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Extract from the Register of European Patents

EP About this file: EP3840854

EP3840854 - NOVEL CANNABINOIDS AND CANNABINOID ACIDS AND THEIR DERIVATIVES [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 01.11.2024 Database last updated on 30.03.2026
Former	Examination is in progress Status updated on 19.01.2024
Former	Request for examination was made Status updated on 28.05.2021
Former	The international publication has been made Status updated on 29.02.2020
Most recent event Tooltip	01.11.2024	Application deemed to be withdrawn	published on 04.12.2024 [2024/49]
Applicant(s)	For all designated states Bessor Pharma, LLC 1 Sage Lane Framingham, MA 01701 / US
	[2021/26]
Inventor(s)	01 / BERKOWITZ, Barry, A. 1 Sage Lane Framingham, MA 01701 / US
	02 / BARRETT, Anthony, G. Nossa Senhora de Copacabane 31, Apt. 606 22010121 Leme, Rio De Janeiro / BR
	03 / ELLIOTT, Daniel Davidsbodenstrasse 8 4056 Basel / CH
	[2021/26]
Representative(s)	Glawe, Delfs, Moll Partnerschaft mbB Hopfenmarkt 33 20457 Hamburg / DE
	[N/P]
Former [2021/26]	Glawe, Delfs, Moll Partnerschaft mbB von Patent- und Rechtsanwälten Postfach 13 03 91 20103 Hamburg / DE
Application number, filing date	19853072.7	20.08.2019
	[2021/26]
	WO2019US47280
Priority number, date	US201862719813P	20.08.2018 Original published format: US 201862719813 P
	[2021/26]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2020041322
	Date:	27.02.2020
	Language:	EN
	[2020/09]
	Type:	A1 Application with search report
	No.:	EP3840854
	Date:	30.06.2021
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 27.02.2020 takes the place of the publication of the European patent application.
	[2021/26]
Search report(s)	International search report - published on:	US	27.02.2020
	(Supplementary) European search report - dispatched on:	EP	27.05.2022
Classification	IPC:	C07C37/50, C07C39/23, A61K31/05, A61K31/35, A61P25/00	[2022/26]
	CPC:	A61K31/05 (EP,KR); A61K31/658 (KR,US); C07D311/78 (US); A61K31/352 (EP,KR); A61P29/00 (KR); C07C37/50 (KR,US); (+) C07C37/56 (US); C07C39/23 (KR,US); C07D311/80 (KR); C07D319/08 (US); C07D493/04 (US); A61K2300/00 (KR); C07C2601/16 (US) (-)
	C-Set:	A61K31/05, A61K2300/00 (US,EP); A61K31/352, A61K2300/00 (US,EP); C07C37/50, C07C39/23 (US)
	Former IPC [2021/26]	B01D11/04, C07C37/00, C07C37/70
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2021/26]
Title	German:	NEUARTIGE CANNABINOIDE UND CANNABINOIDSÄUREN UND DEREN DERIVATE	[2021/26]
	English:	NOVEL CANNABINOIDS AND CANNABINOID ACIDS AND THEIR DERIVATIVES	[2021/26]
	French:	NOUVEAUX CANNABINOÏDES ET ACIDES CANNABINOÏDES ET LEURS DÉRIVÉS	[2021/26]
Entry into regional phase	17.03.2021	National basic fee paid
	17.03.2021	Search fee paid
	17.03.2021	Designation fee(s) paid
	17.03.2021	Examination fee paid
Examination procedure	17.03.2021	Examination requested [2021/26]
	13.12.2022	Amendment by applicant (claims and/or description)
	18.01.2024	Despatch of a communication from the examining division (Time limit: M06)
	19.07.2024	Application deemed to be withdrawn, date of legal effect [2024/49]
	08.08.2024	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2024/49]
Fees paid	Renewal fee
