blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

Italy joins the Federated Register

Click here for more information on the Federated Register.

2025-06-12

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register User Manual
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3908680

EP3908680 - METHODS FOR SCREENING INHIBITORS AGAINST CHIKUNGUNYA VIRUS AND FOR DETERMINING WHETHER SUBJECTS ARE PREDISPOSED TO INFECTION BY SAID VIRUS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  05.01.2024
Database last updated on 28.03.2026
FormerThe patent has been granted
Status updated on  27.01.2023
FormerGrant of patent is intended
Status updated on  11.08.2022
FormerRequest for examination was made
Status updated on  15.10.2021
FormerThe international publication has been made
Status updated on  18.07.2020
Formerunknown
Status updated on  15.01.2020
Most recent event   Tooltip26.12.2025Lapse of the patent in a contracting state
New state(s): TR		published on 28.01.2026  [2026/05]
Applicant(s)For all designated states
Institut National de la Santé et de la Recherche Médicale (INSERM)
101 rue de Tolbiac
75013 Paris / FR
For all designated states
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
3, rue Michel-Ange
75016 Paris / FR
For all designated states
Université Paris Cité
85 boulevard Saint-Germain
75006 Paris / FR
[2022/32]
Former [2021/46]For all designated states
Institut National de la Santé et de la Recherche Médicale (INSERM)
101 rue de Tolbiac
75013 Paris / FR
For all designated states
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
3, rue Michel-Ange
75016 Paris / FR
For all designated states
Université de Paris
85 Boulevard Saint Germain
75006 Paris 6 / FR
Inventor(s)01 / AMARA, Ali
U944 - HOPITAL ST LOUIS
1 Avenue Claude Vellefaux
Bâtiment Jean Bernard
75010 PARIS / FR
02 / MEERTENS, Laurent
U944 - HOPITAL ST LOUIS
1 Avenue Claude Vellefaux
Bâtiment Jean Bernard
75010 PARIS / FR
03 / HAFIRASSOU, Mohamed Lamine
U944 - HOPITAL ST LOUIS
1 Avenue Claude Vellefaux
Bâtiment Jean Bernard
75010 PARIS / FR
 [2023/09]
Former [2021/46]01 / AMARA, Ali
75010 PARIS / FR
02 / MEERTENS, Laurent
75010 PARIS / FR
03 / HAFIRASSOU, Mohamed Lamine
75010 PARIS / FR
Representative(s)Inserm Transfert
PariSanté Campus
10 rue d'Oradour-sur-Glane
75015 Paris / FR
[N/P]
Former [2021/46]Inserm Transfert
7, rue Watt
75013 Paris / FR
Application number, filing date20700162.910.01.2020
[2021/46]
WO2020EP50541
Priority number, dateEP2019030503611.01.2019         Original published format: EP 19305036
EP2019030597824.07.2019         Original published format: EP 19305978
[2021/46]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2020144324
Date:16.07.2020
Language:EN
[2020/29]
Type: A1 Application with search report 
No.:EP3908680
Date:17.11.2021
Language:EN
The application published by WIPO in one of the EPO official languages on 16.07.2020 takes the place of the publication of the European patent application.
[2021/46]
Type: B1 Patent specification 
No.:EP3908680
Date:01.03.2023
Language:EN
[2023/09]
Search report(s)International search report - published on:EP16.07.2020
ClassificationIPC:C12Q1/70, C12N15/10, A61P31/14, G01N33/569
[2021/46]
CPC:
G01N33/56983 (EP); C12Q1/701 (US); A61P31/14 (EP);
C12N15/1055 (EP,US); C12N7/00 (US); C12Q1/70 (EP);
C12Q2600/136 (EP); Y02A50/30 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/46]
Extension statesBANot yet paid
MENot yet paid
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:VERFAHREN ZUM SCREENING VON INHIBITOREN GEGEN DAS CHIKUNGUNYA-VIRUS UND ZUM BESTIMMEN, OB PROBANDEN FÜR EINE INFEKTION MIT DIESEM VIRUS PRÄDISPONIERT SIND[2021/46]
English:METHODS FOR SCREENING INHIBITORS AGAINST CHIKUNGUNYA VIRUS AND FOR DETERMINING WHETHER SUBJECTS ARE PREDISPOSED TO INFECTION BY SAID VIRUS[2021/46]
French:PROCÉDÉS POUR DÉPISTER DES INHIBITEURS CONTRE LE VIRUS DU CHIKUNGUNYA ET POUR DÉTERMINER SI DES SUJETS SONT PRÉDISPOSÉS À UNE INFECTION PAR LEDIT VIRUS[2022/34]
