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EP About this file: EP3645530

EP3645530 - BRANCHED MULTI-FUNCTIONAL MACROMONOMERS AND RELATED POLYMERS AND USES THEREOF [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  23.04.2021
Database last updated on 09.09.2024
FormerRequest for examination was made
Status updated on  03.04.2020
FormerThe international publication has been made
Status updated on  04.01.2019
Formerunknown
Status updated on  24.08.2018
Most recent event   Tooltip28.06.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge, MA 02139 / US
[2020/19]
Inventor(s)01 / JOHNSON, Jeremiah, A.
46 Lawrence Street
Boston MA 02116 / US
02 / GALLAGHER, Nolan
513 Putname Avenue
Cambridge MA 02139 / US
03 / VOHIDOV, Farrukh
133 Reed Street
Cambridge MA 02140-1706 / US
04 / JIANG, Yivan
27 Kettell Plain Road
Stow MA 02105 / US
05 / NGUYEN, Hung, Vanthanh
4 Bishop Allen Drive Apt. 2
Cambridge MA 02139 / US
[N/P]
Former [2020/19]01 / JOHNSON, Jeremiah, A.
46 Lawrence Street
Boston MA 02116 / US
02 / GALLAGHER, Nolan
513 Putname Avenue
Cambridge MA 02139 / US
03 / VOHIDOV, Farrukh
120 Palmer Street
Arlington MA 02474 / US
04 / JIANG, Yivan
27 Kettell Plain Road
Stow MA 02105 / US
05 / NGUYEN, Hung, Vanthanh
4 Bishop Allen Drive Apt. 2
Cambridge MA 02139 / US
Representative(s)Crooks, Elizabeth Caroline, et al
Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL / GB
[2020/19]
Application number, filing date18753265.029.06.2018
[2020/19]
WO2018US40496
Priority number, dateUS201762528010P30.06.2017         Original published format: US 201762528010 P
[2020/19]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2019006426
Date:03.01.2019
Language:EN
[2019/01]
Type: A2 Application without search report 
No.:EP3645530
Date:06.05.2020
Language:EN
The application published by WIPO in one of the EPO official languages on 03.01.2019 takes the place of the publication of the European patent application.
[2020/19]
Search report(s)International search report - published on:EP14.02.2019
ClassificationIPC:C07D405/14, C07D403/14, C08G61/08, A61P35/00, A61K31/785, A61K47/50
[2020/19]
CPC:
A61K47/595 (EP,KR,US); C07D403/14 (EP,KR,US); A61K47/18 (US);
A61K47/34 (KR,US); A61K49/0054 (KR); A61P35/00 (EP,KR,US);
A61P9/12 (KR); B01J31/2278 (US); C07D405/14 (EP,KR,US);
C08G61/08 (EP,KR,US); C08G69/48 (US); C08G83/00 (US);
C08G83/008 (KR); C08L71/02 (EP,US); G01N33/574 (US);
B01J2523/821 (US); C08G2261/135 (EP,KR,US); C08G2261/136 (EP,KR,US);
C08G2261/1414 (EP,KR,US); C08G2261/1424 (EP,KR,US); C08G2261/1426 (EP,KR,US);
C08G2261/1432 (EP,KR,US); C08G2261/418 (EP,KR,US); C08G2261/76 (EP,KR,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/19]
TitleGerman:VERZWEIGTE MULTIFUNKTIONELLE MAKROMONOMERE UND VERWANDTE POLYMERE UND DEREN VERWENDUNG[2020/19]
English:BRANCHED MULTI-FUNCTIONAL MACROMONOMERS AND RELATED POLYMERS AND USES THEREOF[2020/19]
French:MACROMONOMÈRES MULTIFONCTIONNELS RAMIFIÉS ET POLYMÈRES APPARENTÉS ET UTILISATIONS ASSOCIÉES[2020/19]
Entry into regional phase29.01.2020National basic fee paid 
29.01.2020Designation fee(s) paid 
29.01.2020Examination fee paid 
Examination procedure29.01.2020Examination requested  [2020/19]
29.01.2020Date on which the examining division has become responsible
07.09.2020Amendment by applicant (claims and/or description)
22.04.2021Despatch of a communication from the examining division (Time limit: M04)
31.08.2021Reply to a communication from the examining division
26.10.2022Despatch of a communication from the examining division (Time limit: M04)
03.03.2023Reply to a communication from the examining division
Fees paidRenewal fee
29.06.2020Renewal fee patent year 03
28.06.2021Renewal fee patent year 04
27.06.2022Renewal fee patent year 05
27.06.2023Renewal fee patent year 06
27.06.2024Renewal fee patent year 07
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Cited inInternational search[AD]WO2014169073  (MASSACHUSETTS INST TECHNOLOGY [US]) [AD] 1,2,13-156 * figures 1A-1, 1A-2,7,8A, 8B, 15A; claims 11-30 *;
 [A]  - JEREMIAH A JOHNSON ET AL, "Core-Clickable PEG-Branch-Azide Bivalent-Bottle-Brush Polymers by ROMP: Grafting-Through and Clicking-To", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY|, vol. 133, no. 3, doi:10.1021/JA108441D, ISSN 0002-7863, (20111107), pages 559 - 566, (20101213), XP002662878 [A] 1,2,13-156 * the whole document *

