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Extract from the Register of European Patents

EP About this file: EP3461912

EP3461912 - USE OF MICROVESICLES IN ANALYZING NUCLEIC ACID PROFILES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  19.05.2023
Database last updated on 18.01.2025
FormerThe patent has been granted
Status updated on  10.06.2022
FormerGrant of patent is intended
Status updated on  27.01.2022
FormerExamination is in progress
Status updated on  19.03.2021
FormerRequest for examination was made
Status updated on  04.10.2019
FormerThe application has been published
Status updated on  01.03.2019
Most recent event   Tooltip13.09.2024Lapse of the patent in a contracting state
New state(s): MT
published on 16.10.2024  [2024/42]
Applicant(s)For all designated states
The General Hospital Corporation
55 Fruit Street
Boston, MA 02114 / US
[2019/14]
Inventor(s)01 / NOERHOLM, Mikkel
Preysingstraße 21
82131 Gauting / DE
02 / SKOG, Johan Karl Olov
120 Lexington Rd.
Lincoln, MA 01773 / US
03 / BREAKEFIELD, Xandra O.
127 Homer Street
Newton, MA 02459 / US
04 / CARTER, Bob
303 Marsh St.
Belmont, MA 02478 / US
 [2022/28]
Former [2019/16]01 / NOERHOLM, Mikkel
Preysingstrasse 21
D-82131 Gauting / DE
02 / SKOG, Johan Karl Olov
120 Lexington Rd.
Lincoln, MA 01773 / US
03 / BREAKEFIELD, Xandra O.
127 Homer Street
Newton, MA Massachusetts 02459 / US
04 / CARTER, Bob
303 Marsh St.
Belmont, MA 02478 / US
Former [2019/14]01 / NOERHOLM, Mikkel
Preysingstrasse 21
D-82131 Gauting / DE
02 / SKOG, Johan Karl Olov
400 West 63rd Street
Apt. 407
New York, NY New York 10069 / US
03 / BREAKEFIELD, Xandra O.
127 Homer Street
Newton, MA Massachusetts 02459 / US
04 / CARTER, Bob
4829 Thurston Place
San Diego, CA California 92130 / US
Representative(s)Kehoe, Laura Ellen, et al
Keltie LLP
No.1 London Bridge
London SE1 9BA / GB
[2019/14]
Application number, filing date18199345.209.09.2010
[2019/14]
Priority number, dateUS200924101409P09.09.2009         Original published format: US 24101409 P
[2019/14]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3461912
Date:03.04.2019
Language:EN
[2019/14]
Type: B1 Patent specification 
No.:EP3461912
Date:13.07.2022
Language:EN
[2022/28]
Search report(s)(Supplementary) European search report - dispatched on:EP07.01.2019
ClassificationIPC:C12Q1/6806, G01N33/48, C12Q1/6886
[2019/14]
CPC:
C12Q1/6886 (EP,US); C12Q1/6806 (EP,US); G01N33/57407 (EP,US);
C12Q2600/158 (EP,US)
C-Set:
C12Q1/6806, C12Q2563/161 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2019/45]
Former [2019/14]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  SM,  TR 
TitleGerman:VERWENDUNG VON MIKROVESIKELN BEI DER ANALYSE VON NUKLEINSÄUREPROFILEN[2019/14]
English:USE OF MICROVESICLES IN ANALYZING NUCLEIC ACID PROFILES[2019/14]
French:UTILISATION DE MICROVÉSICULES DANS L'ANALYSE DE PROFILS D'ACIDES NUCLÉIQUES[2019/14]
Examination procedure25.09.2019Amendment by applicant (claims and/or description)
25.09.2019Examination requested  [2019/45]
25.09.2019Date on which the examining division has become responsible
23.03.2021Despatch of a communication from the examining division (Time limit: M02)
28.05.2021Reply to a communication from the examining division
28.01.2022Communication of intention to grant the patent
07.06.2022Fee for grant paid
07.06.2022Fee for publishing/printing paid
07.06.2022Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP10816090.4  / EP2475988
Opposition(s)14.04.2023No opposition filed within time limit [2023/25]
Fees paidRenewal fee
08.11.2018Renewal fee patent year 03
08.11.2018Renewal fee patent year 04
08.11.2018Renewal fee patent year 05
08.11.2018Renewal fee patent year 06
08.11.2018Renewal fee patent year 07
08.11.2018Renewal fee patent year 08
08.11.2018Renewal fee patent year 09
27.09.2019Renewal fee patent year 10
28.09.2020Renewal fee patent year 11
27.09.2021Renewal fee patent year 12
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU09.09.2010
AL13.07.2022
AT13.07.2022
BG13.07.2022
CY13.07.2022
CZ13.07.2022
DK13.07.2022
EE13.07.2022
ES13.07.2022
FI13.07.2022
HR13.07.2022
LT13.07.2022
LV13.07.2022
MC13.07.2022
MK13.07.2022
MT13.07.2022
NL13.07.2022
PL13.07.2022
RO13.07.2022
SE13.07.2022
SI13.07.2022
SK13.07.2022
SM13.07.2022
TR13.07.2022
IE09.09.2022
LU09.09.2022
BE30.09.2022
NO13.10.2022
GR14.10.2022
IS13.11.2022
PT14.11.2022
[2024/42]
Former [2024/34]HU09.09.2010
AL13.07.2022
AT13.07.2022
BG13.07.2022
CY13.07.2022
CZ13.07.2022
DK13.07.2022
EE13.07.2022
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FI13.07.2022
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MC13.07.2022
MK13.07.2022
NL13.07.2022
PL13.07.2022
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SE13.07.2022
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SK13.07.2022
SM13.07.2022
TR13.07.2022
IE09.09.2022
LU09.09.2022
BE30.09.2022
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GR14.10.2022
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Former [2024/29]HU09.09.2010
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IE09.09.2022
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BE30.09.2022
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Former [2024/27]HU09.09.2010
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IE09.09.2022
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BE30.09.2022
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IE09.09.2022
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BE30.09.2022
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IS13.11.2022
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Former [2024/18]HU09.09.2010
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IE09.09.2022
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Documents cited:Search[I]WO2009100029  (GEN HOSPITAL CORP [US], et al) [I] 1-6 * paragraphs [0044] , [0106] , [0113]; examples 6-9; claims 1,3,5-6,10-11 *;
 [IP]WO2009155505  (PROXY LIFE SCIENCE HOLDINGS IN [US], et al) [IP] 1-6 * paragraph [0072]; figures 4A,4B; claims 1,5 *;
 [E]WO2011009104  (GEN HOSPITAL CORP [US], et al) [E] 1 * claim 58 *;
 [E]WO2011127219  (CARIS LIFE SCIENCES LUXEMBOURG HOLDINGS [LU], et al) [E] 1-6 * paragraphs [0517] - [0520]; figure 22 *;
 [I]  - SKOG JOHAN ET AL, "Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers", NATURE CELL BIOLOGY, MACMILLAN MAGAZINES LTD, vol. 10, no. 12, doi:10.1038/NCB1800, ISSN 1465-7392, (20081201), pages 1470 - 1476, (20081116), XP002526160 [I] 1-6 * page 1471 * * page 1475, column l, paragraph 1 *

