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EP3811945
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| EP3811945 - COMPOUNDS FOR TREATING AND PREVENTING GROWTH HORMONE RECEPTOR-DEPENDENT CONDITIONS [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 04.03.2022 Database last updated on 04.11.2024 | |
| Former | Request for examination was made Status updated on 20.08.2021 | ||
| Former | The application has been published Status updated on 26.03.2021 | Most recent event Tooltip | 04.03.2022 | Application deemed to be withdrawn | published on 06.04.2022 [2022/14] | Applicant(s) | For all designated states UMC Utrecht Holding B.V. Yalelaan 40 3584 CM Utrecht / NL | For all designated states Universiteit Utrecht Holding B.V. Yalelaan 40 3584 CM Utrecht / NL | For all designated states Bimini Biotech BV Angsteloord 73 1391 ED Abcoude / NL | [2021/17] | Inventor(s) | 01 /
STROUS, Gerardus Jacobus Antonius Maria Gendershof 6 4175 AP HAAFTEN / NL | 02 /
MOL, Jan Adrianus Bloementuin 18 3994 ZP HOUTEN / NL | 03 /
VAN DER VELDEN, Lieke Maria Roerkuip 20 5271 ZL SINT-MICHIELSGESTEL / NL | 04 /
KLUMPERMAN, Judith van Renesseweg 1 3628 BB KOCKENGEN / NL | 05 /
MAAS, Petrus Emmanuel Marie Larikslaan 197 3053 LB ROTTERDAM / NL | 06 /
PIET, Dennis Patrick Wijnkoopsbaai 60 2904 BR CAPELLE AAN DEN IJSSEL / NL | 07 /
DE KLERK-SPRENKELS, Nanda Elisabeth Rosa Manuslaan 56 2642 DR PIJNACKER / NL | 08 /
TIJHUIS, Johann Heinrich Ruys de Beerenbrouckstraat 24 2613 AT DELFT / NL | 09 /
VIËTOR, Hendrik Engelbertus Angsteloord 73 1391 ED ABCOUDE / NL | 10 /
MAURICE, Madelon Maria Groen van Prinstererweg 5 3731 HA DE BILT / NL | 11 /
VAN DER KRIFT, Felix Kanaalstraat 22 3531 CK UTRECHT / NL | [2021/17] | Representative(s) | Wensvoort, Gert Kallenkoterallee 82 A 8331 AJ Steenwijk / NL | [2021/17] | Application number, filing date | 19205268.6 | 25.10.2019 | [2021/17] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP3811945 | Date: | 28.04.2021 | Language: | EN | [2021/17] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 14.04.2020 | Classification | IPC: | A61K31/505, A61K31/506, A61K31/5377, A61P3/10, A61P11/00, A61P25/28, A61P29/00, A61P35/00, A61P35/02, A61P35/04, A61P37/06, A61P43/00 | [2021/17] | CPC: |
A61K31/505 (EP);
A61K31/506 (EP);
A61K31/5377 (EP);
A61P11/00 (EP);
A61P25/28 (EP);
A61P29/00 (EP);
A61P3/10 (EP);
A61P35/00 (EP);
A61P35/02 (EP);
A61P35/04 (EP);
A61P37/06 (EP);
A61P43/00 (EP);
| C-Set: |
C12Q1/6804, C12Q2523/109, C12Q2527/125 (EP)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2021/38] |
| Former [2021/17] | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | KH | Not yet paid | MA | Not yet paid | MD | Not yet paid | TN | Not yet paid | Title | German: | VERBINDUNGEN ZUR BEHANDLUNG UND VORBEUGUNG VON WACHSTUMSHORMONREZEPTORABHÄNGIGEN ZUSTÄNDEN | [2021/17] | English: | COMPOUNDS FOR TREATING AND PREVENTING GROWTH HORMONE RECEPTOR-DEPENDENT CONDITIONS | [2021/17] | French: | COMPOSÉS POUR LE TRAITEMENT ET LA PRÉVENTION DE MALADIES DÉPENDANTES DU RÉCEPTEUR DE L'HORMONE DE CROISSANCE | [2021/17] | Examination procedure | 12.08.2021 | Examination requested [2021/38] | 12.08.2021 | Date on which the examining division has become responsible | 29.10.2021 | Application deemed to be withdrawn, date of legal effect [2022/14] | 19.11.2021 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time [2022/14] | Fees paid | Renewal fee | 27.10.2021 | Renewal fee patent year 03 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [AD]WO9820878 (FMC CORP [US]) [AD] 1-18 * abstract * * pages 46-62; table 1 ** claim - *; | [X]WO2009025919 (UNIV CONNECTICUT [US], et al) [X] 1-4,6,9-12,14,17,18 * page 4, paragraphs 3-5 * * page 25; table 1 * * pages 30-31; table 2 * * page 33, paragraph 4 - page 34, paragraph 4 * * page 39, paragraph l - page 41, paragraph l; claims 1,7 *; | [X]WO2013070620 (UNIV CONNECTICUT [US]) [X] 1-4,6,9-12,14,17,18 * page 4, paragraph 4 - page 5, paragraph l * * page 30 - page 31; table 1 * * page 38 - page 39; table 3 * * page 41, paragraphs 3-4 * * page 93 - page 94; table 7 * * claims 1,15-19 *; | [X] - OZTEKIN ALGUL ET AL, "2,4-Diamino-5-(2-arylpropargyl)pyrimidine derivatives as new nonclassical antifolates for human dihydrofolate reductase inhibition", JOURNAL OF MOLECULAR GRAPHICS AND MODELLING, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 29, no. 5, doi:10.1016/J.JMGM.2010.11.004, ISSN 1093-3263, (20101105), pages 608 - 613, (20101111), XP028141150 [X] 1-4,6,9-12,14,17,18 * whole document and more particularly Table 1 * DOI: http://dx.doi.org/10.1016/j.jmgm.2010.11.004 | [X] - KISHORE VISWANATHAN ET AL, "Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes", PLOS ONE, (20120207), vol. 7, no. 2, doi:10.1371/journal.pone.0029434, page e29434, XP055171409 [X] 1,9,18 * abstract * * page 3; tables 1,2 * * page 5; compound 31 * DOI: http://dx.doi.org/10.1371/journal.pone.0029434 | [X] - PAULSEN J L ET AL, "In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans", BIOORGANIC & MEDICINAL CHEMISTRY : A TETRAHEDRON PUBLICATION FOR THE RAPID DISSEMINATION OF FULL ORIGINAL RESEARCH PAPERS AND CRITICAL REVIEWS ON BIOMOLECULAR CHEMISTRY, MEDICINAL CHEMISTRY AND RELATED DISCIPLINES, ELSEVIER, NL, vol. 17, no. 14, doi:10.1016/J.BMC.2009.06.021, ISSN 0968-0896, (20090715), pages 4866 - 4872, (20090617), XP026302948 [X] 1,9,18 * the whole document * DOI: http://dx.doi.org/10.1016/j.bmc.2009.06.021 | by applicant | WO9820878 | - BUCHMAN, M.S. BELLJ.J. KOPCHICK, "Growth Hormone Discovery and Structure", Pediatr Endocrinol Rev., (20180000), vol. 16, pages 2 - 10 | - CHHABRA, Y.WATERS, M.J.BROOKS, A.J., "Role of the growth hormone-IGF-1 axis in cancer", Expert. Rev.Endocrinol. Metab., (20110000), doi:10.1586/eem.10.73, pages 71 - 84, XP009167646 DOI: http://dx.doi.org/10.1586/eem.10.73 | - CHRISTGEN, M.P. DERKSEN, "Lobular breast cancer: molecular basis, mouse and cellular models", Breast Cancer Res., (20150000), vol. 17, doi:10.1186/s13058-015-0517-z, page 16, XP021213340 DOI: http://dx.doi.org/10.1186/s13058-015-0517-z | - DEHKHODA, F.C.M.M. LEEJ. MEDINAA.J. BROOKS, "The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects", Frontiers in endocrinology, (20180000), vol. 9, page 35 | - FURQAN, M.N. MUKHIB. LEED. 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WIT., "Growth hormone - past, present and future", Nat Rev Endocrinol., vol. 14, (20180000), pages 285 - 300, URL: http://www.ncbi.nlm.nih.gov/pubmed/29546874 | - SEDEK, M.L.M. VAN DERVELDENG.J. STROUS, "Multimeric growth hormone receptor complexes serve as signaling platforms", J. Biol. Chem., (20140000), vol. 289, pages 65 - 73 | - THEODOROPOULOU, M.G.K. STALLA, "Somatostatin receptors: from signaling to clinical practice", Frontiers in neuroendocrinology, (20130000), vol. 34, pages 228 - 252 | - TIMMERMANS-SPRANG, E.P.M.A. GRACANINJ.A. MOL, "Molecular Signaling of Progesterone, Growth Hormone, Wnt, and HE in Mammary Glands of Dogs, Rodents, and Humans: New Treatment Target Identification", Frontiers in veterinary science, (20170000), vol. 4, page 53 | - VERMEULEN, J.F.A.S. VAN BRUSSELA. ADAMSW.P. MALIE. VAN DER WALLP.J. VAN DIESTP.W. 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