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EP About this file: EP3714053

EP3714053 - CHEMICAL PROBE-DEPENDENT EVALUATION OF PROTEIN ACTIVITY AND USES THEREOF [Right-click to bookmark this link]
Status	Examination is in progress Status updated on 24.05.2024 Database last updated on 31.08.2024
Former	Request for examination was made Status updated on 28.08.2020
Former	The international publication has been made Status updated on 01.06.2019
Most recent event Tooltip	24.07.2024	Change: Despatch of examination report + time limit
Applicant(s)	For all designated states The University of Chicago 5801 South Ellis Avenue Chicago, IL 60637 / US
	[2020/40]
Inventor(s)	01 / MOELLERING, Raymond E. Polsky Center for Entrepreneurship and Innovation University of Chicago 5113 S. Harper Ave. Suite 2C Chicago Illinois 60615 / US
	02 / LI, Gang Polsky Center for Entrepreneurship and Innovation University of Chicago 5113 S. Harper Ave. Suite 2C Chicago Illinois 60615 / US
	[2020/40]
Representative(s)	J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB
	[N/P]
Former [2020/40]	J A Kemp LLP 14 South Square Gray's Inn London WC1R 5JJ / GB
Application number, filing date	18880198.9	21.11.2018
	[2020/40]
	WO2018US62231
Priority number, date	US201762589946P	22.11.2017 Original published format: US 201762589946 P
	[2020/40]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO2019104155
	Date:	31.05.2019
	Language:	EN
	[2019/22]
	Type:	A2 Application without search report
	No.:	EP3714053
	Date:	30.09.2020
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 31.05.2019 takes the place of the publication of the European patent application.
	[2020/40]
Search report(s)	International search report - published on:	US	02.04.2020
	(Supplementary) European search report - dispatched on:	EP	26.10.2021
Classification	IPC:	G01N33/50, G01N33/542	[2021/32]
	CPC:	G01N33/542 (EP,US); G01N33/5035 (EP,US); A61K31/7088 (US); C07K14/003 (US); C07K16/44 (US); C12P19/34 (US); (+) C07K2317/622 (US); C07K2318/20 (US); G01N2458/10 (EP,US) (-)
	Former IPC [2020/40]	C12N15/10, C40B40/10, C40B70/00
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2020/40]
Title	German:	VON CHEMISCHER SONDE ABHÄNGIGE BEWERTUNG DER PROTEINAKTIVITÄT UND VERWENDUNG DAVON	[2020/40]
	English:	CHEMICAL PROBE-DEPENDENT EVALUATION OF PROTEIN ACTIVITY AND USES THEREOF	[2020/40]
	French:	ÉVALUATION SONDE CHIMIQUE-DÉPENDANTE DE L'ACTIVITÉ PROTÉIQUE ET SES UTILISATIONS	[2020/40]
Entry into regional phase	21.05.2020	National basic fee paid
	21.05.2020	Search fee paid
	21.05.2020	Designation fee(s) paid
	21.05.2020	Examination fee paid
Examination procedure	21.05.2020	Examination requested [2020/40]
	20.05.2022	Amendment by applicant (claims and/or description)
	27.05.2024	Despatch of a communication from the examining division (Time limit: M06)
Fees paid	Renewal fee
	13.11.2020	Renewal fee patent year 03
	21.10.2021	Renewal fee patent year 04
	13.10.2022	Renewal fee patent year 05
	29.09.2023	Renewal fee patent year 06
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[A]US2002064779 (LANDEGREN ULF [SE], et al) [A] 10-12* figure 13 *;
		[I]WO2012006556 (LIFE TECHNOLOGIES CORP [US], et al) [I] 1-9 * page 9, line 30; examples 1,2 * * page 20, lines 30-34 * * page 36, lines 14-25 *;
		[A] - LIU Y ET AL, "ACTIVITY-BASED PROTEIN PROFILING: THE SERINE HYDROLASES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, (19991221), vol. 96, no. 26, doi:10.1073/PNAS.96.26.14694, ISSN 0027-8424, pages 14694 - 14699, XP000986505 [A] 1 * relevant for non unity scheme 1; figures 1,2; compound 7 * DOI: http://dx.doi.org/10.1073/pnas.96.26.14694
		[A] - KIDD D ET AL, "PROFILING SERINE HYDROLASE ACTIVITIES IN COMPLEX PROTEOMES", BIOCHEMISTRY,, (20010403), vol. 40, no. 13, doi:10.1021/BI002579J, ISSN 0006-2960, pages 4005 - 4015, XP009079423 [A] 1 * relevant for non unity scheme 1; compound 9 * DOI: http://dx.doi.org/10.1021/bi002579j
		[A] - DONGWOOK KIM ET AL, "A DNA-assisted immunoassay for enzyme activity via a DNA-linked, activity-based probe", CHEMICAL COMMUNICATIONS, (20170101), vol. 53, no. 68, doi:10.1039/C7CC05236G, ISSN 1359-7345, pages 9474 - 9477, XP055698212 [A] 1-9 * scheme 1 * DOI: http://dx.doi.org/10.1039/C7CC05236G
		[XP] - GANG LI ET AL, "An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells", NATURE COMMUNICATIONS, (20171124), vol. 8, no. 1, doi:10.1038/s41467-017-01854-0, XP055548348 [XP] 1-9 * the whole document * DOI: http://dx.doi.org/10.1038/s41467-017-01854-0
