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Extract from the Register of European Patents

EP About this file: EP3700513

EP3700513 - NON-STEROIDAL SELECTIVE GLUCOCORTICOID RECEPTOR AGONISTIC MODULATORS (SEGRAMS) AND USES THEREOF [Right-click to bookmark this link]
Former [2020/36]NON-STEROIDAL SELECTIVE GLUCOCORTICOID RECEPTOR AGONISTIC MODULATORS (SEGRAMs) AND USES THEREOF
[2022/14]
StatusNo opposition filed within time limit
Status updated on  30.06.2023
Database last updated on 03.10.2024
FormerThe patent has been granted
Status updated on  22.07.2022
FormerGrant of patent is intended
Status updated on  24.03.2022
FormerExamination is in progress
Status updated on  11.12.2020
FormerRequest for examination was made
Status updated on  31.07.2020
FormerThe international publication has been made
Status updated on  04.05.2019
Formerunknown
Status updated on  27.10.2018
Most recent event   Tooltip27.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 30.10.2024 [2024/44]
Applicant(s)For all designated states
Association pour la recherche à l'IGBMC (ARI)
4 rue du Dr Albert Schweitzer
67113 Blaesheim / FR
[2022/16]
Former [2020/36]For all designated states
Association pour la recherche à l'IGBMC (ARI)
4 rue du Dr. Albert
67113 Blaesheim / FR
Inventor(s)01 / CHAMBON, Pierre
4 rue du Dr Albert Schweitzer
67113 Blaesheim / FR
02 / HUA, Guoqiang
4 rue Georges Laufenburger
67400 Illkirch-Graffenstaden / FR
 [2020/36]
Representative(s)Icosa
83 avenue Denfert-Rochereau
75014 Paris / FR
[2020/36]
Application number, filing date18786823.723.10.2018
[2020/36]
WO2018EP79049
Priority number, dateUS201762578036P27.10.2017         Original published format: US 201762578036 P
EP2018030561217.05.2018         Original published format: EP 18305612
[2020/36]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2019081517
Date:02.05.2019
Language:EN
[2019/18]
Type: A2 Application without search report 
No.:EP3700513
Date:02.09.2020
Language:EN
The application published by WIPO in one of the EPO official languages on 02.05.2019 takes the place of the publication of the European patent application.
[2020/36]
Type: B1 Patent specification 
No.:EP3700513
Date:24.08.2022
Language:EN
[2022/34]
Search report(s)International search report - published on:EP20.06.2019
ClassificationIPC:A61K31/137, A61K31/365, A61K31/381, A61K31/343, A61P11/06, A61P17/00, A61P29/00, A61P17/06, A61P1/00, C07D307/88, C07D201/00
[2022/14]
CPC:
A61K31/343 (EP,KR,US); C07D307/88 (EP,KR); A61K31/137 (EP);
A61K31/365 (EP); A61K31/381 (EP); A61P1/00 (EP,KR);
A61P1/04 (US); A61P11/06 (EP,KR,US); A61P17/00 (EP,KR,US);
A61P17/06 (EP,KR,US); A61P19/02 (US); A61P27/14 (US);
A61P29/00 (EP,KR,US) (-)
Former IPC [2020/36]A61K31/137, A61K31/343, A61K31/381, C07D201/00, C07D307/88, A61P1/00, A61P17/06, A61P29/00, A61P17/00, A61P11/06
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/36]
Extension statesBA27.05.2020
ME27.05.2020
Validation statesKH27.05.2020
MA27.05.2020
MD27.05.2020
TN27.05.2020
TitleGerman:NICHTSTEROIDALE SELEKTIVE GLUCOCORTICOID-REZEPTOR-AGONISTISCHE MODULATOREN (SEGRAMS) UND VERWENDUNGEN DAVON[2020/36]
English:NON-STEROIDAL SELECTIVE GLUCOCORTICOID RECEPTOR AGONISTIC MODULATORS (SEGRAMS) AND USES THEREOF[2022/14]
French:MODULATEURS AGONISTES DE RÉCEPTEURS DE GLUCOCORTICOÏDES SÉLECTIFS (SEGRAMS) NON STÉROÏDIENS ET LEURS UTILISATIONS[2020/36]
Former [2020/36]NON-STEROIDAL SELECTIVE GLUCOCORTICOID RECEPTOR AGONISTIC MODULATORS (SEGRAMs) AND USES THEREOF
Entry into regional phase27.05.2020National basic fee paid 
27.05.2020Designation fee(s) paid 
27.05.2020Examination fee paid 
Examination procedure29.04.2020Amendment by applicant (claims and/or description)
27.05.2020Examination requested  [2020/36]