Former [2021/46]PROCÉDÉS POUR CRIBLER DES INHIBITEURS CONTRE LE VIRUS CHIKUNGUNYA ET POUR DÉTERMINER SI DES SUJETS SONT PRÉDISPOSÉS À UNE INFECTION PAR LEDIT VIRUS
Entry into regional phase15.07.2021National basic fee paid 
15.07.2021Designation fee(s) paid 
15.07.2021Examination fee paid 
Examination procedure15.07.2021Examination requested  [2021/46]
15.07.2021Date on which the examining division has become responsible
12.08.2022Communication of intention to grant the patent
07.12.2022Fee for grant paid
07.12.2022Fee for publishing/printing paid
07.12.2022Receipt of the translation of the claim(s)
Opposition(s)04.12.2023No opposition filed within time limit [2024/06]
Fees paidRenewal fee
20.01.2022Renewal fee patent year 03
19.01.2023Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY10.01.2020
HU10.01.2020
AT01.03.2023
BG01.03.2023
CZ01.03.2023
DK01.03.2023
EE01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
MC01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SI01.03.2023
SK01.03.2023
SM01.03.2023
TR01.03.2023
NO01.06.2023
GR02.06.2023
IS01.07.2023
PT03.07.2023
[2026/05]
Former [2025/41]CY10.01.2020
HU10.01.2020
AT01.03.2023
BG01.03.2023
CZ01.03.2023
DK01.03.2023
EE01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
MC01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SI01.03.2023
SK01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
IS01.07.2023
PT03.07.2023
Former [2025/37]CY10.01.2020
AT01.03.2023
BG01.03.2023
CZ01.03.2023
DK01.03.2023
EE01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
MC01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SI01.03.2023
SK01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
IS01.07.2023
PT03.07.2023
Former [2024/51]AT01.03.2023
BG01.03.2023
CZ01.03.2023
DK01.03.2023
EE01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
MC01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SI01.03.2023
SK01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
IS01.07.2023
PT03.07.2023
Former [2024/40]AT01.03.2023
CZ01.03.2023
DK01.03.2023
EE01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
MC01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SI01.03.2023
SK01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
IS01.07.2023
PT03.07.2023
Former [2024/10]AT01.03.2023
CZ01.03.2023
DK01.03.2023
EE01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SI01.03.2023
SK01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
IS01.07.2023
PT03.07.2023
Former [2023/50]AT01.03.2023
CZ01.03.2023
EE01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SK01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
IS01.07.2023
PT03.07.2023
Former [2023/49]AT01.03.2023
CZ01.03.2023
EE01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
NL01.03.2023
PL01.03.2023
RO01.03.2023
RS01.03.2023
SE01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
PT03.07.2023
Former [2023/48]AT01.03.2023
EE01.03.2023
FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
NL01.03.2023
PL01.03.2023
RS01.03.2023
SE01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
PT03.07.2023
Former [2023/46]FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
NL01.03.2023
PL01.03.2023
RS01.03.2023
SE01.03.2023
SM01.03.2023
NO01.06.2023
GR02.06.2023
PT03.07.2023
Former [2023/38]FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
NL01.03.2023
PL01.03.2023
RS01.03.2023
SE01.03.2023
NO01.06.2023
GR02.06.2023
Former [2023/37]FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
RS01.03.2023
SE01.03.2023
NO01.06.2023
GR02.06.2023
Former [2023/36]FI01.03.2023
HR01.03.2023
LT01.03.2023
LV01.03.2023
RS01.03.2023
SE01.03.2023
NO01.06.2023
Former [2023/35]HR01.03.2023
LT01.03.2023
RS01.03.2023
NO01.06.2023
Former [2023/34]LT01.03.2023
RS01.03.2023
Former [2023/33]LT01.03.2023
Cited inInternational search[A]   RATHORE ABHAY P S ET AL: "Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammationin vivo", ANTIVIRAL RESEARCH, vol. 103, 1 August 2018 (2018-08-01) - 13 June 2018 (2018-06-13), pages 7 - 16, XP028615960, ISSN: 0166-3542, DOI: 10.1016/J.ANTIVIRAL.2013.12.010

