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EP About this file: EP3852526

EP3852526 - ENZYMATIC COMPOSITIONS FOR CARBOHYDRATE ANTIGEN CLEAVAGE ON DONOR ORGANS, METHODS AND USES ASSOCIATED THEREWITH [Right-click to bookmark this link]
Status	Request for examination was made Status updated on 25.06.2021 Database last updated on 03.09.2024
Former	The international publication has been made Status updated on 24.02.2020
Most recent event Tooltip	28.08.2024	New entry: Renewal fee paid
Applicant(s)	For all designated states The University of British Columbia University Industry Liaison Office 103-6190 Agronomy Road Vancouver, British Columbia V6T 1Z3 / CA
	For all designated states University Health Network 190 Elizabeth Street R. Fraser Elliott Building - Room 1S-417 Toronto, Ontario M5G 2C4 / CA
	[2021/30]
Inventor(s)	01 / CYPEL, Marcelo 655 Broadway Ave Toronto, Ontario M4G 2S8 / CA
	02 / WANG, Aizhou 199 Richmond Street West, Suite 212 Toronto, Ontario M5V 0H4 / CA
	03 / KESHAVJEE, Shafique 29 Riverview Drive Toronto, Ontario M4N 3C6 / CA
	04 / WITHERS, Stephen G. 3835 West 30th Avenue Vancouver, British Columbia V6S 1W9 / CA
	05 / RAHFELD, Peter c/o The University of British Columbia Department of Chemistry Vancouver, British Columbia V6T 1Z1 / CA
	06 / KIZHAKKEDATHU, Jayachandran 177 Dockside Crescent New Westminster, British Columbia V3M 0B2 / CA
	[2021/30]
Representative(s)	Novitas Patent AB P.O. Box 55557 102 04 Stockholm / SE
	[2021/30]
Application number, filing date	19849296.9	16.08.2019
	[2021/30]
	WO2019CA51121
Priority number, date	US201862719272P	17.08.2018 Original published format: US 201862719272 P
	[2021/30]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2020034043
	Date:	20.02.2020
	Language:	EN
	[2020/08]
	Type:	A1 Application with search report
	No.:	EP3852526
	Date:	28.07.2021
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 20.02.2020 takes the place of the publication of the European patent application.
	[2021/30]
Search report(s)	International search report - published on:	CA	20.02.2020
	(Supplementary) European search report - dispatched on:	EP	05.10.2022
Classification	IPC:	C12N15/56, A01N1/02, A61K35/14, C12N15/55, C12N15/63, C12N5/078, C12N9/24, C12P19/00, C12P19/14, C12N9/78	[2022/44]
	CPC:	A01N1/0226 (EP,US); C12N9/2402 (EP,CN,US); C12N9/80 (EP,US); A01N1/021 (CN); A61K38/54 (EP); C12N11/00 (US); (+) C12N9/78 (CN); C12Y302/01049 (EP,US); C12Y305/01025 (EP,US); C07K2319/00 (EP,US) (-)
	Former IPC [2021/30]	A01N1/02, A61K35/12, C12N9/24, C12P19/00
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2021/30]
Title	German:	ENZYMATISCHE ZUSAMMENSETZUNGEN ZUR KOHLENHYDRATANTIGENSPALTUNG AUF SPENDERORGANEN, VERFAHREN UND VERWENDUNGEN IM ZUSAMMENHANG DAMIT	[2021/30]
	English:	ENZYMATIC COMPOSITIONS FOR CARBOHYDRATE ANTIGEN CLEAVAGE ON DONOR ORGANS, METHODS AND USES ASSOCIATED THEREWITH	[2021/30]
	French:	COMPOSITIONS ENZYMATIQUES POUR LE CLIVAGE D'ANTIGÈNE CARBOHYDRATE SUR DES ORGANES DONNEURS, PROCÉDÉS ET UTILISATIONS ASSOCIÉS	[2021/30]
Entry into regional phase	17.05.2021	National basic fee paid
	17.05.2021	Search fee paid
	17.05.2021	Designation fee(s) paid
	17.05.2021	Examination fee paid
