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Extract from the Register of European Patents

EP About this file: EP3564243

EP3564243 - PRODUCTION INTERMEDIATE OF ERIBULIN MESYLATE, AND METHOD FOR PRODUCING SAME [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  15.09.2023
Database last updated on 19.03.2026
FormerThe patent has been granted
Status updated on  07.10.2022
FormerGrant of patent is intended
Status updated on  25.08.2022
FormerExamination is in progress
Status updated on  19.07.2022
FormerGrant of patent is intended
Status updated on  18.04.2022
FormerExamination is in progress
Status updated on  22.07.2021
FormerRequest for examination was made
Status updated on  04.10.2019
FormerThe international publication has been made
Status updated on  07.07.2018
Most recent event   Tooltip19.12.2025Lapse of the patent in a contracting state
New state(s): TR		published on 21.01.2026  [2026/04]
Applicant(s)For all designated states
Yonsung Fine Chemical Co., Ltd.
207 Sujeong-ro
Jangan-myeon
Hwaseong-si, Gyeonggi-do 18581 / KR
[2020/01]
Former [2019/45]For all designated states
Yonsung Fine Chemical Co. Ltd.
207 Sujeong-ro
Jangan-myeon
Hwaseong-si, Gyeonggi-do 18581 / KR
Inventor(s)01 / LEE, Hyoseon
2F, 15-16 Simjung-ro 114beon-gil
Bucheon-si Gyeonggi-do 14610 / KR
02 / SHIN, Hyunik
8906-303
130 Wellbeing town-ro
Yeongtong-gu
Suwon-si Gyeonggi-do 16224 / KR
03 / LEE, Keeyoung
103-901
29 Baumoe-ro 7-gil
Seocho-gu
Seoul 06762 / KR
04 / OH, Changyoung
1110-801
147 Seopangyo-ro
Bundang-gu
Seongnam-si Gyeonggi-do 13475 / KR
 [2019/45]
Representative(s)V.O.
P.O. Box 87930
2508 DH Den Haag / NL
[2019/45]
Application number, filing date18734042.702.01.2018
[2019/45]
WO2018KR00043
Priority number, dateKR2017000038002.01.2017         Original published format: KR 20170000380
KR2017017207714.12.2017         Original published format: KR 20170172077
[2019/45]
Filing languageKO
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018124847
Date:05.07.2018
Language:KO
[2018/27]
Type: A1 Application with search report 
No.:EP3564243
Date:06.11.2019
Language:EN
[2019/45]
Type: B1 Patent specification 
No.:EP3564243
Date:09.11.2022
Language:EN
[2022/45]
Search report(s)International search report - published on:KR05.07.2018
(Supplementary) European search report - dispatched on:EP28.08.2020
ClassificationIPC:C07D493/04, A61K31/357, A61P35/00, A61K31/35
[2019/45]
CPC:
A61P35/00 (EP); C07D493/04 (EP,US); C07D309/10 (US);
Y02P20/55 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/45]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON ERIBULINMESYLAT UND VERFAHREN ZUR HERSTELLUNG DAVON[2019/45]
English:PRODUCTION INTERMEDIATE OF ERIBULIN MESYLATE, AND METHOD FOR PRODUCING SAME[2019/45]
French:INTERMÉDIAIRE DE PRODUCTION DE MÉSYLATE D'ÉRIBULINE, ET SON PROCÉDÉ DE PRODUCTION[2019/45]
Entry into regional phase19.07.2019Translation filed 
19.07.2019National basic fee paid 
19.07.2019Search fee paid 
19.07.2019Designation fee(s) paid 
19.07.2019Examination fee paid 
Examination procedure19.07.2019Examination requested  [2019/45]
12.03.2021Amendment by applicant (claims and/or description)
21.07.2021Despatch of a communication from the examining division (Time limit: M04)
08.11.2021Reply to a communication from the examining division
19.04.2022Communication of intention to grant the patent
13.07.2022Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
26.08.2022Communication of intention to grant the patent
04.10.2022Fee for grant paid
04.10.2022Fee for publishing/printing paid
04.10.2022Receipt of the translation of the claim(s)
Opposition(s)10.08.2023No opposition filed within time limit [2023/42]
Fees paidRenewal fee
17.12.2019Renewal fee patent year 03
22.12.2020Renewal fee patent year 04
14.12.2021Renewal fee patent year 05
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY02.01.2018
HU02.01.2018
AL09.11.2022
AT09.11.2022
BG09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
MC09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SI09.11.2022
SK09.11.2022
SM09.11.2022
TR09.11.2022
IE02.01.2023
LU02.01.2023
BE31.01.2023
CH31.01.2023
LI31.01.2023
GB09.02.2023
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
[2026/04]
Former [2025/39]CY02.01.2018
HU02.01.2018
AL09.11.2022
AT09.11.2022
BG09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
MC09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SI09.11.2022
SK09.11.2022
SM09.11.2022
IE02.01.2023
LU02.01.2023
BE31.01.2023
CH31.01.2023
LI31.01.2023
GB09.02.2023
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2025/36]CY02.01.2018
AL09.11.2022
AT09.11.2022
BG09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
MC09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SI09.11.2022
SK09.11.2022
SM09.11.2022
IE02.01.2023
LU02.01.2023
BE31.01.2023
CH31.01.2023
LI31.01.2023
GB09.02.2023
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2024/51]AL09.11.2022
AT09.11.2022
BG09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
MC09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SI09.11.2022
SK09.11.2022
SM09.11.2022
IE02.01.2023
LU02.01.2023
BE31.01.2023
CH31.01.2023
LI31.01.2023
GB09.02.2023
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2024/29]AL09.11.2022
AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
MC09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SI09.11.2022
SK09.11.2022
SM09.11.2022
IE02.01.2023
LU02.01.2023
BE31.01.2023
CH31.01.2023
LI31.01.2023
GB09.02.2023
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2024/08]AL09.11.2022
AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SI09.11.2022
SK09.11.2022
SM09.11.2022
IE02.01.2023
LU02.01.2023
BE31.01.2023
CH31.01.2023
LI31.01.2023
GB09.02.2023
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/51]AL09.11.2022
AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SI09.11.2022
SK09.11.2022
SM09.11.2022
LU02.01.2023
BE31.01.2023
CH31.01.2023
LI31.01.2023
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/49]AL09.11.2022
AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SK09.11.2022
SM09.11.2022
LU02.01.2023
BE31.01.2023
CH31.01.2023
LI31.01.2023
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/47]AL09.11.2022
AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SK09.11.2022
SM09.11.2022
LU02.01.2023
CH31.01.2023
LI31.01.2023
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/43]AL09.11.2022
AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SK09.11.2022
SM09.11.2022
LU02.01.2023
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/38]AL09.11.2022
AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SK09.11.2022
SM09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/37]AL09.11.2022
AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SM09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/35]AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SM09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/34]AT09.11.2022
DK09.11.2022
EE09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RS09.11.2022
SE09.11.2022
SM09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/33]AT09.11.2022
DK09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RS09.11.2022
SE09.11.2022
SM09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/29]AT09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RS09.11.2022
SE09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/25]AT09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
PL09.11.2022
RS09.11.2022
SE09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/23]AT09.11.2022
FI09.11.2022
LT09.11.2022
LV09.11.2022
SE09.11.2022
NO09.02.2023
GR10.02.2023
PT09.03.2023
Former [2023/22]AT09.11.2022
FI09.11.2022
LT09.11.2022
SE09.11.2022
NO09.02.2023
PT09.03.2023
Former [2023/20]LT09.11.2022
NO09.02.2023
Documents cited:Search[YA] WO2005118565  (EISAI CO LTD et al.) [Y] 12-20 * the whole document *[A] 1-11
 [XAY]   DUAN J J-W ET AL: "Synthetic studies on halichondrins: A new practical synthesis of the C.1-C.12 segment", TETRAHEDRON LETTERS, ELSEVIER LTD, AMSTERDAM, NL, vol. 34, no. 47, 19 November 1993 (1993-11-19), pages 7541 - 7544, XP028085834, ISSN: 0040-4039, [retrieved on 19931119], DOI: 10.1016/S0040-4039(00)60394-5 [X] 9 * the whole document *[A] 1-8,10,11 [Y] 12-20