DOI:   http://dx.doi.org/10.1038/ncb1800
 [IP]  - MIRANDA K C ET AL, "Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, NEW YORK, vol. 78, no. 2, doi:10.1038/KI.2010.106, ISSN 1523-1755, (20100701), pages 191 - 199, (20100428), XP002686137 [IP] 1 * figure 4 *

DOI:   http://dx.doi.org/10.1038/ki.2010.106
 [T]  - MIKKEL NOERHOLM ET AL, "RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls", BMC CANCER, BIOMED CENTRAL, LONDON, GB, (20120117), vol. 12, no. 1, doi:10.1186/1471-2407-12-22, ISSN 1471-2407, page 22, XP021118100 [T] * the whole document *

DOI:   http://dx.doi.org/10.1186/1471-2407-12-22
by applicantUS5219727
 US5538871
 US5556773
 US5582981
 US5639606
 US5639611
 US5840867
 US6004755
 US6525154
 WO03023065
 WO03050290
 US6812023
 US6893837
 US6899863
 US6913879
 US6994960
 US7074563
 US7081340
 US7117188
 WO2006113590
 US7186512
 US7198923
 US7198893
 US7332553
 US7364848
 US7378245
 US7384589
    - ABRAVAYA, K.; J.J. CARRINO; S. MULDOON; H.H. LEE, "Detection of point mutations with a modified ligase chain reaction (Gap-LCR", Nucleic Acids Res., (19950000), vol. 23, pages 675 - 682, XP002210106
    - AL-NEDAWI, K.; B. MEEHAN; J. MICALLEF; V. LHOTAK; L. MAY; A. GUHA; J. RAK, "Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells", Nat Cell Biol., (20080000), vol. 10, doi:doi:10.1038/ncb1725, pages 619 - 624, XP002526161

