EP3395947 - ENZYMES [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 22.10.2021 Database last updated on 18.11.2024 | |
Former | The patent has been granted Status updated on 13.11.2020 | ||
Former | Grant of patent is intended Status updated on 02.07.2020 | ||
Former | Examination is in progress Status updated on 16.09.2019 | ||
Former | Request for examination was made Status updated on 19.04.2019 | ||
Former | The application has been published Status updated on 28.09.2018 | Most recent event Tooltip | 13.09.2024 | Lapse of the patent in a contracting state New state(s): MT | published on 16.10.2024 [2024/42] | Applicant(s) | For all designated states United Kingdom Research and Innovation Polaris House North Star Avenue Swindon SN2 1FL / GB | [2020/08] |
Former [2018/44] | For all designated states Medical Research Council 2nd Floor David Phillips Building Polaris House North Star Avenue, Swindon Wiltshire SN2 1FL / GB | Inventor(s) | 01 /
COZENS, Christopher MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge Biomedical Campus Cambridge, Cambridgeshire CB2 0QH / GB | 02 /
PINHEIRO, Vitor B. Institute of Structural and Molecular Biology University College London and Birkbeck College Gower Street London, WC1E 6BT / GB | 03 /
HOLLIGER, Philipp MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge Biomedical Campus Cambridge, Cambridgeshire CB2 0QH / GB | 04 /
TAYLOR, Alexander I. MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge Biomedical Campus Cambridge, Cambridgeshire CB2 0QH / GB | [2018/44] | Representative(s) | Cooley (UK) LLP 22 Bishopsgate London EC2N 4BQ / GB | [N/P] |
Former [2020/51] | Cooley (UK) LLP Dashwood 69 Old Broad Street London EC2M 1QS / GB | ||
Former [2018/44] | Script IP Limited Turnpike House 18 Bridge Street Frome Somerset BA11 1BB / GB | Application number, filing date | 18175595.0 | 14.04.2011 | [2018/44] | Priority number, date | GB20100007384 | 30.04.2010 Original published format: GB 201007384 | US201039600810P | 20.05.2010 Original published format: US 39600810 P | [2018/44] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP3395947 | Date: | 31.10.2018 | Language: | EN | [2018/44] | Type: | B1 Patent specification | No.: | EP3395947 | Date: | 16.12.2020 | Language: | EN | [2020/51] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 20.07.2018 | Classification | IPC: | C12N9/10, C12N9/12, C12N15/09 | [2018/44] | CPC: |
C12N9/1241 (EP,US);
C12N9/1247 (EP,US);
C12P19/34 (EP,US);
C12Y207/07 (EP,US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2019/21] |
Former [2018/44] | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR | Title | German: | ENZYME | [2018/44] | English: | ENZYMES | [2018/44] | French: | ENZYMES | [2018/44] | Examination procedure | 11.04.2019 | Examination requested [2019/21] | 11.04.2019 | Date on which the examining division has become responsible | 05.06.2019 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time | 14.08.2019 | Amendment by applicant (claims and/or description) | 19.09.2019 | Despatch of a communication from the examining division (Time limit: M04) | 24.01.2020 | Reply to a communication from the examining division | 03.07.2020 | Communication of intention to grant the patent | 04.11.2020 | Fee for grant paid | 04.11.2020 | Fee for publishing/printing paid | 04.11.2020 | Receipt of the translation of the claim(s) | Parent application(s) Tooltip | EP11731447.6 / EP2563913 | Divisional application(s) | EP19205073.0 / EP3640328 | Opposition(s) | 17.09.2021 | No opposition filed within time limit [2021/47] | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report | 14.08.2019 | Request for further processing filed | 14.08.2019 | Full payment received (date of receipt of payment) Request granted | 23.08.2019 | Decision despatched | Fees paid | Renewal fee | 01.06.2018 | Renewal fee patent year 03 | 01.06.2018 | Renewal fee patent year 04 | 01.06.2018 | Renewal fee patent year 05 | 01.06.2018 | Renewal fee patent year 06 | 01.06.2018 | Renewal fee patent year 07 | 01.06.2018 | Renewal fee patent year 08 | 29.04.2019 | Renewal fee patent year 09 | 12.03.2020 | Renewal fee patent year 10 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 14.04.2011 | AL | 16.12.2020 | AT | 16.12.2020 | CY | 16.12.2020 | CZ | 16.12.2020 | DK | 16.12.2020 | EE | 16.12.2020 | ES | 16.12.2020 | FI | 16.12.2020 | HR | 16.12.2020 | IT | 16.12.2020 | LT | 16.12.2020 | LV | 16.12.2020 | MC | 16.12.2020 | MK | 16.12.2020 | MT | 16.12.2020 | NL | 16.12.2020 | PL | 16.12.2020 | RO | 16.12.2020 | RS | 16.12.2020 | SE | 16.12.2020 | SI | 16.12.2020 | SK | 16.12.2020 | SM | 16.12.2020 | BG | 16.03.2021 | NO | 16.03.2021 | GR | 17.03.2021 | LU | 14.04.2021 | IS | 16.04.2021 | PT | 16.04.2021 | BE | 30.04.2021 | [2024/42] |
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Former [2021/20] | FI | 16.12.2020 | Documents cited: | Search | [I]EP1350841 (ROCHE DIAGNOSTICS GMBH [DE], et al) [I] 1-13 * sequence 191 *; | [T] - JESSICA A. BROWN ET AL, "Unlocking the Sugar "Steric Gate" of DNA Polymerases", BIOCHEMISTRY, (20110222), vol. 50, no. 7, doi:10.1021/bi101915z, ISSN 0006-2960, pages 1135 - 1142, XP055009914 [T] * the whole document * DOI: http://dx.doi.org/10.1021/bi101915z | by applicant | GB97143002 | GB98063936 | GB1275643 | US2003228616 | - DEVEREUX et al., Nucleic Acids Research, (19840000), vol. 12, page 387 | - ALTSCHUL et al., J. Mol. Biol., (19900000), vol. 215, pages 403 - 410 | - J. L. ONG; D. LOAKES; S. JAROSLAWSKI; K. TOO; P. HOLLIGER, Journal of Molecular Biology, (20060800), vol. 361, page 537 | - N. RAMSAY et al., J Am Chem Soc, (20100414), vol. 132, page 5096 | - M. C. FRANKLIN; J. WANG; T. A. STEITZ, Cell, (20010601), vol. 105, page 657 | - A. J. BERMAN et al., EMBO J, (20070725), vol. 26, page 3494 | - M. J. FOGG; L. H. PEARL; B. A. CONNOLLY, Not Struct Biol, (20021200), vol. 9, page 922 | - C. M. JOYCE; V. DERBYSHIRE, Methods Enzymol, (19950000), vol. 262, page 3 | - L. BLANCO; A. BERNAD; M. SALAS, Gene, (19920301), vol. 112, page 139 | - A. BERNAD; L. BLANCO; J. M. LAZARO; G. MARTIN; M. SALAS, Cell, (19891006), vol. 59, page 219 | - A. F. GARDNER; W. E. JACK, Nucleic Acids Research, (19990615), vol. 27, page 2545 | - S. W. LOCKLESS; R. RANGANATHAN, Science, (19991008), vol. 286, page 295 | - G. M. SUEL; S. W, LOCKLESS; M. Å, WALL; R. RANGANATHAN, Not Struct Biol, (20030100), vol. 10, page 59 | - N. HALABI; O. RIVOIRE; S. LEIBLER; R. RANGANATHAN, Cell, (20090821), vol. 138, page 774 | - J. K. ICHIDA et al., J Am Chem Soc, (20050309), vol. 127, page 2802 | - Y. BRUDNO; M. E. BIRNBAUM; R. E. KLEINER; D. R. LIU, Not Chem Biol, (20100200), vol. 6, page 148 | - C. TUERK; L. GOLD, Science, (19900803), vol. 249, page 505 | - J. K. ICHIDA; A. HORHOTA; K. ZOU; L. W. MCLAUGHLIN; J. W. SZOSTAK, Nucleic Acids Res, (20050000), vol. 33, page 5219 | - V. TRUNIGER; J. M. LAZARO; M. SALAS; L. BLANCO, EMBO J, (19960701), vol. 15, page 3430 | - K. BOHLKE, Nucleic Acids Res, (20001015), vol. 28, page 3910 | - BENNER, S. A., "Understanding nucleic acids using synthetic chemistry", Acc Chem Res, (20040000), vol. 