EP3601325 - NEW TAU SPECIES [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 24.05.2024 Database last updated on 31.08.2024 | |
Former | The patent has been granted Status updated on 16.06.2023 | ||
Former | Grant of patent is intended Status updated on 27.02.2023 | ||
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Former | The international publication has been made Status updated on 06.10.2018 | ||
Former | unknown Status updated on 19.04.2018 | Most recent event Tooltip | 02.08.2024 | Lapse of the patent in a contracting state New state(s): SI | published on 04.09.2024 [2024/36] | Applicant(s) | For all designated states INSERM (Institut National de la Santé et de la Recherche Médicale) 101, rue de Tolbiac 75013 Paris / FR | For all designated states Université de Lille 42, rue Paul Duez 59800 Lille / FR | For all designated states Centre Hospitalier Regional Universitaire de Lille 2, avenue Oscar Lambret 59000 Lille / FR | For all designated states Centre National de la Recherche Scientifique (CNRS) 3, rue Michel Ange 75016 Paris / FR | For all designated states Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris 10, rue Vauquelin 75005 Paris / FR | [2020/06] | Inventor(s) | 01 /
BUEE, Luc UMR-S U1172 Faculté de Médecine Henri Warembourg 1 Place de Verdun 59045 Lille Cedex / FR | 02 /
HAMDANE, Malika UMR-S U1172 Faculté de Médecine Henri Warembourg 1 Place de Verdun 59045 Lille Cedex / FR | 03 /
BLUM, David UMR-S U1172 Faculté de Médecine Henri Warembourg 1 Place de Verdun 59045 Lille Cedex / FR | 04 /
DERISBOURG, Maxime UMR-S U1172 Faculté de Médecine Henri Warembourg 1 Place de Verdun 59045 Lille Cedex / FR | 05 /
LEGHAY, Coline UMR-S U1172 Faculté de Médecine Henri Warembourg 1 Place de Verdun 59045 Lille Cedex / FR | 06 /
CHIAPPETTA, Giovanni USR 3149 ESPCI CNRS 10 Rue Vauquelin 75231 Paris Cedex 5 / FR | 07 /
VINH, Joëlle USR 3149 ESPCI CNRS 10 Rue Vauquelin 75231 Paris Cedex 5 / FR | 08 /
VERDIER, Yann USR 3149 ESPCI CNRS 10 Rue Vauquelin 75231 Paris Cedex 5 / FR | [2020/06] | Representative(s) | Inserm Transfert PariSanté Campus 10 rue d'Oradour-sur-Glane 75015 Paris / FR | [2023/29] |
Former [2020/06] | Inserm Transfert 7, rue Watt 75013 Paris / FR | Application number, filing date | 18715588.2 | 27.03.2018 | [2020/06] | WO2018EP57772 | Priority number, date | EP20170305355 | 28.03.2017 Original published format: EP 17305355 | [2020/06] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2018178078 | Date: | 04.10.2018 | Language: | EN | [2018/40] | Type: | A1 Application with search report | No.: | EP3601325 | Date: | 05.02.2020 | Language: | EN | The application published by WIPO in one of the EPO official languages on 04.10.2018 takes the place of the publication of the European patent application. | [2020/06] | Type: | B1 Patent specification | No.: | EP3601325 | Date: | 19.07.2023 | Language: | EN | [2023/29] | Search report(s) | International search report - published on: | EP | 04.10.2018 | Classification | IPC: | C07K14/47, G01N33/53, G01N33/68 | [2020/06] | CPC: |
C07K14/471 (EP);
C07K14/4711 (EP,US);
C07K16/18 (US);
G01N33/6896 (EP,US);
G01N2800/2821 (EP,US);
G01N2800/7047 (EP,US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2020/06] | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | KH | Not yet paid | MA | Not yet paid | MD | Not yet paid | TN | Not yet paid | Title | German: | NEUE ARTEN VON TAU | [2023/09] | English: | NEW TAU SPECIES | [2020/06] | French: | NOUVELLES ESPECES DE TAU | [2023/09] |