DOI:   http://dx.doi.org/10.1021/ja108441d
 [A]  - ALAN O. BURTS ET AL, "Using EPR To Compare PEG- branch -nitroxide "Bivalent-Brush Polymers" and Traditional PEG Bottle-Brush Polymers: Branching Makes a Difference", MACROMOLECULES, US, (20121023), vol. 45, no. 20, doi:10.1021/ma301874d, ISSN 0024-9297, pages 8310 - 8318, XP055316511 [A] 1,2,13-156 * the whole document *

DOI:   http://dx.doi.org/10.1021/ma301874d
 [A]  - BARNES JONATHAN C ET AL, "Using an RNAi Signature Assay To Guide the Design of Three-Drug-Conjugated Nanoparticles with Validated Mechanisms, In Vivo Efficacy, and Low Toxicity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY|, vol. 138, no. 38, doi:10.1021/JACS.6B06321, ISSN 0002-7863, (20160928), pages 12494 - 12501, (20160914), XP002773230 [A] 1,2,13-156 * the whole document *

DOI:   http://dx.doi.org/10.1021/jacs.6b06321
by applicantUS5811515
 WO03079972
 US7495099
 US8513390
 US8541203
 US8580244
 WO2013169739
 US9381253
    - Macromolecules, (20100000), vol. 43, page 10326
    - LIAO, L.; LIU, J.; DREADEN, E. C.; MORTON, S. W.; SHOPSOWITZ, K. E.; HAMMOND, P. T; JOHNSON, J. A., JACS, (20140000), vol. 136, page 5896
    - BARNES, J. C.; BRUNO, P. M.; NGUYEN, H. V.-T.; LIAO, L.; LIU, J.; HEMANN, M. T.; JOHNSON, J. A., JACS, (20160000), vol. 138, page 12494
    - Handbook of Chemistry and Physics
    - WILEN et al., Tetrahedron, (19770000), vol. 33, page 2725
    - WILEN, S.H., Tables of Resolving Agents and Optical Resolutions, Univ. of Notre Dame Press, (19720000), page 268
    - J. Pharmaceutical Sciences, (19770000), vol. 66, pages 1 - 19
    - KOLB; FINN; SHARPLESS, Angewandte Chemie International Edition, (20010000), vol. 40, pages 2004 - 2021
    - EVANS, Australian Journal of Chemistry, (20070000), vol. 60, pages 384 - 395
    - KOLB, H. C.; FINN, M. G.; SHARPLESS, K. B., Angew. Chem. Int. Ed., (20010000), vol. 40, pages 2004 - 2021
    - KOLB, H. C.; SHARLESS, K. B., Drug Disc. Today, (20030000), vol. 8, pages 112 - 1137
    - ROSTOVTSEV, V. V.; GREEN L. G.; FOKIN, V. V.; SHRAPLESS, K. B., Angew. Chem. Int. Ed., (20020000), vol. 41, pages 2596 - 2599
    - TOMOE, C. W.; CHRISTENSEN, C.; MELDAL, M., J. Org. Chem., (20020000), vol. 67, pages 3057 - 3064
    - WANG, Q. et al., J. Am. Chem. Soc., (20030000), vol. 125, pages 3192 - 3193
    - LEE, L. V. et al., J. Am. Chem. Soc., (20030000), vol. 125, pages 9588 - 9589
    - LEWIS, W. G. et al., Angew. Chem. Int. Ed., (20020000), vol. 41, pages 1053 - 41057