37, doi:doi:10.1021/ar040004z, pages 784 - 797, XP009171332 DOI: http://dx.doi.org/10.1021/ar040004z | - LECONTE, A. M., "Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet", J Am Chem Soc, (20080000), vol. 130, pages 2336 - 2343 | - HIRAO, I, "Unnatural base pair systems for DNA/RNA-based biotechnology", Current Opinion in Chemical Biology, (20060000), vol. 10, doi:doi:10.1016/j.cbpa.2006.09.021, pages 622 - 627, XP028014520 DOI: http://dx.doi.org/10.1016/j.cbpa.2006.09.021 | - NIELSEN, P. E., "DNA analogues with nonphosphodiester backbones", Annu Rev Biophys Biomol Struct, (19950000), vol. 24, doi:doi:10.1146/annurev.bb.24.060195.001123, pages 167 - 183, XP009061010 DOI: http://dx.doi.org/10.1146/annurev.bb.24.060195.001123 | - ESCHENMOSER, A., "Chemical etiology of nucleic acid structure", Science, (19990000), vol. 284, pages 2118 - 2124 | - HERDEWIJN. P., "Nucleic acids with a six-membered 'carbohydrate' mimic in the backbone", Chem Bicrdivers, (20100000), vol. 7, pages 1 - 59 | - JOYCE, G. F.; NOUE, T.; ORGEL, L. E., "Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C. U) templates", J Mol Biol, (19840000), vol. 176, doi:doi:10.1016/0022-2836(84)90425-X, pages 279 - 306, XP024011157 DOI: http://dx.doi.org/10.1016/0022-2836(84)90425-X | - MANSY, S. S. et al., "Template-directed synthesis of a genetic polymer in a model protocell", Nature, (20080000), vol. 454, pages 122 - 125 | - ROSENBAUM, D. M.; LIU, D. R., "Efficient and sequence-specific DNA-templated polymerization of peptide nucleic acid aldehydes", J Am Chem Soc, (20030000), vol. 125, doi:doi:10.1021/ja038058b, pages 13924 - 13925, XP002415943 DOI: http://dx.doi.org/10.1021/ja038058b | - KOOL, E. T., "Hydrogen bonding, base stacking, and steric effects in dna replication", Annu Rev Biophys Biomol Struct, (20010000), vol. 30, pages 1 - 22 | - GARDNER, A. F.; JACK, W. E., "Determinants of nucleotide sugar recognition in an archaeon DNA polymerase", Nucleic Acids Research, (19990000), vol. 27, doi:doi:10.1093/nar/27.12.2545, pages 2545 - 2553, XP002328832 DOI: http://dx.doi.org/10.1093/nar/27.12.2545 | - LOAKES, D.; GALLEGO, J.; PINHEIRO, V. B.; KOOL, E, T.; HOLLIGER, P., "Evolving a polymerase for hydrophobic base analogues", J Am Chem Soc, (20090000), vol. 131, doi:doi:10.1021/ja9039696, pages 14827 - 14837, XP055009412 DOI: http://dx.doi.org/10.1021/ja9039696 | - VANDERMEEREN, M. et al., "Biological activity of hexitol nucleic acids targeted at Ha-ras and intracellular adhesion molecule-1 mRNA", Biochem Pharmacol, (20000000), vol. 59, pages 655 - 663 | - VASTMANS, K.; FROEYEN, M.; KERREMANS, L.; POCHET, S.; HERDEWIJN, P., "Reverse transcriptase incorporation of 1 ,5-anhydrohexitol nucleotides", Nucleic Acids Res, (20010000), vol. 29, pages 3154 - 3163 | - KEMPENEERS, V.; RENDERS, M.; FROEYEN, M.; HERDEWIJN, P., "Investigation of the DNA-dependent cyclohexenyl nucleic acid polymerization and the cyclohexenyl nucleic acid-dependent DNA polymerization", Nucleic Acids Res, (20050000), vol. 33, pages 3828 - 3836 | - SWEASY, J. B.; LOEB, L. A., "Detection and characterization of mammalian DNA polymerase beta mutants by functional complementation in Escherichia coli", Proc Natl Acad Sci U S A, (19930000), vol. 90, pages 4626 - 4630 | - GHADESSY, F. J.; ONG, J. L; HOLLIGER, P., "Directed evolution of polymerase function by compartmentalized self-replication", Proceedings of the National Academy of Sciences of the United States of America, (20010000), vol. 98, doi:doi:10.1073/pnas.071052198, pages 4552 - 4557, XP002189673 DOI: