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EP About this file: EP3760638

EP3760638 - COMPOSITIONS AND METHODS UTILIZING LYSOPHOSPHATIDYLCHOLINE SCAFFOLDS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  28.07.2023
Database last updated on 24.08.2024
FormerRequest for examination was made
Status updated on  26.11.2021
FormerThe application has been published
Status updated on  04.12.2020
Most recent event   Tooltip28.07.2023Application deemed to be withdrawnpublished on 30.08.2023  [2023/35]
Applicant(s)For all designated states
National University of Singapore
21 Lower Kent Ridge Road
Singapore 119077 / SG
[2021/01]
Inventor(s)01 / SILVER, David, Lawrence
C/o NationalUniversity Of Singapore
Due-NUS Graduate Medical School
21 Lower Kent Ridge Road
119077 Singapore / SG
02 / NGUYEN, Nam, Long
C/o NationalUniversity Of Singapore
Duke-NUS Graduate Medical School
21 Lower Kent Road
119077 Singapore / SG
03 / ZAHLER, Robert
c/o PharmD
5 East Welling Avenue
Pennington, NJ 08534 / US
 [2021/01]
Representative(s)Grünecker Patent- und Rechtsanwälte PartG mbB
Leopoldstraße 4
80802 München / DE
[N/P]
Former [2021/01]Goodfellow, Hugh Robin
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
Application number, filing date20173024.926.09.2014
[2021/01]
Priority number, dateUS201361882693P26.09.2013         Original published format: US 201361882693 P
US201461973136P31.03.2014         Original published format: US 201461973136 P
US201461992822P13.05.2014         Original published format: US 201461992822 P
[2021/01]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP3760638
Date:06.01.2021
Language:EN
[2021/01]
Type: A3 Search report 
No.:EP3760638
Date:26.05.2021
Language:EN
[2021/21]
Search report(s)(Supplementary) European search report - dispatched on:EP26.04.2021
ClassificationIPC:C07K14/00
[2021/01]
CPC:
G01N33/92 (EP,US); A01K67/0276 (EP,US); A23L33/10 (EP,US);
A61K31/685 (EP,US); A61K47/544 (US); A61K49/0008 (EP,US);
A61K49/0052 (US); C12Q1/6883 (US); G01N33/502 (US);
G01N33/5088 (US); A01K2227/105 (EP,US); A01K2267/03 (EP,US);
A23V2002/00 (US); C12Q2600/156 (US); C12Q2600/158 (US);
G01N2333/705 (US); G01N2405/04 (US); G01N2500/10 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/52]
Former [2021/01]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:ZUSAMMENSETZUNGEN UND VERFAHREN UNTER VERWENDUNG VON LYSOPHOSPHATIDYLCHOLINGERÜSTEN[2021/01]
English:COMPOSITIONS AND METHODS UTILIZING LYSOPHOSPHATIDYLCHOLINE SCAFFOLDS[2021/01]
French:COMPOSITIONS ET PROCÉDÉS UTILISANT DES ÉCHAFAUDAGES DE LYSOPHOSPHATIDYLCHOLINE[2021/01]
Examination procedure24.11.2021Examination requested  [2021/52]
24.11.2021Date on which the examining division has become responsible
03.08.2022Amendment by applicant (claims and/or description)
01.04.2023Application deemed to be withdrawn, date of legal effect  [2023/35]
25.04.2023Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time  [2023/35]
Parent application(s)   TooltipEP14847279.8  / EP3049429
Divisional application(s)EP22181887.5
Fees paidRenewal fee
05.05.2020Renewal fee patent year 03
05.05.2020Renewal fee patent year 04
05.05.2020Renewal fee patent year 05
05.05.2020Renewal fee patent year 06
28.09.2020Renewal fee patent year 07
12.09.2021Renewal fee patent year 08
Penalty fee
Additional fee for renewal fee
30.09.202209   M06   Not yet paid
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Cited inby applicantUS4338397
 US4425437
 US4431739
 US4439356
 US4452720
 US5066580
 US5227487
 US5543295
 US5750409
 US5936087
 US6008379
 US6025505
 US6080852
 US2004143461
 US2009026082
    - CROSET, M.BROSSARD, N.POLETTE, A.LAGARDE, M., "Characterization of plasma unsaturated lysophosphatidylcholines in human and rat", The Biochemical Journal, (20000000), vol. 345, pages 61 - 67
    - QUEHENBERGER, O. et al., "Lipidomics reveals a remarkable diversity of lipids in human plasma", Journal of lipid research, (20100000), vol. 51, doi:10.1194/jlr.M009449, pages 3299 - 3305, XP055068776