    - MANETSCH, R. et al., J. Am. Chem. Soc., (20040000), vol. 126, pages 12809 - 12818
    - MOCHARLA, V. P. et al., Angew. Chem., Int. Ed., (20050000), vol. 44, pages 116 - 120
    - CHU, B., Annual Review of Physical Chemistry, (19700000), vol. 21, pages 145 - 174
    - STEPTO, R. F. T. et al., Pure Appl. Chem., (20090000), vol. 81, pages 351 - 353
    - Harrison's Principles of Internal Medicine, McGraw-Hill
    - GOODMAN; OILMAN, The Pharmacological Basis of Therapeutics
    - AIME et al., Chemical Society Reviews, (19980000), vol. 27, pages 19 - 29
    - VAN KEMPEN et al., Eur Cancer, (20060000), vol. 42, pages 728 - 734
    - DESNOYERS, L.R. et al., Sci Transl Med, (20130000), vol. 5, page 207ra144
    - RICE, J.J. et al., Protein Sci, (20060000), vol. 15, pages 825 - 836
    - BOULWARE, K.T.; DAUGHERTY, P.S., Proc Natl Acad Sci USA, (20060000), vol. 103, pages 7583 - 7588
    - DEPERTHES, D. Biol Chem, (20020000), vol. 383, pages 1107 - 1112
    - HARRIS, J.L., Proc Natl Acad Sci USA, (20000000), vol. 97, pages 7754 - 7759
    - SALMASO S.; CALICETI, P., J Drug Deliv, (20130000), vol. 2013, pages 1 - 19
    - S. ULISSE et al., Curr. Cancer Drug Targets, (20090000), vol. 9, pages 32 - 71
    - K. UHLAND, Cell. Mol. Life Sci., (20060000), vol. 63, pages 2968 - 2978
    - A. M. LEBEAU et al., Proc. Natl. Acad. Sci. U.S.A., (20130000), vol. 110, pages 93 - 98
    - C. LIU et al., Cancer Res., (20030000), vol. 63, pages 2957 - 2964
    - K. T. BOULWARE; P. S. DAUGHERTY, Proc. Natl. Acad. Sci. U.S.A., (20060000), vol. 103, pages 7583 - 7588
    - LIU et al., J. Am. Chem. Soc., (20120000), vol. 134, page 16337
    - LIU, J.; GAO, A. X.; JOHNSON, J. A., J Vis Exp, (20130000), page e50874
    - GRUBBS et al., Acc. Chem. Res., (19950000), vol. 28, pages 446 - 452
    - SCHROCK et al., Organometallics, (19820000), page 1 1645
    - GALLIVAN et al., Tetrahedron Letters, (20050000), vol. 46, pages 2577 - 2580
    - FURSTNER et al., J. Am. Chem. Soc., (19990000), vol. 121, page 9453
    - Chem. Eur. J., (20010000), vol. 7, page 5299
    - RZAYEV, J., "Molecular Bottlebrushes: New Opportunities in Nanomaterials Fabrication", ACS Macro Letters, (20120000), vol. 1, pages 1146 - 1149
    - SHEIKO, S. S.; SUMERLIN, B. S.; MATYJASZEWSKI, K., "Cylindrical molecular brushes: Synthesis, characterization, and properties", Progress in Polymer Science, (20080000), vol. 33, doi:doi:10.1016/j.progpolymsci.2008.05.001, pages 759 - 785, XP023906892