		[A] - JESSANI NADIM ET AL, "A streamlined platform for high-content functional proteomics of primary human specimens", NATURE METHODS, NATURE PUB. GROUP, NEW YORK, (20050901), vol. 2, no. 9, doi:10.1038/NMETH778, ISSN 1548-7091, pages 691 - 697, XP009107768 [A] 10-12 * page 692, column 2, paragraph 3; table 1 * DOI: http://dx.doi.org/10.1038/NMETH778
		[A] - Jessani Nadim ET AL, "Supplementary Figure 1 to: A streamlined platform for high-content functional proteomics of primary human specimens", Nat Methods . 2005 Sep;2(9):691-7, (20050901), pages 1 - 2, URL: https://static-content.springer.com/esm/art%3A10.1038%2Fnmeth778/MediaObjects/41592_2005_BFnmeth778_MOESM1_ESM.pdf, (20211018), XP055852300 [A] 10-12
		[A] - JESSANI N ET AL, "Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 99, no. 16, doi:10.1073/PNAS.162187599, ISSN 0027-8424, (20020806), pages 10335 - 10340, (20020729), XP008104839 [A] 10-12 * figure 4c * DOI: http://dx.doi.org/10.1073/pnas.162187599
		[A] - DANIELK NOMURA ET AL, "Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer", CHEMISTRY & BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 18, no. 7, doi:10.1016/J.CHEMBIOL.2011.05.009, ISSN 1074-5521, (20110520), pages 846 - 856, (20110613), XP028248849 [A] 11,12 * figure 1A * DOI: http://dx.doi.org/10.1016/j.chembiol.2011.05.009
		[A] - CHANG J W ET AL, "A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis", CHEMISTRY & BIOLOGY, CURRENT BIOLOGY, LONDON, GB, (20110422), vol. 18, no. 4, doi:10.1016/J.CHEMBIOL.2011.02.008, ISSN 1074-5521, pages 476 - 484, XP002721482 [A] 11,12 * figure 1a * DOI: http://dx.doi.org/10.1016/j.chembiol.2011.02.008
		[XP] - Li Gang ET AL, "A Concise, Modular Antibody-Oligonucleotide Conjugation Strategy Based on Disuccinimidyl Ester Activation Chemistry", ChemBioChem, 2019, 20, doi:10.1002/cbic.201900027, (20190503), pages 1 - 8, URL: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cbic.201900027, (20211018), XP055852159 [XP] 10-12 * page 3, column 1, line 10 - column 2, paragraph 1; figure 3 * DOI: http://dx.doi.org/10.1002/cbic.201900027
	International search	WO2012006556 [x] (LIFE TECHNOLOGIES CORP [US], et al) [x] 1,54,56 * the whole document *;
		US8940497 [a] (CRAVATT BENJAMIN F [US], et al) [a] 1-4,43-47,54-56 * the whole document *;
		WO2017192633 [x] (PROCURE LIFE SCIENCES INC [US]) [x] 54;
		[xX] - Thompson et al., "SH2-PLA: a sensitive in-solution approach for quantification of modular domain binding by proximity ligation and real-time PCR", BMC Biotechnology, (20150626), vol. 15, doi:10.1186/s12896-015-0169-1, pages 1 - 13, XP055548769 [x] 54,56 * the whole document * DOI: http://dx.doi.org/10.1186/s12896-015-0169-1
		[xX] - Nomura et al., "Activity-based protein profiling for biochemical pathway discovery in cancer", Nat. Rev. Cancer, (20100900), vol. 10, no. 9, doi: 10.1038/nrc2901, pages 630 - 638, XP055698185 [x] 54,56 * the whole document * DOI: http://dx.doi.org/10.1038/nrc2901
		[xX] - Li, "An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells", Nature Communications, (20171124), vol. 8, no. 1775, doi:10.1038/s41467-017-01854-0, XP055548348 [x] 1,54,56 * the whole document * DOI: http://dx.doi.org/10.1038/s41467-017-01854-0
		[aA] - Schedin-Weiss, Sophia et al., "Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation - Application on γ-Secretase", PLoS One, (20130500), vol. 8, no. 5, doi: 10.1371/journal.pone.0063962, pages 1 - 10, XP055318695 [a] 1-4,43-47,54-56 * the whole document * DOI: http://dx.doi.org/10.1371/journal.pone.0063370
		[aA] - Greenwood et al., "Proximity assays for sensitive quantification of proteins", Biomolecular Detection and Quantification , (20150520), vol. 4, doi:10.1016/j.bdq.2015.04.002, pages 10 - 16, XP055364680 [a] 1-4,43-47,54-56 * the whole document * DOI: http://dx.doi.org/10.1016/j.bdq.2015.04.002
		[aA] - Dongwook Kim, Rachael R. Jetson‡ and Casey J. Krusemark, " A DNA-assisted immunoassay for enzyme activity via a DNA-linked, activity-based probe", Chemical Communications, (2017), vol. 53, doi:10.1039/c7cc05236g, pages 9474 - 9477, XP055698212 [a] 1-4,43-47,54-56 * the whole document * DOI: http://dx.doi.org/10.1039/C7CC05236G

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