DOI:   http://dx.doi.org/10.1038/ncb1725
    - ALTER, O.; P.O. BROWN; D. BOTSTEIN, "Singular value decomposition for genome-wide expression data processing and modeling", Proc Natl Acad Sci US A, (20000000), vol. 97, doi:doi:10.1073/pnas.97.18.10101, pages 10101 - 10106, XP002962133

DOI:   http://dx.doi.org/10.1073/pnas.97.18.10101
    - BALZAR, M.; M.J. WINTER; C.J. DE BOER; S.V. LITVINOV, "The biology of the 17-1A antigen (Ep-CAM", JMolMed., (19990000), vol. 77, doi:doi:10.1007/s001099900038, pages 699 - 712, XP000925817

DOI:   http://dx.doi.org/10.1007/s001099900038
    - BENJAMINI, J.; Y. HOCHBERG, "Controlling the false discovery rate: a practical and powerful approach to multiple testing", J Roy Statist Soc Ser B (Methodological), (19950000), vol. 57, pages 289 - 300
    - BOSSI, A.; F. BONINI; A.P. TURNER; S.A. PILETSKY, "Molecularly imprinted polymers for the recognition of proteins: the state of the art", Biosens Bioelectron., (20070000), vol. 22, doi:doi:10.1016/j.bios.2006.06.023, pages 1131 - 1137, XP005730920

DOI:   http://dx.doi.org/10.1016/j.bios.2006.06.023
    - CHERUVANKY, A.; H. ZHOU; T. PISITKUN; J.B. KOPP; M.A. KNEPPER; P.S. YUEN; R.A. STAR, "Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator", Am JPhysiol Renal Physiol., (20070000), vol. 292, pages f1657 - f1661
    - COTTON, R.G.; N.R. RODRIGUES; R.D. CAMPBELL, "Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations", Proc Natl Acad Sci USA, (19880000), vol. 85, doi:doi:10.1073/pnas.85.12.4397, pages 4397 - 4401, XP002086182

DOI:   http://dx.doi.org/10.1073/pnas.85.12.4397
    - CRISTOFANILLI, M.; J. MENDELSOHN, "Circulating tumor cells in breast cancer: Advanced tools for ''tailored'' therapy?", Proc Natl Acad Sci USA, (20060000), vol. 103, pages 17073 - 17074
    - DABNEY, A.R., "Classification of microarrays to nearest centroids", Bioinformatics, (20050000), vol. 21, pages 4148 - 4154
    - EISEN, M.B.; P.T. SPELLMAN; P.O. BROWN; D. BOTSTEIN, "Cluster analysis and display of genome-wide expression patterns", Proc Natl Acad Sci USA, (19980000), vol. 95, doi:doi:10.1073/pnas.95.25.14863, pages 14863 - 14868, XP002939285

DOI:   http://dx.doi.org/10.1073/pnas.95.25.14863
    - FISCHER, S.G.; L.S. LERMAN, "Length-independent separation of DNA restriction fragments in two-dimensional gel electrophoresis", Cell, (19790000), vol. 16, doi:doi:10.1016/0092-8674(79)90200-9, pages 191 - 200, XP023910996

DOI:   http://dx.doi.org/10.1016/0092-8674(79)90200-9
    - FISCHER, S.G.; L.S. LERMAN, "Two-dimensional electrophoretic separation of restriction enzyme fragments of DNA", Methods Enzymol., (19790000), vol. 68, doi:doi:10.1016/0076-6879(79)68013-8, pages 183 - 191, XP009066767

DOI:   http://dx.doi.org/10.1016/0076-6879(79)68013-8
    - GEISS, G.K.; R.E. BUMGARNER; B. BIRDITT; T. DAHL; N. DOWIDAR; D.L. DUNAWAY; H.P. FELL; S. FERREE; R.D. GEORGE; T. GROGAN, "Direct multiplexed measurement of gene expression with color-coded probe pairs", Nat Biotechnol., (20080000), vol. 26, doi:doi:10.1038/NBT1385, pages 317 - 325, XP002505107