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)60394-5
International search[A] KR20070003026  (HYUNDAI MOTOR CO LTD et al.) [A] 1-20 * See pages 52-60. *
 [A] KR20160023816  (EISAI R&D MAN CO LTD et al.) [A] 1-20 * See the entire document. *
 [A] WO2016004805  (UNITRIS BIOPHARMA CO LTD et al.) [A] 1-20 * See the entire document. *
 [A]   YU , M. J. ET AL.: "From Micrograms to Grams: Scale-up Synthesis of Eribulin Mesylate", NATURAL PRODUCT REPORTS, vol. 30, no. 9, 2013, pages 1158 - 1164, XP055508104 [A] 1-20 * See abstract; and formulas 1, 2. *

DOI:   http://dx.doi.org/10.1039/c3np70051h
 [A]   CHASE, C. E. ET AL.: "Process Development of Halaven: Synthesis of the C1-C13 Fragment from D-(-)-Gulono-1,4-lactone", SYNLETT, vol. 24, no. 3, 2013, pages 323 - 326, XP055518043 [A] 1-20 * See the entire document. *

DOI:   http://dx.doi.org/10.1055/s-0032-1317919
by applicantUS6214865
   TETRAHEDRON LETTER, vol. 37, 1996, pages 8643 - 8646
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.