http://dx.doi.org/10.1073/pnas.071052198 | - XIA, G. et al., "Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase", Proc Natl Acad Sci U S A, (20020000), vol. 99, doi:doi:10.1073/pnas.102577799, pages 6597 - 6602, XP001111463 DOI: http://dx.doi.org/10.1073/pnas.102577799 | - FRANKLIN, M. C.; WANG, J.; STEITZ, T. A., "Structure of the replicating complex of a pol alpha family DNA polymerase", Cell, (20010000), vol. 105, pages 657 - 667 | - WANG, J. et al., "Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69", Cell, (19970000), vol. 89, doi:doi:10.1016/S0092-8674(00)80296-2, pages 1087 - 1099, XP002164082 DOI: http://dx.doi.org/10.1016/S0092-8674(00)80296-2 | - LOCKLESS, S. W.; MUIR, T. W., "Traceless protein splicing utilizing evolved split inteins", Proc Natl Acad Sci U S A, (20090000), vol. 106, pages 10999 - 11004 | - RUSS, W. P.; LOWERY, D. M.; MISHRA. P.; YAFFE, M. B.; RANGANATHAN. R., "Natural-like function in artificial WW domains", Nature, (20050000), vol. 437, doi:doi:10.1038/nature03990, pages 579 - 583, XP055013751 DOI: http://dx.doi.org/10.1038/nature03990 | - ICHIDA, J. K.; HORHOTA, A.; ZOU, K.; MCLAUGHLIN, L. W.; SZOSTAK, J. W., "High fidelity TNA synthesis by Therminator polymerase", Nucleic Acids Res, (20050000), vol. 33, pages 5219 - 5225 | - BOIZIAU, C.; DAUSSE, E.; YURCHENKO, L.; TOULME, J. J., "DNA aptamers selected against the HIV-1 trans-activation-responsive RNA element form RNA-DNA kissing complexes", J Bίοl Chem, (19990000), vol. 274, pages 12730 - 12737, XP055420321 | - DUCONGE, F.; TOULME, J. J., "In vitro selection identifies key determinants for loop-loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1", RNA, (19990000), vol. 5, doi:doi:10.1017/S1355838299991318, pages 1605 - 1614, XP055106255 DOI: http://dx.doi.org/10.1017/S1355838299991318 | - KIM, S. W.; KIM, D. U.; KIM, J. K.; KANG, L. W.; CHO, H. S., "Crystal structure of Pfu, the high fidelity DNA polymerase from Pyrococcus furiosus", Int J Biol Macromol, (20080000), vol. 42, doi:doi:10.1016/j.ijbiomac.2008.01.010, pages 356 - 361, XP022588693 DOI: http://dx.doi.org/10.1016/j.ijbiomac.2008.01.010 | - RODRIGUEZ, A. C.; PARK, H. W.; MAO, C.; BEESE, L. S., "Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7", J Mol Biol, (20000000), vol. 299, pages 447 - 462 | - HASHIMOTO, H. et al., "Crystal structure of DNA polymerase from hyperthermophilic archaeon Pyrococcus kodakaraensis KODI", J Mol Biol, (20010000), vol. 306, doi:doi:10.1006/jmbi.2000.4403, pages 469 - 477, XP004469251 DOI: http://dx.doi.org/10.1006/jmbi.2000.4403 | - WANG, F.; YANG, W., "Structural insight into translesion synthesis by DNA Pol II", Cell, (20090000), vol. 139, pages 1279 - 1289 | - KOLB, G. et al., "Hexitol nucleic acid-containing aptamers are efficient ligands of HIV-1 TAR RNA", Biochemistry, (20050000), vol. 44, pages 2926 - 2933 | - RAMSAY, N. et al., "CyDNA: synthesis and replication of highly Cy-Dye substituted DNA by an evolved polymerase", J Am Chem Soc, (20100000), vol. 132, doi:doi:10.1021/ja909180c, pages 5096 - 5104, XP055545262 DOI: http://dx.doi.org/10.1021/ja909180c | - BOUDOU, V. et al., "Base pairing of anhydrohexitol nucleosides with 2,6-diaminopurine, 5-methylcytosine and uracil asbase moiety", Nucleic Acids Res, (19990000), vol. 27, no. 6, pages 1450 - 6 | - TROUT, T.W., "Physiological concentrations of purines and pyrimidines", Mol Cell Biochem, (19940000), vol. 140, no. 1, pages 1 - 22 | - NICK MCELHINNY. S.A. et al., "Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases", PNAS, (20100000), vol. 107, no. 