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Extract from the Register of European Patents

EP About this file: EP3720546

EP3720546 - A SYSTEM FOR PLANNING AND/OR PROVIDING NEUROSTIMULATION FOR A PATIENT [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  05.01.2024
Database last updated on 03.09.2024
FormerThe patent has been granted
Status updated on  27.01.2023
FormerGrant of patent is intended
Status updated on  24.10.2022
FormerRequest for examination was made
Status updated on  11.09.2020
FormerThe international publication has been made
Status updated on  14.06.2019
Formerunknown
Status updated on  05.12.2018
Most recent event   Tooltip19.07.2024Lapse of the patent in a contracting state
New state(s): CH, LU		published on 21.08.2024  [2024/34]
Applicant(s)For all designated states
Ecole Polytechnique Fédérale de Lausanne (EPFL)
EPFL-TTO EPFL
Innovation Park J
1015 Lausanne / CH
For all designated states
ONWARD Medical N.V.
High Tech Campus 32
5656 AE Eindhoven / NL
[2022/51]
Former [2020/42]For all designated states
Ecole Polytechnique Fédérale de Lausanne (EPFL)
EPFL-TTO EPFL
Innovation Park J
1015 Lausanne / CH
For all designated states
GTX medical B.V.
High Tech Campus 32
5656 AE Eindhoven / NL
Inventor(s)01 / RASCHELLA, Flavio
Rue du Clos-de-Bulle 9
1004 Lausanne / CH
02 / MISERA, Silvestro
Rue de la Cité 9b
1204 Geneve / CH
03 / COURTINE, Gregoire
Place de l'Europe 2
1003 Lausanne / CH
04 / MILEKOVIC, Tomislav
Route des Arsenaux 31
1700 Fribourg / CH
05 / WAGNER, Fabien
25 Rue du Ruat
33000 Bordeaux / FR
06 / CAPOGROSSO, Marco
Rue de la Grotte 5
1003 Lausanne / CH
07 / BAKKER, Jurriaan
c/o GTX medical B.V.
High Tech Campus 32
5656 AE Eindhoven / NL
08 / BROUNS, Robin
c/o GTX medical B.V.
High Tech Campus 32
5656 AE Eindhoven / NL
09 / DELATTRE, Vincent
c/o GTX medical B.V.
High Tech Campus 32
5656 AE Eindhoven / NL
 [2023/09]
Former [2020/43]01 / RASCHELLA, Flavio
Rue du Clos-de-Bulle 9
1004 Lausanne / CH
02 / MISERA, Silvestro
Rue de la Cité 9b
1204 Geneve / CH
03 / COURTINE, Gregoire
Place de l'Europe 2
1003 Lausanne / CH
04 / MILEKOVIC, Tomislav
Rue de Lausanne 91
1202 Geneve / CH
05 / WAGNER, Fabien
25 Rue du Ruat
33000 Bordeaux / FR
06 / CAPOGROSSO, Marco
Rue de la Grotte 5
1003 Lausanne / CH
07 / BAKKER, Jurriaan
c/o GTX medical B.V.
High Tech Campus 32
5656 AE Eindhoven / NL
08 / BROUNS, Robin
c/o GTX medical B.V.
High Tech Campus 32
5656 AE Eindhoven / NL
09 / DELATTRE, Vincent
c/o GTX medical B.V.
High Tech Campus 32
5656 AE Eindhoven / NL
Former [2020/42]01 / RASCHELLA, Flavio
Rue du Clos-de-Bulle 9
1004 Lausanne / CH
02 / MISERA, Silvestro
Rue de la Cité 9b
1204 Geneve / CH
03 / COURTINE, Gregoire
Place de l'Europe 2
1003 Lausanne / CH
04 / MILEKOVIC, Tomislav
Rue de Lausanne 91
1202 Geneve / CH
05 / WAGNER, Fabien
Rue Pré-du-Marché 9B
1004 Lausanne / CH
06 / CAPOGROSSO, Marco
Rue de la Grotte 5
1003 Lausanne / CH
07 / BAKKER, Jurriaan
c/o GTX medical B.V.
High Tech Campus 32
5656 AE Eindhoven / NL
08 / BROUNS, Robin
c/o GTX medical B.V.
High Tech Campus 32
5656 AE Eindhoven / NL
09 / DELATTRE, Vincent
c/o GTX medical B.V.
High Tech Campus 32
5656 AE Eindhoven / NL
Representative(s)DTS Patent- und Rechtsanwälte PartmbB
Brienner Straße 1
80333 München / DE
[N/P]
Former [2023/09]DTS Patent- und Rechtsanwälte Schnekenbühl und Partner mbB
Brienner Straße 1
80333 München / DE
Former [2020/42]DTS Patent- und Rechtsanwälte Schnekenbühl und Partner mbB
Marstallstrasse 8
80539 München / DE
Application number, filing date18807368.829.11.2018
[2020/42]
WO2018EP82946
Priority number, dateEP2017020536205.12.2017         Original published format: EP 17205362
[2020/42]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019110401
Date:13.06.2019
Language:EN
[2019/24]
Type: A1 Application with search report 
No.:EP3720546
Date:14.10.2020
Language:EN
The application published by WIPO in one of the EPO official languages on 13.06.2019 takes the place of the publication of the European patent application.
[2020/42]
Type: B1 Patent specification 
No.:EP3720546
Date:01.03.2023
Language:EN
[2023/09]
Search report(s)International search report - published on:EP13.06.2019
ClassificationIPC:A61N1/36, A61B5/00
[2022/44]
CPC:
A61N1/36062 (EP,US); A61N1/36139 (EP,US); A61B5/395 (US);
A61N1/36067 (EP); G16H20/30 (EP); A61B5/389 (EP);
A61B5/4836 (EP); G16H50/50 (EP) (-)