Former [2020/06] | NEUE TAU-SPEZIES | ||
Former [2020/06] | NOUVELLE ESPÈCE TAU | Entry into regional phase | 27.09.2019 | National basic fee paid | 27.09.2019 | Designation fee(s) paid | 27.09.2019 | Examination fee paid | Examination procedure | 27.09.2019 | Examination requested [2020/06] | 27.09.2019 | Date on which the examining division has become responsible | 19.05.2020 | Amendment by applicant (claims and/or description) | 24.07.2020 | Despatch of a communication from the examining division (Time limit: M06) | 18.01.2021 | Reply to a communication from the examining division | 04.10.2021 | Despatch of a communication from the examining division (Time limit: M02) | 06.12.2021 | Reply to a communication from the examining division | 28.02.2023 | Communication of intention to grant the patent | 07.06.2023 | Fee for grant paid | 07.06.2023 | Fee for publishing/printing paid | 07.06.2023 | Receipt of the translation of the claim(s) | Opposition(s) | 22.04.2024 | No opposition filed within time limit [2024/26] | Fees paid | Renewal fee | 20.03.2020 | Renewal fee patent year 03 | 23.03.2021 | Renewal fee patent year 04 | 23.03.2022 | Renewal fee patent year 05 | 22.03.2023 | Renewal fee patent year 06 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | AT | 19.07.2023 | CZ | 19.07.2023 | DK | 19.07.2023 | EE | 19.07.2023 | ES | 19.07.2023 | FI | 19.07.2023 | HR | 19.07.2023 | LT | 19.07.2023 | LV | 19.07.2023 | NL | 19.07.2023 | PL | 19.07.2023 | RO | 19.07.2023 | RS | 19.07.2023 | SE | 19.07.2023 | SI | 19.07.2023 | SK | 19.07.2023 | SM | 19.07.2023 | NO | 19.10.2023 | GR | 20.10.2023 | IS | 19.11.2023 | PT | 20.11.2023 | [2024/36] |
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Former [2024/05] | NL | 19.07.2023 | Cited in | International search | [A]WO2011056300 (DAVID GLADSTONE INST [US], et al) [A] 1-14 * paragraph [[0006]] - paragraph [[0016]]; figures 1-10 * * Detailed description. Examples; paragraph [[0029]] - paragraph [[0046]]; table 1 *; | [X] - MAXIME DERISBOURG ET AL, "Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms", SCIENTIFIC REPORTS, (20150514), vol. 5, no. 1, doi:10.1038/srep09659, XP055395382 [X] 1-14 * abstract * * Introduction * * Results, page 2, 1st column Paragraph 1. N-terminal truncates of Tau. * * Discussion, pages 4-6.;; figures 1, 2; table 1 * DOI: http://dx.doi.org/10.1038/srep09659 | [A] - ROBERT A RISSMAN ET AL, "Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, (20040701), vol. 114, no. 1, doi:10.1172/JCI200420640, ISSN 0021-9738, pages 121 - 130, XP002734348 [A] 1-14 * abstract * * Introduction, p. 121 * * Discussion, Figure 11 * DOI: http://dx.doi.org/10.1172/JCI200420640 | [A] - TODD J. COHEN ET AL, "The acetylation of tau inhibits its function and promotes pathological tau aggregation", NATURE COMMUNICATIONS, (20110322), vol. 2, doi:10.1038/ncomms1255, page 252, XP055397255 [A] 1-14 * abstract * * Introduction * DOI: http://dx.doi.org/10.1038/ncomms1255 | [A] - HANNA TRZECIAKIEWICZ ET AL, "A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy", SCIENTIFIC REPORTS, (20170313), vol. 7, doi:10.1038/srep44102, page 44102, XP055397271 [A] 1-14 * abstract * * Introduction * DOI: http://dx.doi.org/10.1038/srep44102 | [A] - DAVID J. IRWIN ET AL, "Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies", BRAIN., GB, (20120224), vol. 135, no. 3, doi:10.1093/brain/aws013, ISSN 0006-8950, pages 