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Extract from the Register of European Patents

EP About this file: EP3668841

EP3668841 - SUBSTITUTED BENZIMIDAZOLES AS POTASSIUM CHANNEL INHIBITORS [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  25.02.2022
Database last updated on 14.11.2024
FormerRequest for examination was made
Status updated on  22.05.2020
FormerThe international publication has been made
Status updated on  22.02.2019
Formerunknown
Status updated on  18.08.2018
Most recent event   Tooltip28.08.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
Acesion Pharma ApS
Ole Maaløes Vej 3
2200 Copenhagen N / DK
[2020/26]
Inventor(s)01 / SØRENSEN, Ulrik Svane
Ole Maaloes Vej 3
2200 Copenhagen / DK
02 / METE, Antonio
Ole Maaloes Vej 3
2200 Copenhagen / IT
 [2020/26]
Representative(s)Kjerrumgaard, Lars Bo
Nex & Phister Law & IP ApS
Cobis Ole Maaløes Vej 3
2200 København N / DK
[N/P]
Former [2020/26]Kjerrumgaard, Lars Bo
LBKPATENT APS
Cobis Ole Maaløes Vej 3
2200 Copenhagen / DK
Application number, filing date18750455.013.08.2018
[2020/26]
WO2018EP71911
Priority number, dateEP2017002035314.08.2017         Original published format: EP 17020353
[2020/26]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019034603
Date:21.02.2019
Language:EN
[2019/08]
Type: A1 Application with search report 
No.:EP3668841
Date:24.06.2020
Language:EN
The application published by WIPO in one of the EPO official languages on 21.02.2019 takes the place of the publication of the European patent application.
[2020/26]
Search report(s)International search report - published on:EP21.02.2019
ClassificationIPC:C07D235/30, A61P9/00, A61K31/4184
[2020/26]
CPC:
C07D235/30 (EP,US); A61P9/00 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/26]
TitleGerman:SUBSTITUIERTE BENZIMIDAZOLE ALS KALIUMKANALINHIBITOREN[2020/26]
English:SUBSTITUTED BENZIMIDAZOLES AS POTASSIUM CHANNEL INHIBITORS[2020/26]
French:BENZIMIDAZOLES SUBSTITUÉS UTILES EN TANT QU'INHIBITEURS DU CANAL POTASSIUM[2020/26]
Entry into regional phase10.03.2020National basic fee paid 
10.03.2020Designation fee(s) paid 
10.03.2020Examination fee paid 
Examination procedure10.03.2020Examination requested  [2020/26]
10.03.2020Date on which the examining division has become responsible
24.09.2020Amendment by applicant (claims and/or description)
28.02.2022Despatch of a communication from the examining division (Time limit: M04)
29.06.2022Reply to a communication from the examining division
11.10.2023Despatch of a communication from the examining division (Time limit: M04)
19.02.2024Reply to a communication from the examining division
Fees paidRenewal fee
27.08.2020Renewal fee patent year 03
27.08.2021Renewal fee patent year 04
29.08.2022Renewal fee patent year 05
28.08.2023Renewal fee patent year 06
27.08.2024Renewal fee patent year 07
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[AD]WO2006013210  (NEUROSEARCH AS [DK], et al) [AD] 1-36 * example - ** claim - *;
 [A]WO2008113747  (NEUROSEARCH AS [DK], et al) [A] 1-36 * example - * * claim - *;
 [A]WO2013104577  (ACESION PHARMA APS [DK], et al) [A] 1-36 * example - * * claim - *;
 [IP]WO2017144183  (ACESION PHARMA APS [DK]) [IP] 1-36 * example - * * claim - *;
 [X]  - ANDREJS KRASIKOVS ET AL, "Iodoacetic Acid is an Efficient Reagent for the Synthesis of Amino Acid Derived 2-Aminobenzimidazoles", SYNTHESIS, STUTTGART, DE., (20130206), vol. 45, no. 05, doi:10.1055/s-0032-1316849, ISSN 0039-7881, pages 683 - 693, XP055502524 [X] 1,2,4,6-24,31 * table 3; compounds 11b,11c *

DOI:   http://dx.doi.org/10.1055/s-0032-1316849
 [X]  - AJAY L. CHANDGUDE ET AL, "Direct Amination of [alpha]-Hydroxy Amides", ASIAN JOURNAL OF ORGANIC CHEMISTRY , 1(2), 160-165 CODEN: AJOCC7; ISSN: 2193-5807, Germany, (20170614), vol. 6, no. 8, doi:10.1002/ajoc.201700277, ISSN 2193-5807, pages 981 - 983, XP055502526 [X] 1,2,4,6-22,25-28,31 * page 983; compound 3k *

DOI:   http://dx.doi.org/10.1002/ajoc.201700277
 [X]  - R. SRIRAM ET AL, "Retracted : Microwave Assisted Synthesis of Trifluoro Substituted 2-Aminobenzimidazole Derivatives via Iodoacetic Acid Mediated One-pot Condensation : Trifluoro substituted 2-Aminobenzimidazole Derivatives", JOURNAL OF HETEROCYCLIC CHEMISTRY, US, (20170701), vol. 54, no. 4, doi:10.1002/jhet.2841, ISSN 0022-152X, pages 2440 - 2446, XP055502565 [X] 1-3,6-24,31 * example 12f; table 3 *

DOI:   http://dx.doi.org/10.1002/jhet.2841
 [X]  - FLOCH L ET AL, "2-AMINO-SUBSTITUTED DERIVATIVES OF BENZIMIDAZOLES FROM 2-ISOTHIOCYANATO CARBOXYLATES", COLLECTION SYMPOSIUM SERIES (XIIITH SYMPOSIUM ON CHEMISTRY OF NUCLEIC ACID COMPONENTS SPINDLERUV MLYN, CZECH REPUBLIC; SEPTEMBER 03 -09, 2005); [COLLECTION SYMPOSIUM SERIES], XX, XX, (19880101), vol. 54, ISSN 0010-0765, ISBN 978-80-86241-25-8, pages 206 - 214, XP000929228 [X] 1,2,4,6-24,31 * RN: 121928-35-6; CN:Phenylalanine, N-1H-benzimidazol-2-yl-, ethyl ester;;; table IV *
by applicantWO2006013210
    - WULFF H et al., "Modulators of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels and their Therapeutic Indications", Currrent Medicinal Chemistry, (20070000), vol. 14, doi:doi:10.2174/092986707780831186, pages 1437 - 1457, XP002470707

DOI:   http://dx.doi.org/10.2174/092986707780831186
    - LIEGEOIS J-F et al., "Modulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry", Current Medicinal Chemistry, (20030000), vol. 10, doi:doi:10.2174/0929867033457908, pages 625 - 647, XP009078299

DOI:   http://dx.doi.org/10.2174/0929867033457908
    - NATTEL S, J. Physiol., (20090000), vol. 587, pages 1385 - 1386
    - DINESS JG; SORENSEN US; NISSEN JD; AL-SHAHIB B; JESPERSEN T; GRUNNET M; HANSEN RS, Circ. Arrhythm. Electrophysiol., (20100000), vol. 3, pages 380 - 90
    - DINESS et al., Hypertension, (20110000), vol. 57, pages 1129 - 1135
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.