11, pages 4949 - 54 | - BOCHNER, B.R.; B.N. AMES, "Complete analysis of cellular nucleotides by two-dimensional thin layer chromatography", J Biol Chem, (19820000), vol. 257, no. 16, pages 9759 - 69 | - NICK MCELHINNY, S.A. et al., "Genome instability due to ribonucleotide incorporation into DNA", Nature Chemical Biology, (20100000), vol. 6, no. 10, pages 774 - 81 | - EVANS, R.J. et al., "Structure of PolC reveals unique DNA binding and fidelity determinants", Proc Natl Acad 5ci U S A, (20080000), vol. 105, no. 52, pages 20695 - 700 | - BONNIN, A. et al., "A single tyrosine prevents insertion of ribonucleotides in the eukaryotic-type phi29 DNA polymerase", J Mol Biol, (19990000), vol. 290, no. 1, doi:doi:10.1006/jmbi.1999.2900, pages 241 - 51, XP004462037 DOI: http://dx.doi.org/10.1006/jmbi.1999.2900 | - YANG. G. et al., "A conserved Tyr residue is required for sugar selectivity in a Pol alpha DNA polymerase", Biochemistry, (20020000), vol. 41, no. 32, doi:doi:10.1021/bi0202171, pages 10256 - 61, XP002413785 DOI: http://dx.doi.org/10.1021/bi0202171 | - GARDNER, A.F.; W.E. JACK, "Determinants of nucleotide sugar recognition in on archaeon DNA polymerase", Nucleic Acids Res., (19990000), vol. 27, no. 12, doi:doi:10.1093/nar/27.12.2545, pages 2545 - 53, XP002328832 DOI: http://dx.doi.org/10.1093/nar/27.12.2545 | - ASLATKE, M. et al., "A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides", Proc Natl Acad Sci U S A, (19980000), vol. 95, no. 7, doi:doi:10.1073/pnas.95.7.3402, pages 3402 - 7, XP055242309 DOI: http://dx.doi.org/10.1073/pnas.95.7.3402 | - DELUCIA, A.M.; N.D. GRINDLEY; C.M. JOYCE, "An error-prone family Y DNA polymerase (DinB homolog from Sulfolobus solfotaficus) uses a 'steric gate' residue for discrimination against ribonucleotides", Nucleic Acids Res, (20030000), vol. 31, no. 14, pages 4129 - 37 | - JAROSZ, D.F. et al., "A single amino acid governs enhanced activity, of DinS DNA polymerases on damaged templates", Nature, (20060000), vol. 439, no. 7073, pages 225 - 8 | - BROWN. J.A. et al., "A novel mechanism of sugar selection utilized by a human X-family DNA polymerase", J Mol Biol, (20100000), vol. 395, no. 2, doi:doi:10.1016/j.jmb.2009.11.003, pages 282 - 90, XP026826639 DOI: http://dx.doi.org/10.1016/j.jmb.2009.11.003 | - RUIZ, J.F. et al., "Lack of sugar discrimination by human Pol mu requires a single glycine residue", Nucleic Acids Res, (20030000), vol. 31, no. 15, pages 4441 - 9 | - GAO, G. et al., "Conferring RNA polymerase activity to a DNA polymerase: a single residue in reverse transcriptase controls substrate selection", Proc Natl Acad Sci U S A, (19970000), vol. 94, no. 2, doi:doi:10.1073/pnas.94.2.407, pages 407 - 11, XP002435980 DOI: http://dx.doi.org/10.1073/pnas.94.2.407 | - CASES-GONZALEZ, C.E.; M. GUTIERREZ-RIVAS; L. MENENDEZ-ARIAS, "Coupling ribose selection to fidelity of DNA synthesis. The role of Tyr-115 of human immunodeficiency virus type I reverse transcriptase", J Biol Chem, (20000000), vol. 275, no. 26, pages 19759 - 67 | - ENTIN-MEER, M.; Z. SEVILYA; A. HIZI, "The role of phenylolanine-119 of the reverse transcriptase of mouse mammary tumour virus in DNA synthesis, ribose selection and drug resistance", Biochem J, (20020000), vol. 347, pages 381 - 91 | - BOYER, P.L. et al., "Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase", Proc Natl Acad Sci U S A, (20000000), vol. 97, no. 7, pages 3056 - 61 | - ASTATKE, M.; N.D. GRINDLEY; C.M. JOYCE, "How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides", J Mol Biol, (19980000), vol. 278, no. 