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Extract from the Register of European Patents

EP About this file: EP3418929

EP3418929 - AUTOMATED SCREENING OF ENZYME VARIANTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  21.10.2021
Database last updated on 20.07.2024
FormerThe patent has been granted
Status updated on  06.11.2020
FormerGrant of patent is intended
Status updated on  25.06.2020
FormerExamination is in progress
Status updated on  17.08.2019
FormerRequest for examination was made
Status updated on  14.06.2019
FormerThe application has been published
Status updated on  23.11.2018
Most recent event   Tooltip03.05.2024Lapse of the patent in a contracting state
New state(s): MK		published on 05.06.2024  [2024/23]
Applicant(s)For all designated states
Codexis, Inc.
200 Penobscot Drive
Redwood City, CA 94063 / US
[2018/52]
Inventor(s)01 / ZHANG, Xiyun
200 Penobscot Drive
Redwood City, CA 94063 / US
02 / SARMIENTO, Russell Javiniar
200 Penobscot Drive
Redwood City, CA 94063 / US
03 / BASKERVILLE, Donald Scott
200 Penobscot Drive
Redwood City, CA 94063 / US
04 / HUISMAN, Gjait W.
200 Penobscot Drive
Redwood City, CA 94063 / US
 [2020/30]
Former [2018/52]01 / ZHANG, Xiyun
200 Penobscot Drive
Redwood City, CA California 94063 / US
02 / SARMIENTO, Russell Javiniar
200 Penobscot Drive
Redwood City, CA California 94063 / US
03 / BASKERVILLE, Donald Scott
200 Penobscot Drive
Redwood City, CA California 94063 / US
04 / HUISMAN, Gjait W.
200 Penobscot Drive
Redwood City, CA California 94063 / US
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2018/52]Chapman, Desmond Mark
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
Application number, filing date18187438.926.09.2014
[2018/52]
Priority number, dateUS201361883838P27.09.2013         Original published format: US 201361883838 P
[2018/52]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3418929
Date:26.12.2018
Language:EN
[2018/52]
Type: B1 Patent specification 
No.:EP3418929
Date:09.12.2020
Language:EN
[2020/50]
Search report(s)(Supplementary) European search report - dispatched on:EP20.09.2018
ClassificationIPC:G16B35/00, G16C20/50, C12N15/00, G16C20/60
[2020/08]
CPC:
C12N15/1089 (EP,IL,KR,US); C12N15/1058 (EP,IL,KR,US); G16C99/00 (IL,KR);
G16B35/00 (EP,IL,US); G16B35/20 (EP,IL,KR,US); G16C20/60 (IL,US);
G16C20/64 (EP,IL) (-)
Former IPC [2018/52]G06F19/00, G06F19/16
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/29]
Former [2018/52]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:AUTOMATISIERTES SCREENING VON ENZYMVARIANTEN[2018/52]
English:AUTOMATED SCREENING OF ENZYME VARIANTS[2018/52]
French:SÉLECTION AUTOMATIQUE DE VARIANTES ENZYMATIQUES[2018/52]
Examination procedure06.06.2019Amendment by applicant (claims and/or description)
06.06.2019Examination requested  [2019/29]
06.06.2019Date on which the examining division has become responsible
21.08.2019Despatch of a communication from the examining division (Time limit: M04)
19.12.2019Reply to a communication from the examining division
26.06.2020Communication of intention to grant the patent
29.10.2020Fee for grant paid
29.10.2020Fee for publishing/printing paid
29.10.2020Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP14781426.3  / EP3049973
Opposition(s)10.09.2021No opposition filed within time limit [2021/46]
Fees paidRenewal fee
06.08.2018Renewal fee patent year 03
06.08.2018Renewal fee patent year 04
06.08.2018Renewal fee patent year 05
27.09.2019Renewal fee patent year 06
28.09.2020Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL09.12.2020
AT09.12.2020
CY09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
MC09.12.2020
MK09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
[2024/23]
Former [2023/30]AL09.12.2020
AT09.12.2020
CY09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
MC09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2022/25]AL09.12.2020
AT09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
MC09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2022/23]AL09.12.2020
AT09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2022/10]AL09.12.2020
AT09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
PT09.04.2021
Former [2021/50]AL09.12.2020
AT09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2021/45]AL09.12.2020
AT09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2021/42]AT09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2021/39]AT09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
PT09.04.2021
Former [2021/37]AT09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
PT09.04.2021
Former [2021/36]CZ09.12.2020
EE09.12.2020
FI09.12.2020
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LT09.12.2020
LV09.12.2020
RO09.12.2020
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SE09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
PT09.04.2021
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FI09.12.2020
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LT09.12.2020
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RO09.12.2020
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SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
PT09.04.2021
Former [2021/33]FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
RS09.12.2020
SE09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
PT09.04.2021
Former [2021/32]FI09.12.2020
HR09.12.2020
LV09.12.2020
RS09.12.2020
SE09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
Former [2021/28]FI09.12.2020
HR09.12.2020
LV09.12.2020
RS09.12.2020
SE09.12.2020
BG09.03.2021
NO09.03.2021
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LV09.12.2020
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BG09.03.2021
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Documents cited:Search[X]US2006121455  (GODDARD WILLIAM A [US], et al) [X] 1-15 * whole document, in particular claim 84 and fig. 1 *;
 [X]WO2010077470  (UNIV WASHINGTON [US], et al) [X] 1-15 * whole document, in particular claim 24, [00118]-[00121], [00125-00126], fig. 1,5 and 6 *;
 [X]  - MARTIN R. HEDIGER ET AL, "A Computational Methodology to Screen Activities of Enzyme Variants", PLOS ONE, (20121217), vol. 7, no. 12, doi:10.1371/journal.pone.0049849, page e49849, XP055155714 [X] 1-15 * whole document, in particular Methods and fig. 13 *

