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Extract from the Register of European Patents

EP About this file: EP3819389

EP3819389 - METHOD OF DETERMINING MICROSATELLITE INSTABILITY [Right-click to bookmark this link]
Former [2021/19]COMPOSITIONS AND METHODS FOR DETERMINING ENDOMETRIAL CANCER PROGNOSIS
[2023/43]
StatusThe patent has been granted
Status updated on  16.02.2024
Database last updated on 31.08.2024
FormerGrant of patent is intended
Status updated on  05.10.2023
FormerExamination is in progress
Status updated on  24.02.2023
FormerRequest for examination was made
Status updated on  09.04.2021
Most recent event   Tooltip08.08.2024Lapse of the patent in a contracting state
New state(s): SE		published on 11.09.2024 [2024/37]
Applicant(s)For all designated states
Quest Diagnostics Investments LLC
500 Plaza Drive
Secaucus, NJ 07094 / US
[2024/22]
Former [2021/19]For all designated states
Quest Diagnostics Investments LLC
3 Giralda Farms
Madison, New Jersey 07940 / US
Inventor(s)01 / Arvai, Kevin J.
Quest Diagnostics Investments Incorporated
33608 Ortega Highway
San Juan Capistrano, California 92675 / US
02 / Wang, Yongbao
Quest Diagnostics Investments Incorporated
33608 Ortega Highway
San Juan Capistrano, California 92675 / US
03 / Jones, Daniel
Quest Diagnostics Investments LLC
33608 Ortega Highway
San Juan Capistrano, California 92675 / US
 [2021/19]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2021/19]
Application number, filing date20200749.805.02.2016
[2021/19]
Priority number, dateUS201562113340P06.02.2015         Original published format: US 201562113340 P
US201562113990P09.02.2015         Original published format: US 201562113990 P
[2021/19]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3819389
Date:12.05.2021
Language:EN
[2021/19]
Type: B1 Patent specification 
No.:EP3819389
Date:20.03.2024
Language:EN
[2024/12]
Search report(s)(Supplementary) European search report - dispatched on:EP13.04.2021
ClassificationIPC:C12Q1/6886, C07H21/02, C07H21/04, C12Q1/6809
[2021/19]
CPC:
C12Q1/6886 (EP,CN,US); C12Q1/6811 (US); C12Q1/68 (US);
C12Q1/6809 (EP,CN); C12Q1/686 (US); C12Q2600/118 (EP,CN,US);
C12Q2600/156 (EP,CN,US) (-)
C-Set:
C12Q1/6809, C12Q2525/151, C12Q2535/122, C12Q2537/16 (CN);
C12Q1/6809, C12Q2535/122 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/19]
TitleGerman:VERFAHREN ZUR BESTIMMUNG VON MIKROSATELLITENINSTABILITÄT[2023/43]
English:METHOD OF DETERMINING MICROSATELLITE INSTABILITY[2023/43]
French:MÉTHODE DE DÉTERMINATION DE L'INSTABILITÉ MICROSATELLITAIRE[2023/43]
Former [2021/19]ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BESTIMMUNG DER ENDOMENTRIUMKREBSPROGNOSE
Former [2021/19]COMPOSITIONS AND METHODS FOR DETERMINING ENDOMETRIAL CANCER PROGNOSIS
Former [2021/19]COMPOSITIONS ET MÉTHODES PERMETTANT DE DÉTERMINER LE PRONOSTIC DU CANCER DE L'ENDOMÈTRE
Examination procedure08.10.2020Examination requested  [2021/19]
13.10.2021Amendment by applicant (claims and/or description)
23.02.2023Despatch of a communication from the examining division (Time limit: M04)
04.07.2023Reply to a communication from the examining division
06.10.2023Communication of intention to grant the patent
14.02.2024Fee for grant paid
14.02.2024Fee for publishing/printing paid
14.02.2024Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP16747343.8  / EP3253891
Fees paidRenewal fee
08.10.2020Renewal fee patent year 03
08.10.2020Renewal fee patent year 04
08.10.2020Renewal fee patent year 05
12.02.2021Renewal fee patent year 06
16.12.2021Renewal fee patent year 07
14.12.2022Renewal fee patent year 08
14.12.2023Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipBG20.03.2024
FI20.03.2024
HR20.03.2024
LT20.03.2024
LV20.03.2024
SE20.03.2024
NO20.06.2024
RS20.06.2024
GR21.06.2024
[2024/37]
Former [2024/36]BG20.03.2024
FI20.03.2024
HR20.03.2024
LT20.03.2024
LV20.03.2024
NO20.06.2024
RS20.06.2024
GR21.06.2024
Former [2024/34]BG20.03.2024
FI20.03.2024
HR20.03.2024
LT20.03.2024
NO20.06.2024
RS20.06.2024
GR21.06.2024
Former [2024/33]LT20.03.2024
NO20.06.2024
Documents cited:Search[A]  - S. J. SALIPANTE ET AL, "Microsatellite Instability Detection by Next Generation Sequencing", CLINICAL CHEMISTRY, (20140901), vol. 60, no. 9, doi:10.1373/clinchem.2014.223677, ISSN 0009-9147, pages 1192 - 1199, XP055571285 [A] 1-14 * abstract * * Materials and Methods *

