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Extract from the Register of European Patents

EP About this file: EP3797115

EP3797115 - NEW SYNTHETIC METHODS USING NATIVE CHEMICAL LIGATION IN FLOW [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  26.02.2021
Database last updated on 19.07.2024
FormerThe international publication has been made
Status updated on  30.11.2019
Most recent event   Tooltip28.05.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
The University Of Sydney
Parramatta Road The University of Sydney
New South Wales 2006 / AU
[2021/13]
Inventor(s)01 / PAYNE, Richard J
c/- Parramatta Road The University of
Sydney, New South Wales 2006 / AU
02 / CHISHOLM, Tim
c/- Parramatta Road The University of Sydney
New South Wales 2006 / AU
 [2021/15]
Former [2021/13]01 / PAYNE, Richard J
c/- Parramatta Road The University of
Sydney, New South Wales 2006 / AU
02 / CHISHOLM, Tim
c/- Parramatta Road The University of
Sydney, New South Wales 2006 / AU
Representative(s)McNamara, Kathryn
Novagraaf UK
Centrum
Norwich Research Park
Colney Lane
Norwich, Norfolk NR4 7UG / GB
[2021/13]
Application number, filing date19807175.522.05.2019
[2021/13]
WO2019AU50502
Priority number, dateAU2018090179922.05.2018         Original published format: AU 2018901799
[2021/13]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019222805
Date:28.11.2019
Language:EN
[2019/48]
Type: A1 Application with search report 
No.:EP3797115
Date:31.03.2021
Language:EN
The application published by WIPO in one of the EPO official languages on 28.11.2019 takes the place of the publication of the European patent application.
[2021/13]
Search report(s)International search report - published on:AU28.11.2019
(Supplementary) European search report - dispatched on:EP09.06.2022
ClassificationIPC:C07K1/02, C07K1/107, C07C327/22, C07C391/02, C07C323/36, C07C323/25
[2022/11]
CPC:
C07C323/25 (EP,AU,KR); C07K14/001 (AU,KR); C07K1/026 (EP,KR);
C07K1/1075 (US); C07C323/36 (EP,AU); C07C327/22 (EP,AU,KR);
C07C391/02 (EP,AU,KR); C07K1/08 (AU); C07K1/107 (EP);
C07K7/06 (KR,US) (-)
Former IPC [2021/13]C07K14/00, C07K1/08, C07C327/22, C07C391/02, C07C323/25, C07C323/36
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/13]
TitleGerman:NEUE SYNTHETISCHE VERFAHREN MIT NATIVER CHEMISCHER LIGATION IM STROM[2021/13]
English:NEW SYNTHETIC METHODS USING NATIVE CHEMICAL LIGATION IN FLOW[2021/13]
French:NOUVEAUX PROCÉDÉS SYNTHÉTIQUES UTILISANT UNE LIGATURE CHIMIQUE NATIVE EN FLUX[2021/13]
Entry into regional phase21.12.2020National basic fee paid 
21.12.2020Search fee paid 
21.12.2020Designation fee(s) paid 
21.12.2020Examination fee paid 
Examination procedure21.12.2020Examination requested  [2021/13]
19.12.2022Amendment by applicant (claims and/or description)
Fees paidRenewal fee
18.05.2021Renewal fee patent year 03
25.05.2022Renewal fee patent year 04
26.05.2023Renewal fee patent year 05
27.05.2024Renewal fee patent year 06
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XYI]WO2013177221  (MASSACHUSETTS INST TECHNOLOGY [US]) [X] 1,2,4-6 * claim 1 * [Y] 7,10,13-15 [I] 3;
 [XY]  - LARA R. MALINS ET AL, "PEPTIDE LIGATION CHEMISTRY AT SELENOL AMINO ACIDS", JOURNAL OF PEPTIDE SIENCE, (20140101), vol. 20, no. 2, doi:10.1002/psc.2581, ISSN 1075-2617, pages 64 - 77, XP055480703 [X] 11-15 * page 70, column r, paragraph l * [Y] 7-10

DOI:   http://dx.doi.org/10.1002/psc.2581
 [Y]  - KULKARNI SAMEER S ET AL, "Rapid and efficient protein synthesis through expansion of the native chemical ligation concept", NATURE REVIEWS CHEMISTRY, NATURE PUBLISHING GROUP UK, LONDON, (20180329), vol. 2, no. 4, doi:10.1038/S41570-018-0122, XP037083894 [Y] 7-10,13-15 * page 3, column l *

