREOF IN OTOLOGICAL REPAIR MATERIAL [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  27.01.2023
Database last updated on 26.04.2025
FormerThe patent has been granted
Status updated on  18.02.2022
FormerGrant of patent is intended
Status updated on  20.12.2021
FormerRequest for examination was made
Status updated on  25.10.2019
FormerThe international publication has been made
Status updated on  11.09.2018
Most recent event   Tooltip27.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 30.10.2024  [2024/44]
Applicant(s)For all designated states
Beijing Biosis Healing Biological Technology Co., Ltd.
Daxing Biopharmaceutical Industrial Base
Beijing Zhongguancun Science Park
No.9 Tianfu Street
Daxing District
Beijing 102629 / CN
[2019/48]
Inventor(s)01 / ZHAO, Bo
Daxing Biopharmaceutical Industrial Base
Beijing Zhongguancun Science Park
No.9 Tianfu Street
Daxing District
Beijing 102629 / CN
02 / WANG, Hongquan
Daxing Biopharmaceutical Industrial Base
Beijing Zhongguancun Science Park
No.9 Tianfu Street
Daxing District
Beijing 102629 / CN
03 / XIA, Leilei
Daxing Biopharmaceutical Industrial Base
Beijing Zhongguancun Science Park
No.9 Tianfu Street
Daxing District
Beijing 102629 / CN
04 / ZHAO, Yanrui
Daxing Biopharmaceutical Industrial Base
Beijing Zhongguancun Science Park
No.9 Tianfu Street
Daxing District
Beijing 102629 / CN
05 / LI, Xuejun
Daxing Biopharmaceutical Industrial Base
Beijing Zhongguancun Science Park
No.9 Tianfu Street
Daxing District
Beijing 102629 / CN
06 / ZHANG, Jinhui
Daxing Biopharmaceutical Industrial Base
Beijing Zhongguancun Science Park
No.9 Tianfu Street
Daxing District
Beijing 102629 / CN
 [2019/48]
Representative(s)Müller-Boré & Partner Patentanwälte PartG mbB
Friedenheimer Brücke 21
80639 München / DE
[2019/48]
Application number, filing date17898715.218.04.2017
[2019/48]
WO2017CN80894
Priority number, dateCN20171012670303.03.2017         Original published format: CN201710126703
CN20171012481903.03.2017         Original published format: CN201710124819
[2019/48]
Filing languageZH
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018157456
Date:07.09.2018
Language:ZH
[2018/36]
Type: A1 Application with search report 
No.:EP3572103
Date:27.11.2019
Language:EN
[2019/48]
Type: B1 Patent specification 
No.:EP3572103
Date:23.03.2022
Language:EN
[2022/12]
Search report(s)International search report - published on:CN07.09.2018
(Supplementary) European search report - dispatched on:EP30.01.2020
ClassificationIPC:A61L27/36, A61L27/58, A61L27/56, A61L27/54, A61F2/18
[2020/10]
CPC:
A61L27/56 (EP,US); A61L27/3633 (EP,US); A61F2/18 (US);
A61L27/36 (EP); A61L27/3654 (EP,US); A61L27/3691 (EP,US);
A61L27/54 (EP,US); A61L27/58 (EP,US); A61F2002/183 (EP,US);
A61L2300/414 (EP,US); A61L2430/14 (EP,US); A61L2430/40 (EP,US) (-)
Former IPC [2019/48]A61L27/36, A61L27/58, A61L27/56
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/48]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:MATRIXMATERIAL AUS BIOLOGISCHEM GEWEBE, HERSTELLUNGSVERFAHREN DAFÜR UND VERWENDUNG DAVON IN OTOLOGISCHEM REPARATURMATERIAL[2019/48]
English:BIOLOGICAL TISSUE MATRIX MATERIAL, PREPARATION METHOD THEREFOR AND USE THEREOF IN OTOLOGICAL REPAIR MATERIAL[2019/48]
French:MATÉRIAU DE MATRICE DE TISSU BIOLOGIQUE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION DANS UN MATÉRIAU DE RÉPARATION OTOLOGIQUE[2019/48]
Entry into regional phase21.08.2019Translation filed 
22.08.2019National basic fee paid 
22.08.2019Search fee paid 
22.08.2019Designation fee(s) paid 
22.08.2019Examination fee paid 
Examination procedure22.08.2019Examination requested  [2019/48]
07.08.2020Amendment by applicant (claims and/or description)
21.12.2021Communication of intention to grant the patent
04.02.2022Receipt of the translation of the claim(s)
10.02.2022Fee for grant paid
10.02.2022Fee for publishing/printing paid
Opposition(s)02.01.2023No opposition filed within time limit [2023/09]
Fees paidRenewal fee
22.08.2019Renewal fee patent year 03
06.03.2020Renewal fee patent year 04
15.04.2021Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU18.04.2017
AL23.03.2022
AT23.03.2022
CY23.03.2022
CZ23.03.2022
DK23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
MC23.03.2022
MK23.03.2022
MT23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SI23.03.2022
SK23.03.2022
SM23.03.2022
IE18.04.2022
LU18.04.2022
BE30.04.2022
CH30.04.2022
LI30.04.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
IS23.07.2022
PT25.07.2022
[2024/44]
Former [2024/23]HU18.04.2017
AL23.03.2022
AT23.03.2022
CY23.03.2022
CZ23.03.2022
DK23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
MC23.03.2022
MK23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SI23.03.2022
SK23.03.2022
SM23.03.2022
IE18.04.2022
LU18.04.2022
BE30.04.2022
CH30.04.2022
LI30.04.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
IS23.07.2022
PT25.07.2022
Former [2024/20]HU18.04.2017
AL23.03.2022
AT23.03.2022
CY23.03.2022
CZ23.03.2022
DK23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
MC23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SI23.03.2022
SK23.03.2022
SM23.03.2022
IE18.04.2022
LU18.04.2022
BE30.04.2022
CH30.04.2022
LI30.04.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
IS23.07.2022
PT25.07.2022
Former [2024/18]HU18.04.2017
