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Extract from the Register of European Patents

EP About this file: EP3360881

EP3360881 - 11-HYDROXYL-6-SUBSTITUTED-DERIVATIVES OF BILE ACIDS AND AMINO ACID CONJUGATES THEREOF AS FARNESOID X RECEPTOR MODULATORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  21.10.2021
Database last updated on 20.07.2024
FormerThe patent has been granted
Status updated on  06.11.2020
FormerGrant of patent is intended
Status updated on  15.07.2020
FormerRequest for examination was made
Status updated on  15.02.2019
FormerThe application has been published
Status updated on  13.07.2018
Most recent event   Tooltip03.05.2024Lapse of the patent in a contracting state
New state(s): MK		published on 05.06.2024  [2024/23]
Applicant(s)For all designated states
Intercept Pharmaceuticals, Inc.
10 Hudson Yards, 37th FL
New York, NY 10001 / US
[2018/33]
Inventor(s)01 / PELLICCIARI, Roberto
via Palmiro Togliatti 20
06073 Loc, Taverne Corciano (Perugia) / IT
 [2018/36]
Former [2018/33]01 / PELLICCIARI, Roberto
TES Pharma S.r.l
via Settevalli 556
I-06129 Perugia / IT
Representative(s)Cooley (UK) LLP
22 Bishopsgate
London EC2N 4BQ / GB
[N/P]
Former [2018/33]Cooley (UK) LLP
Dashwood
69 Old Broad Street
London EC2M 1QS / GB
Application number, filing date18163622.614.05.2014
[2018/33]
Priority number, dateUS201361823169P14.05.2013         Original published format: US 201361823169 P
[2018/33]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3360881
Date:15.08.2018
Language:EN
[2018/33]
Type: B1 Patent specification 
No.:EP3360881
Date:09.12.2020
Language:EN
[2020/50]
Search report(s)(Supplementary) European search report - dispatched on:EP13.07.2018
ClassificationIPC:C07J9/00, C07J41/00, A61K31/575, A61P1/16, A61P1/00, // C07J71/00, C07J31/00
[2018/33]
CPC:
A61K31/575 (EP,IL,US); A61P1/00 (EP,IL,US); A61P1/16 (EP,IL,US);
A61P11/00 (EP); A61P13/00 (EP); A61P43/00 (EP);
C07J31/006 (EP,IL,US); C07J41/0061 (EP,IL,US); C07J71/001 (EP,IL,US);
C07J9/005 (EP,IL,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/12]
Former [2018/33]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
Extension statesBA08.02.2019
ME08.02.2019
TitleGerman:11-HYDROXYL-6-SUBSTITUIERTE-DERIVATIVE VON GALLENSÄUREN UND AMINOSÄUREKONJUGATE DAVON ALS FARNESOID-X-REZEPTORMODULATOREN[2018/33]
English:11-HYDROXYL-6-SUBSTITUTED-DERIVATIVES OF BILE ACIDS AND AMINO ACID CONJUGATES THEREOF AS FARNESOID X RECEPTOR MODULATORS[2018/33]
French:DÉRIVÉS 11-HYDROXYLE D'ACIDES BILIAIRES SUBSTITUÉS EN POSITION 6 ET LEURS CONJUGUÉS D'ACIDES AMINÉS EN TANT QUE MODULATEURS DU RÉCEPTEUR DE FARNÉSOÏDE X[2018/33]
Examination procedure08.02.2019Amendment by applicant (claims and/or description)
08.02.2019Examination requested  [2019/12]
08.02.2019Date on which the examining division has become responsible
16.07.2020Communication of intention to grant the patent
30.10.2020Fee for grant paid
30.10.2020Fee for publishing/printing paid
30.10.2020Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP14723820.8  / EP2997035
Divisional application(s)EP20211780.0  / EP3848038
EP22205874.5   Application withdrawn  : 23.11.2022
Opposition(s)10.09.2021No opposition filed within time limit [2021/46]
Fees paidRenewal fee
23.03.2018Renewal fee patent year 03
23.03.2018Renewal fee patent year 04
23.03.2018Renewal fee patent year 05
28.05.2019Renewal fee patent year 06
27.05.2020Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU14.05.2014
AL09.12.2020
CY09.12.2020
EE09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
MC09.12.2020
MK09.12.2020
RO09.12.2020
RS09.12.2020
SM09.12.2020
BG09.03.2021
GR10.03.2021
IS09.04.2021
SE15.05.2021
[2024/23]
Former [2023/33]HU14.05.2014
AL09.12.2020
CY09.12.2020
EE09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
MC09.12.2020
RO09.12.2020
RS09.12.2020
SM09.12.2020
BG09.03.2021
GR10.03.2021
IS09.04.2021
SE15.05.2021
Former [2023/30]AL09.12.2020
CY09.12.2020
EE09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
MC09.12.2020
RO09.12.2020
RS09.12.2020
SM09.12.2020
BG09.03.2021
GR10.03.2021
IS09.04.2021
SE15.05.2021
Former [2022/09]AL09.12.2020
EE09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
MC09.12.2020
RO09.12.2020
RS09.12.2020
SM09.12.2020
BG09.03.2021
GR10.03.2021
IS09.04.2021
SE15.05.2021
Former [2022/07]AL09.12.2020
EE09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
MC09.12.2020
RO09.12.2020
RS09.12.2020
SM09.12.2020
BG09.03.2021
GR10.03.2021
IS09.04.2021
Former [2021/45]AL09.12.2020
EE09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
RO09.12.2020
RS09.12.2020
SM09.12.2020
BG09.03.2021
GR10.03.2021
IS09.04.2021
Former [2021/42]EE09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
RO09.12.2020
RS09.12.2020
SM09.12.2020
BG09.03.2021
GR10.03.2021
IS09.04.2021
Former [2021/36]EE09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
RO09.12.2020
RS09.12.2020
SM09.12.2020
BG09.03.2021
GR10.03.2021
Former [2021/35]HR09.12.2020
LT09.12.2020
LV09.12.2020
RO09.12.2020
RS09.12.2020
SM09.12.2020
BG09.03.2021
GR10.03.2021
Former [2021/33]HR09.12.2020
LT09.12.2020
LV09.12.2020
RS09.12.2020
SM09.12.2020
BG09.03.2021
GR10.03.2021
Former [2021/32]HR09.12.2020
LV09.12.2020
RS09.12.2020
SM09.12.2020
BG09.03.2021
GR10.03.2021
Former [2021/28]HR09.12.2020
LV09.12.2020
RS09.12.2020
BG09.03.2021
GR10.03.2021
Former [2021/23]LV09.12.2020
RS09.12.2020
BG09.03.2021
GR10.03.2021
Former [2021/22]RS09.12.2020
Documents cited:Search[A]US2802775  (DULANEY EUGENE L, et al) [A] 1-15 * examples 8,11 *;
 [A]EP0124903  (KURARAY CO [JP]) [A] 1-15 * page 11; claim 7 *;
 [A]WO2004007521  (PELLICCIARI ROBERTO [IT]) [A] 1-15 * page 1, paragraph 1 * * page 10; compound 1 *;
 [A]EP1568706  (INTERCEPT PHARMACEUTICALS INC [US]) [A] 1-15 * page 1, paragraph [0001]; example 3 *;
 [A]  - HITOSHI ISHIDA ET AL, "Study on the Bile Salts from Sunfish, Mola mola L. I. The Structures of Sodium Cyprinol Sulfates, the Sodium Salt of a New Bile Acid Conjugated with Taurine, and a New Bile Alcohol and Its New Sodium Sulfates.", CHEMICAL & PHARMACEUTICAL BULLETIN, (19980101), vol. 46, no. 1, doi:10.1248/cpb.46.12, ISSN 0009-2363, pages 12 - 16, XP055128539 [A] 1-15 * page 15; compound 3 *

