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EP About this file: EP3652318

EP3652318 - ENGINEERED IMMUNOSTIMULATORY BACTERIAL STRAINS AND USES THEREOF [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  11.06.2021
Database last updated on 06.07.2024
FormerRequest for examination was made
Status updated on  17.04.2020
FormerThe international publication has been made
Status updated on  18.01.2019
Formerunknown
Status updated on  22.08.2018
Most recent event   Tooltip28.07.2023New entry: Renewal fee paid 
Applicant(s)For all designated states
Actym Therapeutics, Inc.
626 Bancroft Way
Suite A
Berkeley, CA 94710 / US
[2020/21]
Inventor(s)01 / THANOS, Christopher, D.
38 Meadow Hill Drive
Tiburon, CA 94920 / US
02 / GLICKMAN, Laura, Hix
36 Rydal Court
Oakland, CA 94611 / US
03 / SKOBLE, Justin
2423 Roosevelt Avenue
Berkeley, CA 94703 / US
 [2020/21]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2020/21]
Application number, filing date18752908.611.07.2018
[2020/21]
WO2018US41713
Priority number, dateUS201762531327P11.07.2017         Original published format: US 201762531327 P
US201862648380P26.03.2018         Original published format: US 201862648380 P
[2020/21]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019014398
Date:17.01.2019
Language:EN
[2019/03]
Type: A1 Application with search report 
No.:EP3652318
Date:20.05.2020
Language:EN
The application published by WIPO in one of the EPO official languages on 17.01.2019 takes the place of the publication of the European patent application.
[2020/21]
Search report(s)International search report - published on:EP17.01.2019
(Supplementary) European search report - dispatched on:EP10.06.2021
ClassificationIPC:C12N15/113, C12N1/36, A61K35/74, A61P35/00
[2020/21]
CPC:
C12N15/1135 (EP,US); A61P35/00 (EP,US); C12N1/205 (US);
C12N1/36 (EP,US); C12N15/113 (EP,US); C12N15/74 (US);
C12N2310/14 (EP,US); C12N2310/141 (EP,US); C12N2310/17 (EP,US);
C12N2310/531 (EP,US); C12N2320/32 (EP,US); C12R2001/42 (US);
Y02A50/30 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/21]
Extension statesBA11.02.2020
ME11.02.2020
TitleGerman:MANIPULIERTE IMMUNSTIMULIERENDE BAKTERIENSTÄMME UND VERWENDUNGEN DAVON[2020/21]
English:ENGINEERED IMMUNOSTIMULATORY BACTERIAL STRAINS AND USES THEREOF[2020/21]
French:SOUCHES BACTÉRIENNES IMMUNOSTIMULATRICES MODIFIÉES ET UTILISATIONS[2020/21]
Entry into regional phase11.02.2020National basic fee paid 
11.02.2020Designation fee(s) paid 
11.02.2020Examination fee paid 
Examination procedure13.05.2019Request for preliminary examination filed
International Preliminary Examining Authority: EP
11.02.2020Amendment by applicant (claims and/or description)
11.02.2020Examination requested  [2020/21]
11.02.2020Date on which the examining division has become responsible
10.06.2021Despatch of a communication from the examining division to which search results under Rule 164(2) EPC are annexed (Time limit: M06) [2021/28]
10.06.2021Despatch of a communication from the examining division (Time limit: M06)
18.01.2022Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
25.03.2022Reply to a communication from the examining division
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
25.03.2022Request for further processing filed
25.03.2022Full payment received (date of receipt of payment)
Request granted
01.04.2022Decision despatched
Fees paidRenewal fee
14.07.2020Renewal fee patent year 03
08.07.2021Renewal fee patent year 04
25.07.2022Renewal fee patent year 05
27.07.2023Renewal fee patent year 06
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[Y]WO2008091375  (US GOV HEALTH & HUMAN SERV [US], et al) [Y] 1,2,5-54,56-103,105-115,117,119-165,171-177,179-217,225 * example 1; claims 1,8; tables 2,7 *;
 [Y]WO2010057009  (CEQUENT PHARMACEUTICALS INC [US], et al) [Y] 3-54,57,58,60-103,105-114,119-165,171-177,185,194,196,202-207,210-215,225 * examples 31,32; claims 1,2,20 *;
 [Y]WO2011100489  (BRIGHAM & WOMENS HOSPITAL [US], et al) [Y] 3-54,57,58,60-103,105-114,119-165,171-177,185,194,196,202-207,210-215,225 * paragraph [0040]; claims 1-3 *;
 [Y]US2014127284  (CHERESH DAVID [US], et al) [Y] 41,45,47,69,70 * claims 6,22 *;
 [Y]WO2015032165  (UNIV HONG KONG [CN]) [Y] 1,2,5-54,56-103,105-115,117,119-165,171-177,179-217,225 * page 56 - page 72; claims 31,33,34; table 1 *;
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DOI:   http://dx.doi.org/10.1016/j.jconrel.2015.12.005
 [A]  - C. A. BLACHE ET AL, "Systemic Delivery of Salmonella typhimurium Transformed with IDO shRNA Enhances Intratumoral Vector Colonization and Suppresses Tumor Growth", CANCER RESEARCH, US, (20121022), vol. 72, no. 24, doi:10.1158/0008-5472.CAN-12-0193, ISSN 0008-5472, pages 6447 - 6456, XP055305466 [A] 1,2,5-54,56-103,105-115,117,119-165,171-177,179-217,225 * figures 2-4 *

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-12-0193
 [Y]  - CLAIRE VANPOUILLE-BOX ET AL, "DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity", NATURE COMMUNICATIONS, GB, (20170609), vol. 8, doi:10.1038/ncomms15618, ISSN 2041-1723, page 15618, XP055512079 [Y] 1,2,5-54,56-103,105-115,117,119-165,171-177,179-217,225 * figures 4,6 *

