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Extract from the Register of European Patents

EP About this file: EP3763716

EP3763716 - NOVEL PHARMACEUTICAL USE OF THIOPHENE [3, 2-D] PYRIMIDINE-4-KETONE COMPOUND [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  26.01.2024
Database last updated on 02.11.2024
FormerRequest for examination was made
Status updated on  11.12.2020
FormerThe international publication has been made
Status updated on  14.09.2019
Most recent event   Tooltip18.05.2024New entry: Reply to examination report 
Applicant(s)For all designated states
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
555 Zu Chong Zhi Road
Zhang Jiang
Pudong, Shanghai 201203 / CN
[2021/02]
Inventor(s)01 / LIU, Hong
555 Zu Chong Zhi Road, Zhang Jiang, Pudong
Shanghai 201203 / CN
02 / LI, Jia
555 Zu Chong Zhi Road, Zhang Jiang, Pudong
Shanghai 201203 / CN
03 / WANG, Jiang
555 Zu Chong Zhi Road, Zhang Jiang, Pudong
Shanghai 201203 / CN
04 / ZANG, Yi
555 Zu Chong Zhi Road, Zhang Jiang, Pudong
Shanghai 201203 / CN
05 / LI, Jian
555 Zu Chong Zhi Road, Zhang Jiang, Pudong
Shanghai 201203 / CN
06 / LI, Jingya
555 Zu Chong Zhi Road, Zhang Jiang, Pudong
Shanghai 201203 / CN
07 / SUN, Dandan
555 Zu Chong Zhi Road, Zhang Jiang, Pudong
Shanghai 201203 / CN
08 / JIANG, Hualiang
555 Zu Chong Zhi Road, Zhang Jiang, Pudong
Shanghai 201203 / CN
09 / CHEN, Kaixian
555 Zu Chong Zhi Road, Zhang Jiang, Pudong
Shanghai 201203 / CN
 [2021/02]
Representative(s)Neumann, Ditmar
KEENWAY Patentanwälte Neumann
Heine Taruttis PartG mbB
Postfach 103363
40024 Düsseldorf / DE
[2021/02]
Application number, filing date19763907.308.03.2019
[2021/02]
WO2019CN77560
Priority number, dateCN20181019496709.03.2018         Original published format: CN201810194967
[2021/02]
Filing languageZH
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019170157
Date:12.09.2019
Language:ZH
[2019/37]
Type: A1 Application with search report 
No.:EP3763716
Date:13.01.2021
Language:EN
[2021/02]
Search report(s)International search report - published on:CN12.09.2019
(Supplementary) European search report - dispatched on:EP18.11.2021
ClassificationIPC:A61K31/519, A61K31/00, C07D201/00, A61P1/16, A61K9/00
[2021/51]
CPC:
A61K45/06 (EP); A61K31/519 (EP,KR,RU,US); C07D495/04 (CN,KR,RU);
A61K31/5377 (KR,RU,US); A61K31/55 (RU); A61K9/0019 (EP);
A61K9/0021 (EP); A61K9/0043 (EP); A61K9/0048 (EP);
A61K9/0053 (EP); A61K9/0095 (EP); A61K9/02 (EP);
A61K9/06 (EP); A61K9/2004 (EP); A61K9/4841 (EP);
A61K9/7007 (EP); A61K9/7015 (EP); A61P1/16 (EP,KR,RU,US);
A61P43/00 (KR,RU) (-)
Former IPC [2021/02]C07D495/04, A61K31/55, A61P1/16
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/02]
TitleGerman:NEUARTIGE PHARMAZEUTISCHE VERWENDUNG VON THIOPHEN[3,2-D]PYRIMIDIN-4-KETON-VERBINDUNGEN[2021/02]
English:NOVEL PHARMACEUTICAL USE OF THIOPHENE [3, 2-D] PYRIMIDINE-4-KETONE COMPOUND[2021/02]
French:NOUVELLE UTILISATION PHARMACEUTIQUE DU COMPOSÉ THIOPHÈNE [3, 2-D] PYRIMIDINE-4-CÉTONE[2021/02]
Entry into regional phase23.09.2020Translation filed 
23.09.2020National basic fee paid 
23.09.2020Search fee paid 
23.09.2020Designation fee(s) paid 
23.09.2020Examination fee paid 
Examination procedure23.09.2020Examination requested  [2021/02]
07.06.2022Amendment by applicant (claims and/or description)
29.01.2024Despatch of a communication from the examining division (Time limit: M04)
17.05.2024Reply to a communication from the examining division
Fees paidRenewal fee
23.09.2020Renewal fee patent year 03
25.03.2022Renewal fee patent year 04
23.03.2023Renewal fee patent year 05
27.03.2024Renewal fee patent year 06
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Documents cited:Search[Y]WO2009147125  (BOEHRINGER INGELHEIM INT [DE], et al) [Y] 1-10 * title, abstract; claims 5-8 *;
 [XY]CN101817833  (JIANGSU CHIATAI TIANQING PHARMACEUTICAL LTD, et al) [X] 1-10 * [0080], compound 1, and [0097], compound 2 * [Y] 1-10;
 [Y]WO2011118976  (DONG A PHARM CO LTD [KR], et al) [Y] 1-10 * [0075]; Fig. 10 *;
 [Y]US2012121530  (KLEIN THOMAS [DE], et al) [Y] 1-10 * [0163], [0338]; claim 4 *;
 [XY]WO2013078765  (SHANGHAI INST MATERIA MEDICA [CN]) [X] 1-10 * compounds 1-144 in table at p. 12 ff.; [0036]; [0395] * [Y] 1-10;
 [Y]US2016354380  (DUGI KLAUS [GB], et al) [Y] 1-10 * [0071]; example 19; cl. 22 *;
 [XY]CA3018800  (SHANGHAI INST MATERIA MEDICA CAS [CN]) [X] 1-10 * [0001], [0009], [0020] * [Y] 1-10;
 [XY]  - DENG J ET AL, "The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 46, no. 1, ISSN 0223-5234, (20110101), pages 71 - 76, (20101218), XP027565690 [X] 1-10 * scheme 1, compound 10d; title, abstract * [Y] 1-10
 [Y]  - KAJI KOSUKE ET AL, "Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats", JOURNAL OF GASTROENTERLOGY, SPRINGER JAPAN KK, JP, vol. 49, no. 3, doi:10.1007/S00535-013-0783-4, ISSN 0944-1174, (20130312), pages 481 - 491, (20130312), XP035346264 [Y] 1-10 * title, abstract *