	27.08.2021	Renewal fee patent year 03
	29.08.2022	Renewal fee patent year 04
	28.08.2023	Renewal fee patent year 05
	Penalty fee
	Additional fee for renewal fee
	31.08.2024	06 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[XI] WO2017072762 (YISSUM RES DEV CO et al.) [X] 12,13,15 * claim 5 * * claim 6: 11-OH-THC *[I] 1-15
		[XI] WO2014062965 (UNIV NORTHEASTERN et al.) [X] 1,2,4 * page 119, 4th row, 3rd compound and 5th row, 1st compound *[I] 1-15
		[XI] WO2015198078 (GW PHARMA LTD et al.) [X] 1,2,4 * page 6, compounds 7-OH-CBD, 7-OH-CBDV *[I] 1-15
		[XI] WO0195899 (YISSUM RES DEV CO et al.) [X] 1,2,4 * page 4, lines 7-8 * * figure 3B, last formula * * claims 1-8 *[I] 1-15
		[XP] WO2019033164 (UNIV SYDNEY et al.) [XP] 1,2,4,12,13,15 * page 14, four compounds at the top *
		[XI] FRIDE E ET AL: "Peripheral, but not central effects of cannabidiol derivatives: Mediation by CB"1 and unidentified receptors", NEUROPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 48, no. 8, 1 June 2005 (2005-06-01), pages 1117 - 1129, XP027632874, ISSN: 0028-3908, [retrieved on 20050601] [X] 1,2,4 * page 1120, second row of compounds [I] 1-15 DOI:* http://dx.doi.org/10.1016/j.neuropharm.2005.01.023
		[XI] LUMIR O. HANUS ET AL: "Enantiomeric cannabidiol derivatives: synthesis and binding to cannabinoid receptors", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 3, no. 6, 16 February 2005 (2005-02-16), pages 1116 - 1123, XP055585857, ISSN: 1477-0520, DOI: 10.1039/b416943c [X] 1,2,4 * page 117, table 1, compound 12 [I] 1-15 DOI:* http://dx.doi.org/10.1039/b416943c
		[X] HARVEY D J ET AL: "In vitro metabolism of cannabidiol in seven common laboratory mammals", RESEARCH COMMUNICATIONS IN SUBSTANCES OF ABUSE, P J D PUBLICATIONS LTD, US, vol. 11, no. 1-2, 1990, pages 27 - 37, XP009535634, ISSN: 0193-0818 [X] 1-4 * page 27: 10-Hydroxy-CBD, 7-Hydroxy-CBD * * page 32, 4'',7-dihydroxy-CBD * * page 34, 5'',7-dihydroxy-CBD * * page 33; figure 1 *
		[X] HARVEY D J ET AL: "In vitro metabolism of cannabidiol in the rabbit: identification of seventeen new metabolites including thirteen dihydroxylated in the isopropenyl chain", BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, JOHN WILEY & SONS LTD, GB, vol. 19, no. 9, 1 September 1990 (1990-09-01), pages 559 - 567, XP009535633, ISSN: 0887-6134, DOI: 10.1002/BMS.1200190907 [X] 1-4 * page 562, table 1, compounds III, IV, XVII to XXII * DOI: http://dx.doi.org/10.1002/bms.1200190907
		[X] ARNOLD WILLIAM R. ET AL: "Cross-talk of cannabinoid and endocannabinoid metabolism is mediated via human cardiac CYP2J2", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 184, 1 July 2018 (2018-07-01), US, pages 88 - 99, XP055920204, ISSN: 0162-0134, Retrieved from the Internet DOI: 10.1016/j.jinorgbio.2018.03.016 [X] 1,2,4,12,13,15 * page 94, top four compounds in the right column * DOI: http://dx.doi.org/10.1016/j.jinorgbio.2018.03.016
		[X] HARVEY D J ET AL: "Urinary metabolites of cannabidiol in dog, rat and man and their identification by gas chromatography-mass spectrometry", JOURNAL OF CHROMATOGRAPHY B, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 562, no. 1-2, 2 January 1991 (1991-01-02), pages 299 - 322, XP026508226, ISSN: 0378-4347, [retrieved on 19910102], DOI: 10.1016/0378-4347(91)80587-3 [X] 1,2,4 * table III, compounds II, V * * table IV, compound XLI * DOI: http://dx.doi.org/10.1016/0378-4347(91)80587-3
