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Extract from the Register of European Patents

EP About this file: EP3866852

EP3866852 - COMPOSITIONS AND METHODS FOR TREATMENT OF LIVER DISEASE [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  23.07.2021
Database last updated on 13.11.2024
FormerThe international publication has been made
Status updated on  24.04.2020
Most recent event   Tooltip28.10.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
The General Hospital Corporation
55 Fruit Street
Boston, Massachusetts 02114 / US
[2021/34]
Inventor(s)01 / CHOI, Michael Yoonsuk
c/o The General Hospital Corporation 55 Fruit
Street
Boston, Massachusetts 02114 / US
 [2021/34]
Representative(s)Forresters IP LLP
Skygarden
Erika-Mann-Straße 11
80636 München / DE
[2021/34]
Application number, filing date19873989.818.10.2019
[2021/34]
WO2019US56910
Priority number, dateUS201862747903P19.10.2018         Original published format: US 201862747903 P
[2021/34]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2020081920
Date:23.04.2020
Language:EN
[2020/17]
Type: A1 Application with search report 
No.:EP3866852
Date:25.08.2021
Language:EN
The application published by WIPO in one of the EPO official languages on 23.04.2020 takes the place of the publication of the European patent application.
[2021/34]
Search report(s)International search report - published on:US23.04.2020
(Supplementary) European search report - dispatched on:EP09.06.2022
ClassificationIPC:A61K39/395, A61K35/407, C07K16/22, C07K16/30, A61P35/04, A61P1/16, C12N5/071, G01N33/68
[2021/34]
CPC:
A61P35/04 (EP); C07K16/22 (EP,KR,US); A61K31/7088 (US);
A61K31/7105 (KR); A61K35/407 (US); A61P1/16 (EP,KR,US);
C12N15/113 (EP); C12N15/1136 (US); C12N5/067 (US);
G01N33/68 (KR); G01N33/6893 (EP); A61K2039/505 (KR);
A61K38/00 (EP); A61K48/00 (US); C07K2317/76 (EP);
C12N2310/141 (EP,US); G01N2500/02 (EP); G01N2800/085 (EP);
G01N2800/52 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/34]
TitleGerman:ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON LEBERERKRANUNGEN[2021/34]
English:COMPOSITIONS AND METHODS FOR TREATMENT OF LIVER DISEASE[2021/34]
French:COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE MALADIES HÉPATIQUES[2021/34]
Entry into regional phase26.04.2021National basic fee paid 
26.04.2021Search fee paid 
26.04.2021Designation fee(s) paid 
26.04.2021Examination fee paid 
Examination procedure26.04.2021Examination requested  [2021/34]
05.01.2023Amendment by applicant (claims and/or description)
Fees paidRenewal fee
27.10.2021Renewal fee patent year 03
27.10.2022Renewal fee patent year 04
27.10.2023Renewal fee patent year 05
28.10.2024Renewal fee patent year 06
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XAI]  - LI XIAOFEI ET AL, "Experimental research Blockade of CCN4 attenuates CCl 4 -induced liver fibrosis", ARCHIVES OF MEDICAL SCIENCE, (20150601), vol. 3, doi:10.5114/aoms.2015.52371, ISSN 1734-1922, pages 647 - 653, XP055922391 [X] 1,2,4,5,7-10 * figures 2-6 * [A] 13-15 [I] 3,6,11,12

DOI:   http://dx.doi.org/10.5114/aoms.2015.52371
 [A]  - TAE WOO JUNG ET AL, "WISP1 promotes non-alcoholic fatty liver disease and skeletal muscle insulin resistance via TLR4/JNK signaling", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY SUBSCRIPTION SERVICES, INC, US, (20180306), vol. 233, no. 8, doi:10.1002/JCP.26449, ISSN 0021-9541, pages 6077 - 6087, XP071323246 [A] 1-15

