-
EP3498709
European procedure
- EP About this file
- EP Legal status
- EP Federated register
- EP Event history
- EP Citations
- EP Patent family
- EP All documents
Extract from the Register of European Patents
EP About this file: EP3498709
| EP3498709 - OPLOPHORUS-DERIVED LUCIFERASES, NOVEL COELENTERAZINE SUBSTRATES, AND METHODS OF USE [Right-click to bookmark this link] | Status | Examination is in progress Status updated on 31.07.2020 Database last updated on 29.06.2024 | |
| Former | Request for examination was made Status updated on 17.05.2019 | Most recent event Tooltip | 27.11.2023 | New entry: Renewal fee paid | Applicant(s) | For all designated states Promega Corporation 2800 Woods Hollow Road Madison, WI 53711-5399 / US | [2019/25] | Inventor(s) | 01 /
Binkowski, Brock E9121 State Road 60 Sauk City, WI 53583 / US | 02 /
Encell, Lance P. 5637 Kinsale Drive Fitchburg, WI 53711 / US | 03 /
Hall, Mary P. 504 Skyview Drive Waunakee, WI 53597 / US | 04 /
Robers, Matthew B. 13 Oak Glen Court Madison, WI 53717 / US | 05 /
Slater, Michael R. 2806 Marshall Court Madison, WI 53704 / US | 06 /
Wood, Keith V. 8380 Swan Road Mount Horeb, WI 53572 / US | 07 /
Wood, Monika G. 8380 Swan Road Mount Horeb, WI 53572 / US | 08 /
Klaubert, Dieter 250 Blue Sky Drive Arroyo Grande, CA 93420 / US | 09 /
Meisenheimer, Poncho 1155 Palm Street Nº5 San Luis Obispo, CA 93401 / US | 10 /
Unch, James 257 Ruth Ann Way Arroyo Grande, CA 93420 / US | 11 /
Valley, Michael P. 5463 Shale Road Fitchburg, WI 53711 / US | [2019/25] | Representative(s) | Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | [2019/25] | Application number, filing date | 19150036.2 | 02.11.2011 | [2019/25] | Priority number, date | US201040942210P | 02.11.2010 Original published format: US 40942210 P | [2019/25] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP3498709 | Date: | 19.06.2019 | Language: | EN | [2019/25] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 13.03.2019 | Classification | IPC: | C07D487/04, C12Q1/66 | [2019/25] | CPC: |
C12Q1/66 (EP,CN,IL,US);
C12N15/52 (EP,IL,KR,US);
C12N9/0069 (EP,CN,IL,US);
C07D487/04 (EP,IL,US);
C07K14/435 (IL,KR);
C07K19/00 (IL,KR);
C12N15/1086 (CN,IL);
C12N9/0004 (EP,IL,KR,US);
C12Y113/12005 (EP,CN,IL,US);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2019/25] | Title | German: | AUS OPLOPHORUS GEWONNENE LUCIFERASEN, NEUARTIGE COELENTERAZINSUBSTRATE UND VERFAHREN ZUR VERWENDUNG | [2019/25] | English: | OPLOPHORUS-DERIVED LUCIFERASES, NOVEL COELENTERAZINE SUBSTRATES, AND METHODS OF USE | [2019/25] | French: | LUCIFÉRASES ISSUES D'OPLOPHORUS NOUVEAUX SUBSTRATS DE COÉLENTÉRAZINE ET LEURS PROCÉDÉS D'UTILISATION | [2019/25] | Examination procedure | 02.01.2019 | Examination requested [2019/25] | 11.11.2019 | Amendment by applicant (claims and/or description) | 30.07.2020 | Despatch of a communication from the examining division (Time limit: M06) | 09.02.2021 | Reply to a communication from the examining division | 09.12.2021 | Despatch of a communication from the examining division (Time limit: M06) | 20.06.2022 | Reply to