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Extract from the Register of European Patents

EP About this file: EP3581575

EP3581575 - DISUBSTITUTED OCTAHYDROPYRROLO[3,4-C]PYRROLES AS OREXIN RECEPTOR MODULATORS [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  10.09.2020
Database last updated on 13.07.2024
FormerRequest for examination was made
Status updated on  19.06.2020
FormerThe application has been published
Status updated on  15.11.2019
Most recent event   Tooltip13.09.2023New entry: Renewal fee paid 
Applicant(s)For all designated states
Janssen Pharmaceutica NV
Turnhoutseweg 30
2340 Beerse / BE
[2019/51]
Inventor(s)01 / CHAI, Wenying
4318 Corte Al Fresco
San Diego, CA California 92130 / US
02 / LETAVIC, Michael, A.
4379 Mistral Place
San Diego, CA California 92130 / US
03 / LY, Kiev, S.
P.O. Box 927992
San Diego, CA California 92192 / US
04 / PIPPEL, Daniel, J.
12795 Via Cortina
Del Mar, CA California 92014 / US
05 / RUDOLPH, Dale, A.
12721 Alondra Court
San Diego, CA California 92128 / US
06 / STROTHER, Kathleen, C.
3429 Borreson Street
San Diego, CA California 92117 / US
07 / SAVALL, Brad, M.
9512 Ronda Avenue
San Diego, CA California 92123 / US
08 / SHAH, Chandravadan, R.
14213 Dalhouside Road
San Diego, CA California 92129 / US
09 / SHIREMAN, Brock, T.
12625 Birchbrook Court
Poway, CA California 92064 / US
10 / SOYODE-JOHNSON, Akinola
4155 Executive Dr.
Unit 212
La Jolla, CA California 92037-1361 / US
11 / STOCKING, Emily, M.
310 Melrose Avenue
Encinitas, CA California 92024 / US
12 / SWANSON, Devin, M.
3121 Morning Way
La Jolla, CA California 92037 / US
 [2019/51]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2019/51]McGuire, Gillian Margaret
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
Application number, filing date19172579.521.10.2010
[2019/51]
Priority number, dateUS200925450909P23.10.2009         Original published format: US 25450909 P
[2019/51]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3581575
Date:18.12.2019
Language:EN
[2019/51]
Search report(s)(Supplementary) European search report - dispatched on:EP14.11.2019
ClassificationIPC:C07D487/04, A61K31/407, A61P25/00
[2019/51]
CPC:
C07D487/04 (EP,KR,US); A61K31/407 (KR); A61K31/4192 (KR);
A61K31/428 (EP,KR,US); A61K31/4439 (EP,KR,US); A61K31/4709 (EP,KR,US);
A61K31/498 (EP,KR,US); A61K31/506 (EP,KR,US); A61K31/53 (EP,KR,US);
A61K31/5377 (EP,KR,US); A61P1/00 (EP); A61P1/04 (EP);
A61P1/12 (EP); A61P1/16 (EP); A61P11/00 (EP);
A61P15/00 (EP); A61P19/02 (EP); A61P25/00 (EP);
A61P25/04 (EP); A61P25/14 (EP); A61P25/16 (EP);
A61P25/18 (EP); A61P25/20 (EP); A61P25/22 (EP);
A61P25/24 (EP); A61P25/28 (EP); A61P3/00 (EP);
A61P3/04 (EP); A61P3/06 (EP); A61P3/10 (EP);
A61P43/00 (EP); A61P5/50 (EP); A61P9/00 (EP);
A61P9/04 (EP); A61P9/06 (EP); A61P9/12 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/30]
Former [2019/51]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
Extension statesBA15.06.2020
ME15.06.2020
TitleGerman:DISUBSTITUIERTE OCTAHYDROPYRROLO[3,4-C]PYRROLE ALS OREXIN-REZEPTOR-MODULATOREN[2019/51]
English:DISUBSTITUTED OCTAHYDROPYRROLO[3,4-C]PYRROLES AS OREXIN RECEPTOR MODULATORS[2019/51]
French:OCTAHYDROPYRROLO[3,4-C]PYRROLES DISUBSTITUÉS EN TANT QUE MODULATEURS DE RÉCEPTEUR D'OREXINE[2019/51]
Examination procedure15.06.2020Examination requested  [2020/30]
15.06.2020Date on which the examining division has become responsible
09.09.2020Despatch of a communication from the examining division (Time limit: M06)
23.06.2021Reply to a communication from the examining division
15.12.2021Despatch of a communication from the examining division (Time limit: M06)