1, doi:doi:10.1006/jmbi.1998.1672, pages 147 - 65, XP004453984 DOI: http://dx.doi.org/10.1006/jmbi.1998.1672 | - BROWN, J.A.; Z. SUO, "Unlocking the sugar ''steric gate'' of DNA polymerases", Biochemistry, (20110000), vol. 50, no. 7, doi:doi:10.1021/bi101915z, pages 1135 - 42, XP055009914 DOI: http://dx.doi.org/10.1021/bi101915z | - PATEL, P.H.; L.A. LOEB, "Multiple amino acid substitutions allow DNA polymerases to synthesize RNA", J Biol Chem, (20000000), vol. 275, no. 51, doi:doi:10.1074/jbc.M005757200, pages 40266 - 72, XP055009920 DOI: http://dx.doi.org/10.1074/jbc.M005757200 | - STAIGER, N; A. MARX, "A DNA polymerase with increased reactivity for ribonucleotides and C5-modified deoxyribonucleotides", Chembiochem, (20100000), vol. 11, no. 14, doi:doi:10.1002/cbic.201000384, pages 1963 - 6, XP055038534 DOI: http://dx.doi.org/10.1002/cbic.201000384 | - XIA, G. et al., "Directed evolution of novel polymerase activities: mutation of a DNA polymerase info an efficient RNA polymerase", Proc Natl Acad Sci U S A, (20020000), vol. 99, no. 10, doi:doi:10.1073/pnas.102577799, pages 6597 - 602, XP001111463 DOI: http://dx.doi.org/10.1073/pnas.102577799 | - ONG, J.L. et al., "Directed evolution of DNA polymerase, RNA polymerase and reverse transcriptase activity in a single polypeptide", J Mol Biol, (20060000), vol. 361, no. 3, doi:doi:10.1016/j.jmb.2006.06.050, pages 537 - 50, XP024951300 DOI: http://dx.doi.org/10.1016/j.jmb.2006.06.050 | - MCCULLUM, E.O.; J.C. CHOPUT, "Transcription of an RNA optamer by a DNA polymerase", Chem Commun (Camb, (20090000), vol. 20, pages 2938 - 40 | - SHINKAI, A.; P.H. PATEL; L.A. LOEB, "The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutable", J Biol Chem, (20010000), vol. 276, no. 22, doi:doi:10.1074/jbc.M011472200, pages 18836 - 42, XP055242326 DOI: http://dx.doi.org/10.1074/jbc.M011472200 | - DELARUE, M. et al., "An attempt to unify the structure of polymerases", Protein Eng, (19900000), vol. 3, no. 6, pages 461 - 7 | - MORAS, D., "Two sisters and their cousin", Nature, (19930000), vol. 364, no. 6438, pages 572 - 3 | - SOUSA, R., "Structural and mechanistic relationships between nucleic acid polymerases", Trends Biochem Sci, (19960000), vol. 21, no. 5, doi:doi:10.1016/0968-0004(96)10023-2, pages 186 - 90, XP022258008 DOI: http://dx.doi.org/10.1016/0968-0004(96)10023-2 | - CERMAKIAN. N. et al., "On the evolution of the single-subunit RNA polymerases", J Mol Evol, (19970000), vol. 45, no. 6, pages 671 - 81 | - HERDEWIJN, P., "Nucleic acids with a six-membered 'carbohydrate' mimic in the backbone", Chem Biodivers, (20100000), vol. 7, no. 1, pages 1 - 59 | - LESCRINIER, E. et al., "Solution structure of a HNA-RNA hybrid", Chem Biol, (20000000), vol. 7, no. 9, pages 719 - 31 | - FOGG, M.J.; L.H. PEART; B.A. CONNOLLY, "Structural basis for uracil recognition by archaeal family 8 DNA polymerases", Nat Struct Biol, (20020000), vol. 9, no. 12, doi:doi:10.1038/nsb867, pages 922 - 7, XP002250141 DOI: http://dx.doi.org/10.1038/nsb867 | - GARDNER, A.F.; W.E. JACK, "Acyclic and dideoxy terminator preferences denote divergent sugar recognition by orchaeon and Taq DNA polymerases", Nucleic Acids Res, (20020000), vol. 30, no. 2, pages 605 - 13, XP002309458 | - BLASCO, M.A. et al., "Phi 29 DNA polymerase active site. Mutants in conserved residues Tyr254 and Tyr390 ore affected in dNTP binding", J Biol Chem, (19920000), vol. 267, no. 27, pages 19427 - 34 | - YANG, W.; J.Y. LEE; M. NOWOTNY, "Making and breaking nucleic acids: two-Mg2+-ion catalysis and substrate specificity", Mol Cell, (20060000), vol. 