AL23.03.2022
AT23.03.2022
CZ23.03.2022
DK23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
MC23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SI23.03.2022
SK23.03.2022
SM23.03.2022
IE18.04.2022
LU18.04.2022
BE30.04.2022
CH30.04.2022
LI30.04.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
IS23.07.2022
PT25.07.2022
Former [2023/25]AL23.03.2022
AT23.03.2022
CZ23.03.2022
DK23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
MC23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SI23.03.2022
SK23.03.2022
SM23.03.2022
IE18.04.2022
LU18.04.2022
BE30.04.2022
CH30.04.2022
LI30.04.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
IS23.07.2022
PT25.07.2022
Former [2023/20]AL23.03.2022
AT23.03.2022
CZ23.03.2022
DK23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
MC23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SK23.03.2022
SM23.03.2022
IE18.04.2022
LU18.04.2022
BE30.04.2022
CH30.04.2022
LI30.04.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
IS23.07.2022
PT25.07.2022
Former [2023/10]AL23.03.2022
AT23.03.2022
CZ23.03.2022
DK23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
MC23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SK23.03.2022
SM23.03.2022
LU18.04.2022
BE30.04.2022
CH30.04.2022
LI30.04.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
IS23.07.2022
PT25.07.2022
Former [2023/09]AL23.03.2022
AT23.03.2022
CZ23.03.2022
DK23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
MC23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SK23.03.2022
SM23.03.2022
LU18.04.2022
CH30.04.2022
LI30.04.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
IS23.07.2022
PT25.07.2022
Former [2023/08]AL23.03.2022
AT23.03.2022
CZ23.03.2022
DK23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
MC23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SK23.03.2022
SM23.03.2022
LU18.04.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
IS23.07.2022
PT25.07.2022
Former [2023/07]AL23.03.2022
AT23.03.2022
CZ23.03.2022
DK23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
MC23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SK23.03.2022
SM23.03.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
IS23.07.2022
PT25.07.2022
Former [2023/06]AL23.03.2022
AT23.03.2022
CZ23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
MC23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SK23.03.2022
SM23.03.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
IS23.07.2022
PT25.07.2022
Former [2023/01]AL23.03.2022
AT23.03.2022
CZ23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SK23.03.2022
SM23.03.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
IS23.07.2022
PT25.07.2022
Former [2022/51]AT23.03.2022
CZ23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SK23.03.2022
SM23.03.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
IS23.07.2022
PT25.07.2022
Former [2022/50]AT23.03.2022
CZ23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
NL23.03.2022
PL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SK23.03.2022
SM23.03.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
PT25.07.2022
Former [2022/49]AT23.03.2022
CZ23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
NL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SK23.03.2022
SM23.03.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
PT25.07.2022
Former [2022/48]AT23.03.2022
CZ23.03.2022
EE23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
NL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SM23.03.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
PT25.07.2022
Former [2022/47]AT23.03.2022
ES23.03.2022
FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
NL23.03.2022
RO23.03.2022
RS23.03.2022
SE23.03.2022
SM23.03.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
PT25.07.2022
Former [2022/44]FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
NL23.03.2022
RS23.03.2022
SE23.03.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
Former [2022/39]FI23.03.2022
HR23.03.2022
LT23.03.2022
LV23.03.2022
RS23.03.2022
SE23.03.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
Former [2022/36]HR23.03.2022
LT23.03.2022
LV23.03.2022
RS23.03.2022
SE23.03.2022
BG23.06.2022
NO23.06.2022
GR24.06.2022
Former [2022/35]HR23.03.2022
LT23.03.2022
RS23.03.2022
SE23.03.2022
BG23.06.2022
NO23.06.2022
Former [2022/33]LT23.03.2022
NO23.06.2022
Documents cited:Search[X]US2008286268  (JOHNSON CHAD E [US]) [X] 15 * abstract *;
 [X]WO2009023276  (UNIV LELAND STANFORD JUNIOR [US], et al) [X] 15* claim 1 *;
 [X]CN101433735  (BEIJING DAQING BIOTECHNOLOGY C [CN]) [X] 15 * claims 1-8, * * paragraphs [0011] , [ 0013] *;
 [XI]CN104971380  (YANTAI JUANXIU BIOLOG SCIENCE & TECHNOLOGY CO LTD) [X] 15 * abstract * * claims 1, 3 * [I] 3-14;
 [X]CN105233343  (BEIJING QINGYUAN WEIYE BIO TISSUE ENGINEERING CO LTD) [X] 1,15 * claim 1 * * paragraph [0058] *;
 [X]  - D'EREDITÀ RICCA, "Porcine small intestinal submucosa (SIS) myringoplasty in children: A randomized controlled study", INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, ELSEVIER, AMSTERDAM, NL, (20150430), vol. 79, no. 7, doi:10.1016/J.IJPORL.2015.04.037, ISSN 0165-5876, pages 1085 - 1089, XP029185020 [X] 1,2,15 * abstract * * page 1086, paragraph 2. * * page 1088, column 1, lines 11-22 *

