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Extract from the Register of European Patents

EP About this file: EP3800189

EP3800189 - PREPARATION OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.05.2024
Database last updated on 16.11.2024
FormerThe patent has been granted
Status updated on  26.05.2023
FormerGrant of patent is intended
Status updated on  19.01.2023
FormerRequest for examination was made
Status updated on  01.10.2021
FormerThe application has been published
Status updated on  05.03.2021
Most recent event   Tooltip03.05.2024No opposition filed within time limitpublished on 05.06.2024  [2024/23]
Applicant(s)For all designated states
Loxo Oncology, Inc.
281 Tresser Boulevard 9th Floor
Stamford, Connecticut 06901 / US
For all designated states
Array Biopharma, Inc.
3200 Walnut Street
Boulder, CO 80301 / US
[2021/14]
Inventor(s)01 / REYNOLDS, Mark
Loxo Oncology, Inc.
281 Tresser Blvd.
Stamford, CT 06901 / US
02 / EARY, Charles Todd
Loxo Oncology, Inc.
281 Tresser Blvd.
Stamford, CT 06901 / US
03 / SPENCER, Stacey
873 Stagecoach Trail
Lyons, CO 80540 / US
04 / JUENGST, Derrick
4529 Canterbury Drive
Boulder, CO 80301 / US
05 / HACHE, Bruno
Loxo Oncology, Inc.
281 Tresser Blvd.
Stamford, CT 06901 / US
06 / JIANG, Yutong
Array Biopharma Inc.
3200 Walnut Street
Boulder, CO 80301 / US
07 / HAAS, Julia
Array Biopharma Inc.
3200 Walnut Street
Boulder, CO 80301 / US
08 / ANDREWS, Steven W.
Array Biopharma Inc.
3200 Walnut Street
Boulder, CO 80301 / US
 [2021/14]
Representative(s)HGF
HGF Limited
1 City Walk
Leeds LS11 9DX / GB
[2023/26]
Former [2021/14]HGF
1 City Walk
Leeds LS11 9DX / GB
Application number, filing date20208218.618.05.2017
[2021/14]
Priority number, dateUS201662338359P18.05.2016         Original published format: US 201662338359 P
[2021/14]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3800189
Date:07.04.2021
Language:EN
[2021/14]
Type: B1 Patent specification 
No.:EP3800189
Date:28.06.2023
Language:EN
[2023/26]
Search report(s)(Supplementary) European search report - dispatched on:EP10.12.2020
ClassificationIPC:C07D487/04, A61K31/5025, A61P35/00, A61P43/00
[2021/14]
CPC:
C07D487/04 (EP,IL,KR,RU,US); A61K31/519 (IL,KR,RU); A61P35/00 (EP,KR,RU);
A61P43/00 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/44]
Former [2021/14]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:HERSTELLUNG VON (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE[2023/03]
English:PREPARATION OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE[2021/14]
French:PRÉPARATION DE (S)-N-(5-((R)-2-(2,5-DIFLUOROPHÉNYL)PYRROLIDIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE[2023/03]
Former [2021/14]VERFAHREN ZUR HERSTELLUNG VON (S)-N-(5-((R)-2-(2,5-DIFLUORPHENYL)PYRROLIDIN-1-YL)-PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDIN-1-CARBOXAMID UND DESSEN SALZEN
Former [2021/14]PROCÉDÉ DE PRÉPARATION DE (S)-N-(5-((R)-2-(2,5-DIFLUOROPHÉNYL)PYRROLIDIN-1-YL)-PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE -1-CARBOXAMIDE ET DE SES SELS
Examination procedure27.09.2021Amendment by applicant (claims and/or description)
27.09.2021Examination requested  [2021/44]
27.09.2021Date on which the examining division has become responsible
20.01.2023Communication of intention to grant the patent
19.05.2023Fee for grant paid
19.05.2023Fee for publishing/printing paid
19.05.2023Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP17726442.1  / EP3458456
Opposition(s)02.04.2024No opposition filed within time limit [2024/23]
Fees paidRenewal fee
17.11.2020Renewal fee patent year 03
17.11.2020Renewal fee patent year 04
13.05.2021Renewal fee patent year 05
14.03.2022Renewal fee patent year 06
14.03.2023Renewal fee patent year 07
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Lapses during opposition  TooltipSM28.06.2023
GR29.09.2023
[2024/08]
Former [2023/50]GR29.09.2023
Documents cited:Search[AD]WO2010048314  (ARRAY BIOPHARMA INC [US], et al) [AD] 1-12 * page 59 - page 60; examples 14,14A *;
 [XDPI]WO2016077841  (ARRAY BIOPHARMA INC [US], et al) [XDP] 1,5-12 * page 57 - page 65 * * scheme 1 *[I] 1-12
by applicantWO2010048314
    - REVISED AND EXPANDED, Pharmaceutical Dosage Forms: Parenteral Medications, American Pharmaceutical association and the Pharmaceutical Society of Great Britain, vol. 1-2
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.