807 - 818, XP055397395 [A] 1-14 * abstract * * Introduction * DOI: http://dx.doi.org/10.1093/brain/aws013 | [A] - MAR PEREZ ET AL, "Tau - an inhibitor of deacetylase HDAC6 function", JOURNAL OF NEUROCHEMISTRY, (20090601), vol. 109, no. 6, doi:10.1111/j.1471-4159.2009.06102.x, ISSN 0022-3042, pages 1756 - 1766, XP055044600 [A] 1-14 * abstract * * Introduction * DOI: http://dx.doi.org/10.1111/j.1471-4159.2009.06102.x | [A] - SANG-WON MIN ET AL, "Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits", NATURE MEDICINE, (20150921), vol. 21, no. 10, doi:10.1038/nm.3951, ISSN 1078-8956, pages 1154 - 1162, XP055397314 [A] 1-14 * Abstract and Introduction * DOI: http://dx.doi.org/10.1038/nm.3951 | by applicant | EP0368684 | US2004161738 | WO2006003388 | WO2006030220 | - "Uniprot", Database accession no. P10636-8 | - REYNOLDS, C. H. et al., J. Neurochem., (19970000), vol. 69, pages 191 - 198 | - "Uniprot", Database accession no. P10636-2 | - "Uniprot", Database accession no. P10636-4 | - "Uniprot", Database accession no. P10636-6 | - "Uniprot", Database accession no. P10636-5 | - "Uniprot", Database accession no. P10636-7 | - "Uniprot", Database accession no. P10636-9 | - KENT S.B.H., Chem. Soc. Rev., (20090000), vol. 38, pages 338 - 351 | - BRADLEY L. et al., Annu Rev Biophys Biomol Struct., (20050000), vol. 34, pages 91 - 118 | - R. B. MERRIFIELD, "Solid-phase peptide synthesis", Advances in enzymology and related areas of molecular biology, (19690000), vol. 32, pages 221 - 96, XP002957003 | - R. B. MERRIFIELD, "The synthesis of biologically active peptides and proteins", JAMA, (19690000), vol. 210, no. 7, pages 1247 - 54 | - Ausubel et al., Current Protocols in Molecular Biology, John Wiley & sons, Inc., (19940000), vol. 1 | - HOLLIGER et al., Nature Biotechnology, (20050000), vol. 23, no. 9, pages 1126 - 1136 | - WARD et al., Nature, (19891012), vol. 341, no. 6242, pages 544 - 6 | - HOLT et al., Trends Biotechnol., (20030000), vol. 21, no. 11, pages 484 - 490 | - TUERK et al., Science, (19900000), vol. 249, pages 505 - 510 | - COLAS et al., Nature, (19960000), vol. 380, pages 548 - 50 | - IQBAL, K. et al., Biochimica et Biophysica Acta (BBA, (20050000), vol. 1739, pages 198 - 210 | - AKSNES H; DRAZIC A; MARIE M; ARNESEN T, "First Things First: Vital Protein Marks by N-Terminal Acetyltransferases", Trends Biochem Sci, (20160000), vol. 41, doi:doi:10.1016/j.tibs.2016.07.005, pages 746 - 60, XP029703477 DOI: http://dx.doi.org/10.1016/j.tibs.2016.07.005 | - ARNESEN T; VAN DAMME P; POLEVODA B; HELSENS K; EVJENTH R; COLAERT N; VARHAUG JE; VANDEKERCKHOVE J; LILLEHAUG JR; SHERMAN F, "Proteomics analyses reveal the evolutionary conservation and divergence of Nterminal acetyltransferases from yeast and humans", Proc Natl Acad Sci USA, (20090000), vol. 106, pages 8157 - 62 | - BARTHELEMY NR; GABELLE A; HIRTZ C; FENAILLE F; SERGEANT N; SCHRAEN-MASCHKE S; VIALARET J; BUEE L; JUNOT C; BECHER F, "Differential Mass Spectrometry Profiles of Tau Protein in the Cerebrospinal Fluid of Patients with Alzheimer's Disease, Progressive Supranuclear Palsy, and Dementia with Lewy Bodies", J Alzheimers Dis., (20160220), vol. 51, no. 4, pages 1033 - 43 | - BASURTO-ISLAS, G. et al., "Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease", J Neuropathol Exp Neurol, (20080000), vol. 67, doi:doi:10.1097/NEN.0b013e31817275c7, pages 470 - 483, XP009181912 DOI: http://dx.doi.org/10.1097/NEN.0b013e31817275c7 | - BRAAK H; BRAAK