a communication from the examining division | Parent application(s) Tooltip | EP11785534.6 / EP2635595 | Fees paid | Renewal fee | 02.01.2019 | Renewal fee patent year 03 | 02.01.2019 | Renewal fee patent year 04 | 02.01.2019 | Renewal fee patent year 05 | 02.01.2019 | Renewal fee patent year 06 | 02.01.2019 | Renewal fee patent year 07 | 02.01.2019 | Renewal fee patent year 08 | 27.11.2019 | Renewal fee patent year 09 | 27.11.2020 | Renewal fee patent year 10 | 29.11.2021 | Renewal fee patent year 11 | 28.11.2022 | Renewal fee patent year 12 | 27.11.2023 | Renewal fee patent year 13 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [Y]WO2007120522 (PROMEGA CORP [US], et al) [Y] 1-18 * see claims 11-17 and 20-22 and pages 4-15 *; | [XP]WO2010127368 (PROMEGA CORP [US], et al) [XP] 1 * polynucleotide encoding a modified luciferase polypeptide. The modified luciferase polypeptide has at least 60% amino acid sequence identity to a wild-type Oplophorus luciferase and includes at least one amino acid substitution at a position corresponding to an amino acid in a wild-type Oplophorus luciferase of SEQ ID NO:1. The modified luciferase polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the wild-type;; figures 1-4,19,24,25,30-32; examples 1-13; claims 1-37 *; | [E]EP2420573 (NAT INST OF ADVANCED IND SCIEN [JP]) [E] 1 * the whole document *; | [Y] - FUJII ET AL, "Increase in bioluminescence intensity of firefly luciferase using genetic modification", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, (20070621), vol. 366, no. 2, doi:10.1016/J.AB.2007.04.018, ISSN 0003-2697, pages 131 - 136, XP022126352 [Y] 1-18 * the whole document * DOI: http://dx.doi.org/10.1016/j.ab.2007.04.018 | [Y] - INOUYE S ET AL, "Secretional luciferase of the luminous shrimp Oplophorus gracilirostris: cDNA cloning of a novel imidazopyrazinone luciferase<1>", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, (20000908), vol. 481, no. 1, doi:10.1016/S0014-5793(00)01963-3, ISSN 0014-5793, pages 19 - 25, XP004337549 [Y] 1-18 * see abstract and pages 19-22;; figure 2 * DOI: http://dx.doi.org/10.1016/S0014-5793(00)01963-3 | [T] - SATOSHI INOUYE ET AL, "Expression, purification and luminescence properties of coelenterazine-utilizing luciferases from Renilla, Oplophorus and Gaussia: Comparison of substrate specificity for C2-modified coelenterazines", PROTEIN EXPRESSION AND PURIFICATION., SAN DIEGO, CA., (20121227), vol. 88, no. 1, doi:10.1016/j.pep.2012.12.006, ISSN 1046-5928, pages 150 - 156, XP055562858 DOI: http://dx.doi.org/10.1016/j.pep.2012.12.006 | [XY] - SHIMOMURA O ET AL, "PROPERTIES AND REACTION MECHANISM OF THE BIOLUMINESCENCE SYSTEM OF THE DEEP-SEA SHRIMP OPLOPHORUS GRACILOROSTRIS", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, (19780101), vol. 17, doi:10.1021/BI00599A008, ISSN 0006-2960, pages 994 - 998, XP001088626 [X] 1 * the whole document * [Y] 1-18 DOI: http://dx.doi.org/10.1021/bi00599a008 | [Y] - PASCAL BRAUN ET AL, "An experimentally derived confidence score for binary protein-protein interactions", NATURE METHODS, New