Former IPC [2020/42]A61N1/36, A61B5/0488, A61B5/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/42]
Extension statesBANot yet paid
MENot yet paid
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:SYSTEM ZUR PLANUNG UND/ODER BEREITSTELLUNG EINER NEUROSTIMULATION FÜR EINEN PATIENTEN[2020/42]
English:A SYSTEM FOR PLANNING AND/OR PROVIDING NEUROSTIMULATION FOR A PATIENT[2020/42]
French:SYSTÈME DE PLANIFICATION ET/OU DE FOURNITURE DE NEUROSTIMULATION POUR UN PATIENT[2022/44]
Former [2020/42]SYSTÈME DE PLANIFICATION ET/OU D'UTILISATION DE LA NEUROSTIMULATION CHEZ UN PATIENT
Entry into regional phase06.07.2020National basic fee paid 
06.07.2020Designation fee(s) paid 
06.07.2020Examination fee paid 
Examination procedure06.07.2020Examination requested  [2020/42]
06.07.2020Date on which the examining division has become responsible
30.11.2020Amendment by applicant (claims and/or description)
25.10.2022Communication of intention to grant the patent
20.01.2023Fee for grant paid
20.01.2023Fee for publishing/printing paid
20.01.2023Receipt of the translation of the claim(s)
Opposition(s)04.12.2023No opposition filed within time limit [2024/06]
Fees paidRenewal fee
02.11.2020Renewal fee patent year 03
30.11.2021Renewal fee patent year 04
17.11.2022Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT01.03.2023
CZ01.03.2023
DK01.03.2023
EE01.03.2023
ES01.03.2023
FI01.03.2023
HR01.03.2023
IT01.03.2023
LT01.03.2023
LV01.03.2023
MC01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SI01.03.2023
SK01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
IS01.07.2023
PT03.07.2023
LU29.11.2023
CH30.11.2023
[2024/34]
Former [2024/32]AT01.03.2023
CZ01.03.2023
DK01.03.2023
EE01.03.2023
ES01.03.2023
FI01.03.2023
HR01.03.2023
IT01.03.2023
LT01.03.2023
LV01.03.2023
MC01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SI01.03.2023
SK01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
IS01.07.2023
PT03.07.2023
Former [2024/26]AT01.03.2023
CZ01.03.2023
DK01.03.2023
EE01.03.2023
ES01.03.2023
FI01.03.2023
HR01.03.2023
IT01.03.2023
LT01.03.2023
LV01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SI01.03.2023
SK01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
IS01.07.2023
PT03.07.2023
Former [2024/10]AT01.03.2023
CZ01.03.2023
DK01.03.2023
EE01.03.2023
ES01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SI01.03.2023
SK01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
IS01.07.2023
PT03.07.2023
Former [2023/50]AT01.03.2023
CZ01.03.2023
EE01.03.2023
ES01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SK01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
IS01.07.2023
PT03.07.2023
Former [2023/49]AT01.03.2023
CZ01.03.2023
EE01.03.2023
ES01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
PT03.07.2023
Former [2023/48]AT01.03.2023
EE01.03.2023
ES01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
NL01.03.2023
PL01.03.2023
RS01.03.2023
SE01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
PT03.07.2023
Former [2023/46]ES01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
NL01.03.2023
PL01.03.2023
RS01.03.2023
SE01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
PT03.07.2023
Former [2023/38]ES01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
NL01.03.2023
PL01.03.2023
RS01.03.2023
SE01.03.2023
NO01.06.2023
GR02.06.2023
Former [2023/37]ES01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
RS01.03.2023
SE01.03.2023
NO01.06.2023
GR02.06.2023
Former [2023/36]ES01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
RS01.03.2023
SE01.03.2023
NO01.06.2023
Former [2023/35]ES01.03.2023
HR01.03.2023
LT01.03.2023
RS01.03.2023
NO01.06.2023
Former [2023/34]ES01.03.2023
LT01.03.2023
RS01.03.2023
Former [2023/33]ES01.03.2023
LT01.03.2023
Cited inInternational search[A]US2016279418  (COURTINE GREGOIRE [CH], et al) [A] 1-15 * paragraphs [0030] - [0042] - [0049] , [0063]; figures 5, 14 *;
 [I]US2017173326  (BLOCH JOCELYNE [CH], et al) [I] 1-15 * paragraphs [0105] - [0107] - [0120] - [0130] - [0239] - [0240]; figures 7-9, 11 *;
 [I]  - Marco Capogrosso ET AL, "A brainspine interface alleviating gait deficits after spinal cord injury in primates", Nature, vol. 539, doi:10.1038/nature20118, (20161110), pages 284 - 288, URL: https://www.nature.com/articles/nature20118.pdf, (20180530), XP055479559 [I] 1-15 * page 284, column r, paragraph 1 - page 287, column l, paragraph 1; figures 1-4 *

