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Extract from the Register of European Patents

EP About this file: EP3663287

EP3663287 - PROCESS SCALE SYNTHESIS OF UROLITHINS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.07.2024
Database last updated on 03.09.2024
FormerThe patent has been granted
Status updated on  18.08.2023
FormerGrant of patent is intended
Status updated on  05.04.2023
FormerExamination is in progress
Status updated on  24.12.2021
FormerRequest for examination was made
Status updated on  18.12.2020
FormerThe application has been published
Status updated on  08.05.2020
Most recent event   Tooltip30.08.2024Lapse of the patent in a contracting state
New state(s): MC		published on 02.10.2024 [2024/40]
Applicant(s)For all designated states
Amazentis SA
EPFL Innovation Park Bâtiment C
1015 Lausanne / CH
[2020/24]
Inventor(s)01 / Rinsch, Christopher
EPFL Innovation Park
Bâtiment C
1015 Lausanne / CH
02 / Skranc, Wolfgang
Oberfeldgasse 23
1220 Vienna / AT
03 / Müller, Roland
Schwaneplatz 2
93047 Regensburg / DE
 [2020/24]
Representative(s)Abel & Imray LLP
Westpoint Building
James Street West
Bath BA1 2DA / GB
[2023/38]
Former [2020/24]Abel & Imray
Westpoint Building
James Street West
Bath BA1 2DA / GB
Application number, filing date20152975.722.12.2014
[2020/24]
Priority number, dateUS201361919923P23.12.2013         Original published format: US 201361919923 P
[2020/24]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3663287
Date:10.06.2020
Language:EN
[2020/24]
Type: B1 Patent specification 
No.:EP3663287
Date:20.09.2023
Language:EN
[2023/38]
Search report(s)(Supplementary) European search report - dispatched on:EP12.05.2020
ClassificationIPC:C07D311/80
[2020/24]
CPC:
C07D311/80 (EP,US); A61K31/366 (EP,US); A61K33/34 (US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/03]  
Former [2020/24]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:SYNTHESE VON UROLITHINEN IM PROZESSMASSSTAB[2020/24]
English:PROCESS SCALE SYNTHESIS OF UROLITHINS[2020/24]
French:SYNTHÈSE D'UROLITHINES À L'ÉCHELLE DU PROCÉDÉ[2020/24]
Examination procedure10.12.2020Amendment by applicant (claims and/or description)
10.12.2020Examination requested  [2021/03]
10.12.2020Date on which the examining division has become responsible
23.12.2021Despatch of a communication from the examining division (Time limit: M06)
01.07.2022Reply to a communication from the examining division
12.10.2022Despatch of a communication from the examining division (Time limit: M02)
08.12.2022Reply to a communication from the examining division
06.04.2023Communication of intention to grant the patent
11.08.2023Fee for grant paid
11.08.2023Fee for publishing/printing paid
11.08.2023Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP14828105.8  / EP3087065
Opposition(s)21.06.2024No opposition filed within time limit [2024/35]
Fees paidRenewal fee
21.01.2020Renewal fee patent year 03
21.01.2020Renewal fee patent year 04
21.01.2020Renewal fee patent year 05
21.01.2020Renewal fee patent year 06
14.12.2020Renewal fee patent year 07
16.02.2022Renewal fee patent year 08
14.11.2022Renewal fee patent year 09
Penalty fee
Additional fee for renewal fee
31.12.202108   M06   Fee paid on   16.02.2022
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCZ20.09.2023
ES20.09.2023
HR20.09.2023
MC20.09.2023
PL20.09.2023
RO20.09.2023
RS20.09.2023
SK20.09.2023
SM20.09.2023
NO20.12.2023
GR21.12.2023
IS20.01.2024
[2024/40]
Former [2024/25]CZ20.09.2023
ES20.09.2023
HR20.09.2023
PL20.09.2023
RO20.09.2023
RS20.09.2023
SK20.09.2023
SM20.09.2023
NO20.12.2023
GR21.12.2023
IS20.01.2024
Former [2024/23]CZ20.09.2023
ES20.09.2023
HR20.09.2023
RO20.09.2023
RS20.09.2023
SK20.09.2023
SM20.09.2023
NO20.12.2023
GR21.12.2023
IS20.01.2024
Former [2024/20]HR20.09.2023
RS20.09.2023
SM20.09.2023
NO20.12.2023
GR21.12.2023
IS20.01.2024
Former [2024/11]HR20.09.2023
RS20.09.2023
NO20.12.2023
GR21.12.2023
Former [2024/08]NO20.12.2023
GR21.12.2023
Documents cited:Search[I]WO2004073612  (MERCK & CO INC [US], et al) [I] 1-15* Step 3 of examples 12 and 13;; examples 12, 13, 25, 43, 59 *;
 [I]WO2013041461  (MSD OSS BV [NL], et al) [I] 1-15 * conversion of compound 53(f) to 53(g); pages 73, 75; example 52 *;
 [X]  - ITO ET AL, "Identification of Urinary and Intestinal Bacterial Metabolites of Ellagitannin Geraniin in Rats", J. AGRIC. FOOD CHEM,, (20071229), vol. 56, doi:10.1021/JF0726942, pages 393 - 400, XP002768229 [X] 1,2,4-7,9-11,14 * step iii;; figure 7 *

DOI:   http://dx.doi.org/10.1021/jf0726942
 [X]  - DOBROSLAWA BIALONSKA ET AL, "Urolithins, Intestinal Microbial Metabolites of Pomegranate Ellagitannins, Exhibit Potent Antioxidant Activity in a Cell-Based Assay", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, US, (20091111), vol. 57, no. 21, doi:10.1021/jf9025794, ISSN 0021-8561, pages 10181 - 10186, XP055579614 [X] 1,2,4-7,9-11,14 * Urolithin C synthesis left column; page 3 *

DOI:   http://dx.doi.org/10.1021/jf9025794
 [I]  - SUN WANYING ET AL, "6H-Benzo[c]chromen-6-one derivatives as selective ER[beta] agon", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (20060118), vol. 16, no. 6, doi:10.1016/J.BMCL.2005.12.057, ISSN 0960-894X, pages 1468 - 1472, XP028755073 [I] 1-15 * Scheme 1 step b;; table 1 *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2005.12.057
by applicantUS2011065662
 US2012164243
 US2014018415
    - GIL et al., J. Agric. Food Chem., (20000000), vol. 48, pages 4581 - 4589
    - OKUDA et al., Chem. Pharm. Bull., (19820000), vol. 30, pages 4234 - 4236
    - "Strategies for the synthesis of ellagitannins", KHANBABAEE, K., Chemistry and Biology of Ellagitannins, World Scientific Publishing, (20090000), pages 152 - 202
    - J. HASSAN et al., "Aryl-Aryl Bond Formation One Century after the Discovery of the Ullmann Reaction", Chemical Reviews, (20020000), vol. 102, no. 5, doi:10.1021/cr000664r, pages 1359 - 1470, XP002245414

DOI:   http://dx.doi.org/10.1021/cr000664r
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.