DOI:   http://dx.doi.org/10.1373/clinchem.2014.223677
 [A]  - BERND TIMMERMANN ET AL, "Somatic Mutation Profiles of MSI and MSS Colorectal Cancer Identified by Whole Exome Next Generation Sequencing and Bioinformatics Analysis", PLOS ONE, (20101222), vol. 5, no. 12, doi:10.1371/journal.pone.0015661, page e15661, XP055385156 [A] 1-14 * abstract *

DOI:   http://dx.doi.org/10.1371/journal.pone.0015661
 [A]  - T.-M. KIM ET AL, "A Genome-wide View of Microsatellite Instability: Old Stories of Cancer Mutations Revisited with New Sequencing Technologies", CANCER RESEARCH, US, (20141104), vol. 74, no. 22, doi:10.1158/0008-5472.CAN-14-1225, ISSN 0008-5472, pages 6377 - 6382, XP055738231 [A] 1-14 * abstract *

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-14-1225
 [A]  - CIOMBOR KRISTEN K. ET AL, "How Can Next-Generation Sequencing (Genomics) Help Us in Treating Colorectal Cancer?", CURRENT COLORECTAL CANCER REPORTS, Boston, (20140817), vol. 10, no. 4, doi:10.1007/s11888-014-0244-3, ISSN 1556-3790, pages 372 - 379, XP055792422 [A] 1-14 * abstract * * page 375 *

DOI:   http://dx.doi.org/10.1007/s11888-014-0244-3
 [A]  - MONIKA ZAVODNA ET AL, "The Accuracy, Feasibility and Challenges of Sequencing Short Tandem Repeats Using Next-Generation Sequencing Platforms", PLOS ONE, (20141201), vol. 9, no. 12, doi:10.1371/journal.pone.0113862, page e113862, XP055482447 [A] 1-14 * abstract *

DOI:   http://dx.doi.org/10.1371/journal.pone.0113862
by applicant   - THE CANCER GENOME ATLAS RESEARCH NETWORK, "Integrated genomic characterization of endometrial carcinoma", NATURE, (20130000), pages 1 - 8
    - THE CANCER GENOME ATLAS RESEARCH NETWORK, "Integrated genomic characterization of endometrial carcinoma", Nature, (20130000), pages 1 - 8
    - ARABI H et al., "Jmpact of microsatellite instability (MSI) on survival in high grade endometrial carcinoma", Gynecol Oncol, (20090500), vol. 113, no. 2, doi:10.1016/j.ygyno.2009.02.004, pages 153 - 8, XP026035157