27.05.2020Date on which the examining division has become responsible
10.12.2020Despatch of a communication from the examining division (Time limit: M04)
16.02.2021Reply to a communication from the examining division
15.09.2021Despatch of a communication from the examining division (Time limit: M04)
01.10.2021Reply to a communication from the examining division
25.03.2022Communication of intention to grant the patent
13.07.2022Fee for grant paid
13.07.2022Fee for publishing/printing paid
13.07.2022Receipt of the translation of the claim(s)
Opposition(s)25.05.2023No opposition filed within time limit [2023/31]
Fees paidRenewal fee
21.09.2020Renewal fee patent year 03
21.10.2021Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU23.10.2018
AL24.08.2022
BG24.08.2022
CY24.08.2022
CZ24.08.2022
EE24.08.2022
HR24.08.2022
LT24.08.2022
LV24.08.2022
MC24.08.2022
MK24.08.2022
MT24.08.2022
RO24.08.2022
RS24.08.2022
SI24.08.2022
SK24.08.2022
SM24.08.2022
GR25.11.2022
IS24.12.2022
[2024/44]
Former [2024/34]HU23.10.2018
AL24.08.2022
BG24.08.2022
CY24.08.2022
CZ24.08.2022
EE24.08.2022
HR24.08.2022
LT24.08.2022
LV24.08.2022
MC24.08.2022
MK24.08.2022
RO24.08.2022
RS24.08.2022
SI24.08.2022
SK24.08.2022
SM24.08.2022
GR25.11.2022
IS24.12.2022
Former [2024/27]HU23.10.2018
AL24.08.2022
CY24.08.2022
CZ24.08.2022
EE24.08.2022
HR24.08.2022
LT24.08.2022
LV24.08.2022
MC24.08.2022
MK24.08.2022
RO24.08.2022
RS24.08.2022
SI24.08.2022
SK24.08.2022
SM24.08.2022
GR25.11.2022
IS24.12.2022
Former [2024/24]HU23.10.2018
AL24.08.2022
CY24.08.2022
CZ24.08.2022
EE24.08.2022
HR24.08.2022
LT24.08.2022
LV24.08.2022
MC24.08.2022
RO24.08.2022
RS24.08.2022
SI24.08.2022
SK24.08.2022
SM24.08.2022
GR25.11.2022
IS24.12.2022
Former [2024/21]AL24.08.2022
CY24.08.2022
CZ24.08.2022
EE24.08.2022
HR24.08.2022
LT24.08.2022
LV24.08.2022
MC24.08.2022
RO24.08.2022
RS24.08.2022
SI24.08.2022
SK24.08.2022
SM24.08.2022
GR25.11.2022
IS24.12.2022
Former [2023/37]AL24.08.2022
CZ24.08.2022
EE24.08.2022
HR24.08.2022
LT24.08.2022
LV24.08.2022
MC24.08.2022
RO24.08.2022
RS24.08.2022
SI24.08.2022
SK24.08.2022
SM24.08.2022
GR25.11.2022
IS24.12.2022
Former [2023/29]AL24.08.2022
CZ24.08.2022
EE24.08.2022
HR24.08.2022
LT24.08.2022
LV24.08.2022
MC24.08.2022
RO24.08.2022
RS24.08.2022
SK24.08.2022
SM24.08.2022
GR25.11.2022
IS24.12.2022
Former [2023/25]CZ24.08.2022
EE24.08.2022
HR24.08.2022
LT24.08.2022
LV24.08.2022
MC24.08.2022
RO24.08.2022
RS24.08.2022
SK24.08.2022
SM24.08.2022
GR25.11.2022
IS24.12.2022
Former [2023/23]CZ24.08.2022
EE24.08.2022
HR24.08.2022
LT24.08.2022
LV24.08.2022
RO24.08.2022
RS24.08.2022
SK24.08.2022
SM24.08.2022
GR25.11.2022
IS24.12.2022
Former [2023/22]CZ24.08.2022
HR24.08.2022
LT24.08.2022
LV24.08.2022
RO24.08.2022
RS24.08.2022
SM24.08.2022
GR25.11.2022
IS24.12.2022
Former [2023/20]HR24.08.2022
LT24.08.2022
LV24.08.2022
RS24.08.2022
SM24.08.2022
GR25.11.2022
IS24.12.2022
Former [2023/12]HR24.08.2022
LT24.08.2022
LV24.08.2022
RS24.08.2022
GR25.11.2022
IS24.12.2022
Former [2023/10]HR24.08.2022
LT24.08.2022
LV24.08.2022
RS24.08.2022
GR25.11.2022
Former [2023/09]LT24.08.2022
LV24.08.2022
RS24.08.2022
Former [2023/08]LT24.08.2022
RS24.08.2022
Cited inInternational search[XD]US6323199  (LEHMANN MANFRED [DE], et al) [XD] 1,3-10,17,19 * abstract * * column 1, line 29 - column 2, line 62 * * column 6, line 62 - column 10, line 38; example 42; claim - *;
 [A]US2006040933  (JAROCH STEFAN [DE], et al) [A] 1,3-12,15,16 * abstract *;
 [XI]  - GUOQIANG HUA ET AL, "Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (20151228), vol. 113, no. 5, doi:10.1073/pnas.1522826113, ISSN 0027-8424, pages E635 - E643, XP055517008 [X] 1,3-12,15-19 * the whole document * [I] 2,13,14,20,21

DOI:   http://dx.doi.org/10.1073/pnas.1522826113