Examination procedure	deleted	Deletion: Application deemed to be withdrawn, date of legal effect [2021/30]
	17.05.2021	Examination requested [2021/30]
	21.07.2023	Amendment by applicant (claims and/or description)
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
	21.07.2023	Request for further processing filed
	21.07.2023	Full payment received (date of receipt of payment) Request granted
	31.07.2023	Decision despatched
	The application is deemed to be withdrawn due to non-payment of the search fee
	17.05.2021	Request for further processing filed
	17.05.2021	Full payment received (date of receipt of payment) Request granted
	14.06.2021	Decision despatched
	17.05.2021	Request for further processing filed
	17.05.2021	Full payment received (date of receipt of payment) Request granted
	14.06.2021	Decision despatched
	The application is deemed to be withdrawn due to non-payment of the filing fee
	17.05.2021	Request for further processing filed
	17.05.2021	Full payment received (date of receipt of payment) Request granted
	14.06.2021	Decision despatched
	The application is deemed to be withdrawn due to non-payment of the examination fee
	17.05.2021	Request for further processing filed
	17.05.2021	Full payment received (date of receipt of payment) Request granted
	14.06.2021	Decision despatched
	17.05.2021	Request for further processing filed
	17.05.2021	Full payment received (date of receipt of payment) Request granted
	14.06.2021	Decision despatched
	The application is deemed to be withdrawn due to non-payment of designation fees TR, SM, SK, SI, SE, RS, RO, PT, PL, NO, NL, MT, MK, MC, LV, LU, LT, IT, IS, IE, HU, HR, GR, GB, FR, FI, ES, EE, DK, DE, CZ, CY, CH, BG, BE, AT, AL
	17.05.2021	Request for further processing filed
	17.05.2021	Full payment received (date of receipt of payment) Request granted
	14.06.2021	Decision despatched
Fees paid	Renewal fee
	30.08.2021	Renewal fee patent year 03
	16.08.2022	Renewal fee patent year 04
	26.07.2023	Renewal fee patent year 05
	28.08.2024	Renewal fee patent year 06
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[Y]WO03027245 (ZYMEQUEST INC [US], et al) [Y] 1-15 * the whole document *;
		[I] - HARUKO YAMAMOTO ET AL, "Development of H-Specificity in A Substance by A-Decomposing Enzyme from Clostridium tertium A", PROCEEDINGS OF THE JAPAN ACADEMY, JP, (19680412), vol. 44, no. 4, doi:10.2183/pjab1945.44.263, ISSN 0021-4280, pages 263 - 268, XP055685122 [I] 1-15 * the whole document * DOI: http://dx.doi.org/10.2183/pjab1945.44.263
		[Y] - LIU Q P ET AL, "Bacterial glycosidases for the production of universal red blood cells", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 25, no. 4, doi:10.1038/NBT1298, ISSN 1087-0156, (20070401), pages 454 - 464, (20070401), XP002538259 [Y] 1-15 * the whole document * DOI: http://dx.doi.org/10.1038/NBT1298
		[Y] - KWAN DAVID H. ET AL, "Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (20150506), vol. 137, no. 17, doi:10.1021/ja5116088, ISSN 0002-7863, pages 5695 - 5705, XP055910715 [Y] 1-15 * the whole document * DOI: http://dx.doi.org/10.1021/ja5116088
		[Y] - PERI K G ET AL, "CLONING AND CHARACTERIZATION OF THE N-ACETYLGLUCOSAMINE OPERON OF ESCHERICHIA COLI", BIOCHEMISTRY AND CELL BIOLOGY. BIOCHIMIE ET BIOLOGIE CELLULAIRE, NRC RESEARCH PRESS, CA, (19900101), vol. 68, no. 1, ISSN 0829-8211, pages 123 - 137, XP002924981 [Y] 1-15 * the whole document *