22, no. 1, pages 5 - 13 | - KIROUAC, K.N.; Z. SUO; H. LING, "Structural mechanism of ribonucleotide discrimination by a Y-family DNA polymerase", J Mol Biol, (20110000), vol. 407, no. 3, doi:doi:10.1016/j.jmb.2011.01.037, pages 382 - 90, XP028173184 DOI: http://dx.doi.org/10.1016/j.jmb.2011.01.037 | - FREISINGER, E. et al., "Lesion (in)tolerance reveals insights into DNA replication fidelity", EMBO J, (20040000), vol. 23, no. 7, pages 1494 - 505 | - KORMANN, M.S. et al., "Expression of therapeutic proteins after delivery of chemically modified mRNA in mice", Nat Biotechnol, (20110000), vol. 29, no. 2, doi:doi:10.1038/nbt.1733, pages 154 - 7, XP002696192 DOI: http://dx.doi.org/10.1038/nbt.1733 | - WATTS, J.K. et al., "Studies on the hydrolytic sfabifity of 2'-fluoroarabinonucleic acid (2'F-ANA", Org Biomol Chem, (20090000), vol. 7, no. 9, doi:doi:10.1039/b900443b, pages 1904 - 10, XP055201737 DOI: http://dx.doi.org/10.1039/b900443b | - ONO, T.; M. SCALF; L.M. SMITH, "2'-fluoro modified nucleic acids: polymerase-directed synthesis, properties and stability to analysis by matrix-assisted laser desorption/ionization mass spectrometry", Nucleic Acids Research, (19970000), vol. 25, no. 22, doi:doi:10.1093/nar/25.22.4581, pages 4581 - 4588, XP002241554 DOI: http://dx.doi.org/10.1093/nar/25.22.4581 | - SWAN, M.K. et al., "Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta", Nat Struct Mol Biol, (20090000), vol. 16, no. 9, pages 979 - 86 | - WANG, M. et al., "Insights into Base Selectivity from the 1.8 A Resolution Structure of on RB69 DNA Polymerase Ternary Complex", Biochemistry, (20110000), vol. 50, no. 4, pages 581 - 90 | - KIRCHNER, J.M.; H. TRAN; M.A. RESNICK, "A DNA polymerase epsilon mutant that specifically causes + 1 frameshift mutations within homonucleotide runs in yeast", Genetics, (20000000), vol. 155, no. 4, page 1623.1632 | - KOKOSKA, R.J. et al., "Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase delta", Mol Cell Biol, (20000000), vol. 20, no. 20, pages 7490 - 504 | - STOCKI, S.A.; R.L. NONAY; L.J. REHA-KRANTZ, "Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3'→ 5' exonuclease activities", J Mol Biol, (19950000), vol. 254, no. 1, pages 15 - 28 | - KASIVISWONATHAN, R. et al., "Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication", J Biol Chem, (20090000), vol. 284, no. 29, pages 19501 - 10 | - LOH, E.; L. . LOEB, "Mutability of DNA polymerase I: implications for the creation of mutant DNA polymerases", DNA Repair (Amst, (20050000), vol. 4, no. 12, doi:doi:10.1016/j.dnarep.2005.09.006, pages 1390 - 8, XP005171271 DOI: http://dx.doi.org/10.1016/j.dnarep.2005.09.006 | - FRANKLIN, M.C.; J. WANG; T.A. STEITZ, "Structure of the replicating complex of a pol alpha family DNA polymerase", Cell, (20010000), vol. 105, no. 5, pages 657 - 67 | - WANG, F.; W. YANG, "Structural insight into translesion synthesis by DNA Pol II", Cell, (20090000), vol. 139, no. 7, pages 1279 - 89 | - LIU, S., "Crystal structure of the herpes simplex virus I DNA polymerase", J Biol Chem, (20060000), vol. 281, no. 26, pages 18193 - 200 | - SAVINO. C. et al., "Insights into DNA replication: the crystal structure of DNA polymerase B1 from fhe archaeon Sulfolobus solfataricus", Struclure, (20040000), vol. 12, no. 11, doi:doi:10.1016/j.str.2004.09.007, pages 2001 - 8, XP004633313 DOI: http://dx.doi.org/10.1016/j.str.2004.09.007 | - HANTZ, E. et al., "Solution conformation of an RNA--DNA hybrid duplex containing a pyrimidine RNA strand and a purine DNA strand", Int J Bio! Macromol, (20010000), vol. 