DOI:   http://dx.doi.org/10.1038/ncomms15618
 [A]  - LEE ADAM WHEELER ET AL, "TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice", CELL REPORTS, (20160512), vol. 15, no. 8, doi:10.1016/j.celrep.2016.04.048, ISSN 2211-1247, pages 1715 - 1727, XP055511358 [A] 1,2,5-54,56-103,105-115,117,119-165,171-177,179-217,225 * figures 2,4 *

DOI:   http://dx.doi.org/10.1016/j.celrep.2016.04.048
 [A]  - TOMICIC MAJA T ET AL, "Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20130408), vol. 1833, no. 8, doi:10.1016/J.BBAMCR.2013.03.029, ISSN 0167-4889, pages 1832 - 1843, XP028557924 [A] 1,2,5-54,56-103,105-115,117,119-165,171-177,179-217,225 * figure 8 *

DOI:   http://dx.doi.org/10.1016/j.bbamcr.2013.03.029
 [Y]  - RAEANNA WILSON ET AL, "MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment", NATURE COMMUNICATIONS, GB, (20161125), vol. 7, doi:10.1038/ncomms13597, ISSN 2041-1723, page 13597, XP055512101 [Y] 41,45,47,69,70 * figures 3-5 *

DOI:   http://dx.doi.org/10.1038/ncomms13597
 [A]  - BIN YU ET AL, "Explicit hypoxia targeting with tumor suppression by creating an "obligate" anaerobic Salmonella Typhimurium strain", SCIENTIFIC REPORTS, (20120601), vol. 2, doi:10.1038/srep00436, XP055176169 [A] 1,2,5-54,56-103,105-115,117,119-165,171-177,179-217,225 * page 8 *

DOI:   http://dx.doi.org/10.1038/srep00436
 [A]  - ULRICH METHNER ET AL, "Salmonella Enteritidis with double deletion in phoP fliC - A potential live Salmonella vaccine candidate with novel characteristics for use in chickens", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 29, no. 17, doi:10.1016/J.VACCINE.2011.02.030, ISSN 0264-410X, (20110224), pages 3248 - 3253, (20110216), XP028380401 [A] 1,2,5-54,56-103,105-115,117,119-165,171-177,179-217,225 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.vaccine.2011.02.030
 [A]  - YUE JAI KANG ET AL, "Preventive and therapeutic effects of auxotrophic Edwardsiella tarda mutant harboring CpG 1668 motif-enriched plasmids against scuticociliatosis in olive flounder (Paralichthys olivaceus)", EXPERIMENTAL PARASITOLOGY, US, (20140612), vol. 144, doi:10.1016/j.exppara.2014.06.007, ISSN 0014-4894, pages 34 - 38, XP055512164 [A] 1,2,5-54,56-103,105-115,117,119-165,171-177,179-217,225 * figures 1,2 *

DOI:   http://dx.doi.org/10.1016/j.exppara.2014.06.007
 [A]  - DEWAN MD SAKIB HOSSAIN ET AL, "Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity", BLOOD, (20131029), vol. 123, no. 1, doi:10.1182/blood-2013-07-, pages 15 - 25, XP055512071 [A] 1,2,5-54,56-103,105-115,117,119-165,171-177,179-217,225 * abstract *

DOI:   http://dx.doi.org/10.1182/blood-2013-07-
 [A]  - PAULINA CHOROBIK ET AL, "Salmonella and cancer: from pathogens to therapeutics", ACTA BIOCHIMICA POLONICA, (20130705), vol. 60, no. 3, pages 285 - 297, XP055511316 [A] 1,2,5-54,56-103,105-115,117,119-165,171-177,179-217,225 * tables 2,3 *
 [Y]  - A. FAULDS-PAIN ET AL, "Flagellin Redundancy in Caulobacter crescentus and Its Implications for Flagellar Filament Assembly", JOURNAL OF BACTERIOLOGY, US, (20110325), vol. 193, no. 11, doi:10.1128/JB.01172-10, ISSN 0021-9193, pages 2695 - 2707, XP055532473 [Y] 3-54,57,58,60-103,105-114,119-165,171-177,185,194,196,202-207,210-215,225 * table 1 *

DOI:   http://dx.doi.org/10.1128/JB.01172-10
 [A]  - BROADWAY KATHERINE M ET AL, "Rescuing chemotaxis of the anticancer agent Salmonella enterica serovar Typhimurium VNP20009", JOURNAL OF BIOTECHNOLOGY, ELSEVIER, AMSTERDAM, NL, (20150719), vol. 211, doi:10.1016/J.JBIOTEC.2015.07.010, ISSN 0168-1656, pages 117 - 120, XP029273086 [A] 3-54,57,58,60-103,105-114,119-165,171-177,185,194,196,202-207,210-215,225 * page 118; table 1 *

DOI:   http://dx.doi.org/10.1016/j.jbiotec.2015.07.010
 [A]  - QIONG LIU ET AL, "Outer membrane vesicles from flagellin-deficient Salmonella enterica serovar Typhimurium induce cross-reactive immunity and provide cross-protection against heterologous Salmonella challenge", SCIENTIFIC REPORTS, (20161004), vol. 6, no. 1, doi:10.1038/srep34776, XP055486078 [A] 3-54,57,58,60-103,105-114,119-165,171-177,185,194,196,202-207,210-215,225 * table 1 *

DOI:   http://dx.doi.org/10.1038/srep34776
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DOI:   http://dx.doi.org/10.4068/cmj.2016.52.3.173
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