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EP About this file: EP3966219

EP3966219 - CONVERGENT LIQUID PHASE SYNTHESES OF OLIGONUCLEOTIDES [Right-click to bookmark this link]
Status	Request for examination was made Status updated on 11.02.2022 Database last updated on 16.09.2024
Former	The international publication has been made Status updated on 14.11.2020
Former	unknown Status updated on 08.06.2020
Most recent event Tooltip	21.05.2024	New entry: Renewal fee paid
Applicant(s)	For all designated states Biogen MA Inc. 225 Binney Street Cambridge, MA 02142 / US
	For all designated states AJINOMOTO CO., INC. 15-1, Kyobashi 1-chome Chuo-ku Tokyo 104-8315 / JP
	[2022/11]
Inventor(s)	01 / SHI, Xianglin c/o Biogen MA Inc. 225 Binney Street Cambridge, MA 02142 / US
	02 / KIESMAN, William, F. c/o Biogen MA Inc. 225 Binney Street Cambridge, MA 02142 / US
	03 / ANTIA, Firoz c/o Biogen MA Inc. 225 Binney Street Cambridge, MA 02142 / US
	04 / FILLON, Yannick c/o Biogen MA Inc. 225 Binney Street Cambridge, MA 02142 / US
	05 / ZHOU, Xuan c/o Biogen MA Inc. 225 Binney Street Cambridge, MA 02142 / US
	06 / YAN, Wuming c/o Biogen MA Inc. 225 Binney Street Cambridge, MA 02142 / US
	07 / JIANG, Hong c/o Biogen MA Inc. 225 Binney Street Cambridge, MA 02142 / US
	08 / NGUYEN, Hien c/o Biogen MA Inc. 225 Binney Street Cambridge, MA 02142 / US
	09 / GRONKE, Robert, S. c/o Biogen MA Inc. 225 Binney Street Cambridge, MA 02142 / US
	10 / ICHIMARU, Taisuke c/o Research Institute For Bioscience Products Fine Chemicals AJINOMOTO Co., Inc. Suzuki-cho, Kawasaki-ku Kawasaki, 210--8681 / JP
	11 / HAMAGAKI, Takuya c/o Research Institute For Bioscience Products Fine Chemicals AJINOMOTO Co., Inc. Suzuki-cho, Kawasaki-ku Kawasaki, 210--8681 / JP
	12 / TAKAHASHI, Daisuke c/o Research Institute For Bioscience Products Fine Chemicals AJINOMOTO Co., Inc. Suzuki-cho, Kawasaki-ku Kawasaki, 210--8681 / JP
	[2022/11]
Representative(s)	HGF HGF Limited 1 City Walk Leeds LS11 9DX / GB
	[2022/11]
Application number, filing date	20729413.3	08.05.2020
	[2022/11]
	WO2020US32070
Priority number, date	US201962845160P	08.05.2019 Original published format: US 201962845160 P
	[2022/11]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO2020227618
	Date:	12.11.2020
	Language:	EN
	[2020/46]
	Type:	A2 Application without search report
	No.:	EP3966219
	Date:	16.03.2022
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 12.11.2020 takes the place of the publication of the European patent application.
