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Extract from the Register of European Patents

EP About this file: EP3668516

EP3668516 - STABLE LYOPHILISATES COMPRISING 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID AND A DICARBOXYLIC ACID [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  29.07.2022
Database last updated on 02.11.2024
FormerThe patent has been granted
Status updated on  20.08.2021
FormerGrant of patent is intended
Status updated on  07.04.2021
FormerRequest for examination was made
Status updated on  22.05.2020
FormerThe international publication has been made
Status updated on  22.02.2019
Formerunknown
Status updated on  20.08.2018
Most recent event   Tooltip27.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 30.10.2024  [2024/44]
Applicant(s)For all designated states
Merck Patent GmbH
Frankfurter Strasse 250
64293 Darmstadt / DE
[2022/18]
Former [2020/26]For all designated states
Merck Patent GmbH
Frankfurter Strasse 250
64293 Darmstadt / DE
Inventor(s)01 / MOSER, Rudolf
Lahnhalde 11
8200 Schaffhausen / CH
02 / GROEHN, Viola
Neuwingertstrasse 9
8447 Dachsen / CH
03 / AMMANN, Thomas
Seebestrasse 1
8460 Marthalen / CH
 [2020/26]
Application number, filing date18752161.215.08.2018
[2020/26]
WO2018EP72077
Priority number, dateEP2017018651816.08.2017         Original published format: EP 17186518
[2020/26]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019034673
Date:21.02.2019
Language:EN
[2019/08]
Type: A1 Application with search report 
No.:EP3668516
Date:24.06.2020
Language:EN
The application published by WIPO in one of the EPO official languages on 21.02.2019 takes the place of the publication of the European patent application.
[2020/26]
Type: B1 Patent specification 
No.:EP3668516
Date:22.09.2021
Language:EN
[2021/38]
Search report(s)International search report - published on:EP21.02.2019
ClassificationIPC:A61K31/519, C07D475/04, A61K47/12, C07C55/06, C07C55/10, C07C57/145, C07C57/15, C07C59/225, A61K9/19
[2020/26]
CPC:
C07D475/04 (EP); A61K9/19 (EP,KR,US); A61K31/519 (EP,KR,US);
A61K47/12 (EP,KR,US); A61K9/0019 (EP,KR); A61K9/08 (EP,KR);
A61K9/10 (EP,KR); A61P35/00 (KR); C07C55/06 (EP);
C07C55/10 (EP); C07C57/145 (EP); C07C57/15 (EP);
C07C59/245 (EP); C07C59/255 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/26]
Extension statesBANot yet paid
MENot yet paid
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:STABILE LYOPHILISATE MIT 5,10-METHYLENE-(6R)-TETRAHYDROFOLSÄURE UND EINER DICARBONSÄURE[2020/26]
English:STABLE LYOPHILISATES COMPRISING 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID AND A DICARBOXYLIC ACID[2020/26]
French:LYOPHILISATS STABLES COMPRENANT DE L'ACIDE 5,10-MÉTHYLÈNE-(6R)-TÉTRAHYDROFOLIQUE ET UN ACIDE DICARBOXYLIQUE[2020/26]
Entry into regional phase12.02.2020National basic fee paid 
12.02.2020Designation fee(s) paid 
12.02.2020Examination fee paid 
Examination procedure12.02.2020Examination requested  [2020/26]
12.02.2020Date on which the examining division has become responsible
18.09.2020Amendment by applicant (claims and/or description)
08.04.2021Communication of intention to grant the patent