E, "Staging of Alzheimer's disease-related neurofibrillary changes", Neurobiol Aging., (19950000), vol. 16, doi:doi:10.1016/0197-4580(95)00021-6, pages 271 - 8, XP055219625 DOI: http://dx.doi.org/10.1016/0197-4580(95)00021-6 | - BRAAK, H.; THAI, D. R.; GHEBREMEDHIN, E.; DEL TREDICI, K., "Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years", J Neuropathol Exp Neurol, (20110000), vol. 70, pages 960 - 969 | - BRANDT R; LEGER J; LEE G., "Interaction of tau with the neural plasma membrane mediated by tau's aminoterminal projection domain", J Cell Biol., (19950000), vol. 131, pages 1327 - 40 | - BURNOUF S; BELARBI K; TROQUIER L; DERISBOURG M; DEMEYER D; LEBOUCHER A; LAURENT C; HAMDANE M; BUEE L; BLUM D, "Hippocampal BDNF expression in a tau transgenic mouse model", Curr Alzheimer Res., (20120000), vol. 9, no. 4, pages 406 - 10 | - BURNOUF S; MARTIRE A; DERISBOURG M; LAURENT C; BELARBI K; LEBOUCHER A; FERNANDEZ-GOMEZ FJ; TROQUIER L; EDDARKAOUI S; GROSJEAN ME, "NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model", Aging Cell, (20130000), vol. 12, pages 11 - 23 | - CARMEL G; MAGER EM; BINDER LI; KURET J, "The structural basis of monoclonal antibody A1z50's selectivity for Alzheimer's disease pathology", J Biol Chem., (19960000), vol. 271, pages 32789 - 95 | - DE CALIGNON, A.; FOX, L. M.; PITSTICK, R.; CARLSON, G. A. et al., "Caspase activation precedes and leads to tangles", Nature, (20100000), vol. 464, pages 1201 - 1204 | - DELACOURTE A; DAVID JP; SERGEANT N; BUEE L; WATTEZ A; VERMERSCH P; GHOZALI F; FALLET-BIANCO C; PASQUIER F; LEBERT F, "The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease", Neurology, (19990000), vol. 52, pages 1158 - 65 | - DERISBOURG M; LEGHAY C; CHIAPPETTA G; FERNANDEZ-GOMEZ FJ; LAURENT C; DEMEYER D; CARRIER S; BUEE-SCHERRER V; BLUM D; VINH J, "Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms", Sci Rep., (20150000), vol. 5, doi:doi:10.1038/srep09659, page 9659, XP055395382 DOI: http://dx.doi.org/10.1038/srep09659 | - DRAZIC A; MYKLEBUST LM; REE R; ARNESEN T, "The world of protein acetylation", Biochim Biophys Acta, (20160000), vol. 1864, doi:doi:10.1016/j.bbapap.2016.06.007, pages 1372 - 401, XP029687293 DOI: http://dx.doi.org/10.1016/j.bbapap.2016.06.007 | - DRIESSEN HP; DE JONG WW; TESSER GI; BLOEMENDAL H, "The mechanism of N-terminal acetylation of proteins", CRC Crit Rev Biochem., (19850000), vol. 18, no. 4, doi:doi:10.3109/10409238509086784, pages 281 - 325, XP008107146 DOI: http://dx.doi.org/10.3109/10409238509086784 | - DUJARDIN S; LECOLLE K; CAILLIEREZ R; BEGARD S; ZOMMER N; LACHAUD C; CARRIER S; DUFOUR N; AUREGAN G; WINDERICKX J, "Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies", Acta Neuropathol Commun, (20140000), vol. 2, doi:doi:10.1186/2051-5960-2-14, page 14, XP021176738 DOI: http://dx.doi.org/10.1186/2051-5960-2-14 | - DUYCKAERTS C; COLLE MA; DESSI F; PIETTE F; HAUW JJ, "Progression of Alzheimer histopathological changes", Acta Neurol Belg., (19980000), vol. 98, pages 180 - 5 | - FROST B; JACKS RL; DIAMOND MI, "Propagation of tau misfolding from the outside to the inside of a cell", J Biol Chem., (20090000), vol. 284, pages 12845 - 52 | - GAMBLIN TC; CHEN F; ZAMBRANO A; ABRAHA A; LAGALWAR S; GUILLOZET AL; LU M; FU Y; GARCIA-SIERRA F; LAPOINTE N, "Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease", Proc Natl Acad Sci USA, (20030000), vol. 100, doi:doi:10.1073/pnas.1630428100, pages 10032 - 7, XP055053496 DOI: http://dx.doi.org/10.1073/pnas.1630428100 | - GOODE BL; FEINSTEIN SC, "Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau", J Cell Biol., (19940000), vol. 124, pages 769 - 82 | - GUO H; ALBRECHT S; BOURDEAU M; PETZKE T; BERGERON C; LEBLANC AC, "Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease", Am J Pathol., (20040000), vol. 165, pages 523 - 31 | - GUSTKE N; TRINCZEK B; BIERNAT J; MANDELKOW EM; MANDELKOW E, "Domains of tau protein and interactions with microtubules", Biochemistry, (19940000), vol. 33, pages 9511 - 22 | - HAMDANE M; SAMBO AV; DELOBEL P; BEGARD S; VIOLLEAU A; DELACOURTE A; BERTRAND P; BENAVIDES J; BUEE L, "Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex", J Biol Chem., (20030000), vol. 278, pages 34026 - 34 | - HAYASHI, S. et al., "Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation", Ann. Neurol., (20020000), vol. 51, pages 525 - 530 | - HASEGAWA, M. et al., "Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain", J Biol Chem, (19920000), vol. 267, pages 17047 - 17054, XP002433876 | - HELSENS K; VAN DAMME P; DEGROEVE S; MARTENS L; ARNESEN T; VANDEKERCKHOVE J; GEVAERT K, "Bioinformatics analysis of a Saccharomyces cerevisiae N-terminal proteome provides evidence of alternative translation initiation and post-translational N-terminal acetylation", J Proteome Res., (20110000), vol. 10, pages 3578 - 89 | - HOROWITZ PM; PATTERSON KR; GUILLOZET-BONGAARTS AL; REYNOLDS MR; CARROLL CA; WEINTRAUB ST; BENNETT DA; CRYNS VL; BERRY RW; BINDER L, "Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease", J Neurosci, (20040000), vol. 24, doi:doi:10.1523/JNEUROSCI.1988-04.2004, pages 7895 - 902, XP055132970 DOI: http://dx.doi.org/10.1523/JNEUROSCI.1988-04.2004 | - JEGANATHAN S; BERGEN M; BRUTLACH H; STEINHOFF HJ; MANDELKOW E, "Global hairpin folding of tau in solution", Biochemistry, (20060000), vol. 45, pages 2283 - 93 | - JEGANATHAN S; HASCHER A; CHINNATHAMBI S; BIERNAT J; MANDELKOW EM; MANDELKOW E, "Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation", J Biol Chem., (20080000), vol. 283, pages 32066 - 76 | - JOHNSON GV; SEUBERT P; COX TM; MOTTER R; BROWN JP; GALASKO D, "The tau protein in human cerebrospinal fluid in Alzheimer's disease consists of proteolytically derived fragments", J Neurochem., (19970000), vol. 68, doi:doi:10.1046/j.1471-4159.1997.68010430.x, pages 430 - 3, XP008132995 DOI: http://dx.doi.org/10.1046/j.1471-4159.1997.68010430.x | - JUNG D; FILLIOL D; MIEHE M; RENDON A, "Interaction of brain mitochondria with microtubules reconstituted from brain tubulin and MAP2 or TAU", Cell Motil Cytoskeleton, (19930000), vol. 24, pages 245 - 55 | - KOVACECH B; NOVAK M, "Tau truncation is a productive posttranslational modification of neurofibrillary degeneration in Alzheimer's disease", Curr Alzheimer Res., (20100000), vol. 7, doi:doi:10.2174/156720510793611556, pages 708 - 16, XP008132929 DOI: http://dx.doi.org/10.2174/156720510793611556 | - LEE G; NEWMAN ST; GARD DL; BAND H; PANCHAMOORTHY G, "Tau interacts with src-family non-receptor tyrosine kinases", J Cell Sci., (19980000), vol. 111, pages 3167 - 77, XP055072931 | - LOOMIS PA; HOWARD TH; CASTLEBERRY RP; BINDER LI, "Identification of nuclear tau isoforms in human neuroblastoma cells", Proc Natl Acad Sci USA, (19900000), vol. 87, pages 8422 - 6 | - MAGNANI E; FAN J; GASPARINI L; GOLDING M; WILLIAMS M; SCHIAVO G; GOEDERT M; AMOS LA; SPILLANTINI MG, "Interaction of tau protein with the dynactin