EP3564674 - HAPTENS, HAPTEN CONJUGATES, COMPOSITIONS THEREOF AND METHOD FOR THEIR PREPARATION AND USE [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 01.07.2022 Database last updated on 19.07.2024 | |
Former | The patent has been granted Status updated on 23.07.2021 | ||
Former | Grant of patent is intended Status updated on 14.04.2021 | ||
Former | Examination is in progress Status updated on 20.05.2020 | ||
Former | Request for examination was made Status updated on 20.03.2020 | ||
Former | The application has been published Status updated on 04.10.2019 | Most recent event Tooltip | 14.06.2024 | Lapse of the patent in a contracting state New state(s): TR | published on 17.07.2024 [2024/29] | Applicant(s) | For all designated states Ventana Medical Systems, Inc. 1910 E. Innovation Park Drive Tucson, Arizona 85755 / US | [2019/45] | Inventor(s) | 01 /
KOSMEDER, Jerome 1910 E. Innovation Park Drive Tucson, AZ 85755 / US | 02 /
LEFEVER, Mark 13549 N Barlassina Dr Oro Valley, AZ 85755 / US | 03 /
JOHNSON, Donald 1004 W. Blue Crest Dr. Tucson, AZ 85755 / US | 04 /
FARRELL, Michael 8662 Placita Del Cardo Tucson, AZ 85704 / US | 05 /
ZHILINA, Zhanna 7286 W. Clear Canyon Drive Tucson, AZ 85743 / US | 06 /
BIENIARZ, Christopher 2263 E. Quiet Canyon Drive Tucson, AZ 85718 / US | [2021/33] |
Former [2021/24] | 01 /
KOSMEDER, Jerry 1910 E. Innovation Park Drive Tucson, AZ 85755 / US | ||
02 /
LEFEVER, Mark 13549 N Barlassina Dr Oro Valley, AZ 85755 / US | |||
03 /
JOHNSON, Donald 1004 W. Blue Crest Dr. Tucson, AZ 85755 / US | |||
04 /
FARRELL, Michael 8662 Placita Del Cardo Tucson, AZ 85704 / US | |||
05 /
ZHILINA, Zhanna 7286 W. Clear Canyon Drive Tucson, AZ 85743 / US | |||
06 /
BIENIARZ, Christopher 2263 E. Quiet Canyon Drive Tucson, AZ 85718 / US | |||
Former [2019/45] | 01 /
KOSMEDER, Jerry 5530 N. Moccasin Trail Tucson, AZ 85750 / US | ||
02 /
LEFEVER, Mark 13549 N Barlassina Dr Oro Valley, AZ 85755 / US | |||
03 /
JOHNSON, Donald 1004 W. Blue Crest Dr. Tucson, AZ 85755 / US | |||
04 /
FARRELL, Michael 8662 Placita Del Cardo Tucson, AZ 85704 / US | |||
05 /
ZHILINA, Zhanna 7286 W. Clear Canyon Drive Tucson, AZ 85743 / US | |||
06 /
BIENIARZ, Christopher 2263 E. Quiet Canyon Drive Tucson, AZ 85718 / US | Representative(s) | Forresters IP LLP Skygarden Erika-Mann-Straße 11 80636 München / DE | [2021/34] |
Former [2019/45] | Bond, Christopher William Forresters IP LLP Skygarden Erika-Mann-Strasse 11 80636 München / DE | Application number, filing date | 19178774.6 | 01.11.2007 | [2019/45] | Priority number, date | US20060856133P | 01.11.2006 Original published format: US 856133 P | [2019/45] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP3564674 | Date: | 06.11.2019 | Language: | EN | [2019/45] | Type: | B1 Patent specification | No.: | EP3564674 | Date: | 25.08.2021 | Language: | EN | [2021/34] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 25.09.2019 | Classification | IPC: | C07D271/12, G01N33/532, G01N33/58, A61P35/00, A61P37/04 | [2021/15] | CPC: |
C07D495/04 (EP,US);
G01N33/5308 (US);
A61P35/00 (EP);