DOI:   http://dx.doi.org/10.1194/jlr.M009449
    - ISAACS EB et al., "The effect of early human diet on caudate volumes and IQ", Pediatric research, (20080000), vol. 63, no. 3, pages 308 - 314
    - LAPILLONNE AGRIFFIN IJ, "Feeding preterm infants today for later metabolic and cardiovascular outcomes", The Journal of pediatrics, (20130000), vol. 162, no. 3, pages 7 - 16
    - MARGULIES, M et al., Nature, (20050000), vol. 437, pages 376 - 380
    - Journal of pediatric gastroenterology and nutrition, vol. 41, no. 2, pages 1 - 87
    - MARTIN CR et al., "Nutritional practices and growth velocity in the first month of life in extremely premature infants", Pediatrics, (20090000), vol. 124, no. 2, pages 649 - 657
    - OLSEN IERICHARDSON DKSCHMID CHAUSMAN LMDWYER JT, "Intersite differences in weight growth velocity of extremely premature infants", Pediatrics, (20020000), vol. 110, no. 6, pages 1125 - 1132
    - BEARDSALL K et al., "Early insulin therapy in very- low-birth-weight infants", The New England journal of medicine, (20080000), vol. 359, no. 18, pages 1873 - 1884
    - CLARK RHCHACE DHSPITZER AR, "Effects of two different doses of amino acid supplementation on growth and blood amino acid levels in premature neonates admitted to the neonatal intensive care unit: a randomized, controlled trial", Pediatrics, (20070000), vol. 120, no. 6, doi:10.1542/peds.2007-0545, pages 1286 - 1296, XP002638388

DOI:   http://dx.doi.org/10.1542/peds.2007-0545
    - ZAKI M S et al., Brain, (20120000), vol. 135, pages 2416 - 2427
    - KIDD, P. M., "Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids", Alternative medicine review: a journal of clinical therapeutic, (20070000), vol. 12, no. 3, pages 207 - 227
    - HORROCKS, L. A.YEO, Y. K., "Health benefits of docosahexaenoic acid (DHA", Pharmacological research: the official journal of the Italian Pharmacological Society, (19990000), vol. 40, no. 3, doi:10.1006/phrs.1999.0495, pages 211 - 225, XP001153885

DOI:   http://dx.doi.org/10.1006/phrs.1999.0495
    - MOZAFFARIAN, D.WU, J. H., "Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events", Journal of the American College of Cardiology, (20110000), vol. 58, no. 20, pages 2047 - 2067
    - CONNOR, W. E., "Importance of n-3 fatty acids in health and disease", The American journal of clinical nutrition, (20000000), vol. 71, no. 1, pages 171S - 175S
    - BRECKENRIDGE, W. C.GOMBOS, G.MORGAN, I. G., "The lipid composition of adult rat brain synaptosomal plasma membranes", Biochim Biophys Acta, (19720000), vol. 266, doi:10.1016/0005-2736(72)90365-3, pages 695 - 707, XP023576369

DOI:   http://dx.doi.org/10.1016/0005-2736(72)90365-3
    - INNIS, S. M., "Dietary (n-3) fatty acids and brain development", The Journal of nutrition, (20070000), vol. 137, pages 855 - 859, XP055509885
    - SALEM, N., JR.LITMAN, B.KIM, H. Y.GAWRISCH, K., "Mechanisms of action of docosahexaenoic acid in the nervous system", Lipids, (20010000), vol. 36, pages 945 - 959
    - LAW, C. J.MALONEY, P. C.WANG, D. N., "Ins and outs of major facilitator superfamily antiporters", Annu Rev Microbiol, (20080000), vol. 62, pages 289 - 305
    - BERGER, J. H.CHARRON, M. J.SILVER, D. L., "Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism", PLoS One, (20120000), vol. 7, doi:10.1371/journal.pone.0050629, page e50629, XP055329324