 [X]  - MIKE BARKER ET AL, "Design and Synthesis of New Nonsteroidal Glucocorticoid Modulators through Application of an "Agreement Docking" Method", JOURNAL OF MEDICINAL CHEMISTRY, (20050701), vol. 48, no. 14, doi:10.1021/jm050345y, ISSN 0022-2623, pages 4507 - 4510, XP055517287 [X] 1,3-6,15-17,19 * the whole document *

DOI:   http://dx.doi.org/10.1021/jm050345y
 [A]  - FOSTER A B, "Deuterium isotope effects in the metabolism of drugs and xenobiotics: implications for drug design", ADVANCES IN DRUG RESEA, ACADEMIC PRESS, LONDON, GB, (19850101), vol. 14, ISSN 0065-2490, pages 1 - 40, XP009086953 [A] 1-21 * the whole document *
Examination   - GUOQIANG HUA ET AL, "Glucocorticoid receptor modulators CpdX and CpdX-D3 exhibit the same in vivo antiinflammatory activities as synthetic glucocorticoids", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20190621), vol. 116, no. 28, doi:10.1073/pnas.1908258116, ISSN 0027-8424, pages 14191 - 14199
by applicantUS5262165
 US5948433
 US6010715
 US6071531
 US6245804
 US6323199
    - NISSEN; YAMAMOTO, Genes Dev., (20000000), vol. 14, no. 18, pages 2314 - 29
    - YANG-YEN et al., Cell, (19900000), vol. 62, no. 6, pages 1205 - 15
    - SURJIT et al., Cell, (20110000), vol. 145, no. 2, pages 224 - 41
    - CARRYER et al., J Allergy, (19500000), vol. 21, no. 4, pages 282 - 7
    - ORAY et al., Expert Opin Drug Saf., (20160000), vol. 15, no. 4, pages 457 - 65
    - CURTIS et al., Arthritis Rheum., (20060000), vol. 55, no. 3, pages 420 - 6
    - PEREIRA et al., Clinics (Sao Paulo), (20100000), vol. 65, no. 11, pages 1197 - 1205
    - CLARK; BELVISI, Pharmacol Ther., (20120000), vol. 134, no. l, pages 54 - 67
    - SCHACKE et al., Proc Natl Acad Sci U S A., (20040000), vol. 101, no. l, pages 227 - 32
    - VAYSSIERE et al., Mol Endocrinol., (19970000), vol. 11, no. 9, pages 1245 - 55
    - BELVISI et al., J Immunol., (20010000), vol. 166, no. 3, pages 1975 - 82
    - CAVET et al., Mol Vis., (20100000), vol. 16, pages 1791 - 1800
    - SHAFIEE et al., Invest Ophthalmol Vis Sci., (20110000), vol. 52, no. 3, pages 1422 - 30
    - HUA et al., Proc Natl Acad Sci USA, (20160000), vol. 113, no. 5, pages 635 - 43
    - USSAR et al., PLoS Genet., (20080000), vol. 4, no. 12, page el000289
    - BRITTO et al., Am J Physiol Endocrinol Metab., (20140000), vol. 307, no. 11, pages 983 - 93
    - BAIDA et al., EMBO Mol Med., (20150000), vol. 7, no. l, pages 42 - 58
    - LI et al., Proc Natl Acad Sci U S A, (20060000), vol. 103, no. 31, pages 11736 - 41
    - PEARLMAN et al., Ann Allergy Asthma Immunol., (19970000), vol. 78, no. 4, pages 356 - 62
    - VINTER et al., Br J Dermatol., (20150000), vol. 172, no. 2, pages 345 - 53
    - INGLIS et al., Arthritis Res Ther., (20070000), vol. 9, no. 5, page 113
    - GEBOES et al., Arthritis Rheum., (20090000), vol. 60, no. 2, pages 390 - 5
    - GIMENES et al., Experimental Eye Research, (20150000), vol. 134, pages 24 - 32
    - SCHOEPE et al., Exp Dermatol., (20060000), vol. 15, no. 6, pages 406 - 20
    - CANALIS, Curr Opin Rheumatol., (20030000), vol. 15, no. 4, pages 454 - 7
    - GRAHNEMO et al., J Endocrinol., (20150000), vol. 224, no. 1, pages 97 - 108
    - ZHENG et al., PLoS Genet., (20120700), vol. 8, no. 7, page el002745
    - COHEN, Semin Immunol., (19920000), vol. 4, no. 6, pages 363 - 9
    - CLORE; THURBY-HAY, Endocr Pract., (20090000), vol. 15, no. 5, pages 469 - 74
    - GEER et al., Endocrinol Metab Clin North Am., (20140000), vol. 43, no. 1, pages 75 - 102
    - KIM et al., PLoS One, (20140000), vol. 9, no. 6, page e97841
    - ARANHA et al., Eur J Gastroenterol Hepatol., (20080000), vol. 20, no. 6, pages 519 - 25
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