		[X] RAZDAN R K ET AL: "(-)-8.beta.-Hydroxymethyl-.DELTA.1-tetrahydrocannabinol: a novel physiologically active analog of .DELTA.1-tetrahydrocannabinol", EXPERIENTIA, SPRINGER BASEL AG, CH, vol. 32, no. 4, 1976, pages 416 - 417, XP009535641, ISSN: 0014-4754, DOI: 10.1007/BF01920767 [X] 12-14 * page 417, compound 1 * DOI: http://dx.doi.org/10.1007/BF01920767
		[X] JUNG JULIA ET AL: "Studies on the metabolism of the [Delta]9-tetrahydrocannabinol precursor [Delta]9-tetrahydrocannabinolic acid A ([Delta]9-THCA-A) in rat using LC-MS/MS, LC-QTOF MS and GC-MS techniques", JOURNAL OF MASS SPECTROMETRY, vol. 44, no. 10, 1 October 2009 (2009-10-01), GB, pages 1423 - 1433, XP055920284, ISSN: 1076-5174, DOI: 10.1002/jms.1624 [X] 12,13,15 * page 1426, compound in the top-right corner * DOI: http://dx.doi.org/10.1002/jms.1624
		[X] TNIA B E SILVA ET AL: "Study of the structure-activity relationship for theoretical molecular descriptors using density functional theory and chemometric methods in cannabinoid metabolites", INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, WILEY, NEW YORK, NY, US, vol. 108, no. 13, 20 May 2008 (2008-05-20), pages 2530 - 2539, XP071303733, ISSN: 0020-7608, DOI: 10.1002/QUA.21696 [X] 12,13,15 * page 2532, compounds MET 13, MET 14, MET 19 * DOI: http://dx.doi.org/10.1002/qua.21696
		[X] SIEGEL C ET AL: "synthesis of Racemic and Optically Active Delta 9-Tetrahydrocannabinol (THC) Metabolites", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 56, 1991, pages 6865 - 6872, XP002297728, ISSN: 0022-3263, DOI: 10.1021/JO00024A031 [X] 12,13,15 * page 6866; compounds 2a, 2c * DOI: http://dx.doi.org/10.1021/jo00024a031
		[X] BROWN N K ET AL: "In vivo metabolism of the n-butyl homologs of .DELTA.9-tetrahydrocannabinol and .DELTA.8-tetrahydrocannabinol by the mouse", XENOBIOTICA, TAYLOR AND FRANCIS, LONDON, UK, vol. 18, no. 4, 1988, pages 417 - 427, XP009535639, ISSN: 0049-8254, DOI: 10.3109/00498258809041678 [X] 12,13,15 * page 424, table 3, compounds 11-OH, 2',11-d-OH * DOI: http://dx.doi.org/10.3109/00498258809041678
		[X] BROWN N K ET AL: "In vivo metabolism of the methyl homologs of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol and abn-delta-8-tetrahydrocannabinol in the mouse", BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, JOHN WILEY & SONS LTD, GB, vol. 15, no. 7, 1 April 1988 (1988-04-01), pages 389 - 398, XP009535640, ISSN: 0887-6134, DOI: 10.1002/BMS.1200150706 [X] 12,13,15 * page 394, table 3, compound 11-OH * DOI: http://dx.doi.org/10.1002/bms.1200150706
	International search	[A] US2017008869 (DIALER LUKAS et al.) [A] 1-2 * ; para [0182] *
		[A] US2018170846 (MCALLISTER SEAN D et al.) [A] 1-2 * ; para [0024] *
		[A] US2007213369 (GARZON AARON et al.) [A] 1-2 * ; para [0140] *
		[A] DATABASE Pubchem 25 October 2006 (2006-10-25), XP055688131, Database accession no. 9862348 [A] 1-2 * ; pg. 1 *
		[A] DATABASE Pubchem 28 March 2005 (2005-03-28), XP055688135, Database accession no. 37482 [A] 1-2 * ; pg. 2 *

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