		[Y] - Anonymous, "SubName: Full=Carbohydrate-binding protein {ECO:0000313\|EMBL:MSB22528.1}; SubName: Full=O-GlcNAcase nagJ {ECO:0000313\|EMBL:CUQ39266.1}; EC=3.2.1.169 {ECO:0000313\|EMBL:CUQ39266.1};", UniProt, (20171122), Database accession no. A0A174W0P5, URL: https://www.uniprot.org/uniprot/A0A174W0P5.txt?version=9, XP055910719 [Y] 1-15 * abstract *
		[T] - RAHFELD PETER ET AL, "Toward universal donor blood: Enzymatic conversion of A and B to O type", JOURNAL OF BIOLOGICAL CHEMISTRY, US, (20200101), vol. 295, no. 2, doi:10.1074/jbc.REV119.008164, ISSN 0021-9258, pages 325 - 334, XP055910725 [T] 1-15 * the whole document * DOI: http://dx.doi.org/10.1074/jbc.REV119.008164
		[Y] - KOBAYASHI T ET AL, "Removal of blood group A/B antigen in organs by ex vivo and in vivo administration of endo-sz-galactosidase (ABase) for ABO-incompatible transplantation", TRANSPLANT IMMUNOLOGY, ELSEVIER, NL, vol. 20, no. 3, doi:10.1016/J.TRIM.2008.09.007, ISSN 0966-3274, (20090101), pages 132 - 138, (20081216), XP025800107 [Y] 1-15 * the whole document * DOI: http://dx.doi.org/10.1016/j.trim.2008.09.007
		[Y] - LIU TAKAAKI KOBAYASHI DAGE ET AL, "Alternative Strategy for Overcoming ABO Incompatibility", TRANSPLANTATION, GB, (20070515), vol. 83, no. 9, doi:10.1097/01.tp.0000260425.37209.c1, ISSN 0041-1337, pages 1284 - 1286, XP055958621 [Y] 1-15 * the whole document * DOI: http://dx.doi.org/10.1097/01.tp.0000260425.37209.c1
	International search	[A]CA2272925 (ZYMEQUEST INC [US], et al) [A] 1-25 see whole document;
		[A]EP2243793 (ROCHE DIAGNOSTICS GMBH [DE], et al) [A] 1-25see whole document;
		[A] - Kobayashi, T. ; Liu, D. ; Ogawa, H. ; Miwa, Y. ; Nagasaka, T. ; Maruyama, S. ; Li, Y.T. ; Onishi, A. ; Iwamoto, M. ; Kuzuya, T. ; Kadomatsu, K. ; Uchida, K. ; Nakao, A., "Removal of Blood Group A/B Antigen in Organs by ex vivo and in vivo Administration of Endo-beta-galactosidase (ABase) for ABO-incompatible Transplantation", Transplant Immunology, (20090100), vol. 20, no. 3, doi:10.1016/j.trim.2008.09.007, ISSN 0966-3274, pages 132 - 138, XP025800107 [A] 1-25 * . see whole document DOI: http://dx.doi.org/10.1016/j.trim.2008.09.007
		[A] - Qiyong P. Liu, Huaiping Yuan, Eric P. Bennett, Steven B. Levery, Edward Nudelman, Jean Spence, Greg Pietz, Kristen Saunders, Thayer White, Martin L. Olsson, Bernard Henrissat, Gerlind Sulzenbacher, and Henrik Clausen, "Identification of a GH110 Subfamily of Alpha 1,3-galactosidases: Novel Enzymes for Removal of the Alpha 3Gal Xenotransplantation Antigen", Journal of Biological Chemistry, (20080328), vol. 283, no. 13, doi:10.1074/jbc.M709020200, ISSN 0021-9258, pages 8545 - 8554, XP007914978 [A] 1-25 * . see whole document DOI: http://dx.doi.org/10.1074/jbc.M709020200
		[A] - Claude Bagnis, Chiaroni Jacques, Bailly Pascal, "Elimination of blood group antigens: hope and reality", British Journal of Haematology, (20110107), vol. 152, no. 4, doi:10.1111/j.1365-2141.2010.08561.x, ISSN 0007-1048, pages 392 - 400, XP055264660 [A] 1-25 see whole document DOI: http://dx.doi.org/10.1111/j.1365-2141.2010.08561.x

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