DOI:   http://dx.doi.org/10.1016/j.antiviral.2013.12.010
 [A]   CHETAN D. MESHRAM ET AL: "ABSTRACT", JOURNAL OF VIROLOGY., vol. 92, no. 16, 13 June 2018 (2018-06-13), US, XP055581299, ISSN: 0022-538X, DOI: 10.1128/JVI.00838-18

DOI:   http://dx.doi.org/10.1128/JVI.00838-18
 [A]   A. MCCABE ET AL: "The Four and a Half LIM Family Members Are Novel Interactants of the Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein", JOURNAL OF VIROLOGY., vol. 87, no. 13, 24 April 2013 (2013-04-24), US, pages 7435 - 7444, XP055581297, ISSN: 0022-538X, DOI: 10.1128/JVI.00070-13

DOI:   http://dx.doi.org/10.1128/JVI.00070-13
 [AP]   MEERTENS LAURENT ET AL: "FHL1 is a major host factor for chikungunya virus infection", NATURE, MACMILLAN JOURNALS LTD, LONDON, vol. 574, no. 7777, 25 September 2019 (2019-09-25), pages 259 - 263, XP036902293, ISSN: 0028-0836, [retrieved on 20190925], DOI: 10.1038/S41586-019-1578-4

DOI:   http://dx.doi.org/10.1038/s41586-019-1578-4
by applicantUS5283173
 US5667973
 US5468614
 US5525490
 US5637463
 US5162508
 EP0203047
 EP0649020
 WO9600901
 EP0450742
 WO0001663
 US6740756
 US60638166
 US60641139
   SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
   NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443
   PEARSONLIPMAN, PROC. NATL. ACAD. SCI. U.S.A., vol. 85, 1988, pages 2444
   HIGGINSSHARP, GENE, vol. 73, 1988, pages 237 - 244
   HIGGINSSHARP, CABIOS, vol. 4, 1989, pages 151 - 153
   CORPET ET AL., NUC. ACIDS RES., vol. 16, 1988, pages 10881 - 10890
   HUANG ET AL., COMP. APPLS BIOSCI., vol. 8, 1992, pages 155 - 165
   PEARSON ET AL., METH. MOL. BIOL., vol. 24, 1994, pages 307 - 31
   ALTSCHUL ET AL., NAT. GENET., vol. 6, 1994, pages 119 - 129
   ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
   GISH.STATES, NATURE GENET., vol. 3, 1993, pages 266 - 272
   MADDEN ET AL., METH. ENZYMOL., vol. 266, 1996, pages 131 - 141
   ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
   ZHANGMADDEN, GENOME RES., vol. 7, 1997, pages 649 - 656
   BURT, F. J. ET AL.: "Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen", LANCET INFECT. DIS., vol. 17, 2017, pages e107 - e117
   SILVA, L. A.DERMODY, T. S.: "Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies", J. CLIN. INVEST., vol. 127, 2017, pages 737 - 749
   WEAVER, S. C.CHARLIER, C.VASILAKIS, N.LECUIT, M.: "Zika, Chikungunya, and Other Emerging Vector-Borne Viral Diseases", ANNU. REV. MED., vol. 69, 2018, pages 395 - 408
   GREENE, W. K.BAKER, E.RABBITTS, T. H.KEES, U. R.: "Genomic structure, tissue expression and chromosomal location of the LIM-only gene, SLIM1", GENE, vol. 232, 1999, pages 203 - 207, XP004167504, DOI: 10.1016/S0378-1119(99)00125-0

DOI:   http://dx.doi.org/10.1016/S0378-1119(99)00125-0
   SCHESSL, J.FELDKIRCHNER, S.KUBNY, C.SCHOSER, B.: "Reducing body myopathy and other FHL1-related muscular disorders", SEMIN. PEDIATR. NEUROL., vol. 18, 2011, pages 257 - 263, XP028339856, DOI: 10.1016/j.spen.2011.10.007