A61P37/04 (EP);
C07D215/52 (EP,US);
C07D231/16 (EP,US);
C07D241/44 (EP,US);
C07D243/12 (EP,US);
C07D271/08 (EP,US);
C07D271/12 (EP,US);
C07D277/48 (EP,US);
C07D277/76 (EP,US);
C07D311/12 (EP,US);
C07D417/12 (EP,US);
C07D491/052 (EP,US);
C07D491/056 (EP,US);
C07D491/147 (EP,US);
C07D493/04 (EP,US);
C07D493/14 (EP,US);
C07D498/04 (EP,US);
C12Q1/6804 (US);
C12Q1/6841 (US);
C12Q1/6886 (US);
G01N33/532 (EP,US);
G01N33/533 (EP,US);
G01N33/58 (EP,US);
G01N33/582 (EP,US);
|
Former IPC [2019/45] | G01N33/532, G01N33/533, G01N33/58, C12Q1/68, C07D271/12, C07D495/04 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR [2020/17] |
Former [2019/45] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR | Title | German: | HAPTENE, HAPTENKONJUGATE, ZUSAMMENSETZUNGEN DARAUS UND VERFAHREN ZU DEREN HERSTELLUNG UND VERWENDUNG | [2019/45] | English: | HAPTENS, HAPTEN CONJUGATES, COMPOSITIONS THEREOF AND METHOD FOR THEIR PREPARATION AND USE | [2019/45] | French: | HAPTÈNES, CONJUGUÉS DE HAPTÈNES, LEURS COMPOSITIONS ET LEUR PROCÉDÉ DE PRÉPARATION ET D'UTILISATION | [2019/45] | Examination procedure | 16.03.2020 | Amendment by applicant (claims and/or description) | 16.03.2020 | Examination requested [2020/17] | 16.03.2020 | Date on which the examining division has become responsible | 27.05.2020 | Despatch of a communication from the examining division (Time limit: M04) | 21.08.2020 | Reply to a communication from the examining division | 19.02.2021 | Cancellation of oral proceeding that was planned for 23.03.2021 | 02.03.2021 | Despatch of a communication from the examining division (Time limit: M04) | 05.03.2021 | Reply to a communication from the examining division | 23.03.2021 | Date of oral proceedings (cancelled) | 15.04.2021 | Communication of intention to grant the patent | 15.07.2021 | Fee for grant paid | 15.07.2021 | Fee for publishing/printing paid | 15.07.2021 | Receipt of the translation of the claim(s) | Parent application(s) Tooltip | EP07867341.5 / EP2078197 | EP16151995.4 / EP3029461 | EP17192133.1 / EP3276349 | Opposition(s) | 27.05.2022 | No opposition filed within time limit [2022/31] | Fees paid | Renewal fee | 06.06.2019 | Renewal fee patent year 03 | 06.06.2019 | Renewal fee patent year 04 | 06.06.2019 | Renewal fee patent year 05 | 06.06.2019 | Renewal fee patent year 06 | 06.06.2019 | Renewal fee patent year 07 | 06.06.2019 | Renewal fee patent year 08 | 06.06.2019 | Renewal fee patent year 09 | 06.06.2019 | Renewal fee patent year 10 | 06.06.2019 | Renewal fee patent year 11 | 06.06.2019 | Renewal fee patent year 12 | 14.11.2019 | Renewal fee patent year 13 | 10.11.2020 | Renewal fee patent year 14 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 01.11.2007 | AT | 25.08.2021 | CY | 25.08.2021 | CZ | 25.08.2021 | EE | 25.08.2021 | FI | 25.08.2021 | LT | 25.08.2021 | LV | 25.08.2021 | MC | 25.08.2021 | NL | 25.08.2021 | PL | 25.08.2021 | RO | 25.08.2021 | SE | 25.08.2021 | SI | 25.08.2021 | SK | 25.08.2021 | TR | 25.08.2021 | IE | 01.11.2021 | LU | 01.11.2021 | BG | 25.11.2021 | GR | 26.11.2021 | BE | 30.11.2021 | IS | 25.12.2021 | PT | 27.12.2021 | [2024/29] |