DOI:   http://dx.doi.org/10.1016/j.progpolymsci.2008.05.001
    - LEE, H.-I.; PIETRASIK, J.; SHEIKO, S. S.; MATYJASZEWSKI, K., "Stimuli-responsive molecular brushes. Progress in", Polymer Science, (20100000), vol. 35, pages 24 - 44, XP026852561
    - XIA, Y.; OLSEN, B. D.; KORNFIELD, J. A.; GRUBBS, R. H., "Efficient Synthesis of Narrowly Dispersed Brush Copolymers and Study of Their Assemblies: The Importance of Side Chain Arrangement", Journal of the American Chemical Society, (20090000), vol. 131, pages 18525 - 18532
    - XIA, Y.; KORNFIELD, J. A.; GRUBBS, R. H., "Efficient Synthesis of Narrowly Dispersed Brush Polymers via Living Ring-Opening Metathesis Polymerization of Macromonomers", Macromolecules, (20090000), vol. 42, doi:doi:10.1021/ma900280c, pages 3761 - 3766, XP001523725

DOI:   http://dx.doi.org/10.1021/ma900280c
    - VERDUZCO, R.; LI, X.; PESEK, S. L.; STEIN, G. E., "Structure, function, self-assembly, and applications of bottlebrush copolymers", Chemical Society Reviews, (20150000), vol. 44, doi:doi:10.1039/C4CS00329B, pages 2405 - 2420, XP055439360

DOI:   http://dx.doi.org/10.1039/C4CS00329B
    - MIYAKE, G. M.; PIUNOVA, V. A.; WEITEKAMP, R. A.; GRUBBS, R. H., "Precisely Tunable Photonic Crystals From Rapidly Self-Assembling Brush Block Copolymer Blends", Angewandte Chemie International Edition, (20120000), vol. 51, pages 11246 - 11248
    - BARNES, J. C.; BRUNO, P. M.; NGUYEN, H. V. T.; LIAO, L.; LIU, J.; HEMANN, M. T.; JOHNSON, J. A., "Using an RNAi Signature Assay To Guide the Design of Three-Drug-Conjugated Nanoparticles with Validated Mechanisms, In Vivo Efficacy, and Low Toxicity", Journal of the American Chemical Society, (20160000), vol. 138, doi:doi:10.1021/jacs.6b06321, pages 12494 - 12501, XP002773230

DOI:   http://dx.doi.org/10.1021/jacs.6b06321
    - KAWAMOTO, K.; ZHONG, M.; GADELRAB, K. R.; CHENG, L.-C.; ROSS, C. A.; ALEXANDER-KATZ, A.; JOHNSON, J. A., "Graft-through Synthesis and Assembly of Janus Bottlebrush Polymers from A-Branch-B Diblock Macromonomers", Journal of the American Chemical Society, (20160000), vol. 138, pages 11501 - 11504
    - REN, J. M.; MCKENZIE, T. G.; FU, Q.; WONG, E. H. H.; XU, J.; AN, Z.; SHANMUGAM, S.; DAVIS, T. P.; BOYER, C.; QIAO, G. G., "Star Polymers", Chemical Reviews, (20160000), vol. 116, pages 6743 - 6836
    - LIAO, L.; LIU, J.; DREADEN, E. C.; MORTON, S. W.; SHOPSOWITZ, K. E.; HAMMOND, P. T.; JOHNSON, J. A., "A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin", Journal of the American Chemical Society, (20140000), vol. 136, doi:doi:10.1021/ja502011g, pages 5896 - 5899, XP055316305