DOI:   http://dx.doi.org/10.1038/nature20118
 [A]  - N. WENGER ET AL, "Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury", SCIENCE TRANSLATIONAL MEDICINE, US, (20140924), vol. 6, no. 255, doi:10.1126/scitranslmed.3008325, ISSN 1946-6234, pages 255ra133 - 255ra133, XP055410746 [A] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1126/scitranslmed.3008325
by applicantEP2810689
 EP2810690
 US2015066111
 US2016001096
 US2016030750
    - BIZZI, E. et al., "Modular organization of motor behavior in the frog's spinal cord.", Trends in neurosciences, (19950000), vol. 18, doi:doi:10.1016/0166-2236(95)94494-P, pages 442 - 446, XP004556864

DOI:   http://dx.doi.org/10.1016/0166-2236(95)94494-P
    - LEVINE, A. J. et al., "Identification of a cellular node for motor control pathways", Nature neuroscience, (20140000), vol. 17, pages 586 - 593
    - VAN DEN BRAND R et al., "Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury", Science, (20120000), vol. 336, pages 1182 - 1185
    - ANGELI CA et al., "Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans", Brain: a journal of neurology, (20140000), vol. 137, pages 1394 - 1409
    - HARKEMA S et al., "Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study", The Lancet, vol. 377, doi:doi:10.1016/S0140-6736(11)60547-3, pages 1938 - 1947, XP055080635