DOI:   http://dx.doi.org/10.1038/s41570-018-0122
 [Y]  - NORMAN METANIS ET AL, "Traceless Ligation of Cysteine Peptides Using Selective Deselenization", ANGEWANDTE CHEMIE, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, (20100816), vol. 122, no. 39, doi:10.1002/ANGE.201001900, ISSN 0044-8249, pages 7203 - 7207, XP071346591 [Y] 8-10,13-15 * e.g. scheme 1 *

DOI:   http://dx.doi.org/10.1002/ange.201001900
 [Y]  - ROBERT E. THOMPSON ET AL, "Chemoselective Peptide Ligation-Desulfurization at Aspartate", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, (20130724), vol. 52, no. 37, doi:10.1002/anie.201304793, ISSN 1433-7851, pages 9723 - 9727, XP055297184 [Y] 8-10,13-15 * e.g. scheme 1 *

DOI:   http://dx.doi.org/10.1002/anie.201304793
 [IY]  - BAUMANN MARCUS ET AL, "A Continuous-Flow Method for the Desulfurization of Substituted Thioimidazoles Applied to the Synthesis of Etomidate Derivatives", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, DE, vol. 2017, no. 44, doi:10.1002/ejoc.201700833, ISSN 1434-193X, (20171201), pages 6518 - 6524, URL: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejoc.201700833, XP055925475 [I] 8 * e.g. scheme 3 * [Y] 9,10,13-15

DOI:   http://dx.doi.org/10.1002/ejoc.201700833
 [XI]  - CUESTA J ET AL, "Photochemical desulfurization of thiols and disulfides", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, (19990716), vol. 10, no. 14, doi:10.1016/S0957-4166(99)00265-7, ISSN 0957-4166, pages 2643 - 2646, XP004177224 [X] 11,13-15 * the whole document * [I] 12

DOI:   http://dx.doi.org/10.1016/S0957-4166(99)00265-7
International search[X]WO2014194361  (UNIV SYDNEY [AU]) [X] 1-19, 22, 25-28 * see paragraphs [000174]-[000176], pages 64-66; paragraph [00066], page 22 *;
 [X]  - WATSON, E. E. et al., "Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics", ACS Central Science, (20180000), vol. 4, no. 4, pages 468 - 476, XP055655563 [X] 1-19, 22, 25-28 * . Scheme 2, & column 2, page 472; columns 1-2, page 473; and column 1, page 474 *

DOI:   http://dx.doi.org/10.1021/acscentsci.7b00612
 [X]  - MALINS, L. R. et al., "Synthetic Amino Acids for Applications in Peptide Ligation- Desulfurization Chemistry", Australian Journal of Chemistry, (20150000), vol. 68, no. 4, pages 521 - 537, XP055655567 [X] 1-19, 22, 25-28 * . Schemes 1-2, pages 522-523; columns 1-2, page 534; and Scheme 20(a), page 536; column 1, page 530 *

DOI:   http://dx.doi.org/10.1071/CH14568
 [X]  - DANG, B. et al., "Native Chemical Ligation at Asx-Cys, Glx-Cys: Chemical Synthesis and High-Resolution X-ray Structure of ShK Toxin by Racemic Protein Crystallography", Journal of the American Chemical Society, vol. 135, no. 32, pages 11911 - 11919, XP055655571 [X] 1-19, 22, 25-28 * . Abstract; and "Introduction", page 11911; column 2, page 11913; and column 1, page 11914 *

DOI:   http://dx.doi.org/10.1021/ja4046795
 [X]  - MONBALIU, J-C. et al., "Recent trends in Cys- and Ser/Thr-based synthetic strategies for the elaboration of peptide constructs", Chemical Communications, (20120000), vol. 48, no. 95, doi:10.1039/c2cc34434c, pages 11601 - 11622, XP055571155 [X] 1-19, 22, 25-28 * . see Section 2, pages 11602-11612; Section 2.4, pages 11610; and Fig. 5, page 11611; Figs. 4 and 6, page 11605; see Section 5 "Outlook", page 11619 *

DOI:   http://dx.doi.org/10.1039/c2cc34434c
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