complex", EMBO J., (20070000), vol. 26, pages 4546 - 54 | - MAILLIOT, C. et al., "Pathological tau phenotypes. The weight of mutations, polymorphisms, and differential neuronal vulnerabilities", Ann. N. Y. Acad. Sci., (20000000), vol. 920, pages 107 - 114 | - MANDELKOW EM; MANDELKOW E, "Biochemistry and cell biology of tau protein in neurofibrillary degeneration", Cold Spring Harb Perspect Med., (20120000), vol. 2, page a006247 | - MCMILLAN, P. J.; KRAEMER, B. C.; ROBINSON, L.; LEVERENZ, J. B. et al., "Truncation of tau at E391 promotes early pathologic changes in transgenic mice", J Neuropathol Exp Neurol, (20110000), vol. 70, pages 1006 - 1019 | - MUKRASCH MD; BIERNAT J; VON BERGEN M; GRIESINGER C; MANDELKOW E; ZWECKSTETTER M, "Sites of tau important for aggregation populate { beta}-structure and bind to microtubules and polyanions", J Biol Chem., (20050000), vol. 280, pages 24978 - 86 | - NOVAK M; KABAT J; WISCHIK CM, "Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament", EMBO J., (19930000), vol. 12, pages 365 - 70, XP009019837 | - PANDEY, "Hybridoma technology for production of monoclonal antibodies", Hybridoma, (20100000), vol. 1, no. 2, page 017 | - POLEVODA B; SHERMAN F, "Composition and function of the eukaryotic N-terminal acetyltransferase subunits", Biochem Biophys Res Commun., (20030000), vol. 308, doi:doi:10.1016/S0006-291X(03)01316-0, pages 1 - 11, XP004441410 DOI: http://dx.doi.org/10.1016/S0006-291X(03)01316-0 | - POORKAJ, P. et al., "An R5L tau mutation in a subject with a progressive supranuclear palsy phenotype", Ann. Neurol., (20020000), vol. 52, pages 511 - 516 | - RISSMAN RA; POON WW; BLURTON-JONES M; ODDO S; TORP R; VITEK MP; LAFERLA FM; ROHN TT; COTMAN CW, "Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology", J Clin Invest., (20040000), vol. 114, doi:doi:10.1172/JCI200420640, pages 121 - 30, XP002734348 DOI: http://dx.doi.org/10.1172/JCI200420640 | - SCHINDOWSKI K; BRETTEVILLE A; LEROY K; BEGARD S; BRION JP; HAMDANE M; BUEE L, "Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits", Am J Pathol., (20060000), vol. 169, pages 599 - 616 | - SERGEANT N; BRETTEVILLE A; HAMDANE M; CAILLET-BOUDIN ML; GROGNET P; BOMBOIS S; BLUM D; DELACOURTE A; PASQUIER F; VANMECHELEN E, "Biochemistry of Tau in Alzheimer's disease and related neurological disorders", Expert Rev Proteomics, (20080000), vol. 5, pages 207 - 24 | - SULTAN A; NESSLANY F; VIOLET M; BEGARD S; LOYENS A; TALAHARI S; MANSUROGLU Z; MARZIN D; SERGEANT N; HUMEZ S, "Nuclear tau, a key player in neuronal DNA protection", J Biol Chem., (20110000), vol. 286, pages 4566 - 75 | - VAN DER JEUGD A; BLUM D; RAISON S; EDDARKAOUI S; BUEE L; D'HOOGE R, "Observations in THY-Tau22 mice that resemble behavioral and psychological signs and symptoms of dementia", Behav Brain Res., (20130000), vol. 242, doi:doi:10.1016/j.bbr.2012.12.008, pages 34 - 9, XP028969693 DOI: http://dx.doi.org/10.1016/j.bbr.2012.12.008 | - BERGEN M; FRIEDHOFF P; BIERNAT J; HEBERLE J; MANDELKOW EM; MANDELKOW E, "Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure", Proc Natl Acad Sci USA, (20000000), vol. 97, doi:doi:10.1073/pnas.97.10.5129, pages 5129 - 34, XP000982226 DOI: http://dx.doi.org/10.1073/pnas.97.10.5129 | - ZILKA, N. et al., "Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo", FEBS Letters, (20060000), vol. 580, doi:doi:10.1016/j.febslet.2006.05.029, pages 3582 - 3588, XP028030674 DOI: http://dx.doi.org/10.1016/j.febslet.2006.05.029 |