09.08.2021Fee for grant paid
09.08.2021Fee for publishing/printing paid
09.08.2021Receipt of the translation of the claim(s)
Opposition(s)23.06.2022No opposition filed within time limit [2022/35]
Fees paidRenewal fee
13.08.2020Renewal fee patent year 03
13.08.2021Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU15.08.2018
AL22.09.2021
CY22.09.2021
CZ22.09.2021
EE22.09.2021
HR22.09.2021
LT22.09.2021
LV22.09.2021
MC22.09.2021
MK22.09.2021
MT22.09.2021
PL22.09.2021
RO22.09.2021
RS22.09.2021
SI22.09.2021
SK22.09.2021
SM22.09.2021
BG22.12.2021
GR23.12.2021
IS22.01.2022
[2024/44]
Former [2024/27]HU15.08.2018
AL22.09.2021
CY22.09.2021
CZ22.09.2021
EE22.09.2021
HR22.09.2021
LT22.09.2021
LV22.09.2021
MC22.09.2021
MK22.09.2021
PL22.09.2021
RO22.09.2021
RS22.09.2021
SI22.09.2021
SK22.09.2021
SM22.09.2021
BG22.12.2021
GR23.12.2021
IS22.01.2022
Former [2024/24]HU15.08.2018
AL22.09.2021
CY22.09.2021
CZ22.09.2021
EE22.09.2021
HR22.09.2021
LT22.09.2021
LV22.09.2021
MC22.09.2021
PL22.09.2021
RO22.09.2021
RS22.09.2021
SI22.09.2021
SK22.09.2021
SM22.09.2021
BG22.12.2021
GR23.12.2021
IS22.01.2022
Former [2024/21]AL22.09.2021
CY22.09.2021
CZ22.09.2021
EE22.09.2021
HR22.09.2021
LT22.09.2021
LV22.09.2021
MC22.09.2021
PL22.09.2021
RO22.09.2021
RS22.09.2021
SI22.09.2021
SK22.09.2021
SM22.09.2021
BG22.12.2021
GR23.12.2021
IS22.01.2022
Former [2023/16]AL22.09.2021
CZ22.09.2021
EE22.09.2021
HR22.09.2021
LT22.09.2021
LV22.09.2021
MC22.09.2021
PL22.09.2021
RO22.09.2021
RS22.09.2021
SI22.09.2021
SK22.09.2021
BG22.12.2021
GR23.12.2021
IS22.01.2022
Former [2023/01]AL22.09.2021
CZ22.09.2021
EE22.09.2021
HR22.09.2021
LT22.09.2021
LV22.09.2021
PL22.09.2021
RO22.09.2021
RS22.09.2021
SI22.09.2021
SK22.09.2021
BG22.12.2021
GR23.12.2021
IS22.01.2022
Former [2022/29]AL22.09.2021
CZ22.09.2021
EE22.09.2021
HR22.09.2021
LT22.09.2021
LV22.09.2021
PL22.09.2021
RO22.09.2021
RS22.09.2021
SK22.09.2021
BG22.12.2021
GR23.12.2021
IS22.01.2022
Former [2022/24]CZ22.09.2021
EE22.09.2021
HR22.09.2021
LT22.09.2021
LV22.09.2021
PL22.09.2021
RO22.09.2021
RS22.09.2021
SK22.09.2021
BG22.12.2021
GR23.12.2021
IS22.01.2022
Former [2022/23]CZ22.09.2021
EE22.09.2021
HR22.09.2021
LT22.09.2021
LV22.09.2021
PL22.09.2021
RS22.09.2021
SK22.09.2021
BG22.12.2021
GR23.12.2021
Former [2022/10]HR22.09.2021
LT22.09.2021
LV22.09.2021
RS22.09.2021
BG22.12.2021
GR23.12.2021
Former [2022/09]LT22.09.2021
RS22.09.2021
BG22.12.2021
Former [2022/08]LT22.09.2021
BG22.12.2021
Cited inInternational search[AD]WO2004112761  (MERCK EPROVA AG [CH], et al) [AD] 1-11 * examples 1,7 *;
 [A]WO2007064968  (ADVENTRX PHARMACEUTICALS INC [US], et al) [A] 1-11* claim 1 *
by applicantUS4564054
 EP0537492
 EP0579996
 US6069134
 WO0050032
 EP1641460
 EP2837631
    - POE, M. et al., Biochemistry, (19790000), vol. 18, no. 24, page 5527
    - KALLEN, R. G., Methods in Enzymology, (19710000), vol. 18B, page 705
    - ODIN, E. et al., Cancer Investigation, (19980000), vol. 16, no. 7, page 447
    - OSBORN, M. J. et al., J. Am. Chem. Soc., (19600000), vol. 82, page 4921
    - HAWKES, J.; VILLOTA, R., Food Sci. Nutr., (19890000), vol. 28, page 439
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.