DOI:   http://dx.doi.org/10.1016/j.spen.2011.10.007
   GUENEAU, L. ET AL.: "Mutations of the FHL1 gene cause Emery-Dreifuss muscular dystrophy", AM. J. HUM. GENET., vol. 85, 2009, pages 338 - 353
   OOI, Y. S.STILES, K. M.LIU, C. Y.TAYLOR, G. M.KIELIAN, M.: "Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry", PLOS PATHOG, vol. 9, 2013, pages el003835
   KARLAS, A. ET AL.: "A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs", NAT. COMMUN., vol. 7, 2016, pages 11320
   ZHANG, R. ET AL.: "Mxra8 is a receptor for multiple arthritogenic alphaviruses", NATURE, vol. 557, 2018, pages 570 - 574, XP036511176, DOI: 10.1038/s41586-018-0121-3

DOI:   http://dx.doi.org/10.1038/s41586-018-0121-3
   TANAKA, A. ET AL.: "Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection", J. VIROL., vol. 91, 2017
   SHALEM, O. ET AL.: "Genome-scale CRISPR-Cas9 knockout screening in human cells", SCIENCE, vol. 343, 2014, pages 84 - 87, XP055115506, DOI: 10.1126/science.1247005

DOI:   http://dx.doi.org/10.1126/science.1247005
   SCHUFFENECKER, I. ET AL.: "Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak", PLOS MED., vol. 3, 2006, pages e263, XP002543036, DOI: 10.1371/journal.pmed.0030263

DOI:   http://dx.doi.org/10.1371/journal.pmed.0030263
   LI, W. ET AL.: "MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens", GENOME BIOL., vol. 15, 2014, pages 554, XP021208793, DOI: 10.1186/s13059-014-0554-4

DOI:   http://dx.doi.org/10.1186/s13059-014-0554-4
   SHATHASIVAM, T.KISLINGER, T.GRAMOLINI, A. O.: "Genes, proteins and complexes: the multifaceted nature of FHL family proteins in diverse tissues", J. CELL. MOL. MED., vol. 14, 2010, pages 2702 - 2720
   BROWN, S. ET AL.: "Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1. Localization of SLIM1 at focal adhesions and the isoform slimmer in the nucleus of myoblasts and cytoplasm of myotubes suggests distinct roles in the cytoskeleton and in nuclear-cytoplasmic communication", J. BIOL. CHEM., vol. 274, 1999, pages 27083 - 27091
   KREMPLER, A.KOLLERS, S.FRIES, R.BRENIG, B.: "Isolation and characterization of a new FHL1 variant (FHL1C) from porcine skeletal muscle", CYTOGENET. CELL GENET., vol. 90, 2000, pages 106 - 114
   PEN, A. E. ET AL.: "A novel single nucleotide splice site mutation in FHL1 confirms an Emery-Dreifuss plus phenotype with pulmonary artery hypoplasia and facial dysmorphology", EUR. J. MED. GENET., vol. 58, 2015, pages 222 - 229, XP029590714, DOI: 10.1016/j.ejmg.2015.02.003

DOI:   http://dx.doi.org/10.1016/j.ejmg.2015.02.003
   CHAN, K. K. ET AL.: "Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart", GENE, vol. 210, 1998, pages 345 - 350, XP004118187, DOI: 10.1016/S0378-1119(97)00644-6