DOI:   http://dx.doi.org/10.1038/NBT1385
    - GUATELLI, J.C.; K.M. WHITFIELD; D.Y. KWOH; K.J. BARRINGER; D.D. RICHMAN; T.R. GINGERAS, "Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication", Proc Natl Acad Sci USA, (19900000), vol. 87, doi:doi:10.1073/pnas.87.5.1874, pages 1874 - 1878, XP000368702

DOI:   http://dx.doi.org/10.1073/pnas.87.5.1874
    - HAHN, P.J., "Molecular biology of double-minute chromosomes", Bioessays, (19930000), vol. 15, doi:doi:10.1002/bies.950150707, pages 477 - 484, XP002908185

DOI:   http://dx.doi.org/10.1002/bies.950150707
    - HAKONARSON, H.; U.S. BJORNSDOTTIR; E. HALAPI; J. BRADFIELD; F. ZINK; M. MOUY; H. HELGADOTTIR; A.S. GUDMUNDSDOTTIR; H. ANDRASON; A., "Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients", Proc Natl AcadSci USA, (20050000), vol. 102, pages 14789 - 14794
    - JOHNSON, S.; D. EVANS; S. LAURENSON; D. PAUL; A.G. DAVIES; P.K. FERRIGNO; C. WALTI, "Surface-immobilized peptide aptamers as probe molecules for protein detection", Anal Chem., (20080000), vol. 80, doi:doi:10.1021/AC701688Q, pages 978 - 983, XP002536007

DOI:   http://dx.doi.org/10.1021/AC701688Q
    - KAN, Y.W.; A.M. DOZY, "Antenatal diagnosis of sickle-cell anaemia by D.N.A. analysis of amniotic-fluid cells", Lancet, (19780000), vol. 2, pages 910 - 912
    - KAN, Y.W.; A.M. DOZY, "Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation", Proc Natl Acad Sci USA, (19780000), vol. 75, doi:doi:10.1073/pnas.75.11.5631, pages 5631 - 5635, XP009021082

DOI:   http://dx.doi.org/10.1073/pnas.75.11.5631
    - KELLER, S.; C. RUPP; A. STOECK; S. RUNZ; M. FOGEL; S. LUGERT; H.D. HAGER; M.S. ABDEL-BAKKY; P. GUTWEIN; P. ALTEVOGT, "CD24 is a marker of exosomes secreted into urine and amniotic fluid", Kidney Int., (20070000), vol. 72, doi:doi:10.1038/sj.ki.5002486, pages 1095 - 1102, XP009106564

DOI:   http://dx.doi.org/10.1038/sj.ki.5002486
    - KWOH, D.Y.; G.R. DAVIS; K.M. WHITFIELD; H.L. CHAPPELLE; L.J. DIMICHELE; T.R. GINGERAS, "Transcription-based amplification system and detection of amplified human immunodeficiency virus type 1 with a bead-based sandwich hybridization format", Proc Natl Acad Sci USA, (19890000), vol. 86, doi:doi:10.1073/pnas.86.4.1173, pages 1173 - 1177, XP000368676

DOI:   http://dx.doi.org/10.1073/pnas.86.4.1173
    - LANDEGREN, U.; R. KAISER; J. SANDERS; L. HOOD, "A ligase-mediated gene detection technique", Science, (19880000), vol. 241, doi:doi:10.1126/science.3413476, pages 1077 - 1080, XP000676556

DOI:   http://dx.doi.org/10.1126/science.3413476
    - LI, J.; L. WANG; H. MAMON; M.H. KULKE; R. BERBECO; G.M. MAKRIGIORGOS, "Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing", Nat Med., (20080000), vol. 14, doi:doi:10.1038/nm1708, pages 579 - 584, XP055001155

DOI:   http://dx.doi.org/10.1038/nm1708
    - LIU, Q.; J.C. GREIMANN; C.D. LIMA, "Reconstitution, activities, and structure of the eukaryotic RNA exosome", Cell, (20060000), vol. 127, pages 1223 - 1237
    - MIELE, E.A.; D.R. MILLS; F.R. KRAMER, "Autocatalytic replication of a recombinant RNA", JMol Biol., (19830000), vol. 171, doi:doi:10.1016/0022-2836(83)90094-3, pages 281 - 295, XP024020805