DOI:   http://dx.doi.org/10.1021/ja502011g
    - SVEINBJORNSSON, B. R.; WEITEKAMP, R. A.; MIYAKE, G. M.; XIA, Y.; ATWATER, H. A.; GRUBBS, R. H., "Rapid self-assembly of brush block copolymers to photonic crystals", Proceedings of the National Academy of Sciences, (20120000), vol. 109, pages 14332 - 14336
    - FOX, M. E.; SZOKA, F. C.; FRECHET, J. M. J., "Soluble Polymer Carriers for the Treatment of Cancer: The Importance of Molecular Architecture", Accounts of Chemical Research, (20090000), vol. 42, pages 1141 - 1151
    - PEER, D.; KARP, J. M.; HONG, S.; FAROKHZAD, O. C.; MARGALIT, R.; LANGER, R., "Nanocarriers as an emerging platform for cancer therapy", Nat Nano, (20070000), vol. 2, doi:doi:10.1038/nnano.2007.387, pages 751 - 760, XP002531251

DOI:   http://dx.doi.org/10.1038/nnano.2007.387
    - MAEDA, H.; BHARATE, G. Y.; DARUWALLA, J., "Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect", European Journal of Pharmaceutics and Biopharmaceutics, (20090000), vol. 71, doi:doi:10.1016/j.ejpb.2008.11.010, pages 409 - 419, XP025992163

DOI:   http://dx.doi.org/10.1016/j.ejpb.2008.11.010
    - GAO, A. X.; LIAO, L.; JOHNSON, J. A., "Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP", ACS Macro Letters, (20140000), vol. 3, doi:doi:10.1021/mz5004097, pages 854 - 857, XP055316376

DOI:   http://dx.doi.org/10.1021/mz5004097
    - DUNCAN, R., "The dawning era of polymer therapeutics", Nat Rev Drug Discov, (20030000), vol. 2, doi:doi:10.1038/nrd1088, pages 347 - 360, XP008034297

DOI:   http://dx.doi.org/10.1038/nrd1088
    - LIANG, L.; ASTRUC, D., "The copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) ''click'' reaction and its applications. An overview", Coordination Chemistry Reviews, (20110000), vol. 255, doi:doi:10.1016/j.ccr.2011.06.028, pages 2933 - 2945, XP028331278

DOI:   http://dx.doi.org/10.1016/j.ccr.2011.06.028
    - HEIN, J. E.; FOKIN, V. V., "Copper-catalyzed azide-alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(i) acetylides", Chemical Society Reviews, (20100000), vol. 39, pages 1302 - 1315
    - WORRELL, B. T.; MALIK, J. A.; FOKIN, V. V., "Direct Evidence of a Dinuclear Copper Intermediate in Cu(I)-Catalyzed Azide-Alkyne Cycloadditions", Science, (20130000), vol. 340, pages 457 - 460
    - HAN, S.-Y.; KIM, Y.-A., "Recent development of peptide coupling reagents in organic synthesis", Tetrahedron, (20040000), vol. 60, doi:doi:10.1016/j.tet.2004.01.020, pages 2447 - 2467, XP055538655

DOI:   http://dx.doi.org/10.1016/j.tet.2004.01.020
    - VALEUR, E.; BRADLEY, M., "Amide bond formation: beyond the myth of coupling reagents", Chemical Society Reviews, (20090000), vol. 38, pages 606 - 631
    - DUNETZ, J. R.; MAGANO, J.; WEISENBURGER, G. A., "Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals", Organic Process Research & Development, (20160000), vol. 20, doi:doi:10.1021/op500305s, pages 140 - 177, XP055321730

DOI:   http://dx.doi.org/10.1021/op500305s
    - EL-FAHAM, A.; ALBERICIO, F., "Peptide Coupling Reagents, More than a Letter Soup", Chemical Reviews, (20110000), vol. 111, pages 6557 - 6602
    - NEISES, B.; STEGLICH, W., "Simple Method for the Esterification of Carboxylic Acids", Angewandte Chemie International Edition in English, (19780000), vol. 17, doi:doi:10.1002/anie.197805221, pages 522 - 524, XP002656658