	[2022/11]
Search report(s)	International search report - published on:	EP	14.01.2021
Classification	IPC:	C07H1/00, C07H1/02, C07H21/00	[2022/11]
	CPC:	C07H1/00 (EP,CN,IL,KR); C07H21/00 (EP,CN,IL,KR); C07H1/02 (EP,CN,IL,US); C07H21/02 (CN,US); C07H21/04 (CN)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2022/11]
Extension states	BA	06.12.2021
	ME	06.12.2021
Validation states	KH	06.12.2021
	MA	06.12.2021
	MD	06.12.2021
	TN	06.12.2021
Title	German:	KONVERGENTE FLÜSSIGPHASENSYNTHESE VON OLIGONUKLEOTIDEN	[2022/11]
	English:	CONVERGENT LIQUID PHASE SYNTHESES OF OLIGONUCLEOTIDES	[2022/11]
	French:	SYNTHÈSES EN PHASE LIQUIDE CONVERGENTE D'OLIGONUCLÉOTIDES	[2022/11]
Entry into regional phase	06.12.2021	National basic fee paid
	06.12.2021	Designation fee(s) paid
	06.12.2021	Examination fee paid
Examination procedure	06.12.2021	Examination requested [2022/11]
	06.12.2021	Date on which the examining division has become responsible
	14.07.2022	Amendment by applicant (claims and/or description)
	04.08.2022	Observations by third parties
	14.09.2022	Observations by third parties
Fees paid	Renewal fee
	18.03.2022	Renewal fee patent year 03
	23.05.2023	Renewal fee patent year 04
	21.05.2024	Renewal fee patent year 05
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[A]EP0558749 (SANKYO CO [JP]) [A] 1-19,70-104,141-148;
		[A]US2013267697 (HIRAI KUNIHIRO [JP], et al) [A] 1-19,70-104,141-148;
		[A]EP2711370 (AJINOMOTO KK [JP]) [A] 1-19,70-104,141-148;
		[A]EP2857412 (HOKKAIDO SYSTEM SCIENCE CO LTD [JP]) [A] 1-19,70-104,141-148;
		[A]US2018291056 (YAMASHITA KEN [JP], et al) [A] 1-19,70-104,141-148;
		[A]EP3398955 (AJINOMOTO KK [JP]) [A] 1-19,70-104,141-148;
		[A] - SHOKAKU KIM ET AL, "Liquid-Phase RNA Synthesis by Using Alkyl-Chain-Soluble Support", CHEMISTRY - A EUROPEAN JOURNAL, (20130624), vol. 19, no. 26, doi:10.1002/chem.201300655, ISSN 0947-6539, pages 8615 - 8620, XP055211240 [A] 1-19,70-104,141-148 DOI: http://dx.doi.org/10.1002/chem.201300655
		[A] - CHIH-HAU CHEN ET AL, "Convergent Solution Phase Synthesis of Chimeric Oligonucleotides by a 2+2 and 3+3 Phosphoramidite Strategy", AUSTRALIAN JOURNAL OF CHEMISTRY, AU, (20100226), vol. 63, no. 2, doi:10.1071/CH09298, ISSN 0004-9425, pages 227 - 235, XP055648558 [A] 1-19,70-104,141-148 DOI: http://dx.doi.org/10.1071/CH09298
		[A] - G. M. BONORA ET AL, "A Liquid-Phase Process Suitable for Large-Scale Synthesis of Phosphorothioate Oligonucleotides", ORGANIC PROCESS RESEARCH & DEVELOPMENT, US, (20000501), vol. 4, no. 3, doi:10.1021/op990096l, ISSN 1083-6160, pages 225 - 231, XP055399708 [A] 1-19,70-104,141-148 DOI: http://dx.doi.org/10.1021/op990096l
		[A] - HERDERING WILHELM ET AL, "Phosphoramidites of Chiral (Rp)-and (Sp)-Configurated d(T[P-18O]-A): Synthesis, Configurational Assignment, and Use as Dimer Blocks in Oligonucleotide Synthesis", vol. 68, no. 8, doi:10.1002/HLCA.19850680805, ISSN 0018-019X, (19851218), pages 2119 - 2127, HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA, URL: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhlca.19850680805, (20041025), XP009504367 [A] 1-19,70-104,141-148 DOI: http://dx.doi.org/10.1002/hlca.19850680805
	by applicant	WO2007002390
		WO2010148249
		US8980853
		WO2015153800
		- Nat Biotechnol., (20170900), vol. 35, no. 9, pages 845 - 851
		- J. Org. Chem., (19990000), vol. 64, pages 7515 - 7522
		- Biopolymers (Peptide Science), (20010000), vol. 60, page 3
		- K.W. KNOUSEJ. N. DEGRUYTERM.A. SCHMIDT et al., Science, (20180000), vol. 361, no. 6408, pages 1234 - 1238
	other	US2013267697
		US2018291056
		EP3398955
		- Kierzek R., Ito H., Bhatt R., Itakura K., "Selective N-deacylation of N,O-protected nucleosides by zinc bromide", Tetrahedron Letters, Elsevier, Amsterdam , NL, Amsterdam , NL , (19810101), vol. 22, no. 38, doi:10.1016/S0040-4039(01)82014-1, ISSN 0040-4039, pages 3761 - 3764, XP055955636 DOI: http://dx.doi.org/10.1016/S0040-4039(01)82014-1
		- S. BERNARDINI et al., "58. Nucleosides and Nucleotides. Part 21. Synthesis of a Tridecanucleoside Dodecaphosphate Incorporating the Unnatural Base 2(1H)-Pyridone", Helvetica Chimica Acta, (19830000), vol. 66, doi:10.1002/hlca.19830660226, pages 639 - 651, XP009051017 DOI: http://dx.doi.org/10.1002/hlca.19830660226

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