Extract from the Register of European Patents

EP About this file: EP3866923

EP3866923 - CO-CRYSTALS COMPRISING LEVOTHYROXINE AND A DICARBOXYLIC ACID [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  27.10.2023
Database last updated on 30.03.2026
FormerRequest for examination was made
Status updated on  23.07.2021
FormerThe international publication has been made
Status updated on  24.04.2020
Formerunknown
Status updated on  25.10.2019
Most recent event   Tooltip29.01.2026Change: Despatch of examination report + time limit 
Applicant(s)For all designated states
SANDOZ AG
Centralbahnstrasse 4
4051 Basel / CH
[2024/47]
Former [2021/34]For all designated states
Sandoz AG
Lichtstrasse 35
4056 Basel / CH
Inventor(s)01 / STEFINOVIC, Marijan
c/o Sandoz GmbH Biochemiestr. 10
6250 Kundl / AT
02 / ENKELMANN, Dennis, Dimo
c/o University of Innsbruck Innrain 52a
6020 Innsbruck / AT
03 / GRIESSER, Ulrich
c/o Universität Innsbruck Innrain 52a
6020 Innsbruck / AT
04 / GELBRICH, Thomas
c/o University of Innsbruck
6020 Innsbruck / AT
 [2021/34]
Representative(s)Prüfer & Partner mbB Patentanwälte · Rechtsanwälte
Sohnckestraße 12
81479 München / DE
[2021/34]
Application number, filing date19786980.316.10.2019
[2021/34]
WO2019EP78084
Priority number, dateEP2018020086917.10.2018         Original published format: EP 18200869
EP2019020102002.10.2019         Original published format: EP 19201020
[2021/34]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2020079079
Date:23.04.2020
Language:EN
[2020/17]
Type: A1 Application with search report 
No.:EP3866923
Date:25.08.2021
Language:EN
The application published by WIPO in one of the EPO official languages on 23.04.2020 takes the place of the publication of the European patent application.
[2021/34]
Search report(s)International search report - published on:EP23.04.2020
ClassificationIPC:A61P5/00, C07C25/00, A61K31/198
[2021/34]
CPC:
C07C59/255 (EP); C07C229/36 (EP,US); A61K31/198 (EP);
A61P5/14 (EP); C07C55/02 (US); C07C59/08 (EP);
C07B2200/13 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/34]
TitleGerman:CO-KRISTALLE MIT LEVOTHYREXIN UND EINER DICARBONSÄURE[2021/34]
English:CO-CRYSTALS COMPRISING LEVOTHYROXINE AND A DICARBOXYLIC ACID[2021/34]
French:CO-CRISTAUX COMPRENANT DE LA LÉVOTHYROXINE ET UN ACIDE DICARBOXYLIQUE[2021/34]
Entry into regional phase29.03.2021National basic fee paid 
29.03.2021Designation fee(s) paid 
29.03.2021Examination fee paid 
Examination procedure29.03.2021Examination requested  [2021/34]
29.03.2021Date on which the examining division has become responsible
02.11.2021Amendment by applicant (claims and/or description)
27.10.2023Despatch of a communication from the examining division (Time limit: M06)
17.04.2024Reply to a communication from the examining division
19.11.2025Despatch of a communication from the examining division (Time limit: M06)
Fees paidRenewal fee
29.09.2021Renewal fee patent year 03
28.09.2022Renewal fee patent year 04
27.09.2023Renewal fee patent year 05
26.09.2024Renewal fee patent year 06
24.09.2025Renewal fee patent year 07
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Cited inInternational search[XI] US7858663  (BRISTOL DAVID WILLIAM et al.)
 [AD]   MAZEN LEE HAMAD ET AL.: "Impact of hydration state and molecular oxygen on the chemical stability of levothyroxine sodium", PHARM DEV TECHNOL, vol. 20, no. 3, 2015, pages 314 - 319, XP002786835
 [A]   CERREIA VIOGLIO PAOLO ET AL: "Pharmaceutical aspects of salt and cocrystal forms of APIs and characterization challenges", ADVANCED DRUG DELIVERY REVIEWS, vol. 117, 5 July 2017 (2017-07-05), pages 86 - 110, XP085279596, ISSN: 0169-409X, DOI: 10.1016/J.ADDR.2017.07.001

DOI:   http://dx.doi.org/10.1016/j.addr.2017.07.001
 [A]   ANINDITA SARKAR ET AL: "Cocrystals of Acyclovir with Promising Physicochemical Properties", DISSOLUTION PROFILE OF NOVEL COMPOSITE PELLET CORES BASED ON DIFFERENT RATIOS OF MICROCRYSTALLINE CELLULOSE AND ISOMALT, vol. 104, no. 1, 1 January 2015 (2015-01-01), pages 98 - 105, XP055526401, ISSN: 0022-3549, DOI: 10.1002/jps.24248

DOI:   http://dx.doi.org/10.1002/jps.24248
ExaminationUS10183001
by applicant  MAZEN LEE HAMAD ET AL.: "Impact of hydration state and molecular oxygen on the chemical stability of levothyroxine sodium", PHARM DEV TECHNOL, vol. 20, no. 3, 2015, pages 314 - 319, XP055526252, doi:10.3109/10837450.2013.862635

DOI:   http://dx.doi.org/10.3109/10837450.2013.862635
   VITALIJ K PECHARSKYPETER Y. ZAVALIJ: "Fundamentals of Powder Diffraction and Structural Characterization of Materials", 2003, KLUWER ACADEMIC PUBLISHERS, pages: 3
   SHELDRICK, ACTA CRYST, vol. A71, 2015, pages 3 - 8
   PARSONSFLACKWAGNER, ACTA CRYST., vol. B69, 2013, pages 249 - 259
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