DOI:   http://dx.doi.org/10.1248/cpb.46.12
 [A]  - WILLIAM P LONG ET AL, "PARTIAL SYNTHESIS OF COMPOUNDS RELATED TO ADRENAL CORTICAL HORMONES: III. PREPARATION OF 3([alpha]), 11([alpha])-DIHYDROXYCHOLANIC ACID", J. BIOL. CHEM., (19460301), vol. 162, no. 3, pages 511 - 519, XP055128534 [A] 1-15 * page 516, paragraph 2 *
 [A]  - PELLICCIARI R ET AL, "Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure-Activity Relationship of a Series of Body and Side Chain Modified Analogues of Chenodeoxycholic Acid", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, (20040723), vol. 47, doi:10.1021/JM049904B, ISSN 0022-2623, pages 4559 - 4569, XP002370634 [A] 1-15 * page 4565; table 1; compounds 1,6,7,9-11,14,15 *

DOI:   http://dx.doi.org/10.1021/jm049904b
 [A]  - SIMONA DE MARINO ET AL, "Theonellasterols and Conicasterols from Theonella swinhoei . Novel Marine Natural Ligands for Human Nuclear Receptors", JOURNAL OF MEDICINAL CHEMISTRY, (20110428), vol. 54, no. 8, doi:10.1021/jm200169t, ISSN 0022-2623, pages 3065 - 3075, XP055128555 [A] 1-15 * page 3066; figure 2; compounds 6,7 * * page 3070, column 1, paragraph 2 - column 2, paragraph 1 * * page 3071, column 2, paragraph 1 * * page 3072, column 1, paragraph 2 *

DOI:   http://dx.doi.org/10.1021/jm200169t
by applicantWO0037077
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