DOI:   http://dx.doi.org/10.1007/s00535-013-0783-4
 [Y]  - MARQUES ANA PATRÍCIA ET AL, "Dipeptidyl peptidase IV (DPP-IV) inhibition prevents fibrosis in adipose tissue of obese mice", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER, AMSTERDAM, NL, (20171222), vol. 1862, no. 3, doi:10.1016/J.BBAGEN.2017.11.012, ISSN 0304-4165, pages 403 - 413, XP085414871 [Y] 1-10 * title, abstract, Fig. 3 *

DOI:   http://dx.doi.org/10.1016/j.bbagen.2017.11.012
 [Y]  - Fatma A. Mahmoud ET AL, "The Beneficial Effects of Sitagliptin, a Dipeptedyl Peptidase-4 (DPP-4) Inhibitor on Experimentally Induced Non-Alcoholic Fatty Liver Disease in Rats", The Medical Journal of Cairo University, doi:10.21608/mjcu.2018.55786, (20180301), pages 1065 - 1076, URL: https://mjcu.journals.ekb.eg/article_55786_9206f1f6d62d35b99b5249d78e64d36d.pdf, (20211109), XP055859552 [Y] 1-10 * title, abstract *

DOI:   http://dx.doi.org/10.21608/mjcu.2018.55786
International search[X]WO2004014916  (WARNER LAMBERT CO [US], et al) [X] 1-3, 6-10;
 [X]CN102311448  (GUANGZHOU INST BIOMED & HEALTH, et al) [X] 1-9;
 [X]CN102659813  (SHANGHAI INST MATERIA MEDICA) [X] 1-9;
 [XY]CN103130819  (SHANGHAI INST MATERIA MEDICA) [X] 1-9 [Y] 1-10;
 [X]CN107216340  (SHANGHAI INST MATERIA MEDICA CAS)[X] 1-9;
 [Y]  - YU, Yuan et al, "Progress of the Correlation between DPP-4 and Chronic Liver Disease", Chinese Journal of Gastroenterology and Hepatology, (20150930), vol. 24, no. 9, pages 1152 - 1154, XP055736030 [Y] 1-10
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.