EP3760638 - COMPOSITIONS AND METHODS UTILIZING LYSOPHOSPHATIDYLCHOLINE SCAFFOLDS [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 28.07.2023 Database last updated on 24.08.2024 | |
Former | Request for examination was made Status updated on 26.11.2021 | ||
Former | The application has been published Status updated on 04.12.2020 | Most recent event Tooltip | 28.07.2023 | Application deemed to be withdrawn | published on 30.08.2023 [2023/35] | Applicant(s) | For all designated states National University of Singapore 21 Lower Kent Ridge Road Singapore 119077 / SG | [2021/01] | Inventor(s) | 01 /
SILVER, David, Lawrence C/o NationalUniversity Of Singapore Due-NUS Graduate Medical School 21 Lower Kent Ridge Road 119077 Singapore / SG | 02 /
NGUYEN, Nam, Long C/o NationalUniversity Of Singapore Duke-NUS Graduate Medical School 21 Lower Kent Road 119077 Singapore / SG | 03 /
ZAHLER, Robert c/o PharmD 5 East Welling Avenue Pennington, NJ 08534 / US | [2021/01] | Representative(s) | Grünecker Patent- und Rechtsanwälte PartG mbB Leopoldstraße 4 80802 München / DE | [N/P] |
Former [2021/01] | Goodfellow, Hugh Robin Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB | Application number, filing date | 20173024.9 | 26.09.2014 | [2021/01] | Priority number, date | US201361882693P | 26.09.2013 Original published format: US 201361882693 P | US201461973136P | 31.03.2014 Original published format: US 201461973136 P | US201461992822P | 13.05.2014 Original published format: US 201461992822 P | [2021/01] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | EP3760638 | Date: | 06.01.2021 | Language: | EN | [2021/01] | Type: | A3 Search report | No.: | EP3760638 | Date: | 26.05.2021 | Language: | EN | [2021/21] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 26.04.2021 | Classification | IPC: | C07K14/00 | [2021/01] | CPC: |
G01N33/92 (EP,US);
A01K67/0276 (EP,US);
A23L33/10 (EP,US);
A61K31/685 (EP,US);
A61K47/544 (US);
A61K49/0008 (EP,US);
A61K49/0052 (US);
C12Q1/6883 (US);
G01N33/502 (US);
G01N33/5088 (US);
A01K2227/105 (EP,US);
A01K2267/03 (EP,US);
A23V2002/00 (US);
C12Q2600/156 (US);
C12Q2600/158 (US);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2021/52] |
Former [2021/01] | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR | Title | German: | ZUSAMMENSETZUNGEN UND VERFAHREN UNTER VERWENDUNG VON LYSOPHOSPHATIDYLCHOLINGERÜSTEN | [2021/01] | English: | COMPOSITIONS AND METHODS UTILIZING LYSOPHOSPHATIDYLCHOLINE SCAFFOLDS | [2021/01] | French: | COMPOSITIONS ET PROCÉDÉS UTILISANT DES ÉCHAFAUDAGES DE LYSOPHOSPHATIDYLCHOLINE | [2021/01] | Examination procedure | 24.11.2021 | Examination requested [2021/52] | 24.11.2021 | Date on which the examining division has become responsible | 03.08.2022 | Amendment by applicant (claims and/or description) | 01.04.2023 | Application deemed to be withdrawn, date of legal effect [2023/35] | 25.04.2023 | Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time [2023/35] | Parent application(s) Tooltip | EP14847279.8 / EP3049429 | Divisional application(s) | EP22181887.5 | Fees paid | Renewal fee | 05.05.2020 | Renewal fee patent year 03 | 05.05.2020 | Renewal fee patent year 04 | 05.05.2020 | Renewal fee patent year 05 | 05.05.2020 | Renewal fee patent year 06 | 28.09.2020 | Renewal fee patent year 07 | 12.09.2021 | Renewal fee patent year 08 | Penalty fee | Additional fee for renewal fee | 30.09.2022 | 09   M06   Not yet paid |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | by applicant | US4338397 | US4425437 | US4431739 | US4439356 | US4452720 | US5066580 | US5227487 | US5543295 | US5750409 | US5936087 | US6008379 | US6025505 | US6080852 | US2004143461 | US2009026082 | - CROSET, M.BROSSARD, N.POLETTE, A.LAGARDE, M., "Characterization of plasma unsaturated lysophosphatidylcholines in human and rat", The Biochemical Journal, (20000000), vol. 345, pages 61 - 67 | - QUEHENBERGER, O. et al., "Lipidomics reveals a remarkable diversity of lipids in human plasma", Journal of lipid research, (20100000), vol. 51, doi:10.1194/jlr.M009449, pages 3299 - 3305, XP055068776 DOI: http://dx.doi.org/10.1194/jlr.M009449 | - ISAACS EB et al., "The effect of early human diet on caudate volumes and IQ", Pediatric research, (20080000), vol. 63, no. 3, pages 308 - 314 | - LAPILLONNE AGRIFFIN IJ, "Feeding preterm infants today for later metabolic and cardiovascular outcomes", The Journal of pediatrics, (20130000), vol. 162, no. 3, pages 7 - 16 | - MARGULIES, M et al., Nature, (20050000), vol. 437, pages 376 - 380 | - Journal of pediatric gastroenterology and nutrition, vol. 41, no. 2, pages 1 - 87 | - MARTIN CR et al., "Nutritional practices and growth velocity in the first month of life in extremely premature infants", Pediatrics, (20090000), vol. 124, no. 2, pages 649 - 657 | - OLSEN IERICHARDSON DKSCHMID CHAUSMAN LMDWYER JT, "Intersite differences in weight growth velocity of extremely premature infants", Pediatrics, (20020000), vol. 110, no. 6, pages 1125 - 1132 | - BEARDSALL K et al., "Early insulin therapy in very- low-birth-weight infants", The New England journal of medicine, (20080000), vol. 359, no. 18, pages 1873 - 1884 | - CLARK RHCHACE DHSPITZER AR, "Effects of two different doses of amino acid supplementation on growth and blood amino acid levels in premature neonates admitted to the neonatal intensive care unit: a randomized, controlled trial", Pediatrics, (20070000), vol. 120, no. 6, doi:10.1542/peds.2007-0545, pages 1286 - 1296, XP002638388 DOI: http://dx.doi.org/10.1542/peds.2007-0545 | - ZAKI M S et al., Brain, (20120000), vol. 135, pages 2416 - 2427 | - KIDD, P. M., "Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids", Alternative medicine review: a journal of clinical therapeutic, (20070000), vol. 12, no. 3, pages 207 - 227 | - HORROCKS, L. A.YEO, Y. K., "Health benefits of docosahexaenoic acid (DHA", Pharmacological research: the official journal of the Italian Pharmacological Society, (19990000), vol. 40, no. 3, doi:10.1006/phrs.1999.0495, pages 211 - 225, XP001153885 DOI: http://dx.doi.org/10.1006/phrs.1999.0495 | - MOZAFFARIAN, D.WU, J. H., "Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events", Journal of the American College of Cardiology, (20110000), vol. 58, no. 20, pages 2047 - 2067 | - CONNOR, W. E., "Importance of n-3 fatty acids in health and disease", The American journal of clinical nutrition, (20000000), vol. 71, no. 1, pages 171S - 175S | - BRECKENRIDGE, W. C.GOMBOS, G.MORGAN, I. G., "The lipid composition of adult rat brain synaptosomal plasma membranes", Biochim Biophys Acta, (19720000), vol. 266, doi:10.1016/0005-2736(72)90365-3, pages 695 - 707, XP023576369 DOI: http://dx.doi.org/10.1016/0005-2736(72)90365-3 | - INNIS, S. M., "Dietary (n-3) fatty acids and brain development", The Journal of nutrition, (20070000), vol. 137, pages 855 - 859, XP055509885 | - SALEM, N., JR.LITMAN, B.KIM, H. Y.GAWRISCH, K., "Mechanisms of action of docosahexaenoic acid in the nervous system", Lipids, (20010000), vol. 36, pages 945 - 959 | - LAW, C. J.MALONEY, P. C.WANG, D. N., "Ins and outs of major facilitator superfamily antiporters", Annu Rev Microbiol, (20080000), vol. 62, pages 289 - 305 | - BERGER, J. H.CHARRON, M. J.SILVER, D. L., "Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism", PLoS One, (20120000), vol. 7, doi:10.1371/journal.pone.0050629, page