DOI:   http://dx.doi.org/10.1016/0022-2836(83)90094-3
    - MIRANDA, K.C.; D.T. BOND; M. MCKEE; J. SKOG; T.G. PAUNESCU; N. DA SILVA; D. BROWN; L.M. RUSSO, "Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease", Kidney Int., (20100000), vol. 78, doi:doi:10.1038/ki.2010.106, pages 191 - 199, XP055107901

DOI:   http://dx.doi.org/10.1038/ki.2010.106
    - MYERS, R.M.; Z. LARIN; T. MANIATIS, "Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes", Science, (19850000), vol. 230, doi:doi:10.1126/science.4071043, pages 1242 - 1246, XP001022204

DOI:   http://dx.doi.org/10.1126/science.4071043
    - NAGRATH, S.; L.V. SEQUIST; S. MAHESWARAN; D.W. BELL; D. IRIMIA; L. ULKUS; M.R. SMITH; E.L. KWAK; S. DIGUMARTHY; A. MUZIKANSKY, "Isolation of rare circulating tumour cells in cancer patients by microchip technology", Nature, (20070000), vol. 450, pages 1235 - 1239, XP002681217
    - NAKAZAWA, H.; D. ENGLISH; P.L. RANDELL; K. NAKAZAWA; N. MARTEL; B.K. ARMSTRONG; H. YAMASAKI, "UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement", Proc Natl Acad Sci USA, (19940000), vol. 91, pages 360 - 364
    - ORITA, M.; H. IWAHANA; H. KANAZAWA; K. HAYASHI; T. SEKIYA, "Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms", Proc Natl Acad Sci USA, (19890000), vol. 86, pages 2766 - 2770, XP000310584
    - RAPOSO, G.; H.W. NIJMAN; W. STOORVOGEL; R. LIEJENDEKKER; C.V. HARDING; C.J. MELIEF; H.J. GEUZE, "B lymphocytes secrete antigen-presenting vesicles", J Exp Med., (19960000), vol. 183, doi:doi:10.1084/jem.183.3.1161, pages 1161 - 1172, XP002060486

DOI:   http://dx.doi.org/10.1084/jem.183.3.1161
    - SKOG, J.; T. WURDINGER; S. VAN RIJN; D.H. MEIJER; L. GAINCHE; M. SENA-ESTEVES; W.T. CURRY, JR.; B.S. CARTER; A.M. KRICHEVSKY; X.O., "Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers", Nat Cell Biol., (20080000), vol. 10, doi:doi:10.1038/ncb1800, pages 1470 - 1476, XP002633335

DOI:   http://dx.doi.org/10.1038/ncb1800
    - STEEMERS, F.J.; W. CHANG; G. LEE; D.L. BARKER; R. SHEN; K.L. GUNDERSON, "Whole-genome genotyping with the single-base extension assay", Nat Methods, (20060000), vol. 3, doi:doi:10.1038/nmeth842, pages 31 - 33, XP009155366

DOI:   http://dx.doi.org/10.1038/nmeth842
    - TAYLOR, D.D.; C. GERCEL-TAYLOR, "MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer", Gynecol Oncol., (20080000), vol. 110, doi:doi:10.1016/j.ygyno.2008.04.033, pages 13 - 21, XP022795052

DOI:   http://dx.doi.org/10.1016/j.ygyno.2008.04.033
    - VAN DIJK, E.L.; G. SCHILDERS; G.J. PRUIJN, "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways", RNA, (20070000), vol. 13, pages 1027 - 1035
    - VELCULESCU, V.E.; L. ZHANG; B. VOGELSTEIN; K.W. KINZLER, "Serial analysis of gene expression", Science, (19950000), vol. 270, doi:doi:10.1126/science.270.5235.484, pages 484 - 487, XP001024449

DOI:   http://dx.doi.org/10.1126/science.270.5235.484
    - WENT, P.T.; A. LUGLI; S. MEIER; M. BUNDI; M. MIRLACHER; G. SAUTER; S. DIRNHOFER, "Frequent EpCam protein expression in human carcinomas", Hum Pathol., (20040000), vol. 35, doi:doi:10.1016/S0046-8177(03)00502-1, pages 122 - 128, XP002592037

DOI:   http://dx.doi.org/10.1016/S0046-8177(03)00502-1
    - ZWEIG, M.H.; G. CAMPBELL, "Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine", Clin Chem., (19930000), vol. 39, pages 561 - 577, XP009041551
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