Former [2023/33] | HU | 01.11.2007 | |
AT | 25.08.2021 | ||
CY | 25.08.2021 | ||
CZ | 25.08.2021 | ||
EE | 25.08.2021 | ||
FI | 25.08.2021 | ||
LT | 25.08.2021 | ||
LV | 25.08.2021 | ||
MC | 25.08.2021 | ||
NL | 25.08.2021 | ||
PL | 25.08.2021 | ||
RO | 25.08.2021 | ||
SE | 25.08.2021 | ||
SI | 25.08.2021 | ||
SK | 25.08.2021 | ||
IE | 01.11.2021 | ||
LU | 01.11.2021 | ||
BG | 25.11.2021 | ||
GR | 26.11.2021 | ||
BE | 30.11.2021 | ||
IS | 25.12.2021 | ||
PT | 27.12.2021 | ||
Former [2023/24] | AT | 25.08.2021 | |
CY | 25.08.2021 | ||
CZ | 25.08.2021 | ||
EE | 25.08.2021 | ||
FI | 25.08.2021 | ||
LT | 25.08.2021 | ||
LV | 25.08.2021 | ||
MC | 25.08.2021 | ||
NL | 25.08.2021 | ||
PL | 25.08.2021 | ||
RO | 25.08.2021 | ||
SE | 25.08.2021 | ||
SI | 25.08.2021 | ||
SK | 25.08.2021 | ||
IE | 01.11.2021 | ||
LU | 01.11.2021 | ||
BG | 25.11.2021 | ||
GR | 26.11.2021 | ||
BE | 30.11.2021 | ||
IS | 25.12.2021 | ||
PT | 27.12.2021 | ||
Former [2022/48] | AT | 25.08.2021 | |
CZ | 25.08.2021 | ||
EE | 25.08.2021 | ||
FI | 25.08.2021 | ||
LT | 25.08.2021 | ||
LV | 25.08.2021 | ||
MC | 25.08.2021 | ||
NL | 25.08.2021 | ||
PL | 25.08.2021 | ||
RO | 25.08.2021 | ||
SE | 25.08.2021 | ||
SI | 25.08.2021 | ||
SK | 25.08.2021 | ||
IE | 01.11.2021 | ||
LU | 01.11.2021 | ||
BG | 25.11.2021 | ||
GR | 26.11.2021 | ||
BE | 30.11.2021 | ||
IS | 25.12.2021 | ||
PT | 27.12.2021 | ||
Former [2022/36] | AT | 25.08.2021 | |
CZ | 25.08.2021 | ||
EE | 25.08.2021 | ||
FI | 25.08.2021 | ||
LT | 25.08.2021 | ||
LV | 25.08.2021 | ||
MC | 25.08.2021 | ||
NL | 25.08.2021 | ||
PL | 25.08.2021 | ||
RO | 25.08.2021 | ||
SE | 25.08.2021 | ||
SI | 25.08.2021 | ||
SK | 25.08.2021 | ||
LU | 01.11.2021 | ||
BG | 25.11.2021 | ||
GR | 26.11.2021 | ||
BE | 30.11.2021 | ||
IS | 25.12.2021 | ||
PT | 27.12.2021 | ||
Former [2022/34] | AT | 25.08.2021 | |
CZ | 25.08.2021 | ||
EE | 25.08.2021 | ||
FI | 25.08.2021 | ||
LT | 25.08.2021 | ||
LV | 25.08.2021 | ||
MC | 25.08.2021 | ||
NL | 25.08.2021 | ||
PL | 25.08.2021 | ||
RO | 25.08.2021 | ||
SE | 25.08.2021 | ||
SK | 25.08.2021 | ||
LU | 01.11.2021 | ||
BG | 25.11.2021 | ||
GR | 26.11.2021 | ||
BE | 30.11.2021 | ||
IS | 25.12.2021 | ||
PT | 27.12.2021 | ||
Former [2022/33] | AT | 25.08.2021 | |
CZ | 25.08.2021 | ||
EE | 25.08.2021 | ||
FI | 25.08.2021 | ||
LT | 25.08.2021 | ||
LV | 25.08.2021 | ||
MC | 25.08.2021 | ||
NL | 25.08.2021 | ||
PL | 25.08.2021 | ||
RO | 25.08.2021 | ||
SE | 25.08.2021 | ||
SK | 25.08.2021 | ||
BG | 25.11.2021 | ||
GR | 26.11.2021 | ||
BE | 30.11.2021 | ||
IS | 25.12.2021 | ||
PT | 27.12.2021 | ||
Former [2022/24] | AT | 25.08.2021 | |
CZ | 25.08.2021 | ||
EE | 25.08.2021 | ||
FI | 25.08.2021 | ||
LT | 25.08.2021 | ||
LV | 25.08.2021 | ||
NL | 25.08.2021 | ||
PL | 25.08.2021 | ||
RO | 25.08.2021 | ||
SE | 25.08.2021 | ||
SK | 25.08.2021 | ||
BG | 25.11.2021 | ||
GR | 26.11.2021 | ||
IS | 25.12.2021 | ||
PT | 27.12.2021 | ||
Former [2022/16] | AT | 25.08.2021 | |
FI | 25.08.2021 | ||
LT | 25.08.2021 | ||
LV | 25.08.2021 | ||
NL | 25.08.2021 | ||