e50629, XP055329324 DOI: http://dx.doi.org/10.1371/journal.pone.0050629 | - ESNAULT, C. et al., "A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2", Proceedings of the National Academy of Sciences of the United States of America, (20080000), vol. 105, pages 17532 - 17537 | - ANGERS, M.ULDRY, M.KONG, D.GIMBLE, J. M.JETTEN, A. M., "Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis", The Biochemical Journal, (20080000), vol. 416, pages 347 - 355 | - HUANG, Y.LEMIEUX, M. J.SONG, J.AUER, M.WANG, D. N., "Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli", Science, (20030000), vol. 301, pages 616 - 620 | - SHI, Y., "Common folds and transport mechanisms of secondary active transporters", Annual Review of Biophysics, (20130000), vol. 42, pages 51 - 72 | - BOWIE et al., Science, (19900000), vol. 247, pages 1306 - 1310 | - CUNNINGHAM et al., Science, (19890000), vol. 244, pages 1081 - 1085 | - PEARSON, Methods Mol. Biol., (19940000), vol. 243, pages 307 - 31 | - GONNET et al., Science, (19920000), vol. 256, pages 1443 - 45 | - WATKINS et al., J. Lipid Res., (20020000), vol. 43, no. 11, pages 1809 - 1907 | - PAN et al., J. Clin. Invest., (19950000), vol. 96, pages 2802 - 2808 | - TENNESSEN JABIGHAM AWO'CONNOR TD et al., "Evolution and functional impact of rare coding variation from deep sequencing of human exomes", Science, (20120000), vol. 337, pages 531 - 9 | - SONI G VMELLER A, Clin Chem, (20070000), vol. 53, pages 1996 - 2001 | - ARMULIK, A. et al., "Pericytes regulate the blood-brain barrier", Nature, (20100000), vol. 468, doi:10.1038/nature09522, pages 557 - 561, XP055179629 DOI: http://dx.doi.org/10.1038/nature09522 | - BELL, R. D. et al., "Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging", Neuron, (20100000), vol. 68, doi:10.1016/j.neuron.2010.09.043, pages 409 - 427, XP055365625 DOI: http://dx.doi.org/10.1016/j.neuron.2010.09.043 | - DANEMAN RZHOU LAGALLIU DCAHOY JDKAUSHAL ABARRES BA, "The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells", PloS One, (20100000), vol. 5, page e 13 74 1 | - TANG, T. et al., "A mouse knockout library for secreted and transmembrane proteins", Nature Biotechnology, (20100000), vol. 28, pages 749 - 755 | - LAFOURCADE, M. et al., "Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions", Nature Neuroscience, (20110000), vol. 14, pages 345 - 350 | - CARRIE, I.CLEMENT, M.DE JAVEL, D.FRANCES, H.BOURRE, J. M., "Phospholipid supplementation reverses behavioral and biochemical alterations induced by n-3 polyunsaturated fatty acid deficiency in mice", Journal of Lipid Research, (20000000), vol. 41, pages 473 - 480 | - KIM, H. Y., "Novel metabolism of docosahexaenoic acid in neural cells", The Journal of Biological Chemistry, (20070000), vol. 282, pages 18661 - 18665 | - SIMOPOULOS, A. P., "The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases", Exp Biol Med (Maywood, (20080000), vol. 233, pages 674 - 688 | - GRANELL, M.LEON, X.LEBLANC, G.PADROS, E.LORENZ-FONFRIA, V. A., "Structural insights into the activation mechanism of melibiose permease by sodium binding", Proceedings of the National Academy of Sciences of the United States of America, (20100000), vol. 107, pages 22078 - 22083 | - PARODER-BELENITSKY, M. et al., "Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS", Proceedings of the National Academy of Sciences of the United States of America, (20110000), vol. 108, pages 17933 - 17938 | - RAPOPORT, S. I.CHANG, M. C.SPECTOR, A. A., "Delivery and turnover of plasma-derived essential PUFAs in mammalian brain", J Lipid Res, (20010000), vol. 42, pages 678 - 685 | - BARBER MN et al., "Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes", PLoS