DOI:   http://dx.doi.org/10.1371/journal.pone.0049849
by applicantUS4683202
 US5426039
 WO9522625
 US5605793
 WO9720078
 WO9735966
 WO9827230
 US5811238
 US5830721
 US5834252
 US5837458
 US5914245
 US5928905
 WO0042651
 WO0042561
 WO0042559
 US6096548
 US6117679
 US6132970
 US6165793
 US6180406
 US6251674
 US6277638
 US6287861
 US6287862
 US6291242
 US6297053
 WO0175767
 US6303344
 US6309883
 US6319713
 US6319714
 US6323030
 US6326204
 US6335160
 US6335198
 US6344356
 US6352859
 US6355484
 US6358742
 US6358740
 US6365408
 US6365377
 US6368861
 US6372497
 US6376246
 US6379964
 US6387702
 US6391552
 US6391640
 US6395547
 US6406855
 US6406910
 US6413774
 US6413745
 US6420175
 US6423542
 US6426224
 US6436675
 US6444468
 US6455253
 WO02083868
 US6479652
 US6482647
 US6489146
 US6506602
 US6506603
 WO03008563
 US6519065
 US6521453
 US6528311
 US6573098
 US6576467
 US6579678
 US6586182
 US6602986
 US6613514
 US6653072
 US6716631
 WO2005017105
 WO2005017116
 US6917882
 US6946296
 US6961664
 US6995017
 US7024312
 US7058515
 US7105297
 US2006223143
 US7148054
 US7288375
 WO2008103248
 US7421347
 US7430477
 WO2009029554
 WO2009036404
 WO2009042984
 WO2009046153
 WO2009046445
 US7534564
 US7620500
 US7620502
 US7629170
 WO2009152336
 WO2010008828
 WO2010025238
 US2010093560
 US7702464
 WO2010054319
 US7747391
 US7747393
 WO2010075574
 US7751986
 WO2010081053
 WO2010080635
 US7776598
 US7783428
 WO2010099501
 US7795030
 US7853410
 US7868138
 US7873499
 WO2011011630
 US7904249
 US7957912
 WO2011071982
 US8029988
 WO2012078800
    - QU X; SWANSON R; DAY R; TSAI J, "A Guide to Template Based Structure Prediction", Curr Protein Pept Sci., (20090600), vol. 10, no. 3, pages 270 - 85
    - LING et al., Anal. Biochem., (19970000), vol. 254, no. 2, pages 157 - 78
    - DALE et al., Meth. Mol. Biol., (19960000), vol. 57, pages 369 - 74
    - SMITH, Ann. Rev. Genet., (19850000), vol. 19, pages 423 - 462
    - BOTSTEIN et al., Science, (19850000), vol. 229, pages 1193 - 1201
    - CARTER, Biochem. J., (19860000), vol. 237, pages 1 - 7
    - KRAMER et al., Cell, (19840000), vol. 38, pages 879 - 887
    - WELLS et al., Gene, (19850000), vol. 34, pages 315 - 323
    - MINSHULL et al., Curr. Op. Chem. Biol., (19990000), vol. 3, pages 284 - 290
    - CHRISTIANS et al., Nat. Biotechnol., (19990000), vol. 17, pages 259 - 264
    - CRAMERI et al., Nature, (19980000), vol. 391, pages 288 - 291
    - CRAMERI et al., Nat. Biotechnol., (19970000), vol. 15, pages 436 - 438
    - ZHANG et al., Proc. Nat. Acad. Sci. U.S.A., (19970000), vol. 94, pages 4504 - 4509
    - CRAMERI et al., Nat. Biotechnol., (19960000), vol. 14, pages 315 - 319
    - STEMMER, Nature, (19940000), vol. 370, pages 389 - 391
    - STEMMER, Proc. Nat. Acad. Sci. USA, (19940000), vol. 91, pages 10747 - 10751
    - HORTON et al., Biotechniques, (19900000), vol. 8, no. 5, pages 528 - 35
    - WU et al., "Detailed Analysis of Grid-Based Molecular Docking: A Case Study of CDOCKER - A CHARMm-Based MD Docking Algorithm", J. Computational Chem., (20030000), vol. 24, no. 13, pages 1549 - 62
    - SINGH et al., "The resurgence of covalent drugs", Nature Reviews Drug Discovery, (20110000), vol. 10, doi:doi:10.1038/nrd3410, pages 307 - 317, XP055377493

