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Extract from the Register of European Patents

EP About this file: EP3793982

EP3793982 - SMALL MOLECULE INHIBITORS OF THE NUCLEAR TRANSLOCATION OF ANDROGEN RECEPTOR FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  24.03.2023
Database last updated on 03.09.2024
FormerRequest for examination was made
Status updated on  19.02.2021
FormerThe international publication has been made
Status updated on  22.11.2019
Most recent event   Tooltip24.03.2023Application deemed to be withdrawnpublished on 26.04.2023  [2023/17]
Applicant(s)For all designated states
University of Pittsburgh - of the Commonwealth System of Higher Education
1st Floor Gardner Steel Conference Center
130 Thackeray Avenue
Pittsburgh, Pennsylvania 15260 / US
[2021/12]
Inventor(s)01 / MILLIGAN, John
Department of Chemistry Chevron Science Center (
1301 CHVRN) 219 Parkman Avenue
Pittsburgh, Pennsylvania 15260 / US
02 / TAI, Serene
Department of Chemistry Chevron Science Center (
650 CHVRN) 219 Parkman Ave.
Pittsburgh, Pennsylvania 15260 / US
03 / NELSON, Joel B.
UPMC 200 Lothrop St.
Pittsburgh, Pennsylvania 15213-2582 / US
04 / JOHNSON, James K.
University of Pittsburgh Department of Chemistry
Chevron Science Center (650 CHVRN) 219 Parkman
Avenue
Pittsburgh, Pennsylvania 15260 / US
05 / SKODA, Erin M.
1203 Fidler Ln, 413
Silver Spring, Maryland 20910 / US
06 / WANG, Zhou
Shadyside Medical Center, Suite G40 5200 Centre
Ave.
Pittsburgh, Pennsylvania 15232 / US
07 / TAKUBO, Keita
Department of Chemistry Chevron Science Center (
650 CHVRN) 219 Parkman Avenue
Pittsburgh, Pennsylvania 15260 / US
08 / WIPF, Peter
Department of Chemistry Chevron Science Center (
1301 CHVRN) 219 Parkman Avenue
Pittsburgh, Pennsylvania 15260 / US
 [2021/12]
Representative(s)HGF
HGF Limited
1 City Walk
Leeds LS11 9DX / GB
[N/P]
Former [2021/12]HGF
1 City Walk
Leeds LS11 9DX / GB
Application number, filing date19803487.813.05.2019
[2021/12]
WO2019US32033
Priority number, dateUS201862671254P14.05.2018         Original published format: US 201862671254 P
[2021/12]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019222105
Date:21.11.2019
Language:EN
[2019/47]
Type: A1 Application with search report 
No.:EP3793982
Date:24.03.2021
Language:EN
The application published by WIPO in one of the EPO official languages on 21.11.2019 takes the place of the publication of the European patent application.
[2021/12]
Search report(s)International search report - published on:IL21.11.2019
(Supplementary) European search report - dispatched on:EP12.04.2022
ClassificationIPC:C07D295/185, C07D209/52, C07C49/563, C07D409/02, C07D207/06, C07D207/08, C07D233/61, C07D487/04, A61K31/12, A61K31/165, A61K31/40, A61K31/403, A61K31/407, A61K31/495, A61K31/496, A61K31/498, A61P35/00
[2021/12]
CPC:
A61K31/403 (EP); A61K31/4166 (EP); A61K31/495 (EP);
A61K31/58 (EP); A61P35/00 (EP); C07D209/52 (EP);
C07D239/42 (EP); C07D295/185 (EP); C07D309/14 (EP);
C07D333/24 (EP) (-)
C-Set:
A61K31/403, A61K2300/00 (EP);
A61K31/4166, A61K2300/00 (EP);
A61K31/495, A61K2300/00 (EP);
A61K31/58, A61K2300/00 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/12]
TitleGerman:KLEINMOLEKÜLIGE INHIBITOREN DER NUKLEAREN TRANSLOKATION DES ANDROGENREZEPTORS ZUR BEHANDLUNG VON KASTRATIONSRESISTENTEM PROSTATAKREBS[2021/12]
English:SMALL MOLECULE INHIBITORS OF THE NUCLEAR TRANSLOCATION OF ANDROGEN RECEPTOR FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER[2021/12]
French:INHIBITEURS À PETITES MOLÉCULES DE LA TRANSLOCATION NUCLÉAIRE DU RÉCEPTEUR DES ANDROGÈNES POUR TRAITER LE CANCER DE LA PROSTATE RÉSISTANT À LA CASTRATION[2021/12]
Entry into regional phase09.12.2020National basic fee paid 
09.12.2020Search fee paid 
09.12.2020Designation fee(s) paid 
09.12.2020Examination fee paid 
Examination procedure09.12.2020Amendment by applicant (claims and/or description)
09.12.2020Examination requested  [2021/12]
15.11.2022Application deemed to be withdrawn, date of legal effect  [2023/17]
08.12.2022Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2023/17]
Fees paidRenewal fee
13.05.2021Renewal fee patent year 03
28.04.2022Renewal fee patent year 04
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]WO2017165822  (UNIV OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US], et al) [Y] 1-15 * pages 12,26-30; claim 1 *;
 [Y]  - PAOLA CIAPETTI AND BRUNO GIETHLEN ED - CAMILLE GEORGES WERMUTH, Chapter 15 - Molecular Variations Based on Isosteric Replacements, THE PRACTICE OF MEDICINAL CHEMISTRY (THIRD EDITION), ELSEVIER, NL, PAGE(S) 290 - 342, (20080101), ISBN 978-0-12-374194-3, XP009142466 [Y] 1-15 * page 294, section III.B, table 15.8 *