DOI:   http://dx.doi.org/10.1016/j.ygyno.2009.02.004
    - BENSON G et al., "Tandem repeats finder: a program to analyze DNA sequences", Nuc Acids Res, (19990000), vol. 27, no. 2, pages 573 - 580
    - CIRISANO,F.D et al., "The outcome of stage I-II clinically and surgically staged papillary serous and clear cell endometrial cancers when compared with endometrioid carcinoma", Gynecologic oncology, (20000000), vol. 77, no. 1, pages 55 - 65
    - CREUTZBERG CL et al., "Nomograms for Prediction of Outcome With or Without Adjuvant Radiation Therapy for Patients With Endometrial Cancer: A Pooled Analysis ofPORTEC-1 and PORTEC-2 Trials", International Journal of Radiation Oncology* Biology* Physics, (20150000), vol. 91, no. 3, pages 530 - 539
    - DIAZ-PADILLA I et al., "Mismatch repair status and clinical outcome in endometrial cancer: a systematic review and meta-analysis", Crit Rev Oncol Hematol, (20131000), vol. 88, no. 1, doi:10.1016/j.critrevonc.2013.03.002, pages 154 - 67, XP028716295

DOI:   http://dx.doi.org/10.1016/j.critrevonc.2013.03.002
    - DESCHOOLMEESTER V et al., "Comparison of three commonly used PCR-based techniques to analyze MSI status in sporadic colorectal cancer", J Clin Lab Anal, (20060000), vol. 20, no. 2, pages 52 - 61
    - GIARDIELLO FM et al., "Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-society Task Force on colorectal cancer", Am J Gastroenterol, (20140800), vol. 109, no. 8, pages 1159 - 79
    - GOULD-SUAREZ M et al., "Cost-effectiveness and diagnostic effectiveness analyses of multiple algorithms for the diagnosis of Lynch syndrome", DigDis Sci, (20141200), vol. 59, no. 12, pages 2913 - 26
    - HOGBERG T., "Adjuvant Chemotherapy in Endometrial Carcinoma: Overview of Randomised Trials", Clinical Oncol, (20080000), vol. 20, no. 6, doi:10.1016/j.clon.2008.04.001, pages 463 - 469, XP022822672

DOI:   http://dx.doi.org/10.1016/j.clon.2008.04.001
    - KIM, TMLAIRD, PWPARK, PJ., "The landscape of microsatellite instability in colorectal and endometrial cancer genomes", Cell, (20130000), vol. 755, no. 4, doi:10.1016/j.cell.2013.10.015, pages 858 - 868, XP055579620

DOI:   http://dx.doi.org/10.1016/j.cell.2013.10.015
    - MILLS AM et al., "Lynch syndrome screening should be considered for all patients with newly diagnosed endometrial cancer", Am J Surg Pathol, (20141100), vol. 38, no. 11, pages 1501 - 9
    - MISSIAGLIA E et al., "Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features", Ann Oncol, (20141000), vol. 25, no. 10, pages 1995 - 2001
    - MODICA I et al., "Utility of immunohistochemistry in predicting microsatellite instability in endometrial carcinoma", Am J Surg Pathol, (20070500), vol. 31, no. 5, pages 744 - 51
    - NARDON E et al., "A Multicenter Study to Validate the Reproducibility of MSI Testing With a Panel of 5 Quasimonomorphic Mononucleotide Repeats", Diag Molec Pathol, (20100000), vol. 19, no. 4, pages 236 - 242
    - NIU, B et al., "MSIsensor: microsatellite instability detection using paired tumor-normal sequence data", Bioinformatics, (20140000), vol. 30, no. 7, pages 1015 - 1016
    - POPAT SHUBNER RHOULSTON RS, "Systematic Review of Microsatellite Instability and Colorectal Cancer Prognosis", J Clin Oncol, (20050120), vol. 23, no. 3, pages 609 - 618
    - THE CANCER GENOME ATLAS RESEARCH NETWORK, "Integrated genomic characterization of endometrial carcinoma", Nature, (20130502), vol. 497, doi:10.1038/nature12113, pages 67 - 73, XP055496447

DOI:   http://dx.doi.org/10.1038/nature12113
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