DOI:   http://dx.doi.org/10.1016/j.ijporl.2015.04.037
 [X]  - QI XING ET AL, "Decellularization of Fibroblast Cell Sheets for Natural Extracellular Matrix Scaffold Preparation", TISSUE ENGINEERING. PART C, METHODS DEC 2008, US, (20150101), vol. 21, no. 1, doi:10.1089/ten.tec.2013.0666, ISSN 1937-3384, pages 77 - 87, XP055658273 [X] 1,15 * abstract * * paragraphs "Decellularization of fibroplast cell sheet","Collagen content quantification", "Growth factor content quantification"; page 78 - page 79 * * paragraph "Characterization of ECM components"; page 80 - page 81 *

DOI:   http://dx.doi.org/10.1089/ten.tec.2013.0666
 [X]  - A. FARAG ET AL, "Decellularized Periodontal Ligament Cell Sheets with Recellularization Potential", JOURNAL OF DENTAL RESEARCH, US, (20140930), vol. 93, no. 12, doi:10.1177/0022034514547762, ISSN 0022-0345, pages 1313 - 1319, XP055658272 [X] 1,15 * abstract *

DOI:   http://dx.doi.org/10.1177/0022034514547762
 [X]  - LUO J C ET AL, "A multi-step method for preparation of porcine small intestinal submucosa (SIS)", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 32, no. 3, doi:10.1016/J.BIOMATERIALS.2010.09.017, ISSN 0142-9612, (20110101), pages 706 - 713, (20101118), XP027506430 [X] 15 * abstract * * page 707, paragraph 2.1 *

DOI:   http://dx.doi.org/10.1016/j.biomaterials.2010.09.017
 [X]  - GILBERT T W ET AL, "Decellularization of tissues and organs", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 27, no. 19, ISSN 0142-9612, (20060701), pages 3675 - 3683, (20060701), XP027950962 [X] 15 * abstract *
 [X]  - A AZHIM ET AL, "The use of sonication treatment to decellularize aortic tissues for preparation of bioscaffolds", JOURNAL OF BIOMATERIALS APPLICATIONS., US, (20140710), vol. 29, no. 1, doi:10.1177/0885328213517579, ISSN 0885-3282, pages 130 - 141, XP055658175 [X] 15 * abstract * * paragraph "Results"; page 133 - page 136 * * page 137, column 1, lines 1-3, 28-30,40-41 *

DOI:   http://dx.doi.org/10.1177/0885328213517579
International search[A]WO2007030743  (MASSACHUSETTS EYE & EAR INFIRM [US], et al) [A] 1-15 * , entire document *;
 [A]US2008286268  (JOHNSON CHAD E [US]) [A] 1-15* , entire document *;
 [A]WO2009023276  (UNIV LELAND STANFORD JUNIOR [US], et al) [A] 1-15 * , entire document *;
 [X]CN104740685  (YANTAI JUANXIU BIOLOG SCIENCE & TECHNOLOGY CO LTD) [X] 1-2, 7, 15 * , description, paragraphs 5-8 *;
 [X]CN104971380  (YANTAI JUANXIU BIOLOG SCIENCE & TECHNOLOGY CO LTD) [X] 1-15
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.