PL | 25.08.2021 | ||
SE | 25.08.2021 | ||
BG | 25.11.2021 | ||
GR | 26.11.2021 | ||
IS | 25.12.2021 | ||
PT | 27.12.2021 | ||
Former [2022/11] | AT | 25.08.2021 | |
FI | 25.08.2021 | ||
LT | 25.08.2021 | ||
LV | 25.08.2021 | ||
PL | 25.08.2021 | ||
SE | 25.08.2021 | ||
BG | 25.11.2021 | ||
GR | 26.11.2021 | ||
IS | 25.12.2021 | ||
PT | 27.12.2021 | ||
Former [2022/09] | AT | 25.08.2021 | |
FI | 25.08.2021 | ||
LT | 25.08.2021 | ||
SE | 25.08.2021 | ||
BG | 25.11.2021 | ||
PT | 27.12.2021 | ||
Former [2022/08] | AT | 25.08.2021 | |
FI | 25.08.2021 | ||
LT | 25.08.2021 | ||
SE | 25.08.2021 | ||
BG | 25.11.2021 | Documents cited: | Search | [Y]WO9503296 (ABBOTT LAB [US]) [Y] 1-12 * the whole document * * in particular: * * claims 1,23-25,27 * * example 27 * * page 15, line 22 - line 25 * * page 4, line 1 - line 30 * * page 9, line 17 - line 21 *; | [Y]WO2005064018 (VENTANA MED SYST INC [US], et al) [Y] 1-12 * the whole document * * in particular: * * example 11 * * page 8, line 9 - page 11, line 15 *; | [XY] - DARMON A ET AL, "A method for measuring anion transfer across membranes of hemoglobin-free cells and vesicles by continuous monitoring of fluorescence", ANALYTICAL BIOCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 119, no. 2, doi:10.1016/0003-2697(82)90591-7, ISSN 0003-2697, (19820115), pages 313 - 321, (19820115), XP024830638 [X] 10 * abstract * * par. "Anti-NBD antibodies"; page 314 * [Y] 1-9,11,12 DOI: http://dx.doi.org/10.1016/0003-2697(82)90591-7 | [XY] - M. VIGUIER ET AL, "The invariant chain forms complexes with class II major histocompatibility complex molecules and antigenic peptides "in vivo".", NATIONAL ACADEMY OF SCIENCES, US, (19900901), vol. 87, no. 18, doi:10.1073/pnas.87.18.7170, ISSN 0027-8424, pages 7170 - 7174, XP055258750 [X] 10 * abstract * * page 7171, column l, paragraph 1 - paragraph 2 * * page 7171, column r, line 10 - line 37 * [Y] 1-9,11,12 DOI: http://dx.doi.org/10.1073/pnas.87.18.7170 | [Y] - WATKINS B E ET AL, "THE SYNTHESIS OF HAPTENIC DERIVATIVES OF AMINOIMIDAZOAZAARENE COOKED-FOOD MUTAGENS", HETEROCYCLES, JAPAN INSTITUTE OF HETEROCYCLIC CHEMISTRY, JP, (19870101), vol. 26, no. 8, doi:10.3987/R-1987-08-2069, ISSN 0385-5414, pages 2069 - 2072, XP008159115 [Y] 1-12 * page 2071, line 1 - line 5 * * Scheme 2; page 2071 * DOI: http://dx.doi.org/10.3987/R-1987-08-2069 | [Y] - PUTTAIAH S ET AL, "Detection of dideoxyosone intermediates of glycation using a monoclonal antibody: Characterization of major epitope structures", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS, US, vol. 446, no. 2, doi:10.1016/J.ABB.2005.12.002, ISSN 0003-9861, (20060215), pages 186 - 196, (20060215), XP024942997 [Y] 1-12 * the whole document * * in particular: * * abstract * * page 187, column r, line 7 - page 188, column r, line 18 * DOI: http://dx.doi.org/10.1016/j.abb.2005.12.002 | by applicant | US4036945 | US4331647 | US4469797 | US4652441 | US4675189 | US4677191 | US4728721 | US4917893 | US4946778 | US5143854 | US5198537 | WO9617958 | US5585089 | US5650327 | US5654200 | US5759808 | US5800988 | US5840526 | US5874541 | US6005079 | US6015695 | US6194388 | US6207646 | US6214806 | US6218371 | US6239116 | US6296809 | US6326148 | US6339068 | US6352861 | US6406705 | US6429199 | US2003211630 | US6649138 | US6682596 | US2004052685 | US2004057958 | US6815064 | US6827901 | WO2005001889 | US2005012182 | US6943029 | - PAVLIAKOVA et al., Infect. Immun., (20000000), vol. 68, pages 2161 - 66 | - ENGELHARD, Curr. Opin. Immunol., (19940000), vol. 6, page 13 | - "New Biotinylating Reagent Utilizing Carbodiimide Function", Nucleic Acid Symposiums Series, (19950000), pages 69 - 70 | - SINGH et al., Nat. Biotechnol., (19990000), vol. 17, pages 1075 - 1081 | - SCHUMMER, Biotechniques, (19970000), vol. 23, pages 1087 - 1092 | - DEVI et al., PNAS, (19910000), vol. 88, pages 7175 - 79 | - FRANKEL et al., Mol. Immunol., (19790000), vol. 16, pages 101 - 106 | - POZSGAY et al., PNAS, (19990000), vol. 96, pages 5194 - 97 | - LEE et al., J. Immunol., (19760000), vol. 116, pages 1711 - 18 | - DINTZIS et al., PNAS, (19760000), vol. 73, pages 3671 - 75 | - FATTOM et al., Infect. Immun., (19900000), vol. 58, pages 2309 - 12 | - SZU et al., Infect. Immun., (19910000), vol. 59, pages 4555 - 61 | - SZU et al., J. Exp. Med., (19870000), vol. 166, pages 1510 - 24 | - J.C. CONNOLLYR. A. HILL, Triterpenoids, Nat. Prod. Rep., (20020000), vol. 19, pages 494 - 513 | - BAGLIN et al., A Review of Natural and Modified Beculinic, Ursolic and Echinocystic Acid Derivatives as Potential Antitumor and Anti-HIV Agents, Mini Reviews in Medicinal Chemistry, vol. 3, pages 525 - 539 | - W.N.M.C. SETZER, "Plant-Derived Triterpenoids as Potential Antineoplastic Agents", Mini Reviews in Medicinal Chemistry, (20030000), vol. 3, pages 540 - 556 | - BALTINA, "Chemical Modification of Glycyrrhizic Acid as a Route to New Bioactive Compounds for Medicine", Current Medicinal Chemistry, (20030000), vol. 10, pages 155 - 171 | - LESLIE CROMBIEDONALD WHITING, Biosynthesis in the Rotenoids Group of Natural Products: Application of Isotope Methodology, Phytochemistry, (19980000), vol. 49, pages 1479 - 1507 | - STEPHANIE DESBENESYLVIANE GIORGI-RENAULT, "Drugs that Inhibit Tubulin Polymerization: The Particuar Case of Podophyllotoxin and Analogues", Curr. Med. Chem. - Anti-Cancer Agents, (20020000), vol. 2, pages 71 - 90 | - M. GORDALIZA et al., "Podophyllotoxin: Distribution, Sources, Applications and New Cytotoxic Derivatives", Toxicon, (20040000), vol. 44, pages 441 - 459 | - PHILLIPE MERESSE et al., "Etoposide: Discovery and Medicinal Chemistry", Current Medicinal Chemistry, (20040000), vol. 11, pages 2443 - 2466 | - M. PUJOL et al., "Synthesis and Biological Activity of New Class of Dioxygenated Anticancer Agents", Curr. Med. Chem. - Anti-Cancer Agents, (20050000), vol. 5, pages 215 - 237 | - YOUNGJAE YOU, "Podophyllotoxin Derivatives: Current Synthetic Approaches for New Anticancer Agents", Current Pharmaceutical Design, (20050000), vol. 11, doi:doi:10.2174/1381612053764724, pages 1695 - 1717, XP055120074 DOI: http://dx.doi.org/10.2174/1381612053764724 | - WU, X. et al., Nature