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Extract from the Register of European Patents

EP About this file: EP3456813

EP3456813 - ENTEROCOCCUS FAECALIS STRAINS FOR PRODUCTION OF MONOCLONAL PHAGE PREPARATIONS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  04.03.2022
Database last updated on 05.10.2024
FormerThe patent has been granted
Status updated on  26.03.2021
FormerGrant of patent is intended
Status updated on  08.12.2020
FormerExamination is in progress
Status updated on  26.02.2020
FormerRequest for examination was made
Status updated on  27.09.2019
FormerThe application has been published
Status updated on  15.02.2019
Most recent event   Tooltip13.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 16.10.2024 [2024/42]
Applicant(s)For all designated states
Instytut Biochemii I Biofizyki Polskiej Akademii Nauk
Pawinskiego 5A
02-106 Warszawa / PL
For all designated states
Instytut Immunologii i Terapii Doswiadczalnej Polskiej Akademii Nauk
Ul. Rudolfa Weigla 12
53-114 Wroclaw / PL
[2019/12]
Inventor(s)01 / Lobocka, Malgorzata
Polnej Rózy 6/13
02-798 Warszawa / PL
02 / Gozdek, Agnieszka
Czerniakowska 22/45
00-714 Warszawa / PL
03 / Izak, Dariusz
PCK 10
05-803 Pruszków / PL
04 / Zalewska, Agnieszka
Filipiny Plaskowickiej 46/19
02-778 Warszawa / PL
05 / Gawor, Jan
Grochowska 202/107
04-357 Warszawa / PL
06 / Dabrowski, Kamil
Lukasinskiego 108/1
05-071 Sulejówek / PL
07 / Gromadka, Robert
Przy Agorze 3/90
01-960 Warszawa / PL
08 / Weber-Dabrowska, Beata
Pugeta 12
51-628 Wroclaw / PL
09 / Górski, Andrzej
Pasaz Ursynowski 3/1
02-784 Warszawa / PL
 [2019/12]
Representative(s)Witek, Rafal
WTS Patent Attorneys
Witek, Sniezko & Partners
ul. Weigla 12
53-114 Wroclaw / PL
[2019/12]
Application number, filing date18195200.331.08.2015
[2019/12]
Priority number, datePL2014040933231.08.2014         Original published format: PL 40933214
[2019/12]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3456813
Date:20.03.2019
Language:EN
[2019/12]
Type: B1 Patent specification 
No.:EP3456813
Date:28.04.2021
Language:EN
[2021/17]
Search report(s)(Supplementary) European search report - dispatched on:EP21.12.2018
ClassificationIPC:C12N1/20, C12N7/00, // C12R1/46
[2019/12]
CPC:
C12N7/00 (EP); C12N1/205 (EP); C12N2795/00051 (EP);
C12R2001/46 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/44]
Former [2019/12]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:ENTEROCOCCUS-FAECALIS-STÄMME ZUR HERSTELLUNG VON MONOKLONALEN PHAGENPRÄPARATEN[2019/12]
English:ENTEROCOCCUS FAECALIS STRAINS FOR PRODUCTION OF MONOCLONAL PHAGE PREPARATIONS[2019/12]
French:SOUCHES D'ENTEROCOCCUS FAECALIS POUR LA PRODUCTION DE PRÉPARATIONS DE PHAGES MONOCLONAUX[2019/12]
Biological materialThis application mentions deposited biological material, check the file for details
Examination procedure20.09.2019Amendment by applicant (claims and/or description)
20.09.2019Examination requested  [2019/44]
20.09.2019Date on which the examining division has become responsible
02.03.2020Despatch of a communication from the examining division (Time limit: M04)
13.07.2020Reply to a communication from the examining division
09.12.2020Communication of intention to grant the patent
10.03.2021Fee for grant paid
10.03.2021Fee for publishing/printing paid
10.03.2021Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP15778720.1  / EP3186361
Opposition(s)31.01.2022No opposition filed within time limit [2022/14]
Fees paidRenewal fee
18.01.2019Renewal fee patent year 03
18.01.2019Renewal fee patent year 04
02.09.2019Renewal fee patent year 05
31.08.2020Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU31.08.2015
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[2024/42]
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Documents cited:Search[A]  - BOURGOGNE AGATHE ET AL, "Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF", GENOME BIOLOGY, BIOMED CENTRAL LTD., LONDON, GB, (20080708), vol. 9, no. 7, ISSN 1465-6906, page R110, XP021041654 [A] 1-3 * abstract * * page R110.4, column r, paragraph 1 *
 [A]  - M. FRITZENWANKER ET AL, "Complete Genome Sequence of the Probiotic Enterococcus faecalis Symbioflor 1 Clone DSM 16431", GENOME ANNOUNCEMENTS, (20130207), vol. 1, no. 1, doi:10.1128/genomeA.00165-12, pages e00165 - 12, XP055233786 [A] 1-3 * the whole document *

DOI:   http://dx.doi.org/10.1128/genomeA.00165-12
 [A]  - MATOS RENATA C ET AL, "Enterococcus faecalis Prophage Dynamics and Contributions to Pathogenic Traits", PLOS GENETICS, (201306), vol. 9, no. 6, XP055233703 [A] 1-3 * abstract *

DOI:   http://dx.doi.org/10.1371/journal.pgen.1003539
 [AD]  - JUMPEI UCHIYAMA ET AL, "In silico and in vivo evaluation of bacteriophage OEF24C, a candidate for treatment of Enterococcusfaecalis infections", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 74, no. 13, doi:10.1128/AEM.02371-07, ISSN 0099-2240, (20080701), pages 4149 - 4163, (20080502), XP002633409 [AD] 1-3 * the whole document *