York, (20081207), vol. 6, no. 1, doi:10.1038/nmeth.1281, ISSN 1548-7091, pages 91 - 97, XP055563932 [Y] 9-11 * , pages 93-95 and Fig. 2 * DOI: http://dx.doi.org/10.1038/nmeth.1281 | [Y] - RYOICHI ARAI ET AL, "Detection of protein-protein interaction by bioluminescence resonance energy transfer from firefly luciferase to red fluorescent protein", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, NL, (20021001), vol. 94, no. 4, doi:10.1016/S1389-1723(02)80178-5, ISSN 1389-1723, pages 362 - 364, XP055563930 [Y] 9-11 * the whole document * DOI: http://dx.doi.org/10.1016/S1389-1723(02)80178-5 | [A] - LOENING ANDREAS MARKUS ET AL, "Consensus guided mutagenesis of Renilla luciferase yields enhanced stability and light output", PROTEIN ENGINEERING, DESIGN AND SELECTION, OXFORD JOURNAL, LONDON, GB, vol. 19, no. 9, doi:10.1093/PROTEIN/GZL023, ISSN 1741-0126, (20060901), pages 391 - 400, (20060720), XP002524403 [A] 1-18 * the whole document * DOI: http://dx.doi.org/10.1093/PROTEIN/GZL023 | [A] - SATOSHI INOUYE ET AL, "Overexpression, purification and characterization of the catalytic component of Oplophorus luciferase in the deep-sea shrimp, Oplophorus gracilirostris", PROTEIN EXPRESSION AND PURIFICATION., SAN DIEGO, CA., (20070824), vol. 56, no. 2, doi:10.1016/j.pep.2007.08.002, ISSN 1046-5928, pages 261 - 268, XP055563074 [A] 1-18 * the whole document * DOI: http://dx.doi.org/10.1016/j.pep.2007.08.002 | [T] - YURI TOMABECHI ET AL, "Crystal structure of nanoKAZ: The mutated 19 kDa component of Oplophorus luciferase catalyzing the bioluminescent reaction with coelenterazine", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, AMSTERDAM, NL, (20151230), vol. 470, no. 1, doi:10.1016/j.bbrc.2015.12.123, ISSN 0006-291X, pages 88 - 93, XP055562852 [T] * the whole document * DOI: http://dx.doi.org/10.1016/j.bbrc.2015.12.123 | by applicant | WO03040100 | US2005153310 | US2006068395 | WO2007120522 | US2008070299 | US2008090291 | US2008248511 | US2009253131 | US2009305280 | US7728118 | US2010281552 | - SHIMOMURA et al., Biochemistry, (19780000), vol. 17, page 994 | - GenBank, Database accession no. BAB 13776 | - LORENZ et al., PNAS USA, (19910000), vol. 88, page 4438 | - THOMPSON et al., PNAS USA, (19890000), vol. 86, page 6567 | - INOUYE; SASAKI, Protein Expression and Purification, (20070000), vol. 56, pages 261 - 268 | - INOUYE; SHIMOMURA, BBRC, (19970000), vol. 223, page 349 | - NAKAMURA et al., Tetrahedron Lett., (19970000), vol. 38, page 6405 | - JOHNSON; SHIMOMURA, Meth. Enzyme, (19780000), vol. 57, page 331 | - R.D. DENNELL, "Observations on the luminescence of bathypelagic Crustacea decapoda of the Bermuda area", Zool. J. Linn, Soc., Lond., (19550000), vol. 42, pages 393 - 406 | - POUPIN, "Inventaire document^ des especies et bilan des formes les plus communes de la mer d'Iroise", Rapport Scientifique du Laboratoire d'Oceanographte de I'Ecole Navale (LOEN), (19990900), page 83 | - BERGE, J. Pharm. Sci., (19770000), vol. 66, pages 1 - 19 | - SMITH et al., J. Mol. BioI., (19810000), vol. 147, pages 195 - 197 | - NEEDLEMAN; WUNSCH, J Mo . BioI., (19700000), vol. 48, pages 443 - 453 | - PEARSON; LIPMAN, Proc. Natl, Acad. Sci. USA, (19880000), vol. 85, pages 2444 - 2448 | - CHENNA et al., Nucl. Acids Res., (20030000), vol. 31, no. 13, pages 3497 - 3500 | - RAPHAEL et al., Genome Res., (20040000), vol. 14, no. 11, pages 2336 - 2346 | - LANGLEY et al., PNAS, (19750000), vol. 72, pages 1254 - 1257 | - LEVIT; BERGER, J. Biol. Chem., (19760000), vol. 251, pages 1333 - 1339 | - BURBELO et al., Expert Review of Vaccines, (20100000), vol. 9, no. 6, pages 567 - 578 | - WADA et al., Nucl. Acids Res., (19900000), vol. 18, page 2367 | - MURRAY et al., Nucl. Acids Res., (19890000), vol. 17, page 477 | - FREIFELDER; HASBROUCK, "Synthesis of Primary 1,2-Diamines by Hydrogenation of alpha-Aminonitriles", Journal of the American Chemical Society, (19600000), vol. 82, no. 3, pages 696 - 698 | - HAGEDORN et al., Chem. Ber., (19650000), vol. 98, page 193 | - KISHI, "The structure confirmation of the light-emitting moiety of bioluminescent jellyfish", Tetrahedron Lett., (19720000), vol. 13, no. 27, page 2747 | - KAKOI; INOUE, Chem. Lett., (19800000), vol. 11, no. 3, pages 299 - 300 | - INOUE et al., "Squid bioluminescence. II. Isolation from Watasenia scintillans and synthesis of 2-(p-hydroxybenzyl)-6-(p-hydroxyphenyl)-3,7-dihydroimidazo[l,2-a]pyrazin-3-one", Chern. Lett., (19750000), vol. 4, no. 2, pages 141 - 4 | - KISHI, Tetrahedron Lett., (19720000), vol. 13, page 2747 | - MOSRIN, Organic Letters, (20090000), vol. 11, page 3406 | - KAKOI, Chem. Pharm. Bull., (20020000), vol. 50, page 301 | - CHOTHIA; LESK, EMBO J, (19860000), vol. 5, no. 4, pages 823 - 826 | - TRAMONTANO, Genomics, (20030000), vol. 4, pages 402 - 405 | - SIGRIST et al., Nucleic Acids Res., (20100000), vol. 38, no. 1, pages D161 - D166 | - "GenBank", Database accession no. 2021262A, AAA68491, AAC36472, AAV35379, AAV35380, | - DAUGHTERY, PNAS USA, (20000000), vol. 97, no. 5, page 2029 | - ZHENG et al., Nucleic Acids Research, (20040000), vol. 32, page el 15 | - KUNKEL, PNAS USA, (19850000), vol. 82, no. 2, page 488 | - OHANA, Protein Expression and Purification, (20090000), vol. 68, pages 110 - 120 | - SCHAGAT et al., "KRX Autoinduction Protocol: A Convenient Method for Protein Expression", Promega Notes, (20080000), vol. 98, pages 16 - 18 | - WADA et al., Nucleic Acids Res., (19900000), vol. 18, page 2367 | - PAGUIO et al., "pGL4 Vectors: A New Generation of Luciferase Reporter Vectors", Promega Notes, (20050000), vol. 89, pages 7 - 10 | - ZUKER, Nucleic Acid Res., (20030000), vol. 31, no. 13, pages 3406 - 3415 | - ZHANG et al., J Am. Soc, Mass Spectrom., (19980000), vol. 9, pages 225 - 233 | - BENEZRA et al., Cell, (19900000), vol. 61, no. 1, pages 49 - 59 | - BANASZYNSKI et al., J. Am. Chem. Soc, (20050000), vol. 127, no. 13, pages 4715 - 4721 | - LEVIT; BERGER, J. Bioi. Chem., (19760000), vol. 251, pages 1333 - 1339 | - GROSS et al., Nature Methods, (20050000), vol. 2, no. 8, pages 607 - 614 | - MOROZ et al., PLoS One, (20090000), vol. 4, no. 4, page e5077 | WO2007US08176 | US20080056073 | US20100773002 | WO2010US33449 |