DOI:   http://dx.doi.org/10.1002/anie.197805221
    - BURTS, A. O.; LIAO, L.; LU, Y. Y.; TIRRELL, D. A.; JOHNSON, J. A., "Brush-first and Click: Efficient Synthesis of Nanoparticles that Degrade and Release Doxorubicin in Response to Light", Photochemistry and Photobiology, (20140000), vol. 90, pages 380 - 385
    - LIU, J.; BURTS, A. O.; LI, Y.; ZHUKHOVITSKIY, A. V.; OTTAVIANI, M. F.; TURRO, N. J.; JOHNSON, J. A., "Brush-First'' Method for the Parallel Synthesis of Photocleavable, Nitroxide-Labeled Poly(ethylene glycol) Star Polymers", Journal of the American Chemical Society, (20120000), vol. 134, doi:doi:10.1021/ja3067176, pages 16337 - 16344, XP055287280

DOI:   http://dx.doi.org/10.1021/ja3067176
    - SOWERS, M. A.; MCCOMBS, J. R.; WANG, Y.; PALETTA, J. T.; MORTON, S. W.; DREADEN, E. C.; BOSKA, M. D.; OTTAVIANI, M. F.; HAMMOND, P, "Redox-responsive branched-bottlebrush polymers for in vivo MRI and fluorescence imaging", Nature Communications, (20140000), vol. 5, page 5460
    - JOHNSON, J. A.; LU, Y. Y.; BURTS, A. O.; XIA, Y.; DURRELL, A. C.; TIRRELL, D. A.; GRUBBS, R. H., "Drug-Loaded, Bivalent-Bottle-Brush Polymers by Graft-through ROMP", Macromolecules, (20100000), vol. 43, doi:doi:10.1021/ma1021506, pages 10326 - 10335, XP055287259

DOI:   http://dx.doi.org/10.1021/ma1021506
    - PATEL, P. R.; KISER, R. C.; LU, Y. Y.; FONG, E.; HO, W. C.; TIRRELL, D. A.; GRUBBS, R. H., "Synthesis and Cell Adhesive Properties of Linear and Cyclic RGD Functionalized Polynorbomene Thin Films", Biomacromolecules, (20120000), vol. 13, pages 2546 - 2553
    - ROY, O.; FAURE, S.; THERY, V.; DIDIERJEAN, C.; TAILLEFUMIER, C., "Cyclic P-Peptoids", Organic Letters, (20080000), vol. 10, pages 921 - 924
    - "Protection for the Carboxyl Group", WUTS, P. G. M.; GREENE, T. W., Greene's Protective Groups in Organic Synthesis, John Wiley & Sons, Inc., (20060000), pages 533 - 646
    - XIA, Y.; LI, Y.; BURTS, A. O.; OTTAVIANI, M. F.; TIRRELL, D. A.; JOHNSON, J. A.; TURRO, N. J.; GRUBBS, R. H., "EPR Study of Spin Labeled Brush Polymers in Organic Solvents", Journal of the American Chemical Society, (20110000), vol. 133, pages 19953 - 19959
    - JORALEMON, M. J.; MCRAE, S.; EMRICK, T., "PEGylated polymers for medicine: from conjugation to self-assembled systems", Chemical Communications, (20100000), vol. 46, pages 1377 - 1393
    - TORCHILIN, V., "Tumor delivery of macromolecular drugs based on the EPR effect", Advanced Drug Delivery Reviews, (20110000), vol. 63, doi:doi:10.1016/j.addr.2010.03.011, pages 131 - 135, XP028158140

DOI:   http://dx.doi.org/10.1016/j.addr.2010.03.011
    - ANRAKU, Y.; KISHIMURA, A.; KOBAYASHI, A.; OBA, M.; KATAOKA, K., "Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues", Chemical Communications, (20110000), vol. 47, pages 6054 - 6056
    - CABRAL, H.; MATSUMOTO, Y.; MIZUNOK; CHEN, Q.; MURAKAMI, M.; KIMURA, M.; TERADA, Y.; KANO, M. R.; MIYAZONO, K.; UESAKA, M., "Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size", Nat Nano, (20110000), vol. 6, doi:doi:10.1038/nnano.2011.166, pages 815 - 823, XP055243966