DOI:   http://dx.doi.org/10.1128/AEM.02371-07
 [T]  - FRIEDERIKE S. ROSSMANN ET AL, "Phage-mediated Dispersal of Biofilm and Distribution of Bacterial Virulence Genes Is Induced by Quorum Sensing", PLOS PATHOGENS, (20150223), vol. 11, no. 2, doi:10.1371/journal.ppat.1004653, page e1004653, XP055233701 [T] * page 5, paragraph 2 *

DOI:   http://dx.doi.org/10.1371/journal.ppat.1004653
by applicant   - ARIAS CA; MURRAY BE, "The rise of the Enterococcus: beyond vancomycin resistance", Nat Rev Microbiol., (20120000), vol. 10, doi:doi:10.1038/nrmicro2761, pages 266 - 278, XP002731857

DOI:   http://dx.doi.org/10.1038/nrmicro2761
    - BALOGH, B.; JONES, J. B.; IRIARTE, F. B.; MOMOL, M. T., "Phage therapy for plant disease control", Curr. Pharm. Biotechnol., (20100000), vol. 11, doi:doi:10.2174/138920110790725302, pages 48 - 57, XP055273957

DOI:   http://dx.doi.org/10.2174/138920110790725302
    - CANCHAYA C; PROUX C; FOURNOUS G; BRUTTIN A; BRUSSOW H, "Prophage genomics", Microbiol. Mol. Biol. Rev., (20030000), vol. 67, pages 238 - 276
    - CHEETHAM BF; KATZ ME, "A role for bacteriophages in the evolution and transfer of bacterial virulence determinants", Mol Microbiol., (19950000), vol. 18, pages 201 - 208
    - GILL, J.J.; HYMAN, P., "Phage choice, isolation, and preparation for phage therapy", Curr Pharm Biotechnol., (20100000), vol. 11, pages 2 - 14
    - GOLEC, P.; D BROWSKI, K.; HEJNOWICZ, M.S.; GOZDEK, A.; LOS, J.M.; W GRZYN, G.; LOBOCKA, M.B.; LOS, M., "A reliable method for storage of tailed phages", J Microbiol Methods, (20110000), vol. 84, doi:doi:10.1016/j.mimet.2011.01.007, pages 486 - 9, XP028149898

DOI:   http://dx.doi.org/10.1016/j.mimet.2011.01.007
    - GOLKAR Z; BAGASRA O; PACE DG, "Bacteriophage therapy: a potential solution for the antibiotic resistance crisis", J Infect Dev Ctries, (20140000), vol. 8, pages 129 - 136
    - GORSKI A; MIEDZYBRODZKI R; BORYSOWSKI J; WEBER-DABROWSKA B; LOBOCKA M; FORTUNA W; LETKIEWICZ S; ZIMECKI M; FILBY G, "Bacteriophage therapy for the treatment of infections", Curr Opin Investig Drugs, (20090000), vol. 10, pages 766 - 774
    - GIRIDHARA UPADHYAYA PM; RAVIKUMAR KL; UMAPATHY BL, "Review of virulence factors of enterococcus: an emerging nosocomial pathogen", Indian J Med Microbiol., (20090000), vol. 27, pages 301 - 305
    - "Basic phage biology", GUTTMAN, B.; RAYA, P.; KUTTER, E., Bacteriophages: biology and application, CRC Press, (20050000), pages 29 - 66
    - LETKIEWICZ S; MIEDZYBRODZKI R; FORTUNA W; WEBER-DABROWSKA B; GORSKI A, "Eradication of Enterococcus faecalis by phage therapy in chronic bacterial prostatitis-case report", Folia Microbiol (Praha, (20090000), vol. 54, pages 457 - 461
    - "The first step to bacteriophage therapy - how to choose the correct phage. In.: Phage Therapy", LOBOCKA M.; HEJNOWICZ M. S.; GQGATA U.; WEBER-DABROWSKA B.; W GRZYN G.; DADLEZ M., Current Research and Applications, Academic Press, (20140000), pages 23 - 69
    - MATOS RC; LAPAQUE N; RIGOTTIER-GOIS L; DEBARBIEUX L; MEYLHEUC T; GONZALEZ-ZORN B; REPOILA F; LOPES MDE F; SERROR P, "Enterococcus faecalis prophage dynamics and contributions to pathogenic traits", PLoS Genet, (20130000), vol. 9, no. 6, doi:doi:10.1371/journal.pgen.1003539, page e1003539, XP055233703

DOI:   http://dx.doi.org/10.1371/journal.pgen.1003539
    - MERABISHVILI, M.; PIRNAY, J.P.; VERBEKEN, G.; CHANISHVILI, N.; TEDIASHVILI, M.; LASHKHI, N.; GLONTI, T.; KRYLOV, V.; MAST, J.; VAN, "Quality-controlled small-scale production of a well-defined bacteriophage cocktail for use in human clinical trials", PLoS One, (20090000), vol. 4, doi:doi:10.1371/journal.pone.0004944, page e4944, XP002543299

DOI:   http://dx.doi.org/10.1371/journal.pone.0004944
    - UCHIYAMA J; RASHEL M; TAKEMURA I; WAKIGUCHI H; MATSUZAKI S, "In silico and in vivo evaluation of bacteriophage phiEF24C, a candidate for treatment of Enterococcus faecalis infections", Appl Environ Microbiol., (20080000), vol. 74, pages 4149 - 4163
    - WANG, X.; KIM, Y.; MA, Q.; HONG, S.H.; POKUSAEVA, K.; STURINO, J.M.; WOOD, T.K., "Cryptic prophages help bacteria cope with adverse environments", Nature Communications, (20100000), vol. 1, page 147
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