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Extract from the Register of European Patents

EP About this file: EP3781677

EP3781677 - COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITING [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  22.01.2021
Database last updated on 25.09.2024
FormerThe international publication has been made
Status updated on  25.10.2019
Most recent event   Tooltip29.04.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
University of Massachusetts
One Beacon Street
31st Floor
Boston, MA 02108 / US
[2021/08]
Inventor(s)01 / MELLO, Craig, Cameron
25 Fessenden Road
Barrington, RI 02806 / US
02 / GHANTA, Krishna Sumanth
174 Providence Road, Apt. 102
Grafton, MA 01519 / US
03 / DOKSHIN, Gregoriy
177 Lewis Road
Belmont, MA 02478 / US
04 / MIR, Aamir
285 Plantation Street, Apt. 1015
Worcester, MA 01604 / US
05 / GNEID, Hassan
53 Dustin Street
Worcester, MA 01604 / US
06 / WATTS, Jonathan Kenneth
5 Brook Hill Drive
Worcester, MA 01609 / US
07 / SONTHEIMER, Erik Joseph
236 Islington Road
Auburndale, MA 02466 / US
 [2021/08]
Representative(s)Icosa
83 avenue Denfert-Rochereau
75014 Paris / FR
[2021/08]
Application number, filing date19788536.115.04.2019
[2021/08]
WO2019US27531
Priority number, dateUS201862658368P16.04.2018         Original published format: US 201862658368 P
US201862679315P01.06.2018         Original published format: US 201862679315 P
[2021/08]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019204226
Date:24.10.2019
Language:EN
[2019/43]
Type: A1 Application with search report 
No.:EP3781677
Date:24.02.2021
Language:EN
The application published by WIPO in one of the EPO official languages on 24.10.2019 takes the place of the publication of the European patent application.
[2021/08]
Search report(s)International search report - published on:US24.10.2019
(Supplementary) European search report - dispatched on:EP20.12.2021
ClassificationIPC:C12N9/22, C12N15/90
[2021/08]
CPC:
C12N15/102 (EP,US); C12N15/113 (US); C12N15/66 (US);
C12N15/902 (US); C12N9/22 (EP,US); C12N15/111 (EP);
C12N2310/20 (EP); C12N2310/3181 (EP); C12N2310/351 (EP);
C12N2320/50 (EP) (-)
C-Set:
C12N15/102, C12Q2525/117, C12Q2525/191 (EP);
C12N2310/321, C12N2310/3521 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/08]
TitleGerman:ZUSAMMENSETZUNGEN UND VERFAHREN ZUR VERBESSERTEN GENEDITIERUNG[2021/08]
English:COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITING[2021/08]
French:COMPOSITIONS ET MÉTHODES POUR L'ÉDITION GÉNÉTIQUE AMÉLIORÉE[2021/08]
Entry into regional phase16.11.2020National basic fee paid 
16.11.2020Search fee paid 
16.11.2020Designation fee(s) paid 
16.11.2020Examination fee paid 
Examination procedure16.11.2020Examination requested  [2021/08]
20.07.2022Amendment by applicant (claims and/or description)
Fees paidRenewal fee
27.04.2021Renewal fee patent year 03
27.04.2022Renewal fee patent year 04
27.04.2023Renewal fee patent year 05
29.04.2024Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XI]WO2014102688  (CELLECTIS [FR]) [X] 13,14 * the whole document * [I] 15;
 [XI]WO2017205650  (LIFE TECHNOLOGIES CORP [US]) [X] 13,14 * the whole document * [I] 15;
 [XI]  - LEE KUNWOO ET AL, "Synthetically modified guide RNA and donor DNA are a versatile platform for CRISPR-Cas9 engineering", ELIFE, GB, vol. 6, doi:10.7554/eLife.25312, ISSN 2050-084X, (20170502), URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413346/pdf/elife-25312.pdf, XP055859974 [X] 1-8,10-14,16 * the whole document * * page 8 * [I] 9,15

DOI:   http://dx.doi.org/10.7554/eLife.25312
 [X]  - ALICE SOSIC ET AL, "Enzymatic Formation of PEGylated Oligonucleotides", BIOCONJUGATE CHEMISTRY, US, (20140203), vol. 25, no. 2, doi:10.1021/bc400569z, ISSN 1043-1802, pages 433 - 441, XP055732817 [X] 1-6 * the whole document *

DOI:   http://dx.doi.org/10.1021/bc400569z
 [XP]  - Ghanta Krishna S ET AL, "5' Modifications Improve Potency and Efficacy of DNA 1 Donors for Precision Genome Editing", bioRxiv, doi:10.1101/354480, (20180622), URL: https://www.biorxiv.org/content/10.1101/354480v1.full.pdf, (20210629), XP055819401 [XP] 1-16 * the whole document *

DOI:   http://dx.doi.org/10.1101/354480
 [XP]  - DOKSHIN GREGORIY A ET AL, "Robust Genome Editing with Short Single-Stranded and Long, Partially Single-Stranded DNA Donors in Caenorhabditis elegans", GENETICS, vol. 210, no. 3, doi:10.1534/genetics.118.301532, (20180913), pages 781 - 787, URL: https://watermark.silverchair.com/genetics0781.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAvAwggLsBgkqhkiG9w0BBwagggLdMIIC2QIBADCCAtIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMj78vdtH1xCZw0jkZAgEQgIICo585ZG7MkAFhURJueEabS_e3KDhIkXGUvnJolvOIKJuxdjryCyh7Bo5X7OVmMFleiLPKohgQnsdZ9uYW8mervGd, XP055870260 [XP] 13-15 * the whole document *

DOI:   http://dx.doi.org/10.1534/genetics.118.301532
International search[Y]US2008045473  (UHLMANN EUGEN [DE], et al) [Y] 8, 43, 82, 111, 141 * entire document *;
 [A]US2012282699  (BUNDOCK PAUL [NL], et al) [A] 1-26, 36-61, 65-100, 103, 105-129, 139-155* entire document *;
 [Y]US2013326645  (COST GREGORY J [US], et al) [Y] 3, 4, 38, 39, 107, 108 * entire document *;
 [Y]WO2017019867  (DANISCO US INC [US]) [Y] 150 * entire document *;
 [Y]US2017051276  (MAY ANDREW PAUL [US], et al) [Y] 7, 18-23, 42, 53-58, 65, 69, 76, 77, 81, 92-97, 110, 121-126 * entire document *;
 [XY]US2017058298  (KENNEDY ANDREW [US], et al) [X] 1, 2, 5, 6, 9-17, 24-26, 36, 37, 40, 41, 44-52, 59-61, 66-68, 70-75, 78-80, 83-91, 98-100, 103, 105, 106, 109, 112-120, 127-129, 139, 140, 142-145, 155 * entire document * [Y] 3, 4, 7, 8, 18-23, 38, 39, 42, 43, 53-58, 65, 69, 76, 77, 81, 82, 92-97, 107, 108, 110, 111, 121-126, 141;
 [XY]WO2017096041  (UNIV CALIFORNIA [US]) [X] 146-149, 151, 152 * entire document * [Y] 150, 153, 154;
 [Y]WO2017205650  (LIFE TECHNOLOGIES CORP [US]) [Y] 153, 154 * entire document *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.