DOI:   http://dx.doi.org/10.1038/nnano.2011.166
    - BURTS, A. O.; GAO, A. X.; JOHNSON, J. A., "Brush-First Synthesis of Core-Photodegradable Miktoarm Star Polymers via ROMP: Towards Photoresponsive Self-Assemblies", Macromolecular Rapid Communications, (20140000), vol. 35, doi:doi:10.1002/marc.201300618, pages 168 - 173, XP055316517

DOI:   http://dx.doi.org/10.1002/marc.201300618
    - LOVE, J. A.; MORGAN, J. P.; TRNKA, T. M.; GRUBBS, R. H., "A Practical and Highly Active Ruthenium-based Catalyst that Effects the Cross Metathesis of Acrylonitrile", Angew. Chem. Int. Ed., (20020000), vol. 41, pages 4035 - 4037
    - JOHNSON, J. A.; LU, Y. Y.; BURTS, A. O.; XIA, Y.; DURRELL, A. C.; TIRRELL, D. A.; GRUBBS, R. H., "Drug-loaded, Bivalent-bottle-brush Polymers by Graft-through ROMP", Macromolecules, (20100000), vol. 43, doi:doi:10.1021/ma1021506, pages 10326 - 10335, XP055287259

DOI:   http://dx.doi.org/10.1021/ma1021506
    - LIU, J.; BURTS, A. O.; LI, Y.; ZHUKHOVITSKIY, A. V.; OTTAVIANI, M. F.; TURRO, N. J.; JOHNSON, J. A., "Brush-first'' Method for the Parallel Synthesis of Photocleavable, Nitroxide-labeled poly(ethylene glycol) Star Polymers", J. Am. Chem. Soc., (20120000), vol. 134, doi:doi:10.1021/ja3067176, pages 16337 - 16344, XP055287280

DOI:   http://dx.doi.org/10.1021/ja3067176
    - LIAO, L.; LIU, J.; DREADEN, E. C.; MORTON, S. W.; SHOPSOWITZ, K. E.; HAMMOND, P. T.; JOHNSON, J. A., "A Convergent Synthetic Platform for Single-nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin", J. Am. Chem. Soc., (20140000), vol. 136, doi:doi:10.1021/ja502011g, pages 5896 - 5899, XP055316305

DOI:   http://dx.doi.org/10.1021/ja502011g
    - ROY, O.; FAURE, S.; THERY, V.; DIDIERJEAN, C.; TAILLEFUMIER, C., "Cyclic β-peptoids", Org. Lett., (20080000), vol. 10, pages 921 - 924
    - PATEL, P. R.; KISER, R. C.; LU, Y. Y; FONG, E.; HO, W. C.; TIRRELL, D. A.; GRUBBS, R. H., "Synthesis and cell adhesive properties of linear and cyclic RGD functionalized polynorbomene thin films", Biomacromolecules, (20120000), vol. 13, pages 2546 - 2553
    - KAWAMOTO, K.; ZHONG, M.; GADELRAB, K. R.; CHENG, L.-C.; ROSS, C. A.; ALEXANDER-KATZ, A.; JOHNSON, J. A., "Graft-through Synthesis and Assembly of Janus Bottlebrush Polymers from A-Branch-B Diblock Macromonomers", J. Am. Chem. Soc., (20160000), vol. 138, pages 11501 - 11504
    - BURTS, A. O.; GAO, A. X.; JOHNSON, J. A., "Brush-first Synthesis of Core-photodegradable Miktoarm Star Polymer via ROM: Towards Photoresponsive Self-assemblies", Macromol. Rap. Commun., (20140000), vol. 35, pages 168 - 173
    - BUDIL, D. E.; LEE, S.; SAXENA, S.; FREED, J. H., "Nonlinear-least-square Analysis of Slow-motion EPR Spectra in One and Two Dimensions Using a Modified Levenberg- Marquardt-algorithm", J. Magn. Reson., Ser. A., (19960000), vol. 120, pages 155 - 189
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