One, (20120000), vol. 7, no. 7, doi:10.1371/journal.pone.0041456, page e41456, XP055062001 DOI: http://dx.doi.org/10.1371/journal.pone.0041456 | - CROSET MBROSSARD NPOLETTE ALAGARDE M, "Characterization of plasma unsaturated lysophosphatidylcholines in human and rat", Biochem J, (20000000), vol. 345, pages 61 - 67 | - CONNOR, W.E., "Importance of n-3 fatty acids in health and disease", Am J Clin Nutr, (20000000), vol. 71, pages 171S - 175S | - INNIS, S.M., "Dietary (n-3) fatty acids and brain development", The Journal of Nutrition, (20070000), vol. 137, pages 855 - 859, XP055509885 | - NGUYEN LNMA DSHUI G et al., "Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid", Nature, (20140000), vol. 509, doi:10.1038/nature13241, pages 503 - 6, XP055329325 DOI: http://dx.doi.org/10.1038/nature13241 | - ZAKI, M.S.SALEEM, S.N.DOBYNS, W.B.BARKOVICH, A.J.BARTSCH, H.DALE, A.M.ASHTARI, M.AKIZU, N.GLEESON, J.G.GRIJALVO-PEREZ, A.M., "Diencephalic-mesencephalic junction dysplasia: a novel recessive brain malformation", Brain: a journal of neurology, (20120000), vol. 135, pages 2416 - 2427 | - DEPRISTO MABANKS EPOPLIN R et al., "A framework for variation discovery and genotyping using next-generation DNA sequencing data", Nat Genet, (20110000), vol. 43, doi:10.1038/ng.806, pages 491 - 8, XP055046798 DOI: http://dx.doi.org/10.1038/ng.806 | - FROMER MMORAN JLCHAMBERT K et al., "Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth", American Journal of Human Genetics, (20120000), vol. 91, doi:10.1016/j.ajhg.2012.08.005, pages 597 - 607, XP055337767 DOI: http://dx.doi.org/10.1016/j.ajhg.2012.08.005 | - SHUI GSTEBBINS JWLAM BD et al., "Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys?", PloS One, (20110000), vol. 6, page el9731 | - SEELOW DSCHUELKE MHILDEBRANDT FNURNBERG P, "HomozygosityMapper--an interactive approach to homozygosity mapping", Nucleic Acids Research, (20090000), vol. 37, pages W593 - 9 | - ETHAYATHULLA ASYOUSEF MSAMIN ALEBLANC GKABACK HRGUAN L, "Structure-based mechanism for Na(+)/melibiose symport by MelB", Nat Commun, (20140000), vol. 5, page 3009 | - ZHAO ZXU Y, "An extremely simple method for extraction of lysophospholipids and phospholipids from blood samples", J Lipid Res, (20100000), vol. 51, doi:10.1194/jlr.D001503, pages 652 - 9, XP055285767 DOI: http://dx.doi.org/10.1194/jlr.D001503 | - ENGLE PLBLACK MMBEHRMAN JR et al., "Strategies to avoid the loss of developmental potential in more than 200 million children in the developing world", Lancet, (20070000), vol. 369, doi:10.1016/S0140-6736(07)60112-3, pages 229 - 42, XP026859295 DOI: http://dx.doi.org/10.1016/S0140-6736(07)60112-3 | - BEN-ZVI ALACOSTE BKUR E et al., "Mfsd2a is critical for the formation and function of the blood-brain barrier", Nature, (20140000), vol. 509, doi:10.1038/nature13324, pages 507 - 11, XP055329327 DOI: http://dx.doi.org/10.1038/nature13324 | - BERGER JHCHARRON MJSILVER DL, "Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism", PloS One, (20120000), vol. 7, doi:10.1371/journal.pone.0050629, page e50629, XP055329324 DOI: http://dx.doi.org/10.1371/journal.pone.0050629 | - CORDAT ELEBLANC GMUS-VETEAU I, "Evidence for a role of helix IV in connecting cation- and sugar-binding sites of Escherichia coli melibiose permease", Biochemistry, (20000000), vol. 39, pages 4493 - 9 | - HUANG YLEMIEUX MJSONG JAUER MWANG DN, "Structure and mechanism of the glycerol-3 -phosphate transporter from Escherichia coli", Science, (20030000), vol. 301, pages 616 - 20 | - SHI Y, "Common folds and transport mechanisms of secondary active transporters", Annu Rev Biophys, (20130000), vol. 42, pages 51 - 72 |