21.07.2022Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
30.09.2022Reply to a communication from the examining division
Parent application(s)   TooltipEP10773477.4  / EP2491038
EP16163733.5  / EP3093291
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
30.09.2022Request for further processing filed
30.09.2022Full payment received (date of receipt of payment)
Request granted
10.10.2022Decision despatched
The application is deemed to be withdrawn due to failure to reply to the examination report
22.06.2021Request for further processing filed
22.06.2021Full payment received (date of receipt of payment)
Request granted
01.07.2021Decision despatched
Fees paidRenewal fee
03.05.2019Renewal fee patent year 03
03.05.2019Renewal fee patent year 04
03.05.2019Renewal fee patent year 05
03.05.2019Renewal fee patent year 06
03.05.2019Renewal fee patent year 07
03.05.2019Renewal fee patent year 08
03.05.2019Renewal fee patent year 09
15.10.2019Renewal fee patent year 10
14.10.2020Renewal fee patent year 11
29.09.2021Renewal fee patent year 12
15.09.2022Renewal fee patent year 13
13.09.2023Renewal fee patent year 14
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Documents cited:Search[A]WO2004004733  (ACTELION PHARMACEUTICALS LTD [CH], et al) [A] 1-15* the whole document *;
 [A]WO2009016286  (SANOFI AVENTIS [FR], et al) [A] 1-15 * examples 106-118 *;
 [A]WO2009037394  (SANOFI AVENTIS [FR], et al) [A] 1-15 * examples 1,2,26-30,41-45 *
by applicantWO0181347
 US2002019388
 WO03002561
 WO03051872
 WO2004033418
 WO2004041791
 US2005065178
 US2005101602
 US2006258672
 WO2006124897
 WO2006123121
 WO2007126935
 WO2007126934
 WO2008008551
 WO2008008517
 WO2008008518
 US2008132490
 WO2008067121
 WO2008143856
 WO2009022311
 WO2009058238
 US2009163485
 WO2009081197
 WO2009124956
 WO2010017260
 WO2010048012
 WO2010048017
 WO2010048014
 WO2010048010
 WO2010048013
 WO2010051238
 WO2010051237
 WO2010051236
 WO2010060472
 WO2010060471
 WO2010060470
 WO2010063663
 WO2010063662
 US2010160344
 US2010160345
 WO2010072722
    - C. PEYRON et al., J. Neurosci., (19980000), vol. 18, no. 23, pages 9996 - 10015
    - VAN DEN POL, A.N. et al., J. Neuroscience, (19990000), vol. 19, no. 8, pages 3171 - 3182
    - T. SAKURAI, Nature Reviews Neuroscience, (20070000), vol. 8, no. 3, pages 171 - 181
    - J. HARA et al., Neuron, (20010000), vol. 30, pages 345 - 354
    - W.K. SAMSON et al., Brain Res., (19990000), vol. 831, pages 248 - 253
    - T. SHIRASAKA et al., Am. J. Physiol., (19990000), vol. 277, pages R1780 - R1785
    - C.-T. CHEN et al., Am. J. Physiol., (20000000), vol. 278, pages R692 - R697
    - A.L. KIRCHGESSNERM.-T. LIU, Neuron, (19990000), vol. 24, pages 941 - 951
    - N. TAKAHASHI et al., Biochem. Biophys. Res. Commun., (19990000), vol. 254, pages 623 - 627
    - PIPER et al., J. Neurosci., (20000000), vol. 12, pages 726 - 730
    - YAMANAKA et al., Biochem. Biophys. Res. Comm., (20020000), vol. 290, pages 1237 - 1245
    - CHEMELLI et al., Cell, (19990000), vol. 98, pages 437 - 451
    - LIN et al., Cell, (19990000), vol. 98, pages 365 - 376
    - MIGNOT et al., Am. J. Hum. Genet., (20010000), vol. 68, pages 686 - 699
    - MINOTTHORSBY, New England J. Med., (20010000), vol. 344, page 692
    - PEYRON et al., Nature Med., (20000000), vol. 6, pages 991 - 997
    - BRISBARE-ROCH et al., Nature Medicine, (20070000), vol. 13, pages 150 - 155
    - P. MALHERBE et al., Molecular Pharmacology, (20090000), vol. 76, no. 3, pages 618 - 31
    - C. DUGOVIC et al., J. Pharmacol. Exp. Ther., (20090000), vol. 330, no. 1, pages 142 - 151
    - NAKAMURA et al., Brain Research, vol. 873, no. 1, pages 181 - 7