Biotech., (20030000), vol. 21, pages 41 - 46 | - WU, X. et al., "Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots", Nature Biotechnol., (20030000), vol. 21, doi:doi:10.1038/nbt764, pages 41 - 46, XP055509491 DOI: http://dx.doi.org/10.1038/nbt764 | - JAISWAL, J. K.MATTOUSSI, H.MAURO, J. M.SIMON, S. M., "Long-term multiple color imaging of live cells using quantum dot bioconjugates", Nature Biotechnol., (20030000), vol. 21, pages 47 - 51 | - DUBERTRET, B. et al., "In vivo imaging of quantum dots encapsulated in phospholipid micelles", Science, (20020000), vol. 298, doi:doi:10.1126/science.1077194, pages 1759 - 1762, XP002255863 DOI: http://dx.doi.org/10.1126/science.1077194 | - RIGBY, PWDIECKMANN, MRHODES, C.BERG, P., "Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I", J. Mol. Biol., VI, (19770000), vol. 13, doi:doi:10.1016/0022-2836(77)90052-3, pages 237 - 251, XP024012125 DOI: http://dx.doi.org/10.1016/0022-2836(77)90052-3 | - MICHAEL et al., J. Pharmacy Pharmacol., (19910000), vol. 43, pages 1 - 5 | - HARRIS, Nat Rev., (20020000), vol. 2, pages 38 - 47 | - FODOR, Science, (19910000), pages 767 - 773 | - JOHNSTON, Curr. Biol., (19980000), vol. 8, pages R171 - R174 | - HOOS et al., Am J Pathol., (20010000), vol. 158, pages 1245 - 51 | - JONES et al., Nature, (19860000), vol. 321, page 522 | - RIECHMANN et al., Nature, (19880000), vol. 332, page 323 | - VERHOEYEN et al., Science, (19880000), vol. 242, page 1534 | - CARTER et al., Proc. Natl. Acad. Sci. U.S.A., (19920000), vol. 89, page 4285 | - SANDHU, Crit. Rev. Biotech., (19920000), vol. 12, page 437 | - SINGER et al., J. Immunol., (19930000), vol. 150, page 2844 | - WHITLOW et al., Methods: a Companion to Methods in Enzymology, (19910000), vol. 2, page 97 | - PACK et al., BiolTechnology, (19930000), vol. 11, page 1271 | - NISONHOFF et al., Arch. Biochem. Biophys., (19600000), vol. 89, page 230 | - PORTER, Biochem. J., (19590000), vol. 73, page 119 | - EDELMAN et al., Methods in Enzymology, Academic Press, (19670000), vol. 1, page 422 | - BUCHNER et al., Anal. Biochem., (19920000), vol. 205, pages 263 - 270 | - PLUCKTHUN, Biotechnology, (19910000), vol. 9, page 545 | - HUSE et al., Science, (19890000), vol. 246, page 1275 | - WARD et al., Nature, (19890000), vol. 341, page 544 | - SAXENA et al., Biochemistry, (19700000), vol. 9, pages 5015 - 5021 | - BARANYMERRIFIELD, The Peptides: Analysis, Synthesis, Biology. Vol. 2: Special Methods in Peptide Synthesis, vol. 2, pages 3 - 284 | - MERRIFIELD et al., J. Am. Chem. Soc., (19630000), vol. 85, pages 2149 - 2156 | - NOVELLINO et al., Cancer Immunol. Immunother, (20050000), vol. 54, no. 3, pages 187 - 207 | - CHEN et al., Cytotherapy, (20020000), vol. 4, pages 41 - 8 | - SOUTHWOOD et al., J. Immunol., (19980000), vol. 160, page 3363 | - RAMMENSEE et al., Immunogenetics, (19950000), vol. 41, page 178 | - RAMMENSEE et al., J. Curr. Opin. Immunol., (19980000), vol. 10, page 478 | - SETTEGREY, Curr. Opin. Immunol., (19920000), vol. 4, page 79 | US20050675759 | US20050739794 | US20060413415 | US20060413778 | US20070931546 |