DOI:   http://dx.doi.org/10.1371/journal.pone.0050629
    - ESNAULT, C. et al., "A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2", Proceedings of the National Academy of Sciences of the United States of America, (20080000), vol. 105, pages 17532 - 17537
    - ANGERS, M.ULDRY, M.KONG, D.GIMBLE, J. M.JETTEN, A. M., "Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis", The Biochemical Journal, (20080000), vol. 416, pages 347 - 355
    - HUANG, Y.LEMIEUX, M. J.SONG, J.AUER, M.WANG, D. N., "Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli", Science, (20030000), vol. 301, pages 616 - 620
    - SHI, Y., "Common folds and transport mechanisms of secondary active transporters", Annual Review of Biophysics, (20130000), vol. 42, pages 51 - 72
    - BOWIE et al., Science, (19900000), vol. 247, pages 1306 - 1310
    - CUNNINGHAM et al., Science, (19890000), vol. 244, pages 1081 - 1085
    - PEARSON, Methods Mol. Biol., (19940000), vol. 243, pages 307 - 31
    - GONNET et al., Science, (19920000), vol. 256, pages 1443 - 45
    - WATKINS et al., J. Lipid Res., (20020000), vol. 43, no. 11, pages 1809 - 1907
    - PAN et al., J. Clin. Invest., (19950000), vol. 96, pages 2802 - 2808
    - TENNESSEN JABIGHAM AWO'CONNOR TD et al., "Evolution and functional impact of rare coding variation from deep sequencing of human exomes", Science, (20120000), vol. 337, pages 531 - 9
    - SONI G VMELLER A, Clin Chem, (20070000), vol. 53, pages 1996 - 2001
    - ARMULIK, A. et al., "Pericytes regulate the blood-brain barrier", Nature, (20100000), vol. 468, doi:10.1038/nature09522, pages 557 - 561, XP055179629

DOI:   http://dx.doi.org/10.1038/nature09522
    - BELL, R. D. et al., "Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging", Neuron, (20100000), vol. 68, doi:10.1016/j.neuron.2010.09.043, pages 409 - 427, XP055365625

DOI:   http://dx.doi.org/10.1016/j.neuron.2010.09.043
    - DANEMAN RZHOU LAGALLIU DCAHOY JDKAUSHAL ABARRES BA, "The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells", PloS One, (20100000), vol. 5, page e 13 74 1
    - TANG, T. et al., "A mouse knockout library for secreted and transmembrane proteins", Nature Biotechnology, (20100000), vol. 28, pages 749 - 755
    - LAFOURCADE, M. et al., "Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions", Nature Neuroscience, (20110000), vol. 14, pages 345 - 350
    - CARRIE, I.CLEMENT, M.DE JAVEL, D.FRANCES, H.BOURRE, J. M., "Phospholipid supplementation reverses behavioral and biochemical alterations induced by n-3 polyunsaturated fatty acid deficiency in mice", Journal of Lipid Research, (20000000), vol. 41, pages 473 - 480
    - KIM, H. Y., "Novel metabolism of docosahexaenoic acid in neural cells", The Journal of Biological Chemistry, (20070000), vol. 282, pages 18661 - 18665
    - SIMOPOULOS, A. P., "The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases", Exp Biol Med (Maywood, (20080000), vol. 233, pages 674 - 688
    - GRANELL, M.LEON, X.LEBLANC, G.PADROS, E.LORENZ-FONFRIA, V. A., "Structural insights into the activation mechanism of melibiose permease by sodium binding", Proceedings of the National Academy of Sciences of the United States of America, (20100000), vol. 107, pages 22078 - 22083
    - PARODER-BELENITSKY, M. et al., "Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS", Proceedings of the National Academy of Sciences of the United States of America, (20110000), vol. 108, pages 17933 - 17938
    - RAPOPORT, S. I.CHANG, M. C.SPECTOR, A. A., "Delivery and turnover of plasma-derived essential PUFAs in mammalian brain", J Lipid Res, (20010000), vol. 42, pages 678 - 685
    - BARBER MN et al., "Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes", PLoS One, (20120000), vol. 7, no. 7, doi:10.1371/journal.pone.0041456, page e41456, XP055062001