DOI:   http://dx.doi.org/10.1016/S0378-1119(97)00644-6
   REZZA, G.CHEN, R.WEAVER, S. C.: "O'nyong-nyong fever: a neglected mosquito-borne viral disease", PATHOG. GLOB. HEALTH, vol. 111, 2017, pages 271 - 275
   COUDERC, T. ET AL.: "A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease", PLOS PATHOG., vol. 4, 2008, pages e29
   ROBERTS, G. C. ET AL.: "Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research", SCI. REP., vol. 7, 2017, pages 14641
   SCHOLTE, F. E. M. ET AL.: "Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication", J. VIROL., vol. 89, 2015, pages 4457 - 4469
   KIM, D. Y. ET AL.: "New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes", PLOS PATHOG., vol. 12, 2016, pages e1005810
   JOSE, J.TAYLOR, A. B.KUHN, R. J.: "Spatial and Temporal Analysis of Alphavirus Replication and Assembly in Mammalian and Mosquito Cells", MBIO, vol. 8, 2017, pages 1 - 16
   GOTTE, B.LIU, L.MCINERNEY, G. M.: "The Enigmatic Alphavirus Non-Structural Protein 3 (nsP3) Revealing Its Secrets at Last", VIRUSES, vol. 10, 2018, pages 1 - 26
   MESHRAM, C. D. ET AL.: "Multiple Host Factors Interact with Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode", J. VIROL., 2018
   MUTSO, M. ET AL.: "Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus", VIRUSES, vol. 10, 2018
   SCHESSL, J. ET AL.: "Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy", J. CLIN. INVEST., vol. 118, 2008, pages 904 - 912
   BONNE, G.LETURCQ, F.BEN YAOU, R. ET AL.: "GeneReviews@", 1993, UNIVERSITY OF WASHINGTON, article "Emery-Dreifuss Muscular Dystrophy"
   FROLOV, I.KIM, D. Y.AKHRYMUK, M.MOBLEY, J. A.FROLOVA, E. I.: "Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex Assembly", J. VIROL., vol. 91, pages 2017
   UVERSKY, V. N.: "Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder", CURR. OPIN. STRUCT. BIOL., vol. 44, 2017, pages 18 - 30, XP085125621, DOI: 10.1016/j.sbi.2016.10.015

DOI:   http://dx.doi.org/10.1016/j.sbi.2016.10.015
   NIKOLIC, J. ET AL.: "Negri bodies are viral factories with properties of liquid organelles", NAT. COMMUN., vol. 8, 2017, pages 58
   FROS, J. J. ET AL.: "Chikungunya Virus nsP3 Blocks Stress Granule Assembly by Recruitment of G3BP into Cytoplasmic Foci", J. VIROL., vol. 86, 2012, pages 10873 - 10879
   REMENYI, R. ET AL.: "Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3", J. VIROL., vol. 92, 2018
   KADRMAS, J. L.BECKERLE, M. C.: "The LIM domain: from the cytoskeleton to the nucleus", NAT. REV. MOL. CELL BIOL., vol. 5, 2004, pages 920 - 931
   SHEIKH, F. ET AL.: "An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice", J. CLIN. INVEST., vol. 118, 2008, pages 3870 - 3880
   RASKIN, A. ET AL.: "A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics", J. BIOL. CHEM., vol. 287, 2012, pages 29273 - 29284
   MEDINA, F. ET AL.: "Curr. Protoc. Microbiol.", 2012, article "Dengue virus: isolation, propagation, quantification, and storage"
   MEERTENS, L. ET AL.: "The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry", CELL HOST MICROBE, vol. 12, 2012, pages 544 - 557
   JOUNG, J. ET AL.: "Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening", NAT. PROTOC., vol. 12, 2017, pages 828 - 863
   PELLET, J. ET AL.: "ViralORFeome: an integrated database to generate a versatile collection of viral ORFs", NUCLEIC ACIDS RES., vol. 38, 2010, pages D371 - 378
   GLASKER, S. ET AL.: "Virus replicon particle based Chikungunya virus neutralization assay using Gaussia luciferase as readout", VIROL. J., vol. 10, 2013, pages 235, XP021156951, DOI: 10.1186/1743-422X-10-235

DOI:   http://dx.doi.org/10.1186/1743-422X-10-235
   KUMMERER, B. M.GRYWNA, K.GLASKER, S.WIESELER, J.DROSTEN, C.: "Construction of an infectious Chikungunya virus cDNA clone and stable insertion of mCherry reporter genes at two different sites", J. GEN. VIROL., vol. 93, 2012, pages 1991 - 1995
   PLASKON, N. E.ADELMAN, Z. N.MYLES, K. M.: "Accurate strand-specific quantification of viral RNA", PLOS ONE, vol. 4, 2009, pages e7468
   DOMENIGHETTI, A. A. ET AL.: "Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice", HUM. MOL. GENET., vol. 23, 2014, pages 209 - 225, XP055444530, DOI: 10.1093/hmg/ddt412

DOI:   http://dx.doi.org/10.1093/hmg/ddt412
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.