DOI:   http://dx.doi.org/10.1038/nrd3410
    - STEMMER, Proceedings of the National Academy of Sciences, USA, (19940000), pages 10747 - 10751
    - NESS et al., Nature Biotechnology, (20020000), vol. 20, pages 1251 - 1255
    - SANGER, Proceedings of the National Academy of Sciences of the United States of America, (19970000), vol. 74, pages 5463 - 5467
    - MAXAM et al., Proceedings of the National Academy of Sciences of the United States of America, (19770000), vol. 74, pages 560 - 564
    - DRMANAC et al., Mature Biotechnology, (19980000), vol. 16, pages 54 - 58
    - M. MARGULIES et al., "Genome sequencing in microfabricated high-density picolitre reactors", Nature, (20050000), vol. 437, pages 376 - 380
    - J. SHENDURE et al., "Accurate Multiplex Polony Sequencing of an Evolved Bacterial Genome", Science, (20050000), vol. 309, no. 5741, doi:doi:10.1126/science.1117389, pages 1728 - 1732, XP002427180

DOI:   http://dx.doi.org/10.1126/science.1117389
    - I. BRASLAVSKY et al., "Sequence information can be obtained from single DNA molecules", Proceedings of the National Academy of Sciences of the United States of America, (20030000), vol. 100, doi:doi:10.1073/pnas.0230489100, pages 3960 - 3964, XP002388726

DOI:   http://dx.doi.org/10.1073/pnas.0230489100
    - M. RONAGHI et al., "Real-time DNA sequencing using detection of pyrophosphate release", Analytical Biochemistry, (19960000), vol. 242, doi:doi:10.1006/abio.1996.0432, pages 84 - 89, XP002388725