DOI:   http://dx.doi.org/10.1016/B978-0-12-374194-3.00015-9
International search[X]WO2017165822  (UNIV OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US], et al) [X] 1-16 * The whole document. Especially: abstract, page 1, claims 1, 9, 15-21 and 25, Figs. 2H and 21. *;
 [XP]US2019022093  (WIPF PETER [US], et al) [XP] 1-16* The whole document. Especially: claims 9, 15 and Fig. 2J. *
 [X]  - "CA Index Name: 1-Piperazineacetic acid, alpha-(2- chlorophenyl)-4-[[2-[2-(trifluoromethyl)phenyl]cyclopropy1]carbonyl]- , methyl ester", Registry, (20180301), Database accession no. RN 2180239-98-7, URL: STN [X] 1-3
 [X]  - "CA Index Name: 1-Piperazineacetic acid, alpha-(2- chlorophenyl)-4-[[2-(2-chlorophenyl)cyclopropyl]carbonyl]- , methyl ester", Registry, (20110811), Database accession no. RN- 1316002-05-7, URL: STN [X] 1, 2
    [ ] - PubChem, (20120125), Database accession no. 55492389
    [ ] - "Source: AKos Consulting & Solutions", PubChem, (20110811), Database accession no. 132985172
 [X]  - "CA Index Name: Methanone, [4-[1-(2-chlorophenyl) ethyl]-1-piperazinyl][2-(2-fluorophenyl)cyclopropyl", Registry, (20110512), Database accession no. RN 1293729-94-8, URL: STN [X] 1-3, 5, 6
    [ ] - PubChem, (20120125), Database accession no. 55564470
    [ ] - "AKos Consulting & Solutions", PubChem, (20110512), Database accession no. 33095776
 [X]  - "CA Index Name: 1-Piperazineacetic acid, alpha-(4- chlorophenyl)-4-[[2-(3,4-difluorophenyl)cyclopropyl]carbonyl]-, methyl ester", Registry, (20140919), Database accession no. RN 1623249-86-4, URL: STN [X] 1-4
    [ ] - PubChem, (20150207), Database accession no. 86903336
    [ ] - "Aurora Fine Chemicals LLC", PubChem, (20160113), Database accession no. 280705617
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.