DOI:   http://dx.doi.org/10.1016/S0140-6736(11)60547-3
    - DANNER SM, "Human spinal locomotor control is based on flexibly organized burst generators", Brain: a journal of neurology, (20150000), vol. 138, pages 577 - 588
    - COURTINE G et al., "Transformation of nonfunctional spinal circuits into functional states after the loss of brain input", Nature neuroscience, (20090000), vol. 12, doi:doi:10.1038/nn.2401, pages 1333 - 1342, XP055080636

DOI:   http://dx.doi.org/10.1038/nn.2401
    - CAPOGROSSO M et al., "A brain-spine interface alleviating gait deficits after spinal cord injury in primates", Nature, (20160000), vol. 539, pages 284 - 288
    - CAPOGROSSO M et al., "A computational model for epidural electrical stimulation of spinal sensorimotor circuits", The Journal of neuroscience: the official journal of the Society for Neuroscience, (20130000), vol. 33, doi:doi:10.1523/JNEUROSCI.1688-13.2013, pages 19326 - 19340, XP055479489

DOI:   http://dx.doi.org/10.1523/JNEUROSCI.1688-13.2013
    - MORAUD EM, "Mechanisms Underlying the Neuromodulation of Spinal Circuits for Correcting Gait and Balance Deficits after Spinal Cord Injury", Neuron, (20160000), vol. 89, doi:doi:10.1016/j.neuron.2016.01.009, pages 814 - 828, XP029421586

DOI:   http://dx.doi.org/10.1016/j.neuron.2016.01.009
    - RATTAY F et al., "Epidural electrical stimulation of posterior structures of the human lumbosacral cord: 2. quantitative analysis by computer modeling", Spinal cord, (20000000), vol. 38, pages 473 - 489
    - GERASIMENKO Y et al., Soc. Neurosci. Abstr.
    - MINASSIAN K et al., "Human lumbar cord circuitries can be activated by extrinsic tonic input to generate locomotor-like activity", Human Movement Science, (20070000), vol. 26, doi:doi:10.1016/j.humov.2007.01.005, pages 275 - 295, XP022001586

DOI:   http://dx.doi.org/10.1016/j.humov.2007.01.005
    - MORAUD EM et al., "Mechanisms Underlying the Neuromodulation of Spinal Circuits for Correcting Gait and Balance Deficits after Spinal Cord Injury", Neuron, (20160000), vol. 89, doi:doi:10.1016/j.neuron.2016.01.009, pages 814 - 828, XP029421586

DOI:   http://dx.doi.org/10.1016/j.neuron.2016.01.009
    - HARKEMA, S et al., "Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study", The Lancet, vol. 377, doi:doi:10.1016/S0140-6736(11)60547-3, pages 1938 - 1947, XP055080635

DOI:   http://dx.doi.org/10.1016/S0140-6736(11)60547-3
    - BIZZL E et al., "Modular organization of motor behavior in the frog's spinal cord", Trends in neurosciences, (19950000), vol. 18, doi:doi:10.1016/0166-2236(95)94494-P, pages 442 - 446, XP004556864

DOI:   http://dx.doi.org/10.1016/0166-2236(95)94494-P
    - LEVLNE AJ et al., "Identification of a cellular node for motor control pathways", Nature neuroscience, (20140000), vol. 17, pages 586 - 593
    - WENGER N et al., "Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury", Nat Med, (20160000), vol. 22, pages 138 - 145
    - CAPOGROSSO M et al., "A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits", Journal of Neuroscience, (20131204), vol. 33, no. 49, doi:doi:10.1523/JNEUROSCI.1688-13.2013, pages 19326 - 19340, XP055479489

DOI:   http://dx.doi.org/10.1523/JNEUROSCI.1688-13.2013
    - COURTLNE G et al., "Transformation of nonfunctional spinal circuits into functional states after the loss of brain input", Nat Neurvsci., (20091000), vol. 12, no. 10, doi:doi:10.1038/nn.2401, pages 1333 - 1342, XP055080636

DOI:   http://dx.doi.org/10.1038/nn.2401
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DOI:   http://dx.doi.org/10.1016/j.neuron.2016.01.009
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