DOI:   http://dx.doi.org/10.1002/jcp.26449
 [A]  - Markova M ET AL, "Up-regulation of novel proinflammatory adipokine Wnt1 inducible signalling pathway protein 1 (WISP1) in liver fibrosis", (20170912), URL: https://www.easd.org/virtualmeeting/#!resources/up-regulation-of-novel-proinflammatory-adipokine-wnt1-inducible-signalling-pathway-protein-1-wisp1-in-liver-fibrosis, (20220518), XP055922524 [A] 1-15
International search[A]US2011311540  (BOTSTEIN DAVID [US], et al) [A] 1-19, 21-24, 26-27, 29-37, 39-40, 42-43, 45-51, 53-54, 55/47-51, 55/53-54, 56/47-51, 56/53-54, 59-60 * ; entire document *;
 [A]US2016165861  (HERING BERNHARD J [US], et al) [A] 47-51, 53-54, 55/47-51, 55/53-54, 56/47-51, 56/53-54, 59-60* ; entire document *;
 [XY]US2017304442  (ZHOU HEYUE [US], et al) [X] 1, 5-7, 10-14, 16-17, 24, 27, 30-37 * ; paragraphs [0012], [0016], [0024], [0043], [0047], [0055], [0060]. [0069], [0071]-[0072], [0082], [0097]. [0109]-[0110], [0112]-[0113], [0119]-[0120], [0130], [0132] * [Y] 3-4, 23, 26, 29, 46-51, 53-54, 55/47-51, 55/53-54, 56/47-51, 56/53-54;
 [Y]WO2017201422  (MASSACHUSETTS GEN HOSPITAL [US]) [Y] 9, 47-51, 53-54, 55/47-51, 55/53-54, 56/47-51, 56/53-54 * ; paragraphs [0003], [0011], [0023]-[0024], [0026], [0029], [0031], [0040]-[0041], [0053], [0070], [0120], [0150] *;
 [XY]  - Yao Tong , Xi-bing Ding , Zhi-xia Chen , Shu-qing Jin , Xiang Zhao , Xin Wang , Shu-ya Mei , Xi Jiang , Lingyu Wang , Quan Li , "WISP1 Mediates Hepatic Warm Ischemia Reperfusion Injury Via TLR4 Signaling In Mice", Scientific Reports, (20160129), vol. 6, doi:10.1038/srep20141, pages 1 - 11, XP055702105 [X] 1, 6, 8, 18-19, 21, 39-40, 42-43, 59-60 * ; Figures 1-2, Supplementary Figure S6; abstract; page 2, third and fifth-seventh paragraphs; page 3, third paragraph to page 4, second paragraph; page 6, fourth paragraph to page 7, first paragraph; page 7, third paragraph to page 8, first paragraph; doi: 10.1038/srep20141 * [Y] 9, 22-23, 45-46

DOI:   http://dx.doi.org/10.1038/srep20141
 [Y]  - Anonymous, "Recombinant Human WISP-1/CCN4, Catalog Number. 1627-WS", (20180518), R&D systems , URL: https://www.rndsystems.com/products/recombinant-human-wisp-1-ccn4-protein-cf_1627-ws#product-datasheets, (20200219), XP055805200 [Y] 5, 16, 23, 30, 46, 54, 55/54, 56/54 * ; page 1 *
 [XY]  - Shuqing Jin , Zhixia Chen , Xibing Ding , Xiang Zhao , Xi Jiang , Yao Tong , Timothy R Billiar , Quan Li, "Mechanical Ventilation Augments Poly(I:C)-Induced Lung Injury Via A WISP1-lntegrin beta3-Dependent Pathway In Mice", Molecular Medicine, (20160106), vol. 22, no. 1, doi:10.2119/molmed.2015.00233, ISSN 1076-1551, pages 54 - 63, XP055702100 [X] 14-15 * ; abstract; page 55, third column, second paragraph; page 57, third column, second paragraph to page 58, second column, first paragraph; doi: 10.2119/molmed.2015.00233 * [Y] 4, 22, 29, 45, 53, 55/53, 56/53

DOI:   http://dx.doi.org/10.2119/molmed.2015.00233
 [Y]  - Oghenesuvwe Erhirhie Earnest, Ekene, Nwoke E, Ajaghaku Daniel, Lotanna, "Guidelines On Dosage Calculation And Stock Solution Preparation In Experimental Animals' Studies", Journal of Natural Sciences Research, (20140000), vol. 4, no. 18, ISSN 2224-3186, pages 100 - 106, XP055805205 [Y] 14-15 * ; page 100, third-fourth paragraphs; page 103, first-second paragraphs *
 [YD]  - Melchiorre Cervello , Lydia Giannitrapani , Manuela Labbozzetta , Monica notarbartolo , Natale D'alessandro , Nadia Lampiasi , Antonina Azzolina , Giuseppe Montalto , "Expression Of WISPs And Of Their Novel Alternative Variants In Human Hepatocellular Carcinoma Cells", Annals of the New York Academy of Sciences, (20041200), vol. 1028, no. 1, doi:10.1196/annals.1322.051, ISSN 0077-8923, pages 432 - 439, XP055702088 [YD] 3, 26 * ; abstract; page 434, third paragraph; page 437, third paragraph to page 438, first paragraph; doi: 10.1196/annals. 1322.051 *

DOI:   http://dx.doi.org/10.1196/annals.1322.051
 [A]  - Peter D Turnpenny, Sian Ellard, "Alagille Syndrome: Pathogenesis, Diagnosis And Management", European Journal of Human Genetics, (20110301), vol. 20, no. 3, doi:10.1038/ejhg.2011.181, ISSN 1018-4813, pages 251 - 257, XP055590188 [A] 2 * ; abstract; page 254, second column, fifth paragraph to page 255, first column, fifth paragraph; doi:10.1038/ejhg.2011.181 *

DOI:   http://dx.doi.org/10.1038/ejhg.2011.181
 [A]  - Jaimie Chen , Wei Gao , Ping Zhou , Xiaocui Ma , Benjamin Tschudy-Seney , Chenghai Liu , Mark A Zern , Ping Liu , Yuyou Duan , "Enhancement Of Hepatocyte Differentiation From Human Embryonic Stem Cells By Chinese Medicine Fuzhenghuayu", Scientific Reports, (20160106), vol. 6, doi:10.1038/srep18841, pages 1 - 13, XP055702084 [A] 2 * ; page 2, sixth paragraph and page 4, first paragraph; page 10, third paragraph; doi: 10.1 038/srep1 8841 *

DOI:   http://dx.doi.org/10.1038/srep18841
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