28, no. 4, pages 273 - 84 | - KIEFER, J.R., "Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal", Nature, (19980000), vol. 391, no. 6664, pages 304 - 7 | - PELLETIER, H. et al., "Structures of ternary complexes of rat DNA polymerase beta, a DNA template -primer, and ddCTP", Science, (19940000), vol. 244, no. 5167, pages 1891 - 903 | - LI, Y.; S. KOROLEV; G. WAKSMAN, "Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation", EMBO J, (19980000), vol. 17, no. 24, doi:doi:10.1093/emboj/17.24.7514, pages 7514 - 25, XP055386502 DOI: http://dx.doi.org/10.1093/emboj/17.24.7514 | - JOHNSON. S.J.; L.S. BEESE, "Structures of mismatch replication errors observed in a DNA polymerase", Cell, (20040000), vol. 116, no. 6, pages 803 - 16 | - XIONG, Y.; M. SUNDARALINGAM, "Crystal structure of a DNA.RNA hybrid duplex with a polypurine RNA r(googoogag) and a complementary polypyrimidine DNA d(CTCTTCTTC)", Nucleic Acids Res, (20000000), vol. 28, no. 10, pages 2171 - 6 | - SALAZAR, M., "The DNA strand in DNA.RNA hybrid duplexes is neither B-form nor A-form in solution", Biochemistry, (19930000), vol. 32, no. 16, doi:doi:10.1021/bi00067a007, pages 4207 - 15, XP002023769 DOI: http://dx.doi.org/10.1021/bi00067a007 | - FEDOROFF, O.Y.; Y. GE; B.R. REID, "Solution structure of r(gaggacug).d(CAGTCCTC) hybrid: implications for the initiation of HIV-1 (+)-strand synthesis", J Mol Biol, (19970000), vol. 269, no. 2, doi:doi:10.1006/jmbi.1997.1024, pages 225 - 39, XP004453879 DOI: http://dx.doi.org/10.1006/jmbi.1997.1024 | - FIRBANK, S.J. et al., "Uracil recognition in archaeal DNA polymerases captured by X-ray crystallography", J Mol Biol, (20080000), vol. 381, no. 3, doi:doi:10.1016/j.jmb.2008.06.004, pages 529 - 39, XP023315413 DOI: http://dx.doi.org/10.1016/j.jmb.2008.06.004 | - STEITZ, T.A., "The structural basis of the transition from initiation to elongation phases of transcription, as well as translocation and strand separation, by T7 RNA polymerase", Curr Opin Struct Biol, (20040000), vol. 14, no. 1, pages 4 - 9 | - PLOTCH, S.J. et al., "A unique cop(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription", Cell, (19810000), vol. 23, no. 3, pages 847 - 58 | - MIR, M.A. et al., "Storage of cellular 5' mRNA caps in P bodies for viral cop-snatching", Proc Not! Acad Sci U S A, (20080000), vol. 105, no. 49, pages 19294 - 9 | - RUSAKOVA, E.E. et al., "Mutant 77 RNA polymerase is capable of catalyzing DNA primer extension reaction", FEBS Lett, (19980000), vol. 423, no. 2, doi:doi:10.1016/S0014-5793(98)00058-1, pages 189 - 92, XP004261887 DOI: http://dx.doi.org/10.1016/S0014-5793(98)00058-1 | - IVANOV, S.A. et al., "RNA synthesis by T7 RNA polymerase supported primer extension", Mol Blot (Mosk, (20040000), vol. 38, no. 5, pages 798 - 803, XP019288266 | - YIN, Y.W.; T.A. STEITZ, "Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase", Science, (20020000), vol. 298, no. 5597, pages 1387 - 95 | - RAMSAY, N. et al., "CyDNA: synthesis and replication of highly Cy-dye substituted DNA by on evolved polymerase", J Am Chem Soc, (20100000), vol. 132, no. 14, doi:doi:10.1021/ja909180c, pages 5096 - 104, XP055545262 DOI: http://dx.doi.org/10.1021/ja909180c | - HASELOFF, J., "GFP variants tor multispectral imaging of living cells", Methods Cell 8iol, (19990000), vol. 58, pages 139 - 51 | - KOKOSKA, R.J.; S.D. MCCULLOCH; T.A, KUNKEL, "The efficiency and specificity of apurinlc/apyrimidinic site bypass by human DNA polymerase eta and Sulfolobus solfataricus Dpo4", J Biol Chem, (20030000), vol. 278, no. 50, pages 50537 - 45 |