    - KANG et al., Science Express, (20090000), pages 1 - 10
    - G. ASTON-JONES et al., Neuropharmacology, (20090000), vol. 56, no. 1, pages 112 - 121
    - J. K. KANE et al., Endocrinology, (20000000), vol. 141, no. 10, pages 3623 - 3629
    - J. K. KANE et al., Neurosci. Lett., (20010000), vol. 298, no. 1, pages 1 - 4
    - D. GEORGESCU et al., J.Neurosci., (20030000), vol. 23, no. 8, pages 3106 - 3111
    - C. J. WINROW et al., Neuropharmacology, (20100000), vol. 58, no. 1, pages 185 - 94
    - LAWRENCE, Br. J. Pharmacol., (20060000), vol. 148, pages 752 - 759
    - RICHARDS, Psychopharmacology, (20080000), vol. 199, no. 1, pages 109 - 117
    - DAYAS, Biol. Psychiatry, (20080000), vol. 63, no. 2, pages 152 - 157
    - HAMLIN, Neuroscience, (20070000), vol. 146, pages 525 - 536
    - SCHNEIDER, Alcohol. Clin. Exp. Res., (20070000), vol. 31, no. 11, pages 1858 - 1865
    - KIRCHGESSNERLIU, Neuron, (19990000), vol. 24, pages 941 - 951
    - TAKAHASHI et al., Biochem. Biophys. Res. Comm., (19990000), vol. 254, pages 623 - 627
    - T. SAKURAI et al., Cell, (19980000), vol. 92, no. 4, pages 573 - 585
    - T. SAKURAI, Reg. Pept., (19990000), vol. 85, no. 1, pages 25 - 30
    - SAMSON et al., Brain Res., (19990000), vol. 831, pages 248 - 253
    - SHIRASAKA et al., Am. J. Physiol., (19990000), vol. 277, pages R1780 - R1785
    - CHEN et al., Am. J. Physiol., (20000000), vol. 278, pages R692 - R697
    - COX et al., Bioorganic & Medicinal Chemistry Letters, (20090000), vol. 19, no. 11, pages 2997 - 3001
    - BOSS et al., Journal of Medicinal Chemistry, (20090000), vol. 52, no. 4, pages 891 - 903
    - COLEMAN et al., Bioorganic & Medicinal Chemistry Letters, (20100000), vol. 20, no. 14, pages 4201 - 4205
    - COX, Journal of Medicinal Chemistry, (20100000), vol. 53, no. 14, pages 5320 - 5332
    - COLEMAN et al., Bioorganic & Medicinal Chemistry Letters, (20100000), vol. 20, no. 7, pages 2311 - 2315
    - FROST et al., Journal of Medicinal Chemistry, (20060000), vol. 49, no. 26, pages 7843 - 7853
    - Van Nostrand's Encyclopedia of Chemistry, (20050000), page 261
    - Handbook of Chemistry and Physics, pages 8 - 37,8-44
    - PAULEKUHN et al., "Trends in Active Pharmaceutical Ingredient Salt Selection based on Analysis of the Orange Book Database", J. Med. Chem., (20070000), vol. 50, doi:doi:10.1021/jm701032y, pages 6665 - 72, XP055536811

DOI:   http://dx.doi.org/10.1021/jm701032y
    - S.M. BERGE et al., "Pharmaceutical Salts", J Pharm Sci., (19770000), vol. 66, doi:doi:10.1002/jps.2600660104, pages 1 - 19, XP002675560

DOI:   http://dx.doi.org/10.1002/jps.2600660104
    - FLEISHER et al., Adv. Drug Delivery Rev., (19960000), vol. 19, pages 115 - 130
    - ROBINSON et al., J Med Chem., (19960000), vol. 39, no. 1, pages 10 - 18
    - BERTOLINI et al., J Med Chem., (19970000), vol. 40, pages 2011 - 2016
    - SHAN et al., J Pharm Sci., (19970000), vol. 86, no. 7, pages 765 - 767
    - BAGSHAWE, Drug Dev Res., (19950000), vol. 34, pages 220 - 230
    - BODOR, Adv Drug Res., (19840000), vol. 13, pages 224 - 331
    - CHEMICAL ABSTRACTS, Database accession no. 72287-26-4
    - FREDIANI, Catalysis Comm., (20010000), vol. 2, page 125
    - LANGMEAD et al., British Journal of Pharmacology, (20040000), vol. 141, pages 340 - 346
    - MALHERBE et al., British Journal of Pharmacology, (20090000), vol. 156, no. 8, pages 1326 - 1341
    - "Genebank", Database accession no. NM_001526
    - CHEMICAL ABSTRACTS, Database accession no. 288150-92-5
    - CHEMICAL ABSTRACTS, Database accession no. 1089563-88-1
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.