DOI:   http://dx.doi.org/10.1371/journal.pone.0041456
    - CROSET MBROSSARD NPOLETTE ALAGARDE M, "Characterization of plasma unsaturated lysophosphatidylcholines in human and rat", Biochem J, (20000000), vol. 345, pages 61 - 67
    - CONNOR, W.E., "Importance of n-3 fatty acids in health and disease", Am J Clin Nutr, (20000000), vol. 71, pages 171S - 175S
    - INNIS, S.M., "Dietary (n-3) fatty acids and brain development", The Journal of Nutrition, (20070000), vol. 137, pages 855 - 859, XP055509885
    - NGUYEN LNMA DSHUI G et al., "Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid", Nature, (20140000), vol. 509, doi:10.1038/nature13241, pages 503 - 6, XP055329325

DOI:   http://dx.doi.org/10.1038/nature13241
    - ZAKI, M.S.SALEEM, S.N.DOBYNS, W.B.BARKOVICH, A.J.BARTSCH, H.DALE, A.M.ASHTARI, M.AKIZU, N.GLEESON, J.G.GRIJALVO-PEREZ, A.M., "Diencephalic-mesencephalic junction dysplasia: a novel recessive brain malformation", Brain: a journal of neurology, (20120000), vol. 135, pages 2416 - 2427
    - DEPRISTO MABANKS EPOPLIN R et al., "A framework for variation discovery and genotyping using next-generation DNA sequencing data", Nat Genet, (20110000), vol. 43, doi:10.1038/ng.806, pages 491 - 8, XP055046798

DOI:   http://dx.doi.org/10.1038/ng.806
    - FROMER MMORAN JLCHAMBERT K et al., "Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth", American Journal of Human Genetics, (20120000), vol. 91, doi:10.1016/j.ajhg.2012.08.005, pages 597 - 607, XP055337767

DOI:   http://dx.doi.org/10.1016/j.ajhg.2012.08.005
    - SHUI GSTEBBINS JWLAM BD et al., "Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys?", PloS One, (20110000), vol. 6, page el9731
    - SEELOW DSCHUELKE MHILDEBRANDT FNURNBERG P, "HomozygosityMapper--an interactive approach to homozygosity mapping", Nucleic Acids Research, (20090000), vol. 37, pages W593 - 9
    - ETHAYATHULLA ASYOUSEF MSAMIN ALEBLANC GKABACK HRGUAN L, "Structure-based mechanism for Na(+)/melibiose symport by MelB", Nat Commun, (20140000), vol. 5, page 3009
    - ZHAO ZXU Y, "An extremely simple method for extraction of lysophospholipids and phospholipids from blood samples", J Lipid Res, (20100000), vol. 51, doi:10.1194/jlr.D001503, pages 652 - 9, XP055285767

DOI:   http://dx.doi.org/10.1194/jlr.D001503
    - ENGLE PLBLACK MMBEHRMAN JR et al., "Strategies to avoid the loss of developmental potential in more than 200 million children in the developing world", Lancet, (20070000), vol. 369, doi:10.1016/S0140-6736(07)60112-3, pages 229 - 42, XP026859295

DOI:   http://dx.doi.org/10.1016/S0140-6736(07)60112-3
    - BEN-ZVI ALACOSTE BKUR E et al., "Mfsd2a is critical for the formation and function of the blood-brain barrier", Nature, (20140000), vol. 509, doi:10.1038/nature13324, pages 507 - 11, XP055329327

DOI:   http://dx.doi.org/10.1038/nature13324
    - BERGER JHCHARRON MJSILVER DL, "Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism", PloS One, (20120000), vol. 7, doi:10.1371/journal.pone.0050629, page e50629, XP055329324

DOI:   http://dx.doi.org/10.1371/journal.pone.0050629
    - CORDAT ELEBLANC GMUS-VETEAU I, "Evidence for a role of helix IV in connecting cation- and sugar-binding sites of Escherichia coli melibiose permease", Biochemistry, (20000000), vol. 39, pages 4493 - 9
    - HUANG YLEMIEUX MJSONG JAUER MWANG DN, "Structure and mechanism of the glycerol-3 -phosphate transporter from Escherichia coli", Science, (20030000), vol. 301, pages 616 - 20
    - SHI Y, "Common folds and transport mechanisms of secondary active transporters", Annu Rev Biophys, (20130000), vol. 42, pages 51 - 72
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