DOI:   http://dx.doi.org/10.1006/abio.1996.0432
    - HARRIS T.D. et al., Science, (20080000), vol. 320, pages 106 - 109
    - RONAGHI, Analytical Biochemistry, (19960000), vol. 242, pages 84 - 89
    - MARGULIES, Nature, (20050000), vol. 437, pages 376 - 380
    - Nature, (20060000), vol. 441, page 120
    - MARGULIES, M. et al., Nature, (20050000), vol. 437, pages 376 - 380
    - BRENNER, Nature Biotechnology, (20000000), vol. 18, pages 630 - 634
    - RUPAREL et al., Proceedings of the National Academy of Sciences of the United States of America, (20050000), vol. 102, pages 5932 - 5937
    - HARRIS, Science, (20080000), vol. 320, pages 106 - 109
    - BENTLEY et al., Nature, (20090000), vol. 6, pages 53 - 59
    - LEVENE et al., Science, (20030000), vol. 299, pages 682 - 686
    - KORLACH et al., Proceedings of the National Academy of Sciences of the United States of America, (20080000), vol. 105, pages 1176 - 1181
    - EID et al., Science, (20090000), vol. 323, pages 133 - 138
    - "Guide to Molecular Cloning Techniques", BERGER; KIMMEL, Methods in Enzymology, Academic Press, Inc., vol. 152
    - SAMBROOK et al., Molecular Cloning - A Laboratory Manual, Cold Spring Harbor Laboratory, (19890000), vol. 1-3
    - RICCIARDELLI et al., Vitro Cell Dev. Biol., (19890000), vol. 25, pages 1016 - 1024
    - ARNHEIM; LEVINSON, C&EN, (19901001), pages 36 - 47
    - The Journal Of NIH Research, (19910000), vol. 3, pages 81 - 94
    - KWOH et al., Proc. Natl. Acad. Sci. USA, (19890000), vol. 86, page 1173
    - GUATELLI et al., Proc. Natl. Acad. Sci. USA, (19900000), vol. 87, page 1874
    - LOMELL et al., J. Clin. Chem, (19890000), vol. 35, page 1826
    - LANDEGREN et al., Science, (19880000), vol. 241, pages 1077 - 1080
    - VAN BRUNT, Biotechnology, (19900000), vol. 8, pages 291 - 294
    - WU; WALLACE, Gene, (19890000), vol. 4, page 560
    - BARRINGER et al., Gene, (19900000), vol. 89, page 117
    - SOOKNANAN; MALEK, Biotechnology, (19950000), vol. 13, pages 563 - 564
    - CHENG et al., Nature, (19940000), vol. 369, pages 684 - 685
    - PORTER et al., Nucleic Acids Research, (19970000), vol. 25, no. 8, pages 1611 - 1617
    - YOUVAN et al., "Fluorescence Imaging Micro-Spectrophotometer (FIMS", Biotechnology, vol. 1, (19990000), pages 1 - 16, URL: wwwl.let-al.com
    - YANG et al., "High Resolution Imaging Microscope (HIRIM", Biotechnology, vol. 4, (19980000), pages 1 - 20, URL: wwwl.let-al.com
    - YOUVAN et al., Calibration of Fluorescence Resonance Energy Transfer in Microscopy Using Genetically Engineered GFP Derivatives on Nickel Chelating Beads, (19990000), URL: wwwl.lkairos-scientific.com.
    - "A General Framework for the Optimization of Object-Oriented Queries", CLUER et al., Proc SIGMOD International Conference on Management of Data, ACM Press, (19920602), vol. 21, pages 383 - 392
    - "ODBC 2.0 Programmer's Reference and SDK Guide", The Microsoft Open Database Standard for Microsoft Windows?M and Windows NTTM, Microsoft Open Database Connectivity.TM. Software Development Kit, Microsoft Press, (19920000), pages 3 - 30,41-56
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.