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EP3898618

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Extract from the Register of European Patents

EP About this file: EP3898618

EP3898618 - PROCESS AND INTERMEDIATES FOR THE PREPARATION OF VOXELOTOR [Right-click to bookmark this link]
Status	Examination is in progress Status updated on 11.03.2026 Database last updated on 30.03.2026
Former	Grant of patent is intended Status updated on 11.11.2025
Former	Examination is in progress Status updated on 17.10.2025
Former	Grant of patent is intended Status updated on 16.06.2025
Former	Examination is in progress Status updated on 03.03.2023
Former	Request for examination was made Status updated on 24.09.2021
Former	The international publication has been made Status updated on 02.07.2020
Former	unknown Status updated on 11.01.2020
Most recent event Tooltip	11.03.2026	Deletion - Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
Applicant(s)	For all designated states CURIA SPAIN, S.A.U. Parque Tecnológico de Boecillo, parcela 105A 47151 Boecillo, Valladolid / ES
	[2023/14]
Former [2021/43]	For all designated states Crystal Pharma, S.A.U. Parque Tecnológico de Boecillo, parcela 105A 47151 Boecillo - Valladolid / ES
Inventor(s)	01 / FERREIRO GIL, Juan José Crystal Pharma, S.A.U. Parque Tecnológico de Boecillo, parcela 105A 47151 Boecillo, Valladolid / ES
	02 / IGLESIAS RETUERTO, Jesús Miguel Crystal Pharma, S.A.U. Parque Tecnológico de Boecillo, parcela 105A 47151 Boecillo, Valladolid / ES
	03 / LORENTE BONDE-LARSEN, Antonio Crystal Pharma, S.A.U. Parque Tecnológico de Boecillo, parcela 105A 47151 Boecillo, Valladolid / ES
	[2021/43]
Representative(s)	ABG Intellectual Property Law, S.L. Avenida de Burgos, 16D Edificio Euromor 28036 Madrid / ES
	[2021/43]
Application number, filing date	19829590.9	20.12.2019
	[2021/43]
	WO2019EP86606
Priority number, date	EP20180382986	21.12.2018 Original published format: EP 18382986
	[2021/43]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2020127924
	Date:	25.06.2020
	Language:	EN
	[2020/26]
	Type:	A1 Application with search report
	No.:	EP3898618
	Date:	27.10.2021
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 25.06.2020 takes the place of the publication of the European patent application.
	[2021/43]
Search report(s)	International search report - published on:	EP	25.06.2020
Classification	IPC:	C07D405/14, C07C259/10, C07D319/08, C07D401/04, C07D405/12, C07D213/61	[2021/43]
	CPC:	C07D401/04 (EP,US); C07C259/10 (EP); C07D213/61 (EP); C07D319/08 (EP); C07D405/12 (EP); C07D405/14 (EP)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2021/43]
Title	German:	VERFAHREN UND ZWISCHENPRODUKTE ZUR HERSTELLUNG VON VOXELOTOR	[2025/24]
	English:	PROCESS AND INTERMEDIATES FOR THE PREPARATION OF VOXELOTOR	[2021/43]
	French:	PROCÉDÉ ET INTERMÉDIAIRES POUR LA PRÉPARATION DE VOXELOTOR	[2025/24]
	Former [2021/43]	VERFAHREN UND ZWISCHENPRODUKTE ZUR HERSTELLUNG VON VOXELTREIBERN
	Former [2021/43]	PROCÉDÉ ET INTERMÉDIAIRES POUR LA PRÉPARATION DE VOXÉLOTOR
Entry into regional phase	20.07.2021	National basic fee paid
	20.07.2021	Designation fee(s) paid
	20.07.2021	Examination fee paid
Examination procedure	deleted	Communication of intention to grant the patent
	20.07.2021	Examination requested [2021/43]
	20.07.2021	Date on which the examining division has become responsible
	11.02.2022	Amendment by applicant (claims and/or description)
	06.03.2023	Despatch of a communication from the examining division (Time limit: M04)
	05.07.2023	Reply to a communication from the examining division
	31.10.2023	Despatch of a communication from the examining division (Time limit: M04)
	29.02.2024	Reply to a communication from the examining division
	17.06.2025	Communication of intention to grant the patent
	16.10.2025	Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
	11.11.2025	Communication of intention to grant the patent
	10.03.2026	Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
Fees paid	Renewal fee
	23.12.2021	Renewal fee patent year 03
	26.12.2022	Renewal fee patent year 04
	26.12.2023	Renewal fee patent year 05
	25.12.2024	Renewal fee patent year 06
	23.12.2025	Renewal fee patent year 07
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[A] WO2007067615 (NOVARTIS AG et al.)
		[X] WO2017218960 (FRONTHERA U S PHARMACEUTICALS LLC et al.)
		[IDY] WO2017197083 (GLOBAL BLOOD THERAPEUTICS INC et al.)
		[AD] WO2015031285 (GLOBAL BLOOD THERAPEUTICS INC et al.)
		[AD] WO2013102142 (GLOBAL BLOOD THERAPEUTICS INC et al.)
		[A] EP1911738 (TAKEDA PHARMACEUTICAL et al.)
		[A] US2015209443 (METCALF BRIAN W et al.)
		[A] M. A. JALIL MIAH ET AL: "Directed ortho -Metalation of Aryl Amides, O- Carbamates, and Methoxymethoxy Systems: Directed Metalation Group Competition and Cooperation", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2018, no. 4, 5 December 2017 (2017-12-05), DE, pages 447 - 454, XP055558699, ISSN: 1434-193X, DOI: 10.1002/ejoc.201701143 DOI: http://dx.doi.org/10.1002/ejoc.201701143
		[A] JASON C. RIGGS ET AL: "Anionic Snieckus-Fries Rearrangement: Solvent Effects and Role of Mixed Aggregates", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 41, 15 October 2008 (2008-10-15), pages 13709 - 13717, XP055558780, ISSN: 0002-7863, DOI: 10.1021/ja804087r DOI: http://dx.doi.org/10.1021/ja804087r
		[A] DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 4 May 2015 (2015-05-04), XP002789123, Database accession no. 1697989-05-1
		[IY] BRIAN METCALF ET AL: "Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin", ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 3, 11 February 2017 (2017-02-11), pages 321 - 326, XP055553115, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.6b00491 DOI: http://dx.doi.org/10.1021/acsmedchemlett.6b00491
		[A] JARED T. SPLETSTOSER ET AL: "Mild and Selective Hydrozirconation of Amides to Aldehydes Using Cp2Zr(H)Cl: Scope and Mechanistic Insight", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 129, no. 11, 22 February 2007 (2007-02-22), pages 3408 - 3419, XP055559174, DOI: 10.1021/ja066362 DOI: http://dx.doi.org/10.1021/ja066362
		[A] DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 8 November 2016 (2016-11-08), XP002789124, Database accession no. 2027389-58-6 [A] 15 * page 13712; compounds 5a, 5b *
	by applicant	WO2013102142
		WO2014150276
		WO2015031285
		WO2017197083
		US2015209443
		ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 3, 2017, pages 321 - 326
		ORGANIC LETTERS, vol. 2, no. 23, 2000, pages 3731 - 3734
		ORGANIC PROCESS RESEARCH AND DEVELOPMENT, vol. 20, no. 2, 2016, pages 233 - 241
		GREEN TW ET AL.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
		SYNTHETIC COMMUNICATIONS, vol. 24, no. 7, 1994, pages 1025 - 1028
		ACS MED. CHEM. LETT., vol. 8, no. 3, 2017, pages 321 - 326

The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.